•Post-stroke depression (PSD) is common consequence of stroke.•The majority of PSD patients remains untreated or inadequately treated, especially in developing countries.•In this systematic review ...and meta-analysis, our pooled results showed that hyperbaric oxygen therapy is an effective and safe therapeutic approach for PSD.
Post-stroke depression (PSD) is common consequence of stroke. However, today the majority of PSD patients remains untreated or inadequately treated, especially in the developing countries. Herein, we performed a meta-analysis to evaluate efficacy and safety of hyperbaric oxygen (HBOT) therapy for PSD.
Seven electronic databases were comprehensively searched for randomized clinical trials (RCTs) from inception to May 2019. Outcome measures included response rate, depression severity, neurological deficit, physical disability and adverse events.
A total of 27 RCTs involving 2250 participants were identified. Patients in HBOT group had a higher response rate than patients in control group (response rate: 69.4% vs 51.2%, odds ratio OR = 2.51, 95% confidence interval CI 1.83–3.43, P = 0.000). HBOT significantly reduced Hamilton Depression (HAMD) –17 item scores (weighted mean difference WMD = −4.33, 95% CI −4.82 to −3.84, P = 0.000), HAMD-24 item scores (WMD = −4.31, 95% CI −5.01 to −3.62, P = 0.000), National Institute of Health Stroke Scale (NIHSS) scores (WMD = −2.77, 95% CI −3.57 to −1.98, P = 0.000), Chinese Stroke Scale (CSS) scores (WMD = −3.75, 95% CI −5.12 to −2.38, P = 0.000) and Modified Scandinavian Stroke Scale (MASSS) scores (WMD = −3.66, 95% CI −6.26 to −1.06, P = 0.000). HBOT also improved Barthel Index (WMD = 10.68, 95% CI 7.98–13.37, P = 0.000). In subgroup analysis, Group A of studies with hemorrhage patients accounting for less than 20% achieved more reduction of HAMD 17-item score (WMD = −4.47, 95% CI −5.17 to −3.77, P = 0.000) than Group B of studies with hemorrhage patients no less than 20% (WMD = −3.73, 95% CI −4.20 to −3.26, P = 0.000). In addition, patents with HBOT along with antidepressants treatment achieve superior results than patients with antidepressants monotherapy. Patients with HBOT monotherapy achieve a slightly higher response rate than patients with antidepressants monotherapy (OR = 1.29, 95% CI 1.04–1.60, P = 0.000). Besides, HBOT group reported less adverse events (9.6%vs16.6%, P < 0.05). The most frequent side-effect of HBOT is ear pain (26 cases).
Based on our pooled analysis, HBOT is effective and safe therapeutic approach for PSD. However, results should be cautiously interpreted due to a relatively poor methodological quality.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Heterogeneous element doping carbon-coated transition metal oxides has been reported as an effective way to increase conductivity and accommodate volume changes during the charge/discharge of ...lithium-ion batteries thereby improving structural stability and cycle performance. Herein, we have successfully synthesized Co/CoO@N-C nanocomposites using polydopamine as a source of carbon and nitrogen via a simple one-step method. Owing to its desirable structural features, the as-synthesized Co/CoO@N-C nanocomposite anode manifests a greatly improved initial capacity of 1541 mAh g−1 and retains a high reversible value of 1115 mAh g−1 at a current density of 200 mA g−1 after 125 cycles. The morphology and physicochemical properties of the Co/CoO@N-C nanocomposites were characterized to provide insights into the promotional roles of nitrogen-doped carbon matrix and CoO loaded nanoparticles. The results demonstrate the potential of the Co/CoO@N-C nanocomposite as a promising anode material for lithium-ion batteries.
•The synthetic method we applied is effective and simple.•The Co/CoO is embedded into N-C layers to synthesize Co/CoO@N-C materials.•The anode materials exhibit excellent reversible capacities and rate performances.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The yolk–shell-structured Fe
3
O
4
nanocomposite particles (Fe
3
O
4
@Void@C
–
N NPs) with Fe
3
O
4
as the yolk and N
-
doped carbon as the shell were prepared by using melamine formaldehyde resin as ...the N and C sources. When used as anode material for lithium ion battery, the yolk–shell structure could not only afford adequate void to accommodate the large volume change during charge/discharge process but also improve structural stability and electrical conductivity. The anode material demonstrated superior long-term and high-rate performance because of the novel structure and the N-doped carbon shell with mesopore. Thus, Fe
3
O
4
@Void@C–N NPs exhibited a high reversible capacity of 1530 mAh g
−1
after 300 cycles at a current density of 500 mA g
−1
, which were approximately 1.5 and 6 times higher than Fe
3
O
4
@C–N NPs and pure Fe
3
O
4
particles, respectively. Even at the higher current density of 2000 mA g
−1
, the reversible capacity remained at 651 mAh g
−1
after 500 cycles.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
To identify the circRNAs expression pattern and roles in bisphenol A (BPA) induced germ cell apoptosis.
We performed circRNA/miRNA/mRNA-Seq in 120 μM BPA treated and nontreated GC-2 cells. ...Bioinformatic analysis, qPCR, apoptosis assays, luciferase report were done in the function analysis.
A large number of apoptosis related circRNAs/miRNAs/mRNAs were differentially expressed with competing endogenous RNA network constructed. Interestingly, most investigated upregulated circRNAs, including circDcbld2, circMapk1, circMpp6 and circTbc1d20 showed protective effects in antagonizing BPA toxicity, with the effects individually and synergistically observed. CircMapk1 may take its role by sponging miR-214-3p.
circRNAs can play protective roles via sponging miRNAs in toxicity. Some circRNAs may serve as novel targets for BPA toxicity intervention or as biomarkers.
Yolk-shell nanocomposite particles (YSNPs) have been extensively investigated because of their great application potential and unique properties attributed to their distinct structures and multiple ...discrete functions. In this study, Fe
3
O
4
@Void@PMAA@Void@TiO
2
, a special YSNP with double shells and dual cavities (denoted as DDYSNPs), was prepared by conducting dispersion polymerization with a high production rate and by using a hydrothermal strategy. The synthesized DDYSNPs, which effectively integrate inorganic and organic functions, exhibit an outstanding photocatalytic activity under ultraviolet light irradiation for five experimental cycles and show an excellent adsorptive property for heavy metal ions. These comprehensive properties are mainly attributed to the novel structure of double-shelled and dual-cavity structures.
Graphical Abstract
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
•The ferroferric oxide/polystyrene/silver particles with a well-defined core–shell structure have been synthesized.•The composite particles provide excellent SERS performance and have a detecting ...limit of 10−10 M R6G.•The composite particles show superior stability and reproducibility for SERS application.
A novel Ag-coated Fe3O4@Polystyrene core–shell microsphere has been designed via fabrication of Fe3O4@Polystyrene core–shell magnetic microsphere through a seed emulsion polymerization, followed by deposition of Ag nanoparticles using in-situ reduction method. Such magnetic microspheres can be utilized as sensitive surface-enhanced Raman scattering (SERS) substrates, using Rhodamine 6G (R6G) as a probe molecule, with both stable and reproducible performances. The SERS detection limit of R6G decreased to 1×10−10 M and the enhancement factor of this substrate on the order of 106 was obtained. In addition, owing to possessing excellent magnetic properties, the resultant microspheres could be separated rapidly by an external magnetic field and utilized repeatedly for three times at least. Therefore, the unique renewable property suggests a new route to eliminate the single-use problem of traditional SERS substrates and will be promising for the practical application.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Hierarchical composite particles with hollow structure were fabricated in this work. The composite particles were composed of guest particles and host ones, which were achieved by Stöber method, and ...a raspberry-like morphology was produced by the “anchoring” of guest particles on the surface of host ones. Moreover, the hollow structure was obtained by template-assisted approach. The raspberry-like morphology and hollow structure of composite particles were confirmed by scanning electron microscopy and transmission electron microscopy. As multiple distinct functional components were integrated into the raspberry-like particles, the obtained composite particles exhibited enhanced photocatalytic activity under visible light irradiation. The rate of degradation of the as-prepared composite particles was ca. 13 times faster than that of pure TiO
2
under visible light irradiation. Furthermore, a brief photocatalytic mechanism was presented. The composite particles, combining hierarchical morphology and hollow structure, exhibit promising potential in self-cleaning and nanoreactor areas.
Graphical Abstract
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Transition-metal oxides are highly sought as alternative anode materials for rechargeable lithium-ion batteries (LIBs) owing to their high theoretical capacity. However, the large volume variation of ...active materials during cycling leads to poor cycle life, which hinders commercial applications. In this work, we prepared cobalt oxide/copper oxide/reduced graphene oxide (CoO/CuO/rGO) ternary nanocomposites through a facile and cost-effective synthesis method. The products were endowed with a nanoscale distribution of CoO and CuO nanoparticles on the surface of rGO nanosheets. As anode materials for LIBs, the CoO/CuO/rGO nanocomposites delivered an initial discharge capacity of 1732.4 mAh g
−1
and a stabilized capacity of 1364.6 mAh g
−1
at a current density of 200 mA g
−1
after 100 cycles. With increased current density to 1000 mA g
−1
and 2000 mA g
−1
, the nanocomposites retained highly reversible capacities of 602.7 mAh g
−1
and 423.5 mAh g
−1
after 1000 cycles, respectively. These features revealed the potential applications of the CoO/CuO/rGO nanocomposites in anodes of LIBs.
Hammer crusher is widely used in cement, ceramic, mining and electricityother industries, hammer head is one of important parts in crusher, its abrasion performance directly affects the service life ...of hammer crusher and economic cost. According to bimetalcomposite hammer head is often appear “Hammer handle wear and tear”,“Composite difficult” and the set of casting alloy block hammer head set piece of “come off” phenomenon, which design a set piece type bimetal composite casting straight diagonal hammer, make full use of high chromium cast iron wear resistance and the toughness of low alloy steel. Design a protect block structure reasonably that solve the hammer when the actual production of composite interface is difficult to control and “the problem of hammer head wear” for use. Solve the problem of hammer head wear actively, achieve “energy saving, emission reduction and environmental protection”.
To investigate the effects of cis-combretastatin-A1 phosphate (cis-CA1P) on tumor cell proliferation, and its effects on the blood vessel formations.
MTT and IC50 values were used to assess the ...inhibitory effects of cis-CA1P on tumor cell proliferation. Chicken embryo chorioallantoic membrane and thoracic aorta annulations isolated from rats were used to investigate the effects of cis-CAIP on the blood vessel formation.
Cis-CA1P concentration-dependently inhibited the proliferations of several cancer cell lines, including human gastric carcinoma cell line MGC-803, human leukemic monocyte lymphoma cell line U937, human melanoma cell line A375, human colon cancer cell line HCT116, human breast carcinoma cell line MDA-MB-231, and human leukemia cell line K562. Cis-CAIP significantly decreased the formation of blood vessels in chicken embryo chorioallantoic membrane and in thoracic aorta annulations.
Cis-CA1P inhibits cancer cell proliferation and prevents blood vessel formation.
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