Background: NOD1/CARD4 and NOD2/CARD15 are both intracellular pattern‐recognition receptors. The NOD1/CARD4 gene lies within a previously described inflammatory bowel disease (IBD) locus (7p14). An ...association has been suggested between the NOD1/CARD4+32656 deletion*1 variant of a complex deletion*1/insertion*2 polymorphism and IBD in 1 recent study in Europe. Our aim was to assess the influence of NOD1/CARD4+32656 on disease susceptibility and phenotype in the Scottish and Swedish IBD populations.
Methods: A total of 3,962 individuals (1,791 IBD patients, 522 parents, 1,649 healthy controls) from 2 independent populations (Scotland and Sweden) were genotyped for NOD1/CARD4+32656 A/C by TaqMan and direct sequencing. Case‐control, Transmission Disequilibrium Testing (TDT) and detailed genotype–phenotype (Montreal) analyses were performed. The case‐control analysis had 80% power to detect an effect size of odds ratio (OR) 1.21 for IBD.
Results: In case‐control analyses in Scottish and Swedish patients, none of the genotypes studied in IBD, Crohn's disease (CD) or ulcerative colitis (UC), differed significantly from controls (deletion*1 allelic frequency 73.9%, 73.6%, 73.9%, and 73.6%, respectively: all P > 0.8). No epistatic interaction with NOD2/CARD15 was seen for CD susceptibility. TDT analysis in our Scottish early onset cohort was negative.
Conclusions: This variant allele of NOD1/CARD4+32656 is not associated with a strong effect on susceptibility to IBD in children and adults in Northern Europe. A gene‐wide haplotype‐based approach may be preferable to analysis of individual variants to assess the contribution of the NOD1/CARD4 gene to IBD.
(Inflamm Bowel Dis 2007)
We present results of a long-baseline interferometry campaign using the PAVO beam combiner at the CHARA Array to measure the angular sizes of five main-sequence stars, one subgiant and four red giant ...stars for which solar-like oscillations have been detected by either Kepler or CoRoT. By combining interferomettic angular diameters, Hipparcos parallaxes, asteroseismic densities, bolometric fluxes, and high-resolution spectroscopy, we derive a full set of near-model-independent fundamental properties for the sample. We first use these properties to test asteroseismic scaling relations for the frequency of maximum power (v sub(max)) and the large frequency separation ( Delta v). We find excellent agreement within the observational uncertainties, and empirically show that simple estimates of asteroseismic radii for main-sequence stars are accurate to lap4%. We furthermore find good agreement of our measured effective temperatures with spectroscopic and photometric estimates with mean deviations for stars between T sub(eff) = 4600-6200 K of -22 + or - 32 K (with a scatter of 97 K) and -58 + or - 31 K (with a scatter of 93 K), respectively. Finally, we present a first comparison with evolutionary models, and find differences between observed and theoretical properties for the metal-rich main-sequence star HD 173701. We conclude that the constraints presented in this study will have strong potential for testing stellar model physics, in particular when combined with detailed modeling of individual oscillation frequencies.
A search for flavor-changing neutral-current couplings between a top quark, an up or charm quark, and a $Z$ boson is presented, using proton-proton collision data at $\sqrt{s}$ = 13 TeV collected by ...the ATLAS detector at the Large Hadron Collider. The analyzed data set corresponds to an integrated luminosity of 139 fb-1. The search targets both single-top-quark events produced as $gq$ → $tZ$ (with $q$ = $u, c$) and top-quark-pair events, with one top quark decaying through the $t$ → $Zq$ channel. The analysis considers events with three leptons (electrons or muons), a $b$-tagged jet, possible additional jets, and missing transverse momentum. The data are found to be consistent with the background-only hypothesis and 95% confidence-level limits on the $t$ → $Zq$ branching ratios, assuming only tensor operators of the Standard Model effective field theory framework contribute to the $tZq$ vertices. These are 6.2 x 10-5 (13 x 10-5) for $t$ → $Zu$ ($t$ → $Zc$) for a left-handed $tZq$ coupling, and 6.6 x 10-5 (12 x 10-5) in the case of a right-handed coupling. These results are interpreted as 95% CL upper limits on the strength of the corresponding couplings, yielding limits for |${C}^{(13)*}_{uW}$| and |${C}^{(13)*}_{uB}$| (|${C}^{(31)}_{uW}$| and |${C}^{(31)}_{uB}$|) of 0.15 (0.16), and limits for |${C}^{(23)*}_{uW}$| and |${C}^{(23)*}_{uB}$| (|${C}^{(32)}_{uW}$| and |${C}^{(32)}_{uB}$|) of 0.22 (0.21), assuming a new-physics energy scale ΛNP of 1 TeV.
Full text
Available for:
CMK, CTK, FMFMET, IJS, NUK, PNG, UM
We present measurements of cross sections for production of a leptonically decaying $Z$ boson in association with a large-radius jet in 13 TeV proton-proton collisions at the LHC, using 36 fb–1 of ...data from the ATLAS detector. Integrated and differential cross sections are measured at particle level in both a flavor inclusive and a doubly $b$-tagged fiducial phase space. The large-radius jet mass and transverse momentum, its kinematic relationship to the Z boson, and the angular separation of $b$-tagged small-radius track jets within the large-radius jet are measured. This measurement constitutes an important test of perturbative quantum chromodynamics in kinematic and flavor configurations relevant to several Higgs boson and beyond-Standard-Model physics analyses. The results highlight issues with modeling of additional hadronic activity in the flavor-inclusive selection, and a distinction between flavor-number schemes in the $b$-tagged phase space.
Full text
Available for:
CMK, CTK, FMFMET, IJS, NUK, PNG, UM
A search for resonant Higgs boson pair production in the bb¯bb¯ final state is presented. The analysis uses 126 fb-1-139 fb-1 of pp collision data at √s=13 TeV collected with the ATLAS detector at ...the Large Hadron Collider. The analysis is divided into two channels, targeting Higgs boson decays which are reconstructed as pairs of small-radius jets or as individual large-radius jets. Spin-0 and spin-2 benchmark signal models are considered, both of which correspond to resonant HH production via gluon-gluon fusion. The data are consistent with Standard Model predictions. Upper limits are set on the production cross section times branching ratio to Higgs boson pairs of a new resonance in the mass range from 251 GeV to 5 TeV.
Full text
Available for:
CMK, CTK, FMFMET, IJS, NUK, PNG, UM
Several observables sensitive to the fragmentation of $\textit{b}$ quarks into $\textit{b}$ hadrons are measured using 36 fb-1 of $\sqrt{s}$ = 13 TeV proton-proton collision data collected with the ...ATLAS detector at the LHC. Jets containing b hadrons are obtained from a sample of dileptonic $t\bar{t}$ events, and the associated set of charged-particle tracks is separated into those from the primary $\textit{pp}$ interaction vertex and those from the displaced b-decay secondary vertex. This division is used to construct observables that characterize the longitudinal and transverse momentum distributions of the $\textit{b}$ hadron within the jet. The measurements have been corrected for detector effects and provide a test of heavy-quark-fragmentation modeling at the LHC in a system where the top-quark decay products are color connected to the proton beam remnants. The unfolded distributions are compared with the predictions of several modern Monte Carlo parton-shower generators and generator tunes, and a wide range of agreement with the data is observed, with $\textit{p}$ values varying from 5 × 10-4 to 0.98. These measurements complement similar measurements from $e^+e^-$ collider experiments in which the $\textit{b}$ quarks originate from a color singlet $Z/γ^{\ast}$.
Full text
Available for:
CMK, CTK, FMFMET, IJS, NUK, PNG, UM
PDF
