The COVID-19 pandemic poses unique challenges for vulnerable populations, including patients undergoing maintenance hemodialysis (HD). This study explores the relationship between baseline intact ...parathyroid hormone (iPTH) levels and COVID-19 severity, post-acute hospitalization, and mortality rates in HD patients. Methods. A multicenter retrospective cohort study was conducted across multiple centers, encompassing 142 patients undergoing HD treatment in three regions of Ukraine. The study spanned from March 2020 to May 2022. Baseline iPTH levels, demographic characteristics, and relevant clinical indicators were systematically recorded. Key endpoints included the severity of COVID-19, post-acute hospitalization, and mortality rates. Results. Of the initially eligible 165 patients, 23 were excluded, resulting in a final cohort of 142 patients. During the acute phase of COVID-19, distinct patterns emerged in terms of hospitalization rates, oxygen support requirements, and mortality. Lower iPTH levels were significantly associated with severe COVID-19-associated pneumonia (p < 0.0001). A 20-month follow-up revealed a significant association between serum iPTH concentration <174 pg/mL and increased rates of post-acute COVID-19 hospitalization HR 6.3 (95% CI 2.9; 13.7) and all-cause mortality HR 34.3 (95% CI 6.9; 74.5). Conclusion. This multicenter retrospective study suggests potential links between baseline iPTH levels and COVID-19 outcomes in patients undergoing HD. Serum iPTH concentration ≤174 pg/mL was significantly associated with increased post-acute hospitalization and mortality rate in our patient cohort. The findings emphasize the need for further research to elucidate underlying mechanisms and establish the prognostic value of iPTH in this specific patient population.
A solid propellant version of the single-stage launch vehicle with polyethylene case that consumed as fuel is considered as means for launching small satellites. Emphasis is on experimental ...investigating gasification of a polyethylene structure element by a chamber of special design. Photographs and the reference to electronic annex containing an experimental video record are included in the paper. Main previous experiments are also briefly reviewed. Conclusions concern improvements of the gasification chamber design and a speculation about next experiments.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK