A spectral survey of tungsten emission in the ultraviolet region has been completed in the DIII-D tokamak and the CTH torsatron to assess the potential benefit of UV emission for the diagnosis of ...gross W erosion. Here, a total of 29 W I spectral lines are observed from the two experiments using survey spectrometers between 200 and 400 nm with level identifications provided based on a structure calculation for many of the excited states that produce strong emission lines. Of the 29 observed lines, 20 have not previously been reported in fusion relevant plasmas, including an intense line at 265.65 nm which could be important for benchmarking the frequently exploited line at 400.88 nm. Nearly all of the observed spectral lines decay down to one of the six lowest energy levels for neutral W, which are likely to be long-lived metastable states. The impact of metastable level populations on the W I emission spectrum and any erosion measurement utilizing a spectroscopic technique is potentially significant. Yet, the high density of W I emission in the UV region allows for the possibly of determining the relative metastable fractions and plasma parameters local to the erosion region. Additionally, the lines observed in this work could be used to perform multiple independent gross erosion measurements, leading to more accurate diagnosis of gross tungsten erosion.
The Helicity Injected Torus-Steady Inductive (HIT-SI) experiment investigates steady inductive helicity injection with the aim of forming and sustaining a high-beta equilibrium in a spheromak ...geometry using two semi-toroidal injectors. Results of experiments with unequal helicity injection rates produced the highest spheromak current (38 kA), current amplification (
I
tor
/
I
inj_quad
≈ 2) and poloidal flux amplification (ψ
pol
/ψ
inj_quad
> 6) to date. Single-injector operations establish a preferred direction of generated spheromak current for each injector depending on the sign of the injected helicity and its orientation relative to the confinement volume. Yet, the HIT-SI injectors prefer to drive opposing spheromak currents because they are mounted on opposite sides of the confinement volume. Single-injector operations also eliminate the spontaneous spheromak current flipping observed during dual-injector operations.
Experiments carried out on DIII-D using a novel setup of isotopic tungsten (W) sources in the outer divertor have characterized how the W leakage from this region depends on both the exact source ...location and edge-localized mode (ELM) behavior. The sources are toroidally-symmetric and poloidally-localized to two regions: (1) the outer strike point (OSP) with natural abundance of W isotopes; and (2) the far-target with highly-enriched 182W isotopes. With the use of a dual-faced collector probe (CP) in the main scrape-off layer (SOL) near the outside midplane and source-rate spectroscopy, a proxy for divertor impurity leakage is developed herein. Using this proxy, it is found that for the OSP W location, there is a nearly linear increase of leakage with the power across the separatrix (<IMG ALIGN="MIDDLE" alt="" src="https://static.iopscience.com/2.26.1/img/lazy-loading-placeholder.gif" data-src="https://cdn.iopscience.com/images/0029-5515/60/1/016028/nfab537bieqn001.gif"> ), which is consistent with the effect of an increased upstream ion temperature parallel gradient force in the near-SOL; trends in the pedestal density and collisionality are also seen. Conversely, it is found that for the far-target W location leakage falls off rapidly as <IMG ALIGN="MIDDLE" alt="" src="https://static.iopscience.com/2.26.1/img/lazy-loading-placeholder.gif" data-src="https://cdn.iopscience.com/images/0029-5515/60/1/016028/nfab537bieqn002.gif"> increases and ELM size decreases, which is suggestive that ELM size plays a role in the leakage from this location. Indications for main SOL W contamination is evidenced by the measurement of large deposition asymmetries on the two opposite CP faces. These measurements are coupled with interpretive modeling showing SOL W accumulation near the separatrix furthest from both targets driven by forces parallel to the magnetic field. This experimental setup, together with the target and upstream W measurements, provides information on the transport from different divertor W source locations and leakage. These studies help to elucidate the physics driving divertor impurity source rates and leakage, with and without ELMs, and provide better insight on the link in the chain connecting wall impurity sources to core impurity levels in magnetic fusion devices.
Angiogenesis depends on vascular endothelial growth factor (VEGF) for initiation and platelet-derived growth factor (PDGF) for maintenance of blood vessels. We have designed a targeted library of ...compounds from which we identified a novel molecule, GFB-204, that binds PDGF and VEGF, blocks binding of PDGF and VEGF to their receptors (200-500 nM) and subsequently inhibits PDGFR and Flk-1 tyrosine phosphorylation and stimulation of the protein kinases Erk1, Erk2 and Akt and the signal transducer and activator of transcription STAT3. GFB-204 is selective for PDGF and VEGF and does not inhibit EGF, IGF-1 and FGF stimulation of Erk1/2, Akt and STAT3. GFB-204 inhibits endothelial cell migration and capillary network formation in vitro. Finally, treatment of mice with GFB-204 suppresses human tumor growth and angiogenesis. Thus, inhibition of VEGF and PDGF receptor binding with a synthetic molecule results in potent inhibition of angiogenesis and tumorigenesis.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
ColRadPy: A Python collisional radiative solver Johnson, C.A.; Loch, S.D.; Ennis, D.A.
Nuclear materials and energy,
August 2019, 2019-08-00, 2019-08-01, Volume:
20, Issue:
C
Journal Article
Peer reviewed
Open access
•A new python code (ColRadPy) solves collisional radiative & ionization balance equations.•Application of ColRadPy to fusion relevant neutral molybdenum.•Many metastable states are often required to ...accurately model heavy species.•A new method to identify the most important metastable is described.
The properties of emitting ions in a plasma provides both potential for plasma diagnostics and key information required for plasma modeling. Generalized collisional radiative theory provides a powerful tool for the modeling of low and moderately dense plasmas. A new Python program is presented that solves the collisional radiative and ionization balance equations for application to fusion, laboratory, and astrophysical plasmas. It produces generalized coefficients that can be easily imported into existing plasma modeling codes and spectral diagnostics. An overview of the code is presented, along with selected results for applications to high-Z plasma facing components.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Pellet fuelling of improved confinement Madison Symmetric Torus (MST) plasmas has resulted in high density and high plasma beta. The density in improved confinement discharges has been increased ...fourfold, and a record plasma beta (β
tot
= 26%) for the improved confinement reversed-field pinch (RFP) has been achieved. At higher β, a new regime for instabilities is accessed in which local interchange and global tearing instabilities are calculated to be linearly unstable, but experimentally, no severe effect, e.g., a disruption, is observed. The tearing instability, normally driven by the current gradient, is driven by the pressure gradient in this case, and there are indications of increased energy transport (as compared with low-density improved confinement). Pellet fuelling is also compared with enhanced edge fuelling of standard confinement RFP discharges for the purpose of searching for a density limit in MST. In standard-confinement discharges, pellet fuelling peaks the density profile where edge fuelling cannot, but transport appears unchanged. For a limited range of plasma current, MST discharges with edge fuelling are constrained to a maximum density corresponding to the Greenwald limit. This limit is surpassed in pellet-fuelled improved confinement discharges.
Background The purpose of this study was to further elucidate the role of the vascular smooth muscle cells (SMCs) in abdominal aortic aneurysm (AAA) disease. We hypothesized that that AAA SMCs are ...unique and actively participate in the process of degrading the aortic matrix. Methods Whole-genome expression profiles of SMCs from AAAs, nondilated abdominal aorta (NAA), and carotid endarterectomy (CEA) were compared. We quantified elastolytic activity by culturing SMCs in 3 Helastin-coated plates and measuring solubilized tritium in the media after 7 days. Matrix metalloproteinase (MMP)-2 and MMP-9 production was assessed using real-time polymerase chain reaction, zymography, and Western blotting. Results Each SMC type exhibited a unique gene expression pattern. AAA SMCs had greater elastolytic activity than NAA-SMCs (+68%; P < .001) and CEA-SMCs (+45%; P < .001). Zymography showed an increase of active MMP-2 (62 kD) in media from AAA SMCs. AAA SMCs demonstrated twofold greater expression of MMP-2 messenger (m)RNA ( P < .05) and 7.3-fold greater MMP-9 expression ( P < .01) than NAA-SMCs. Culture with U937 monocytes caused a synergistic increase of elastolysis by AAA SMCs (41%; P < .001) but not NAA-SMCs or CEA-SMCs ( P = .99). Coculture with U937 caused a large increase in MMP-9 mRNA in AAA-SMCs and NAA-SMCs ( P < .001). MMP-2 mRNA expression was not affected. Western blots of culture media showed a fourfold increase of MMP-9 (92 kD) protein only in AAA-SMCs/U937 but not in NAA-SMCs/U937 ( P < .001) and a large increase in active-MMP2 (62 kD), which was less apparent in NAA-SMCs/U937 media ( P < .01). Conclusions AAA-SMCs have a unique gene expression profile and a proelastolytic phenotype that is augmented by macrophages. This may occur by a failure of post-transcriptional control of MMP-9 synthesis.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The impurity ion temperature evolution has been measured during three types of impulsive reconnection events in the Madison Symmetric Torus reversed field pinch. During an edge reconnection event, ...the drop in stored magnetic energy is small and ion heating is observed to be limited to the outer half of the plasma. Conversely, during a global reconnection event the drop in stored magnetic energy is large, and significant heating is observed at all radii. For both kinds of events, the drop in magnetic energy is sufficient to explain the increase in ion thermal energy. However, not all types of reconnection lead to ion heating. During a core reconnection event, both the stored magnetic energy and impurity ion temperature remain constant. The results suggest that a drop in magnetic energy is required for ions to be heated during reconnection, and that when this occurs heating is localized near the reconnection layer.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
The first sustainment of toroidal plasma current of 50 kA at up to 3 times the injected currents, added in quadrature, using steady inductive helicity injection is described. Separatrix ...currents-currents not linking the helicity injectors-are sustained up to 40 kA. Decreases in the n=1 toroidal mode of the poloidal magnetic field at higher current amplifications indicate more quiescent, direct toroidal current drive. Results are achieved in HIT-SI (with a spheromak of major radius 0.3 m) during deuterium operations immediately after helium operation. These results represent a breakthrough in the development of this new current drive method for magnetic confinement fusion.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
BACKGROUND:
Controversy surrounds the need for ICU admission, prolonged bed rest, and the duration of activity restrictions for children sustaining blunt trauma. Adult literature supports management ...based on hemodynamic status, not CT grade.
STUDY DESIGN:
A 3-year prospective study of a standardized management algorithm for hemodynamically normal pediatric patients with blunt liver or spleen injury was performed. Patient selection was based on vital signs, irrespective of injury grade on CT. Patients requiring ICU admission for nonliver or nonspleen injury were excluded. Patients were admitted to a surgical ward with serial hematocrit levels. Discharge occurred 48 hours postinjury if patients had no abdominal tenderness, tolerated a regular diet, and had a stable hematocrit. Patients were allowed noncontact activity, including school, after discharge. Patients were followed up at 1 month with ultrasonographic imaging.
RESULTS:
Eighty-nine patients sustained blunt liver or spleen injury. Forty-five patients were excluded for other injuries (Glasgow Coma Scale < 13, 32 of 45); the remaining 44 patients had a mean age of 8.9 years (range 2 to 17 years), Injury Severity Score 10.6 (range 4 to 33), liver grade 2.1, and splenic injury grade 2.3. Mechanisms of injury were predominately motor vehicle collisions (59%). All patients were managed nonoperatively without transfusion; 43 of 44 patients completed the algorithm. Mean observation was 55.2 ± 12.3 hours. One-month followup occurred in 33 of 44 patients, with one complication detected and no delayed bleeding.
CONCLUSIONS:
Management of pediatric solid organ injury should be guided by hemodynamic status and not injury grade on CT. Hemodynamically normal children can be safely managed without intensive care monitoring, do not need prolonged hospitalization, and can resume school on discharge.
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GEOZS, IJS, NUK, OILJ, SBCE, SBJE, UL, UM, UPUK
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