Objective. Adult granulosa cell tumors (AGCTs) represent 2%–5% of all ovarian malignancies. The aim of this study was to analyze clinical and pathohistological parameters and their impact on ...recurrence, overall, and disease-free survival in FIGO stage I AGCT patients. Methods. The tumor specimens analyzed in this retrospective study were obtained from a total of 36 patients with diagnosis of ovarian AGCT surgically treated at the Department of Gynecology, Rijeka University Hospital Centre, between 1994 and 2012. Clinical, pathological, and follow-up data were collected. Results. The mean age at diagnosis was 54.5 years with a range of 24–84. The majority of the patients, 30 (83%), were in FIGO stage IA, 3 (8%) in stage IC1, 1 (3%) in stage IC2, and 2 (6%) in stage IC3. During follow-up period (median 117.5 months, range 26–276), recurrence occurred in 4 patients (12%) with 2 deaths of the disease recorded. In univariate analysis, the 5-year survival rates were significantly shorter in patients with FIGO substage IC (p=0.019), with positive LVSI (p=0.022), with presence of necrosis (p=0.040), and with hemorrhage (p=0.017). In univariate analysis, the 5-year disease-free survival rates were significantly shorter in patients treated with fertility surgery (p=0.004), with diffuse growth pattern (p=0.012), with moderate and severe nuclear atypia (p=0.032), and with presence of hemorrhage (p=0.022). FIGO substage IC proved to be independent predictor for recurrence (OR = 16.87, p=0.015, and OR = 23.49, p=0.023, resp.) and disease-free survival (p=0.0002; HR 20.84, p=0.02) at the uni- and multivariate analyses. Conclusions. FIGO substage IC is predictive of recurrence and disease-free survival in patients with early-stage AGCTs. LVSI, presence of necrosis and hemorrhage, diffuse growth pattern, and nuclear atypia in AGCTs seem to be associated with overall and disease-free survival, so these pathological features should be taken into consideration when managing patients with AGCT.
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DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
A 31-year-old man with left-sided testicular pain lasting a couple of months was referred to our urology department due to a suspected testicular tumor. Physical examination showed a hard, thickened, ...and small left testis on palpation with a diffuse, inhomogeneous ultrasonographic appearance. After a urologic examination, a left-sided inguinal orchiectomy was performed. The testis, epididymis, and spermatic cord were sent to pathology. Gross examination revealed a cystic cavity filled with brown fluid and the surrounding brownish parenchyma measuring up to 3.5 cm in diameter. Histologic examination showed a cystically dilated rete testis lined with cuboidal epithelium and a positive immunohistochemical reaction to cytokeratins. Microscopically, the cystic cavity was a pseudocyst filled with extravasated erythrocytes and abundant clusters of siderophages. The siderophages extended into the testicular parenchyma, surrounding the seminiferous tubules and spreading out around the ducts of the epididymis, which were also cystically dilated with siderophages inside their lumina. On the basis of clinical data, histological, and immunohistochemical analysis, the patient was diagnosed with cystic dysplasia of the rete testis. The literature shows an association between cystic dysplasia of the rete testis and ipsilateral genitourinary anomalies. Therefore, our patient underwent a multi-slice computed tomography scan, which revealed ipsilateral renal agenesis, a right seminal vesicle cyst reaching up to the iliac arteries, and a multicystic formation cranial to the prostate.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
We describe a rare case of an eccrine syringofibroadenoma with a foci of squamous cell carcinoma in situ, which has to best of our knowledge been reported only twice in the English literature. An ...excisional biopsy of an elevated, lobular tumor of the lower leg in an 86-year-old male patient was performed. Histologic examination revealed a tumor consisting of anastomosing strands of epithelial cells originating from the epidermis, occasionally showing ductal eccrine differentiation. Foci of squamous cell carcinoma in situ were observed within the described lesion. The diagnosis of eccrine syringofibroadenoma with squamous cell carcinoma in situ was established. Eccrine syringofibroadenoma is a rare lesion, mostly considered to be a reactive process arising secondarily in association with other cutaneous diseases such as dermatoses or neoplasms, although some researchers do not exclude the possibility that it is a primary neoplasm with a potential for malignant transformation.
Mediterranean ecosystem offers a variety of shrubs that were over long periods of time involved in the evolution of complex plant-animal interactions. Biochemical components of these plants enter ...different metabolic pathways after digestion and absorption, resulting in development of dietary preferences in browsing animals. Herbivores in general were found to perform better when grazing in a mixed plant community composed of diverse species, and show preferential feeding behavioure for mixed vs single species diet. Our findings demonstrate an asymptotic relationship among Mediterranean shrubs species diversity and their voluntary intake by goats. Shrub biomass intake showed linear increase when number of different shrubs in diet increased from one to three. However, goats did not further increase intake when the number of shrub species increased from four to eight. As the number of shrub species offered increased, goats exhibited more preferential feeding behaviour for Quercus pubescens, Fraxinus ornus, Rubus heteromorphus and Arbutus unedo and decreased the intake of Hedera helix, Juniperus oxycedrus and Helichrysum italicum. This asymptotic relationship indicates that the maintenance of plant species richness in Mediterranean shrublands can overall benefit domestic goat farming, goat's productive performance, and the conservation of plant biodiversity.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Proizvodnja sredozemnog smilja (Helichrysum italicum (Roth) G. Don) u Hrvatskoj je u porastu te se javlja potreba za bržom i kvalitetnijom ponudom sadnog materijala. Cilj rada je utvrditi kako na ...visinu biljke, broj postranih izbojaka i masu suhe tvari presadnice utječu dušik, fosfor i kalij pojedinačno i u kombinaciji primijenjeni u hranjivim otopinama različitih koncentracija (električne provodljivosti: 1,5 mS/cm, 2,2 mS/cm i 3,0 mS/cm). Pokus je postavljen na presadnicama u fazi 4 do 5 listova nakon pikiranja. Dobiveni rezultat pokazuje da sve varijante imaju pozitivan učinak na rast i razvoj do određenih koncentracija u odnosu na kontrolu osim kalija. Pojedinačna gnojidba dušikom i fosforom u koncentracijama do 2,2 mS/cm ima pozitivan učinak na rast i razvoj presadnica smilja, dok koncentracije ovih gnojiva iznad 2,2 mS/cm nisu doprinijele boljem rastu presadnica. Gnojidba kalijem u kontroliranim uvjetima nije imala pozitivan učinak u usporedbi s ostalim gnojivima.
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