This paper is based on the use of recurrent neural networks and LSTM deep neural networks to obtain the financial risk prediction feature sequence in the context of big data. The financial risk ...prediction feature sequence is used as the input value of the input gate of the LSTM deep neural network model after data filtering, normalization and loss function optimization, and then the financial risk prediction for the output gate of the LSTM deep neural network model. Considering the availability of data, small and medium-sized enterprises listed in A-share companies in the Wind database are selected as sample enterprises, and evaluation indexes are constructed and detected at the same time so as to complete the experimental design of enterprise financial risk prediction in the context of big data. The prediction of enterprise financial risk is empirically analyzed using simulation analysis and statistical analysis. The results show that in the model performance analysis, the average value of ten years of data, the highest value is still the result obtained by LSTM training, 0.761, compared with other models of LSTM deep neural network in static financial risk prediction in the overall best performance. In the case study of Yibai Pharmaceutical, the minimum value of the rate of return, return on total assets, and return on assets were -10.02%, 2.56%, -20.72%, which reflects the fact that the private enterprises still have large profitability space to be mined. This study helps investors or financial institutions such as funds to find out the possible financial risk crisis of listed companies as early as possible to avoid the parties from incurring large financial losses.
Abstract
As a major source of protein in human diets, pig meat plays a crucial role in ensuring global food security. Key determinants of meat production refer to the chemical and physical ...compositions or characteristics of muscle fibers, such as the number, hypertrophy potential, fiber‐type conversion and intramuscular fat deposition. However, the growth and formation of muscle fibers comprises a complex process under spatio‐temporal regulation, that is, the intermingled and concomitant proliferation, differentiation, migration and fusion of myoblasts. Recently, with the fast and continuous development of next‐generation sequencing technology, the integration of quantitative trait loci mapping with genome‐wide association studies (GWAS) has greatly helped animal geneticists to discover and explore thousands of functional or causal genetic elements underlying muscle growth and development. However, owing to the underlying complex molecular mechanisms, challenges to in‐depth understanding and utilization remain, and the cost of large‐scale sequencing, which requires integrated analyses of high‐throughput omics data, is high. In this review, we mainly elaborate on research advances in integrative analyses (e.g. GWAS, omics) for identifying functional genes or genomic elements for longissimus dorsi muscle growth and development for different pig breeds, describing several successful transcriptome analyses and functional genomics cases, in an attempt to provide some perspective on the future functional annotation of genetic elements for muscle growth and development in pigs.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
The evolution of increased competitive ability (EICA) hypothesis and the novel weapons hypothesis (NWH) are two non-mutually exclusive mechanisms for exotic plant invasions, but few studies have ...simultaneously tested these hypotheses. Here we aimed to integrate them in the context of Chromolaena odorata invasion.
We conducted two common garden experiments in order to test the EICA hypothesis, and two laboratory experiments in order to test the NWH.
In common conditions, C. odorata plants from the nonnative range were better competitors but not larger than plants from the native range, either with or without the experimental manipulation of consumers. Chromolaena odorata plants from the nonnative range were more poorly defended against aboveground herbivores but better defended against soilborne enemies. Chromolaena odorata plants from the nonnative range produced more odoratin (Eupatorium) (a unique compound of C. odorata with both allelopathic and defensive activities) and elicited stronger allelopathic effects on species native to China, the nonnative range of the invader, than on natives of Mexico, the native range of the invader.
Our results suggest that invasive plants may evolve increased competitive ability after being introduced by increasing the production of novel allelochemicals, potentially in response to naïve competitors and new enemy regimes.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NMLJ, NUK, OILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK
Cancer‐associated fibroblasts (CAFs) play crucial roles in tumor progression, given the dependence of cancer cells on stromal support. Therefore, understanding how CAFs communicate with endometrial ...cancer cell in tumor environment is important for endometrial cancer therapy. Exosomes, which contain proteins and noncoding RNA, are identified as an important mediator of cell–cell communication. However, the function of exosomes in endometrial cancer metastasis remains poorly understood. In the current study we found that CAF‐derived exosomes significantly promoted endometrial cancer cell invasion comparing to those from normal fibroblasts (NFs). We identified a significant decrease of miR‐148b in CAFs and CAFs‐derived exosomes. By exogenously transfect microRNAs, we demonstrated that miR‐148b could be transferred from CAFs to endometrial cancer cell through exosomes. In vitro and in vivo studies further revealed that miR‐148b functioned as a tumor suppressor by directly binding to its downstream target gene, DNMT1 to suppress endometrial cancer metastasis. In endometrial cancer DNMT1 presented a potential role in enhancing cancer cell metastasis by inducing epithelial–mesenchymal transition (EMT). Therefore, downregulated miR‐148b induced EMT of endometrial cancer cell as a result of relieving the suppression of DNMT1. Taken together, these results suggest that CAFs‐mediated endometrial cancer progression is partially related to the loss of miR‐148b in the exosomes of CAFs and promoting the transfer of stromal cell‐derived miR‐148b might be a potential treatment to prevent endometrial cancer progression.
miR‐148b promotes endometrial cancer cell invasion and metastasis
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Salinity and drought are major environmental factors limiting the growth and productivity of alfalfa worldwide as this economically important legume forage is sensitive to these kinds of abiotic ...stress. In this study, transgenic alfalfa lines expressing both tonoplast NXH and H⁺‐PPase genes, ZxNHX and ZxVP1‐1 from the xerophyte Zygophyllum xanthoxylum L., were produced via Agrobacterium tumefaciens‐mediated transformation. Compared with wild‐type (WT) plants, transgenic alfalfa plants co‐expressing ZxNHX and ZxVP1‐1 grew better with greater plant height and dry mass under normal or stress conditions (NaCl or water‐deficit) in the greenhouse. The growth performance of transgenic alfalfa plants was associated with more Na⁺, K⁺ and Ca²⁺ accumulation in leaves and roots, as a result of co‐expression of ZxNHX and ZxVP1‐1. Cation accumulation contributed to maintaining intracellular ions homoeostasis and osmoregulation of plants and thus conferred higher leaf relative water content and greater photosynthesis capacity in transgenic plants compared to WT when subjected to NaCl or water‐deficit stress. Furthermore, the transgenic alfalfa co‐expressing ZxNHX and ZxVP1‐1 also grew faster than WT plants under field conditions, and most importantly, exhibited enhanced photosynthesis capacity by maintaining higher net photosynthetic rate, stomatal conductance, and water‐use efficiency than WT plants. Our results indicate that co‐expression of tonoplast NHX and H⁺‐PPase genes from a xerophyte significantly improved the growth of alfalfa, and enhanced its tolerance to high salinity and drought. This study laid a solid basis for reclaiming and restoring saline and arid marginal lands as well as improving forage yield in northern China.
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BFBNIB, DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
The Kampmann–Wagner numerical (KWN) model, which has been widely adopted as a precipitation modeling framework accounting for concurrent nucleation, growth and coarsening kinetics, was extended to ...predict the as-cast grain size of inoculated multicomponent aluminum alloys. In the model, the heterogeneous nucleation of grains on inoculant particles was modeled based on the free growth criterion, while the influence of the solute on the nucleation behavior, in terms of the solute suppressed nucleation (SSN) effect, was rigorously defined and integrated. In order to fully address the solidification behavior of multicomponent alloys, a coupling of the KWN model to CALPHAD was carried out. These extensions allow the treatment of two different nucleation-ceasing mechanisms induced by grain growth: recalescence stifling and solute segregation stifling. Given melt composition, inoculation and heat extraction rate, the model is able to predict maximum nucleation undercooling, cooling curve and the final as-cast grain size of multicomponent alloys without invoking the binary equivalence assumption used in the existing models. The proposed model was tested with a variety of binary and multicomponent aluminum alloys, and the predictions were compared with the experimental measurement results and previous grain size prediction models. The simulation results show that the SSN effect has a negligible influence on the nucleation behavior and the final grain size during isothermal melt solidification, but a strong influence on the ceasing of grain nucleation during directional solidification. Reasonable agreement was obtained between the model prediction and measurement results on a direct chill casting experiment of an AA5182 alloy. Our work proves that the application of the precipitation modeling framework for the solidification problem is successful.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Metabolic engineering of Saccharomyces cerevisiae for high‐level production of aromatic chemicals has received increasing attention in recent years. Tyrosol production from glucose by S. cerevisiae ...is considered an environmentally sustainable and safe approach. However, the production of tyrosol and salidroside by engineered S. cerevisiae has been reported to be lower than 2 g/L to date. In this study, S. cerevisiae was engineered with a push‐pull‐restrain strategy to efficiently produce tyrosol and salidroside from glucose. The biosynthetic pathways of ethanol, phenylalanine, and tryptophan were restrained by disrupting PDC1, PHA2, and TRP3. Subsequently, tyrosol biosynthesis was enhanced with a metabolic pull strategy of introducing PcAAS and EcTyrAM53I/A354V. Moreover, a metabolic push strategy was implemented with the heterologous expression of phosphoketolase (Xfpk), and then erythrose 4‐phosphate was synthesized simultaneously by two pathways, the Xfpk‐based pathway and the pentose phosphate pathway, in S. cerevisiae. Furthermore, the heterologous expression of Xfpk alone in S. cerevisiae efficiently improved tyrosol production compared with the coexpression of Xfpk and phosphotransacetylase. Finally, the tyrosol yield increased by approximately 135‐folds, compared with that of parent strain. The total amount of tyrosol and salidroside with glucose fed‐batch fermentation was over 10 g/L and reached levels suitable for large‐scale production.
Highest production of tyrosol and salidroside, obtained via introducing the Xfpk‐based pathway into S. cerevisiae, can pave a green, efficient and sustainable way for large‐scale production of tyrosol and salidroside.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Abstract
Long non-coding RNAs (lncRNAs) have significant functions in a wide range of important biological processes. Although the number of known human lncRNAs has dramatically increased, they are ...poorly annotated, posing great challenges for better understanding their functional significance and elucidating their complex functioning molecular mechanisms. Here, we present LncBook (http://bigd.big.ac.cn/lncbook), a curated knowledgebase of human lncRNAs that features a comprehensive collection of human lncRNAs and systematic curation of lncRNAs by multi-omics data integration, functional annotation and disease association. In the present version, LncBook houses a large number of 270 044 lncRNAs and includes 1867 featured lncRNAs with 3762 lncRNA–function associations. It also integrates an abundance of multi-omics data from expression, methylation, genome variation and lncRNA–miRNA interaction. Also, LncBook incorporates 3772 experimentally validated lncRNA-disease associations and further identifies a total of 97 998 lncRNAs that are putatively disease-associated. Collectively, LncBook is dedicated to the integration and curation of human lncRNAs as well as their associated data and thus bears great promise to serve as a valuable knowledgebase for worldwide research communities.
Thermal evaporation can significantly facilitate scalable, uniform, and conformal perovskite film, particularly well‐suited for the preparation of perovskite/silicon (Si) tandem solar cells . ...However, the perovskite material easily induces a phase transition from a photoactive phase to a photoinactive phase, limiting the development of the stability and efficiency of tandem cells. Introducing lead chloride (PbCl2) into wide‐bandgap perovskite materials is beneficial for the fabrication of efficient and stable light‐absorbing materials, but the microscopic mechanism of the effect of PbCl2 on perovskite is still unclear. The study here reports evidences that the addition of PbCl2 to improve perovskite film stability and optoelectronic performance is due to the minor octahedral tilting of the perovskite structure are reported. It also demonstrates that this strategy accelerates interfacial charge transfer and carrier diffusion in the perovskite bulk and heterojunction interfaces. Therefore, the wide‐bandgap perovskite solar cells (PSCs) prepared by adding PbCl2 exhibit a champion power conversion efficiency (PCE) of 17.80%. The PSCs retain 97% of their performance following 200 h of operation at the maximum power point under full 1‐sun illumination. Finally, monolithic perovskite/Si tandem cells with record PCEs of 27.43% and an open‐circuit voltage of 1.817 V are fabricated.
Lead chloride (PbCl2) is introduced into the co‐evaporated (Cs, FA)Pb(I, Br)3, which has significantly enhanced the structural stability of perovskite and accelerated interfacial charge transfer and carrier diffusion by inducing minor octahedral tilting and improving the crystallinity. Consequently, fully evaporated perovskite/silicon tandem solar cells have achieved a power conversion efficiency of 27.43% with an open‐circuit voltage of 1.810 V.
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In order to quantify the site‐dependent correlation strengths in terms of the quasi‐particle weights and the occupation numbers of 5f electrons in alpha phase plutonium metal with eight ...crystallographically nonequivalent atomic sites Pun (n = 1–8), we perform a first principles calculation by using a many‐body method merging density functional theory with dynamical mean‐field theory plus the relativistic and correlation effects. The quasi‐particle weight, the electronic spectrum function, the hybridization function, as well as the occupation number of Pu 5f electrons all suggest that Pu1 and Pu8 atoms have the most itinerant and the most localized 5f electrons, respectively, while the other atoms Pun (n = 2–7) exhibit an intermediate correlation strength. The quasi‐particle weights demonstrate that only the jj or intermediate coupling scheme is more appropriate for Pu 5f electrons in comparison with the Russel–Saunders (LS) scheme. The electronic spectrum function and the occupation analysis establish that Pu 5f electrons simultaneously have dual itinerant and localized regimes with average 5f occupation numbers of n5f between 4.8994 and 4.9628, which are mainly composed of 5f4, 5f5, and 5f6 configurations, irrespective of different atomic sites. Finally, we also estimate the so‐called quasi‐particle band structure to directly compare with angle‐resolved photoemission spectrum.
DFT+DMFT calculations on alpha (α) phase plutonium (Pu) metal demonstrates that Pu1 and Pu8 atoms have the most itinerant and the most localized 5f electrons, respectively. Pu 5f electrons simultaneously have dual itinerant and localized regimes with average 5f occupation numbers of n5f between 4.8994 and 4.9628 in α‐Pu. The dual feature of 5f electrons allows us to modulate the physical/chemical properties of Pu‐based systems in terms of the external/internal factors.
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