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1.
  • Mechanisms of Jak/STAT sign... Mechanisms of Jak/STAT signaling in immunity and disease
    Villarino, Alejandro V; Kanno, Yuka; Ferdinand, John R ... The Journal of immunology (1950), 2015-Jan-01, 2015-01-01, 20150101, Volume: 194, Issue: 1
    Journal Article
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    Open access

    More than two decades ago, experiments on the antiviral mechanisms of IFNs led to the discovery of JAKs and their downstream effectors, the STAT proteins. This pathway has since become a paradigm for ...
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  • Macrophage metabolic reprog... Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis
    Jing, Chenzhi; Castro-Dopico, Tomas; Richoz, Nathan ... Proceedings of the National Academy of Sciences - PNAS, 06/2020, Volume: 117, Issue: 26
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    IgG antibodies cause inflammation and organ damage in autoimmune diseases such as systemic lupus erythematosus (SLE). We investigated the metabolic profile of macrophages isolated from inflamed ...
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  • A cell atlas of human thymi... A cell atlas of human thymic development defines T cell repertoire formation
    Park, Jong-Eun; Botting, Rachel A; Domínguez Conde, Cecilia ... Science, 02/2020, Volume: 367, Issue: 6480
    Journal Article
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    Open access

    The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic cell types. We used single-cell RNA ...
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  • GM-CSF Calibrates Macrophag... GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation
    Castro-Dopico, Tomas; Fleming, Aaron; Dennison, Thomas W. ... Cell reports, 07/2020, Volume: 32, Issue: 1
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    Macrophages play a central role in intestinal immunity, but inappropriate macrophage activation is associated with inflammatory bowel disease (IBD). Here, we identify granulocyte-macrophage colony ...
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  • Regional Differences in Hum... Regional Differences in Human Biliary Tissues and Corresponding In Vitro–Derived Organoids
    Rimland, Casey A.; Tilson, Samantha G.; Morell, Carola M. ... Hepatology, January 2021, 2021-01-00, 20210101, Volume: 73, Issue: 1
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    Background and Aims Organoids provide a powerful system to study epithelia in vitro. Recently, this approach was applied successfully to the biliary tree, a series of ductular tissues responsible for ...
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  • Distinct microbial and immu... Distinct microbial and immune niches of the human colon
    James, Kylie R; Gomes, Tomas; Elmentaite, Rasa ... Nature immunology, 03/2020, Volume: 21, Issue: 3
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    Gastrointestinal microbiota and immune cells interact closely and display regional specificity; however, little is known about how these communities differ with location. Here, we simultaneously ...
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  • Aldehyde-driven transcripti... Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response
    Mulderrig, Lee; Garaycoechea, Juan I; Tuong, Zewen K ... Nature, 12/2021, Volume: 600, Issue: 7887
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    Endogenous DNA damage can perturb transcription, triggering a multifaceted cellular response that repairs the damage, degrades RNA polymerase II and shuts down global transcription . This response is ...
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  • Using single-cell technolog... Using single-cell technologies to map the human immune system - implications for nephrology
    Stewart, Benjamin J; Ferdinand, John R; Clatworthy, Menna R Nature reviews. Nephrology, 02/2020, Volume: 16, Issue: 2
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    Advances in single-cell technologies are transforming our understanding of cellular identity. For instance, the application of single-cell RNA sequencing and mass cytometry technologies to the study ...
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  • Renal Sodium Gradient Orche... Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone
    Berry, Miriam R.; Mathews, Rebeccah J.; Ferdinand, John R. ... Cell, 08/2017, Volume: 170, Issue: 5
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    Lower urinary tract infections are among the most common human bacterial infections, but extension to the kidneys is rare. This has been attributed to mechanical forces, such as urine flow, that ...
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  • Anti-commensal IgG Drives I... Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis
    Castro-Dopico, Tomas; Dennison, Thomas W.; Ferdinand, John R. ... Immunity, 04/2019, Volume: 50, Issue: 4
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    Inflammatory bowel disease is a chronic, relapsing condition with two subtypes, Crohn’s disease (CD) and ulcerative colitis (UC). Genome-wide association studies (GWASs) in UC implicate a FCGR2A ...
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