In order to achieve drug targeting and controlled release, we have successfully developed a novel drug release system DOX/AuNCs-PM-HA with gold nanocages (AuNCs) as photothermal cores, thermally ...responsive copolymer P(NIPAM-co-Am) (PM) as the near-infrared (NIR) stimuli gatekeeper and hyaluronic acid as a targeting ligand as well as a capping agent.
Cell uptake and cell viability were investigated. In vivo photoacoustic tomography imaging in H22 tumor bearing mice was analyzed for the tumor targeting effect of the nanocomplexes. Antitumor efficacy and the tissue distribution in vivo were investigated.
In vitro results demonstrated that the DOX/AuNCs-PM-HA had significant anticancer activity against SMMC-7721 cells under NIR irradiation. Furthermore, in vivo photoacoustic tomography imaging of the nanocomplexes in H22 tumor bearing mice could indicate effective tumor targeting. Our studies on antitumor efficacy and the tissue distribution in vivo showed that many DOX/AuNCs-PM-HA nanocomplexes could efficiently accumulate at the tumor site so that they could inhibit the tumor growth effectively with limited side effects. The in vitro and in vivo results confirmed that the tumor-targeting and controlled-release drug system DOX/AuNCs-PM-HA with the combination of chemotherapy and photothermal therapy showed strong anti-tumor effect and would have great potential for future cancer therapy.
This tumor targeting DOX/AuNCs-PM-HA nanocomplex responded not only to the external stimuli of NIR, but also the internal stimuli of hyaluronidase, providing the potential for pinpointed and multi-stimuli responsive intracellular drug release.
In magnetic topological insulators (TIs), the interplay between magnetic order and nontrivial topology can induce fascinating topological quantum phenomena, such as the quantum anomalous Hall effect, ...chiral Majorana fermions and axion electrodynamics. Recently, a great deal of attention has been focused on the intrinsic magnetic TIs, where disorder effects can be eliminated to a large extent, which is expected to facilitate the emergence of topological quantum phenomena. In despite of intensive efforts, experimental evidence of the topological surface states (SSs) remains elusive. Here, by combining first-principles calculations and angle-resolved photoemission spectroscopy (ARPES) experiments, we have revealed that EuSn2As2 is an antiferromagnetic TI with observation of Dirac SSs consistent with our prediction. We also observe nearly gapless Dirac SSs in antiferromagnetic TIs MnBi2nTe3n+1 (n = 1 and 2), which were absent in previous ARPES results. These results provide clear evidence for nontrivial topology of these intrinsic magnetic TIs. Furthermore, we find that the topological SSs show no observable changes across the magnetic transition within the experimental resolution, indicating that the magnetic order has quite small effect on the topological SSs, which can be attributed to weak hybridization between the localized magnetic moments, from either 4f or 3d orbitals, and the topological electronic states. This provides insights for further research that the correlations between magnetism and topological states need to be strengthened to induce larger gaps in the topological SSs, which will facilitate the realization of topological quantum phenomena at higher temperatures.
Spark model for 1100kV GIS disconnecting switch Zheng Ji-ling; Zhan Hua-mao; Duan shao-feng ...
2011 1st International Conference on Electric Power Equipment - Switching Technology,
2011-Oct.
Conference Proceeding
In order to make the VFTO simulation more accurate, the spark characteristic of disconnecting switch and modeling is studied. The experimental circuit of the 1100kV GIS is simulated, and according to ...various computing resistance formulas of spark channels, the spark generated by disconnecting switch operation is modeled. The simulated voltage waveforms of the load side are compared with the measurement results. The simulated VFTO is obtained when different disconnecting switch spark models are adopted, with low-frequency oscillations of 200 kHz and 6 MHz, high-frequency of 36 MHz and 56 MHz, and the frequency range is basically consistent with the experimental results. The circuit oscillation frequency is mainly the same compared to different high-frequency decay rate with different spark models. The comparison shows that the simulated voltage waveforms of the load side match the experimental data better than others when Kushner model is adopted. However, the high-frequency attenuation rate of the simulated voltage at the load side is slower than that of the measuring voltage when Kushner model is used. Therefore, further developments in Kushner model are needed in order to reproduce with better accuracy the dynamic behavior of the disconnecting switch spark resistance.
In magnetic topological insulators (TIs), the interplay between magnetic order and nontrivial topology can induce fascinating topological quantum phenomena, such as the quantum anomalous Hall effect, ...chiral Majorana fermions, and axion electrodynamics. Recently, a great deal of attention has been focused on the intrinsic magnetic TIs, where disorder effects can be eliminated to a large extent, which is expected to facilitate the emergence of topological quantum phenomena. Despite intensive efforts, experimental evidence of the topological surface states (SSs) remains elusive. Here, by combining first-principles calculations and angle-resolved photoemission spectroscopy (ARPES) experiments, we reveal that EuSn_{2}As_{2} is an antiferromagnetic TI with the observation of Dirac SSs consistent with our prediction. We also observe nearly gapless Dirac SSs in antiferromagnetic TIs MnBi_{2n}Te_{3n+1} (n=1 and 2), which are absent in previous ARPES results. These results provide clear evidence for nontrivial topology of these intrinsic magnetic TIs. Furthermore, we find that the topological SSs show no observable changes across the magnetic transition within the experimental resolution, indicating that the magnetic order has a quite small effect on the topological SSs, which can be attributed to weak hybridization between the localized magnetic moments, from either 4f or 3d orbitals, and the topological electronic states. This finding provides insights for further research that the correlations between magnetism and topological states need to be strengthened to induce larger gaps in the topological SSs, which will facilitate the realization of topological quantum phenomena at higher temperatures.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UL, UM, UPUK
A stable HMG-CoA reductase （HMGR） reaction in vitro was developed by a sensitive, selective and precise liquid chromatography-tandem mass spectrometry （LC-MS/MS） method. The optimized enzyme reaction ...condition contained 1.5 lag of HMGR, 20 nM of NADPH with 50 rain of reaction time. The method was validated by several intraand inter-day assays. The production transitions of m/z 147.0/59.1 and m/z 154.0/59.1 were used to detect and quantify mevalonolactone （MVAL） and MVAL-DT, respectively. The accuracy and precision of the method were evaluated over the concentration range of 0.005- 1.000 lag/mL for MVAL and 0.010-0.500 lag/mL for lovastatin acid in three validation batch runs. The lower limit of quantitation was found to be 0.005 lag/mL for MVAL and 0.010 lag/mL for lovastatin acid. Intra-day and inter-day precision ranged from 0.95% to 2.39% and 2.26% to 3.38% for MVAL, 1.46% to 3.89% and 0.57% to 5.10% for lovastatin acid, respectively. The results showed that the active ingredients in Xuezhikang capsules were 12.2 and 14.5 mg/g, respectively. This assay method could be successfully anDlied to the oualitv control study of Xuezhikanu caosule for the first time.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
We offer an intrinsic theoretical framework to reveal the inner relationships among three theories for Euler characteristic number, including Gauss Bonnet-Chern theorem, Hop-Poincaré theorem and ...Morse theory. Moreover, we consider the Gauss Bonnet-Chern （GBC） form imbedded in arbitrary higher-dimensional manifold, which suggests a Hodge dual tensor current. We show the brane structure inherent in the GBC tensor current and obtain the generalized Nambu action for the multi branes with quantized topological charge.
A series of new monomeric rare-earth alkoxides (1–6) was successfully synthesized by a one-pot reaction of chiral NNOO-type amine-bridged bis(phenolate) ligands (( S )-L 1–4 -H 2 ), LnN(SiMe 3 ) 2 3 ...(Ln = Y, Sm, Nd) and 2-propanol in a 1 : 1 : 1 molar ratio in THF at room temperature. These complexes were well characterized with X-ray crystallography, elemental analyses, IR spectra and NMR spectra in the case of yttrium complexes. Furthermore, complexes 1–6 were employed as efficient initiators for the stereoselective ring-opening polymerization of rac -LA in THF at 20 °C to provide heterotactically enriched polymers ( P r = 0.80–0.95). All of these polymerizations proceeded in a controlled manner, giving polymers with good controlled molecular weights and narrow molecular weight distributions (PDI = 1.03–1.12). The nature of the substituents of the ligands had a profound impact on the reactivity of rare-earth alkoxides but a slight impact on the stereoselectivity. Also, the reactivity and heterotacticity were strongly dependent on the ionic radii of rare-earth metals and polymerization media. The heterotactic and atactic polymers were obtained, respectively, by changing the reaction solvent.
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