Publication trends in hidradenitis suppurativa from 2008 to 2018 Savage, K.T.; Gonzalez Brant, E.; Flood, K.S. ...
Journal of the European Academy of Dermatology and Venereology,
September 2020, 2020-Sep, 2020-09-00, 20200901, Volume:
34, Issue:
9
Journal Article
Peer reviewed
Background
Increased interest in hidradenitis suppurativa (HS) research is encouraging. A critical analysis of the state of HS literature may demonstrate the strength of existing knowledge and ...highlight current gaps.
Objectives
To analyse changes in HS literature from 2008 to 2018 with focus on quantity and quality of annual publications.
Methods
Review of all indexed publications reporting on HS on PubMed. Publications were categorized based on study design, study topic and treatment type where applicable. Publications were dichotomized into high level of evidence and low level of evidence groups. Linear regression analyses were performed to investigate the change in publication number over time. Annual average growth rate and distribution of high versus low level of evidence publications were calculated.
Results
Publication number increased over time overall (R2 = 0.64, P = 0.003) and for all publication types except randomized clinical trials. Case reports and case series represented the majority of HS publications (n = 479, 40.3%). Treatment was the main focus of publications (n = 445, 37.6%) with increasing interest in medical management evident in recent years. Distribution of low level of evidence studies (n = 974) compared with high level of evidence studies over time (n = 209) was significant (x2: 11.45, P = 0.0007). High level of evidence studies had a higher average annual growth rate (49.9%) compared with low level of evidence studies (23.7%). Few randomized clinical trials were performed (n = 16), focusing equally on medical or procedural treatments.
Conclusions
Hidradenitis suppurativa research is undergoing a tremendous shift, suggesting rapid maturation of the field. Current HS literature, however, remains primarily based on limited clinical observation data, with a particular lack of randomized clinical trials. Despite this, the increase in high level of evidence studies is encouraging and may herald a shift towards improved disease understanding and treatment paradigms.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
OBJECTIVES: To assess latent tuberculous infection (LTBI) treatment completion rates in a large prospective US/Canada multisite cohort and identify associated risk factors.METHODS: This prospective ...cohort study assessed factors associated with LTBI treatment completion through interviews
with persons who initiated treatment at 12 sites. Interviews were conducted at treatment initiation and completion/cessation. Participants received usual care according to each clinic's procedure. Multivariable models were constructed based on stepwise assessment of potential predictors and
interactions.RESULTS: Of 1515 participants initiating LTBI treatment, 1323 had information available on treatment completion; 617 (46.6%) completed treatment. Baseline predictors of completion included male sex, foreign birth, not thinking it would be a problem to take anti-tuberculosis
medication, and having health insurance. Participants in stable housing who received monthly appointment reminders were more likely to complete treatment than those without stable housing or without monthly reminders. End-of-treatment predictors of non-completion included severe symptoms and
the inconvenience of clinic/pharmacy schedules, barriers to care and changes of residence. Common reasons for treatment non-completion were patient concerns about tolerability/toxicity, appointment conflicts, low prioritization of TB, and forgetfulness.CONCLUSIONS: Less than half of treatment
initiators completed treatment in our multisite study. Addressing tangible issues such as not having health insurance, toxicity concerns, and clinic accessibility could help to improve treatment completion rates.
Atmospheric correction of high spatial resolution (10–30 m pixel sizes) satellite imagery for use in large-area land-cover monitoring is difficult due to the lack of aerosol optical depth (AOD) ...estimates made coincident with image acquisition. We present a methodology to determine the upper and lower bounds of AOD estimates that allow the subsequent calculation of a biophysical variable of interest to a pre-determined precision. Knowledge of that range can be used to identify an appropriate method for estimating AOD. We applied the methodology to Landsat 5 Thematic Mapper data in Queensland (QLD) and New South Wales (NSW), Australia, and determined that AOD must be estimated within approximately 0.05 of actual AOD for retrieval of foliage projective cover (FPC) to a precision of 10%. That knowledge was then used to determine the relative merit of using a fixed constant, Aerosol Robotic Network (AERONET) climatology, or dense dark vegetation (DDV) method for estimating AOD in QLD and NSW. It was found that using a fixed AOD of 0.05 allows estimates of FPC within 10% of their true value when the true value of AOD is less than 0.1. Such AOD values account for approximately 90% of all inland observations and 65% of coastal observations as determined by analysis of data obtained from AERONET. Using an AERONET climatology to estimate AOD was found to increase the likelihood of accurate FPC retrieval in coastal locations to 83%, although it should be noted that AERONET data are very sparse. DDV has potential in eastern and central areas for retrieving AOD observations with greater precision than fixed values or climatologies. However, more work is needed to understand the temporal variation of vegetation reflectance before the DDV method can be used operationally.
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BFBNIB, GIS, IJS, KISLJ, NUK, PNG, UL, UM, UPUK
4.
A LYSO calorimeter for the SuperB factory Eigen, G.; Zhou, Z.; Chao, D. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
08/2013, Volume:
718
Journal Article
Peer reviewed
Open access
The SuperB project is an asymmetric e+e− accelerator of 1036cm−2s−1 design luminosity, capable of collecting a data sample of 50–75ab−1 in five years running. The SuperB electromagnetic calorimeter ...(EMC) provides energy and direction measurement of photons and electrons, and is used for identification of electrons versus other charged particles. In particular we present its design, geometry study and related simulations, as well as R&D on LYSO crystals and developments on readout electronics. A matrix of 25 crystals has been tested at the Beam Test Facility of Frascati (BTF) in May 2011 at energies between 200MeV and 500MeV. Results from this test are presented.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The use of dense dark vegetation (DDV) for atmospheric aerosol correction of Landsat imagery is investigated for Australian conditions. Aerosol optical depth (AOD) measurements from sun photometers ...are used as a reference data set and compared against estimates of AOD derived from Landsat imagery using the DDV method. The DDV method makes assumptions that the vegetation is sufficiently dark and the ratio between bottom-of-atmosphere reflectances at different wavelengths is constant. These assumptions were tested using Landsat-5 Thematic Mapper (TM) imagery corrected with AOD measured by field-based sun photometers on the AErosol RObotic NETwork (AERONET) network. The assumptions were found to be correct only for one of the three locations studied. In other locations, the spatial and temporal variability of the vegetation and its relative brightness makes the method unsuitable.
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BFBNIB, GIS, IJS, KISLJ, NUK, PNG, UL, UM, UPUK
Many models of physics beyond the standard model predict the existence of new Abelian forces with new gauge bosons mediating interactions between "dark sectors" and the standard model. We report a ...search for a dark boson Z' coupling only to the second and third generations of leptons in the reaction e super(+) e super(?)arrowrightmu super(+)mu super(?)Z',Z'arrowrightmu super(+) mu? using 514fb super(?1) of data collected by the BABAR experiment. No significant signal is observed for Z' masses in the range 0.212-10 GeV. Limits on the coupling parameter g' as low as 7x10 super(?4) are derived, leading to improvements in the bounds compared to those previously derived from neutrino experiments.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
The SuperB project is an asymmetric e+e− accelerator of 1036 cm−2s−1 luminosity, capable of collecting a 50–75 ab−1 data sample in five years of running. The SuperB electromagnetic calorimeter (EMC) ...provides energy and direction measurement of photons and electrons and identification versus other charged particles for electrons. A matrix of 25 LYSO crystals has been tested at the Beam Test Facility at Frascati in May 2011 at energies between 100 MeV and 500 MeV. Results from this test will be presented. Design and Monte Carlo studies for the general EMC system will also be presented.
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