The electrocatalytic transformation of carbon dioxide (CO2) to formate is a promising route for highly efficient conversion and utilization of CO2 gas, due to the low production cost and the ease of ...storage of formate. In this work, porous poly(ionic liquid) (PPIL)‐based tin‐silver (Sn‐Ag) bimetallic hybrids (PPILm‐SnxAg10‐x) are prepared for high‐performance formate electrolytic generation. Under optimal conditions, an excellent formate Faradaic efficiency of 95.5% with a high partial current density of 214.9 mA cm−2 is obtained at −1.03 V (vs reversible hydrogen electrode). Meanwhile, the high selectivity of formate (>≈83%) is maintained in a wide potential range (>630 mV). Mechanistic studies demonstrate that the presence of Ag‐species is vital for the formation, maintenance, and high dispersion of tetravalent Sn(IV)‐species, which accounts for the active sites for CO2‐to‐formate conversion. Further, the introduction of Ag‐species significantly enhances the activity by increasing the electron density near the Fermi energy level.
Porous poly(ionic liquid) (PPIL)‐based tin‐silver (Sn‐Ag) bimetallic hybrids (PPILm‐SnxAg10‐x) are synthesized for high‐efficient electrocatalytic carbon dioxide (CO2)‐to‐formate conversion. An excellent formate selectivity of 95.5% with a high partial current density of 214.9 mA cm−2 is achieved at −1.03 V (vs. reversible hydrogen electrode). Besides, the formate selectivity of > ≈83% is maintained in a wide potential range (>630 mV).
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
In this study, the pressure-dependent exciton binding energy and other optical properties (i.e., interband emission energy, emission wavelength, etc.) in a wurtzite (In,Ga)N-GaN coupled double ...quantum well structures are investigated theoretically under the built-in electric field. Using a variational approach, numerical calculations are carried out within the effective mass approximation, considering the pressure dependence of effective mass, band-gap energy, and dielectric constants of GaN and InGaN materials. The results reveal that the increasing hydrostatic pressure causes a significant blue-shift in the emission wavelength, and a linear increase of the built-in electric field strength, interband emission energy, and exciton binding energy. In addition, the built-in electric field strength of middle-barrier layer (left- and right-well layers) increases (decreases) gradually with increasing the well width. The oscillator strength and exciton radiation decay time obviously depends on the hydrostatic pressure. It is hope that the above conclusions are helpful to providing the ideas about the optimization of optical properties of light-emitting devices fabricated GaN-based wurtzite coupled double quantum well.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Plumage color, a pivotal attribute delineating diverse Muscovy duck strains, assumes considerable significance within the field of Muscovy duck breeding research. This study extends the existing ...research by delving into the hereditary aspects of genes associated with plumage coloration in Muscovy ducks. The principal objective is to discern marker genes conducive to targeted breeding strategies based on plumage color, thereby furnishing indispensable technical foundations for the development of novel Muscovy duck varieties. Our investigation focused on scrutinizing the impact of MYOT and MB genes on the genetic expression of plumage color at both the RNA and protein levels in Muscovy ducks. The results elucidate that black Muscovy ducks manifest markedly elevated mRNA and protein expression levels of MYOT and MB genes in comparison to their white counterparts, indicating that both genes may play a constructive regulatory role in the context of plumage coloration in Muscovy ducks. The outcomes of this study delineate a discernible correlation between MYOT and MB genes and the plumage coloration in Muscovy ducks. Employing gene expression analysis, we successfully identified candidate genes that may be intricately linked to the determination of plumage color in these ducks.
Nanomaterials have received increasing attentions owing to their potential hazards to the environment and human health; however, the multi-generational toxicity of graphene oxide under consecutive ...multi-generational exposure scenario still remains unclear. In the present study, Caenorhabditis elegans as an in vivo model organism was employed to explore the multi-generational toxicity effects of graphene oxide and the underlying mechanisms. Endpoints including development and lifespan, locomotion behaviors, defecation cycle, brood sizes, and oxidative response were evaluated in the parental generation and subsequent five filial generations. After continuous exposure for several generations, worms grew smaller and lived shorter. The locomotion behaviors were reduced across the filial generations and these reduced trends were following the impairments of locomotion-related neurons. In addition, the extended defecation cycles from the third filial generation were in consistency with the relative size reduction of the defecation related neuron. Simultaneously, the fertility function of the nematode was impaired under consecutive exposure as reduced brood sizes and oocytes numbers, increased apoptosis of germline, and aberrant expression of reproductive related genes ced-3, ced-4, ced-9, egl-1 and ced-13 were detected in exposed worms. Furthermore, the antioxidant enzyme, SOD-3 was significantly increased in the parent and filial generations. Thus, continuous multi-generational exposure to graphene oxide caused damage to the neuron development and the reproductive system in nematodes. These toxic effects could be reflected by indicators such as growth inhibition, shortened lifespan, and locomotion behavior impairment and induced oxidative response.
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•Consecutive six-generational exposure was performed as multigenerational exposure method using in vivo model C. elegans.•Multigenerational toxicity of GO can be detected at low concentration which wouldn’t cause serious toxicity at parent.•The multi-generation effects of GO were produced in a generation dependent manner.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Aim
To make a bibliometric analysis on post‐traumatic growth (PTG) after childbirth.
Methods
The topic advanced search strategy extracted the information from the Web of Science Core Collection. ...Descriptive statistics were performed using Excel, and bibliometric analysis was performed using VOSviewer.
Results
A total of 362 publications were published in 199 journals were obtained in the WoSCC from 1999 to 2022. Postpartum post‐traumatic growth is in a trend of fluctuating growth, and the United States (N = 156) and Bar‐Ilan University (N = 22) were the top contributing countries and institutions, respectively. Research hotspots mainly focus on theoretical models of PTG, postpartum post‐traumatic stress disorder (PTSD) as a predictor of PTG, facilitators of PTG, and the relationship between mother‐infant attachment and PTG.
Conclusion
This bibliometric study provides a comprehensive overview of the current state of research on PTG after childbirth, an area that has received considerable scholarly attention in recent years. However, research on post‐traumatic growth after childbirth is lacking, and further research is needed.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Lung squamous carcinoma (LUSC) is the second most frequent subtype of non-small cell lung cancer. Rarely gene alterations are identified in LUSC. Therefore, identifying LUSC-related genes to explain ...the relevant molecular mechanism is urgently needed. A potential biomarker, calcium-activated nucleotidase 1 (CANT1), was elevated in tissues of LUSC patients relative to normal cases based on the TCGA and/or GTEx database. CCK-8 and transwell tests were then implemented to measure the proliferative, invasive and migratory capacities, and showed that knockdown of CANT1 blocked LUSC cells proliferation. miR-607, predicted as an upstream factor for CANT1, was declined in LUSC using TargetScan analysis and luciferase activity test. Low miR-607 expression was related with unfavorable outcomes of LUSC patients. Moreover, miR-607 downregulation elevated cell viability, invasion and migration in LUSC cells, which was antagonized by si-CANT1. GEPIA website was accessed to estimate the relevance between CANT1 and epithelial-mesenchymal transition (EMT)-related positive factors. The protein levels of Fibronectin, Vimentin, Snail and β-catenin were altered due to the abnormal CANT1 and miR-607 expression. Together, these data unveiled that miR-607/CANT1 pair may exert a vital role in the progression of LUSC through mediating EMT process, which would furnish an available therapeutic therapy for LUSC.
The electrocatalytic transformation of carbon dioxide (CO
) to formate is a promising route for highly efficient conversion and utilization of CO
gas, due to the low production cost and the ease of ...storage of formate. In this work, porous poly(ionic liquid) (PPIL)-based tin-silver (Sn-Ag) bimetallic hybrids (PPIL
-Sn
Ag
) are prepared for high-performance formate electrolytic generation. Under optimal conditions, an excellent formate Faradaic efficiency of 95.5% with a high partial current density of 214.9 mA cm
is obtained at -1.03 V (vs reversible hydrogen electrode). Meanwhile, the high selectivity of formate (>≈83%) is maintained in a wide potential range (>630 mV). Mechanistic studies demonstrate that the presence of Ag-species is vital for the formation, maintenance, and high dispersion of tetravalent Sn(IV)-species, which accounts for the active sites for CO
-to-formate conversion. Further, the introduction of Ag-species significantly enhances the activity by increasing the electron density near the Fermi energy level.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Resveratrol (3,5,4'-trihydroxystilbene, RSV) has been widely used in mammalian cells, but whether it can be used during freezing boar semen is still unknown. The effects of RSV treatment during boar ...semen freezing on its anti-freezing ability, apoptosis, and possible apoptotic pathways were observed in this study. Sperm motility, mitochondrial membrane potential (Δ
Ψ
m), adenosine triphosphate (ATP) content, terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL)-positive apoptotic state, and messenger RNA (mRNA) expression levels of apoptotic genes involved in different apoptotic pathways after freezing with or without RSV treatment were tested. The results showed that: (1) Compared with fresh sperm, the motility, normal acrosome rate, and plasma membrane integrity rate of frozen boar sperm decreased significantly (
P
<0.05), and RSV did not significantly increase the sperm motility (0.44 vs. 0.40,
P
>0.05), but it did significantly improve the normal acrosome rate (57.65% vs. 47.00%,
P
<0.05) and plasma membrane integrity rate (46.67% vs. 38.85%,
P
<0.05). (2) After freezing, most boar sperm showed low mitochondrial Δ
Ψ
m. RSV treatment could increase the rate of high mitochondrial Δ
Ψ
m of boar sperm. (3) RSV treatment significantly decreased reactive oxygen species (ROS) levels (58.65% vs. 88.41%,
P
<0.05) and increased the ATP content (0.49 μmol/L vs. 0.25 μmol/L,
P
<0.05) of boar sperm during freezing. (4) The apoptotic rate of the freezing group (80.41%) with TUNEL detection increased significantly compared to the fresh group (9.70%,
P
<0.05), and RSV treatment greatly decreased the apoptotic rate (68.32%,
P
<0.05). (5) Real-time polymerase chain reaction (RT-PCR) showed that not only the genes from the death receptor-mediated apoptotic pathway (tumor necrosis factor-α (
TNF-α
), Fas ligand (
FasL
), and
Caspase-8
), but also the genes from the mitochondria-mediated apoptotic pathway (manganese superoxide dismutase (
MnSOD
), B-cell lymphoma 2 (
Bcl-2
), Bcl-2-associated X protein (
Bax
), and
Caspase-9
) were both significantly changed after freezing. RSV treatment during freezing greatly changed their expression levels. Although RSV treatment during boar semen freezing did not significantly increase motility after thawing, it still played an efficient antioxidant role, which could enhance the mitochondrial function and decrease the apoptotic level induced by both the death receptor- and mitochondria-mediated apoptotic pathways.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Prostate cancer (PCa) remains the secondary highest cause of cancer‐related death in the United States in men. It has been reported that microRNAs can serve as key regulators in tumor development and ...progression in various cancers including PCa. In this study, we examined the effect of miR‐498 on proliferation, radiosensitivity, invasion, and migration of PCa cells. The proliferation of LNCaP and DU‐145 PCa cells with altered expression of miR‐498 was evaluated by MTT assay. The invasion and migration of LNCaP and DU‐145 PCa cells were assess by matrigel invasion assay and transwell migration assay. The protein expression level in PCa cells was examined by western blot. The function of miR‐498 on radiation‐induced apoptosis in LNCaP and DU‐145 PCa cells was detected by Caspase‐Glo3/7 assay. Forced expression of miR‐498 improved the proliferation, invasion and migration in PCa cells. Furthermore, miR‐498 decreased the sensitivity of PCa cells after ionizing radiation treatment. MiR‐498 reduced the radiation‐induced apoptosis in PCa cells by regulation of BAX and Bcl‐2 expression. Meanwhile, miR‐498 altered the expression of E‐cadherin, N‐cadherin, snail, and Vimentin in both LNCaP and DU‐145 PCa cells and regulated epithelial to mesenchymal transition (EMT). Further study showed that aberrant expression of miR‐498 changed the expression levels of phosphatase and tensin homolog and p‐AKT in LNCaP and DU‐145 PCa cells. In a summary, miR‐498 displayed important roles in tumor development and progression in PCa cells, and might act as a potential prognostic biomarker and predict radiotherapy response in PCa.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
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