The efficient generation of second-harmonic light and squeezed light requires non-linear crystals that have low absorption at the fundamental and harmonic wavelengths. In this work the photo-thermal ...self-phase modulation technique is exploited to measure the absorption coefficient of periodically poled potassium titanyl phosphate (PPKTP) at 1,550 nm and 775 nm. Themeasurement results are (84 plus or minus 40) ppm/cmand (127 plus or minus 24) ppm/cm, respectively. We conclude that the performance of state-of-the-art frequency doubling and squeezed light generation in PPKTP is not limited by absorption.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Prediction of normal QT intervals in children Eberle, Tilman; Hessling, Gabriele; Ulmer, Herbert E ...
Journal of electrocardiology,
1998, 1998-00-00, 1998-1-00, 19980101, Volume:
31
Journal Article
Peer reviewed
Measuring QT intervals in individual children is of great importance, particularly in view of increasing evidence linking long QT syndrome to subsequent risk for sudden death. Three hundred ...seventy-three healthy subjects, 185 women and 188 men, aged 5.2 to 16.5 years, were investigated with a 12-lead-standard electrocardiogram (ECG). Values for predicted QTp50 and QTp95 (percentiles) were calculated by using the cycle length (RR interval RRI) and the measured QT interval. We used multiple regression analysis to test the influence of possible important variables and the resulting data were used to generate tables. Additionally, predicted QTp values were compared to QTc values after Bazett's correction. RRI, body height, age, and sex turned out to influence the QTp values most. For clinical use, data are presented in tabular form by RRI and age for both genders. The tables are of great clinical value in predicting the upper limits of normal QTp95 for individual children. Bazett's correction tends to underestimate the values found in our data when heart rate increases.
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IJS, IMTLJ, KILJ, KISLJ, NUK, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Drastic performance increase and accelerated progress in organic light-emitting diodes from solutions are shown using solution-processable small molecules based on the core structures of ...vacuum-evaporable materials. Systematic modification of small-molecule materials toward better processability from solutions at identical electro-optical properties is shown. This is demonstrated to lead to a significant improvement in the device performance.
Cancer-testis
(CT) genes are expressed in a variety of human cancers but not in
normal tissues, except for testis tissue, and represent promising
targets for immunotherapeutic and gene therapeutic ...approaches. Because
little is known about their composite expression in human brain tumors,
we investigated the expression of seven CT genes (MAGE-3, NY-ESO-1,
HOM-MEL-40/SSX-2, SSX-1, SSX-4,HOM-TES-14/SCP-1, and HOM-TES-85)
in 88 human brain tumor specimens. Meningiomas expressed only
HOM-TES-14/SCP-1 (18% of meningiomas were HOM-TES-14/SCP-1
positive) and did not express any other CT genes. One ependymoma
was negative for all CT genes tested. SSX-4 was the only CT gene
expressed in oligodendrogliomas (2 of 5 cases), and it was also
expressed in oligoastrocytomas (3 of 4 cases) and astrocytomas (10 of
37 cases). Astrocytomas were most frequently positive for
HOM-TES-14/SCP-1 (40%) and SSX-4 (27%), followed by HOM-TES-85
(13%), SSX-2 (11%), and MAGE-3 (7%). Whereas MAGE-3 was detected
only in grade IV astrocytomas, the expression of the other CT genes
showed no clear correlation with histological grade. Of 39
astrocytomas, 60% expressed at least one CT gene, 21% expressed two
CT genes, and 8% coexpressed three CT genes of the seven CT genes
investigated. We conclude that a majority of oligoastrocytomas and
astrocytomas might be amenable to specific immunotherapeutic
interventions. However, the identification of additional tumor-specific
antigens with a frequent expression in gliomas is warranted to allow
for the development of widely applicable polyvalent glioma vaccines.
Cancer/testis antigens (CTA) are an expanding family of immunogenic proteins selectively expressed in human neoplasms. As little is known about the expression of serologically identified CTA in ...leukemias so far, we investigated the expression of 5 CT genes (
SSX-1,
HOM-MEL-40/SSX-2,
HOM-TES-14/SCP-1,
SCP-3 and
NY-ESO-1) in leukemic blood samples obtained from patients with either acute lymphatic leukemias (ALL) or myelocytic leukemia (AML). RT-PCR-analyses showed no expression of any of the CT-genes in the leukemia samples of 19 patients with AML, whereas frequent expression was found in ALL. In the 17 ALL cases studied,
SCP3a,
SSX-1,
HOM-MEL-40/SXX-2 and
HOM-TES-14/SCP-1 were expressed in 47, 29, 29 and 12%, respectively, whereas no case was positive for
NY-ESO-1. 65% of patients with ALL showed expression of at least one, 41% of two or more of the five CT-genes investigated. We conclude that a majority of the ALLs might be amenable for specific immunotherapeutic interventions. However, the identification of additional antigens with a frequent expression in leukemias is warranted to allow the development of widely applicable polyvalent leukemia vaccines.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
We describe here the definition and characterization of antigen CT-8/HOM-TES-85 encoded by a previously unknown gene and identified by serological expression screening using antibodies from a ...seminoma patient. Intriguingly, the leucine zipper region of CT-8/HOM-TES-85 shows an atypical amphipathy with clusters of hydrophobic residues that is exclusively shared by the N-myc proto-oncogene. CT-8/HOM-TES-85 gene is tightly silenced in normal tissues except for testis. However, it is frequently activated in human neoplasms of different types including lung cancer, ovarian cancer, melanoma and glioma. Endogenous as well as heterogeneously expressed CT-8/HOM-TES-85 targets predominantly to the nucleus forming a distinctive speckled pattern of nuclear dots arranged in macromolecular structures. By co-localization studies these speckles were identified as loci of transcriptional activity and splicing, suggesting that CT-8/HOM-TES-85 may be involved in these processes. The aberrant expression of CT-8/HOM-TES-85 in human neoplasms might therefore be involved in cancer associated alterations of transcriptional or post-transcriptional processes and thus may disclose new mechanisms involved in the manifestation of the cancer phenotype.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
CBS reduction of the (chloroacyl)ferrocenes 3 provides the chloro alcohols 5 with ≥98% ee, which upon treatment with cyclopentadienides yield the chiral β- or γ-hydroxy cyclopentadienes 6 and 7. The ...hydroxyl function of 6 and 7 can be substituted with full retention of configuration by a range of N- or S-nucleophiles, giving efficient access to the optically active linked amino−cyclopentadienyl ligands 11−13. These were complexed to an iron center, yielding a ferrocenyl diamine with a large bite angle between the nitrogen donor atoms. Furthermore the first chelating complexation reaction to titanium is presented.
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IJS, KILJ, NUK, PNG, UL, UM
We describe here the definition and characterization of antigen CT-8/HOM-TES-85 encoded by a previously unknown gene and identified by serological expression screening using antibodies from a ...seminoma patient. Intriguingly, the leucine zipper region of CT-8/HOM-TES-85 shows an atypical amphipathy with clusters of hydrophobic residues that is exclusively shared by the N-myc proto-oncogene. CT-8/HOM-TES-85 gene is tightly silenced in normal tissues except for testis. However, it is frequently activated in human neoplasms of different types including lung cancer, ovarian cancer, melanoma and glioma. Endogenous as well as heterogeneously expressed CT-8/HOM-TES-85 targets predominantly to the nucleus forming a distinctive speckled pattern of nuclear dots arranged in macromolecular structures. By co-localization studies these speckles were identified as loci of transcriptional activity and splicing, suggesting that CT-8/HOM-TES-85 may be involved in these processes. The aberrant expression of CT-8/HOM-TES-85 in human neoplasms might therefore be involved in cancer associated alterations of transcriptional or post-transcriptional processes and thus may disclose new mechanisms involved in the manifestation of the cancer phenotype.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
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