Mammalian iron homeostasis is maintained through the concerted action of sensory and regulatory networks that modulate the expression of proteins of iron metabolism at the transcriptional and/or ...post-transcriptional levels. Regulation of gene transcription provides critical developmental, cell cycle, and cell-type-specific controls on iron metabolism. Post-transcriptional control through the action of iron regulatory protein 1 (IRP1) and IRP2 coordinate the use of messenger RNA-encoding proteins that are involved in the uptake, storage, and use of iron in all cells of the body. IRPs may also provide a link between iron availability and cellular citrate use. Multiple factors, including iron, nitric oxide, oxidative stress, phosphorylation, and hypoxia/reoxygenation, influence IRP function. Recent evidence indicates that there is diversity in the function of the IRP system with respect to the response of specific IRPs to the same effector, as well as the selectivity with which IRPs modulate the use of specific messenger RNA.
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DOBA, FSPLJ, IZUM, KILJ, NUK, OILJ, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK, VSZLJ
Purpose: To demonstrate the feasibility of the BRIGHTEN Program (Bridging Resources of an Interdisciplinary Geriatric Health Team via Electronic Networking), an interdisciplinary team intervention ...for assessing and treating older adults for depression in outpatient primary and specialty medical clinics. The BRIGHTEN team collaborates "virtually" to review patient assessment results, develop a treatment plan, and refer to appropriate team members for follow-up care. Design and Methods: Older adults in 9 academic medical center clinics and 2 community-based clinics completed screening forms for symptoms of depression and anxiety. Those with positive screens engaged in comprehensive assessment with the BRIGHTEN Program Coordinator; the BRIGHTEN virtual team provided treatment recommendations based on the results of assessment. A collaborative treatment plan was developed with each participant, who was then connected to appropriate services. Results: Two thousand four hundred twenty-two older adults were screened in participating clinics over a 40-month period. Eight hundred fifty-nine older adults screened positive, and 150 elected to enroll in BRIGHTEN. From baseline to 6 months, significant improvements were found in depression symptoms (Geriatric Depression Scale, p less than 0.01) and general mental health (SF-12 Mental Component, p less than 0.01). Implications: The BRIGHTEN Program demonstrated that an interdisciplinary virtual team linked with outpatient medical clinics can be an effective, nonthreatening, and seamless approach to enable older adults to access treatment for depression.
Purpose: This cross-sectional study takes a unique look at the association between patterns of walking and cognitive functioning by examining whether older adults with mild cognitive impairment ...differ in terms of the community settings where they walk and the frequency, intensity, or duration of walking. Design and Methods: The sample was based on interviews with 884 adults aged 65 years and older, residing in 4 locations across the United States: Alameda County, California; Cook County, Illinois; Allegheny County, Pennsylvania; and Durham/Wake Counties, North Carolina. Cognitive function was assessed using a modified Mini-Mental State Examination (MMSE) and the Mental Alternation Test (MAT). Multiple linear regressions were conducted between self-reported walking activities and cognitive measures, controlling for psychosocial, demographic, health status, functional performance, and neighborhood characteristics. Results: The community setting where people walk and the intensity of walking in their neighborhood were significantly associated with cognitive status. After controlling for individual and neighborhood characteristics, better MAT scores were significantly associated with brisk walking and walking fewer times per week. Compared with the MMSE, the MAT was more likely to be associated with patterns of walking among older adults. Older adults with lower MAT scores were more likely to walk in indoor shopping malls and less in parks, whereas those with higher cognitive function scores on the MMSE were less likely to walk in indoor gyms. Implications: This investigation provides insight into the extent to which walking is associated with preservation of cognitive health, setting the stage for future longitudinal studies and community-based interventions.
Zillah Eisenstein, one of North America's most eminent and politically engaged feminist thinkers, continues her unrelenting critique of neoliberal globalization and its capture of democratic ...possibilities in Against Empire. She is deeply critical of President George W. Bush's headlong recourse to the use of war, the neocon embrace of American empire as something positive for humanity, and the accelerated imposition on the rest of the world of the most negative aspects of American capitalism. Zillah Eisenstein urgently asks that we build a global anti-war movement to counter US power. She believes that it is essential to see beyond the distortions inherent in mainstream presentations of history, and to detect the silencing of racialized, sex/gendered and classed ways of seeing. At the heart of her book is the insistence that the so-called West is as much fiction as reality; as much appropriation as originary; as exclusionary as it is promissory. Eisenstein contends that the sexualized black slave trade was an early form of globalization. The West and western feminisms have no monopoly of authorship; we need to pluralize the understanding of feminisms as other-than-western. The West has debts to places elsewhere, as much as places elsewhere have debts to the Enlightenment. Black America, India, the Islamic world and Africa envision unique conceptions of what it is to be fully, ‘polyversally’, human. Professor Eisenstein gives her readers a rich picture of women's activism across the globe today. If there is to be hope of a more peaceful, more just and happier world, it lies, she believes, in the understandings and activism of women today. This book is written for all people who wish to examine more deeply what the West really is, how it is seen by the rest of the world, and the hidden histories that make up human complexity and diversity below the waterline of conventional narratives.
Disorders of iron metabolism account for some of the most common human diseases. Cellular iron homeostasis is maintained by iron regulatory proteins (IRP)-1 and 2 through their binding to
cis
...-regulatory iron-responsive elements (IREs) in target mRNAs. Mouse models with IRP deficiency have yielded valuable insights into iron biology, but the physiological consequences of gain of IRP function in mammalian organisms have remained unexplored. Here, we report the generation of a mouse line allowing conditional expression of a constitutively active IRP1 mutant (IRP1*) using Cre/Lox technology. Systemic activation of the IRP1* transgene from the
Rosa26
locus yields viable animals with gain of IRE-binding activity in all the organs analyzed. IRP1* activation alters the expression of IRP target genes and is accompanied by iron loading in the same organs. Furthermore, mice display macrocytic erythropenia with decreased hematocrit and hemoglobin levels as well as impaired erythroid differentiation. Thus, inappropriately high IRP1 activity causes disturbed body iron distribution and erythropoiesis. This new mouse model further highlights the importance of appropriate IRP regulation in central organs of iron metabolism. Moreover, it opens novel avenues to study diseases associated with abnormally high IRP1 activity, such as Parkinson’s disease or Friedreich’s ataxia.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
A new understanding of humanity and feminism from the starting point of breast health is the ultimate goal of Zillah Eisenstein's political memoir of her family's experience with breast cancer. The ...well-known feminist author argues that politics always needs the personal, and that the personal is never enough on its own. Her return to the personal side of the political combines the two for a radicalized way of seeing, viewing, and knowing.The author strives to bring together a critique of environmental damage and the health of women's bodies, gain perspective on the role race plays as a factor in breast cancers and in political agendas, link prevention and treatment, and connect individual support and political change.Eisenstein was sixteen when her forty-five-year-old mother successfully battled breast cancer. Her two sisters, Sarah and Giah, were in their twenties when they were diagnosed, but neither of them survived. She received her own diagnosis when she was forty. Despite her family history, however, Eisenstein rejects the simple argument that genes are simply determining, rather than liable to influence by external factors. She also questions the dominance of the theory that breast cancer is caused by high lifetime exposure to estrogen. Instead, she views breast cancer as an environmental disease, best understood in terms of ecological, racial, economic, and sexual influences on individual women. She uses the term manmade to indicate not only industrial carcinogens and other cultural causes, but also the male-dominated and -defined scientific practices of research and treatment.In response, Manmade Breast Cancers offers a retelling of the meaning of breast cancer and a discussion of universal feminist issues about the body. The author says she writes to discover a more just globe which will treasure the health of all of our bodies. The emotional depth and intellectual breadth of her argument adds new dimensions to how we understand breast cancer. A new understanding of humanity and feminism from the starting point of breast health is the ultimate goal of Zillah Eisenstein's political memoir of her family's experience with breast cancer. The well-known feminist author argues that politics always needs the personal, and that the personal is never enough on its own. Her return to the personal side of the political combines the two for a radicalized way of seeing, viewing, and knowing. The author strives to bring together a critique of environmental damage and the health of women's bodies, gain perspective on the role race plays as a factor in breast cancers and in political agendas, link prevention and treatment, and connect individual support and political change. Eisenstein was sixteen when her forty-five-year-old mother successfully battled breast cancer. Her two sisters, Sarah and Giah, were in their twenties when they were diagnosed, but neither of them survived. She received her own diagnosis when she was forty. Despite her family history, however, Eisenstein rejects the simple argument that genes are simply determining, rather than liable to influence by external factors. She also questions the dominance of the theory that breast cancer is caused by high lifetime exposure to estrogen. Instead, she views breast cancer as an environmental disease, best understood in terms of ecological, racial, economic, and sexual influences on individual women. She uses the term manmade to indicate not only industrial carcinogens and other cultural causes, but also the male-dominated and -defined scientific practices of research and treatment. In response, Manmade Breast Cancers offers a retelling of the meaning of breast cancer and a discussion of universal feminist issues about the body. The author says she writes to discover a more just globe which will treasure the health of all of our bodies. The emotional depth and intellectual breadth of her argument adds new dimensions to how we understand breast cancer.
Sexual decoys Eisenstein, Zillah
2008., 2006, 2008-02-29, 2013-07-18
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In this book, Zillah Eisenstein continues her unforgiving indictment of neoliberal imperial politics. She charts its most recent militarist and masculinist configurations through discussions of the ...Afghan and Iraq wars, violations at Guantánamo and Abu Ghraib, the 2004 US Presidential election, and Hurricane Katrina. She warns that women's rights rhetoric is being manipulated, particularly by Condoleeza Rice and other women in the Bush administration, as a ploy for global dominance and a misogynistic capture of democratic discourse. However, Eisenstein also believes that the plural and diverse lives of women will lay the basis for an assault on these fascistic elements. This new politics will both confound and clarify feminisms, and reconfigure democracy across the globe.
To evaluate the effect of a patient-centered rheumatoid arthritis (RA) treat-to-target (T2T) disease management approach on patient outcomes and patient satisfaction with care.
In this longitudinal, ...observational pilot study, rheumatologists implemented a modified T2T approach that integrated Patient Reported Outcomes Measurement Information System (PROMIS) measures for depression, fatigue, pain interference, physical function, and social function into RA care. Study participants selected 1 PROMIS domain to target treatment and completed quarterly follow-up assessments. Participants were classified as improved if their Clinical Disease Activity Index (CDAI) changed by > 5 points. Change in PROMIS
scores was examined for the group with improved CDAI, and then compared to those with unchanged or worsened CDAI. Satisfaction with care was assessed using multiple measures, including the Functional Assessment of Chronic Illness Therapy-Treatment Satisfaction-Patient Satisfaction Scale.
The analytical sample (n = 119, median age 57 years, 90.8% female) was split between those with CDAI > 10 (n = 63) and CDAI ≤ 10 (n = 53). At 1 year, there was improvement in CDAI by > 5 points in 66% and 13% of individuals with baseline CDAI > 10 and baseline CDAI ≤ 10, respectively. Across all participants, improvement in CDAI by > 5 points correlated with improvements in the 5 PROMIS domains. Satisfaction with RA treatment also increased.
The integration of PROMIS measures into the T2T approach for RA care was associated with improvements in disease activity, and improvement in disease activity was associated with improvements in PROMIS measures.
In this exciting and insightful new work, Zillah Eisenstein engages the 2008 election of Barack Obama as a site of new anti-imperial possibility. Contiuning her relentless anti-racist feminist ...narrative to uncover the new shiftings and changes surrounding the meanings and practices of race, gender, and class, she likens the end of the Bush/Cheney presidency to the fall of Stalin, or Pinochet and asks whether this is a key historical moment that will alter race and gender in newly unknown ways. Tracing the social and political presence of Hillary Clinton, Michelle Obama, Sarah Palin and Barack Obama, the book present 25 conceptual "frames" of fast-paced critical analysis that places the US presidential election in the context of; the global economic crisis, the new positions of China and India, Islamic feminisms and new secularisms. Illuminated by Eisenstein's distinctive style and personal narrative as she travels the world, Eisenstein challenges her readers to always be looking for the "newly new" political configurations in order to create a politics of and for the globe.
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