Purpose: Phase I study to determine the maximally tolerated dose (MTD) of cisplatin (cDDP), paclitaxel (P), and concurrent split course hyperfractionated (BID) RT in advanced squamous cell carcinoma ...of the head and neck (SCCHN) and other upper aerodigestive tumors. Materials and Methods: Eligibility stipulated ECOG performance status 0-2 and either Tx-naïve, locally advanced, or locally recurrent, previously radiated, surgically unresectable upper aerodigestive cancer. Metastases were permitted if disease was predominantly locoregional. RT-naïve patients received 150 cGy bid × 5 d Q 2 wks × 4. Previously radiated patients received 150 cGy bid × 5, wk 1; then 120 cGy bid × 5 Q 2 wk × 3 (later increased to 150 cGy BID for the entire treatment). Treatment fields included recurrent tumor only with 2 cm margins. Whenever possible, conventional and 3-D conformal techniques were used. Elective nodal radiation was not administered. Starting doses of cDDP and P were 12 mg/m2/d × 5 and 15 mg/m2/d × 5, respectively, Q 2 wk × 4, each given on RT days only. At dose level 2, cDDP was increased to 15 mg/m2/d × 5. At dose level 3, P was increased to 20 mg/m2/d × 5. Granulocyte colony stimulating factor (G-CSF) days 6-12 (off treatment week) was added if cumulative neutropenia precipitated treatment delays. Results: Thirty-one patients (21 men, 10 women) were treated. Eight had received prior chemotherapy, 27 prior RT. At dose level three, regular treatment delays of ≥1 week due to slow neutrophil recovery occurred. Addition of G-CSF (dose level 3b) reduced treatment delays from 100 percent to 28 percent and decreased the incidence of Grade ≥2 neutropenia and mucositis. Six of 7 patients at this dose level completed all 4 cycles of treatment and all received full dose RT (60 Gy). No other dose-limiting toxicities occurred. Of 22 assessable patients with locally recurrent SCCHN, 12 (55 percent) responded. Median time to progression in this group was 6 months, with median and one-year survival of 9.5 mos and 41 percent, respectively. Conclusion: Concurrent daily cisplatin/paclitaxel and split course hyperfractionated RT (60 Gy) is feasible in previously radiated patients. G-CSF, administered between each cycle, reduces the incidence of treatment delays. Activity is promising and toxicity acceptable.
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DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Against the background of some positions taken up in a recent document of the Pontifical Biblical Commission, the article studies Raymond Brown’s attempt to combine mainstream historical‐critical ...exegesis of the Bible with a Roman Catholic theological pre‐understanding. Particular reference is made to his handling of issues connected with the virginal conception of Jesus. Some of his religious presuppositions such as those concerning the relation between faith and reason, and the development of doctrine, are presented. Biblical criticism in Brown’s understanding is an essentially historical discipline which has as its principal object the literal sense of the text, that is, what the text meant when it was written. His religious presuppositions make the practice of the discipline ineliminable in an integral hermeneutic. From an analysis of his treatment of the virginal conception, it is argued that Catholic pre‐understanding and historical criticism, when combined, inevitably result in a two‐stage hermeneutic. In a first stage appeal is made to presuppostions common to all practitioners of historical criticism. In a second stage religious presuppostions come into play. The distinction between these two stages is seen as more fundamental than Brown’s better known distinction between the literal and more‐than‐literal senses of the text. It is argued that the relation between the two stages is to be understood in chalcedonian terms as exemplifying the dialectic of faith and reason: they must be distinguished, but cannot be separated. Brown’s grasp of an incarnational economy of salvation is presented in terms of David H. Kelsy’s concept of a discrimen, and emerges as fundamental for an ecclesial hermeneutic of the Bible. Questions about the place of the historical‐critical method, the promise of alternative approaches and the role of hermeneutical theory can only be adequately addressed in terms of it.
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BFBNIB, DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
We present the first measurement of differential cross sections for charged-current muon neutrino interactions on argon with one muon, two protons, and no pions in the final state. Such interactions ...leave the target nucleus in a two-particle two-hole state; these states are of great interest, but currently there is limited information about their production in neutrino-nucleus interactions. Detailed investigations of the production of two-particle two-hole states are vital to support upcoming experiments exploring the nature of the neutrino, and the development of the liquid-argon time-projection-chamber has made possible the isolation of such final states. The opening angle between the two protons, the angle between the total proton momentum and the muon, and the total transverse momentum of the final state system are sensitive to the underlying physics processes as embodied in a variety of models. Realistic initial-state momentum distributions are shown to be important in reproducing the data.
