In the past 37 years, human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) has undergone various major transmission routes in China, with the world most complex co-circulating ...HIV-1 subtypes, even the prevalence is still low. In response to the first epidemic outbreak of HIV in injecting drug users and the second one by illegal commercial blood collection, China issued the Anti-Drug Law and launched the Blood Donation Act and nationwide nucleic acid testing, which has avoided 98,232 to 211,200 estimated infections and almost ended the blood product-related infection. China has been providing free antiretroviral therapy (ART) since 2003, which covered >80% of the identified patients and achieved a viral suppression rate of 91%. To bend the curve of increasing the disease burden of HIV and finally end the epidemic, China should consider constraining HIV spread through sexual transmission, narrowing the gaps in identifying HIV cases, and the long-term effectiveness and safety of ART in the future.
In this work we focus on a toy model: (
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)-dimensional Hořava–Lifshitz gravity. This model exhibits a remarkable feature that it has the same velocity for both gravitational and electromagnetic waves. This feature makes it possible to restrict the parameters of the theory from GRB 170817A. In this work we use this feature to discuss possible constraints on the parameter
β
in the theory, by analyzing the possible Lorentz invariance violation effect of the GRB 170817A. This is achieved by analyzing potential time delay of gamma-ray photons in this event. It turns out that it places a stringent constraint on this parameter. In the most ideal case, it gives
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
SiOC/HfO2‐based ceramic nanocomposites with in situ formed HfO2 nanoparticles were prepared via a single‐source precursor (SSP) approach starting from a polymethylsilsesquioxane (PMS) modified by Hf‐ ...and Ti‐alkoxides. By varying the alkyl‐group of the employed Hf‐alkoxides, SiOC/HfO2‐based ceramic nanocomposites with different HfO2 polymorphs formed via thermal decomposition of the SSP under the same heat‐treatment conditions. Using PMS chemically modified by Hf(OnBu)4, tetragonal HfO2 phase was formed after the synthesis at 1100°C in Ar, whereas both, tetragonal and monoclinic HfO2 nanocrystals, were analyzed when replacing Hf(OnBu)4 by Hf(OiPr)4. After oxidation of the synthesized nanocomposites in air at 1500°C, a facile formation of oxidation‐resistant HfSiO4 (hafnon) phase occurred by the reaction of HfO2 nanocrystals with silica present in the SiOC nanocomposite matrix derived from Hf(OiPr)4‐modified SSPs. Moreover the amount of hafnon is dramatically increased by the additional modification of the polysiloxane with Ti‐alkoxides. In contrast, ceramic nanocomposites derived from Hf(OnBu)4‐modified SSPs, almost no HfSiO4 is detected after oxidation at 1500°C even though in the case of Ti‐alkoxide‐modified single‐source precursor.
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BFBNIB, DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
Developing efficient organic solar cells (OSCs) with thick active layers is crucial for roll‐to‐roll printing. However, thicker layers often result in lower efficiency. This study tackles this ...challenge using a polymer adsorption strategy combined with a layer‐by‐layer approach. Incorporating insulator polystyrene (PS) into the PM6:L8‐BO system creates PM6+PS:L8‐BO blends, effectively suppressing trap states and extending exciton diffusion length in the mixed donor domain. Adding insulating polymers with benzene rings to the donor enhances π–π stacking of donors, boosting intermolecular interactions and electron wave function overlap. This results in more orderly molecular stacking, longer exciton lifetimes, and higher diffusion lengths. The promoted long‐range exciton diffusion leads to high power conversion efficiencies of 19.05% and 18.15% for PM6+PS:L8‐BO blend films with 100 and 300 nm thickness, respectively, as well as a respectable 16.00% for 500 nm. These insights guide material selection for better exciton diffusion, and offer a method for thick‐film OSC fabrication, promoting a prosperous future for practical OSC mass production.
This study addresses the challenge of maintaining efficiency in thick‐film organic solar cells (OSCs). A novel polymer adsorption strategy that regulates molecular stacking, leading to enhanced intermolecular interactions. A reduction in trap states and an elongation in exciton diffusion length, resulting in a remarkable increase in power conversion efficiency in thick‐film OSCs, is achieved.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Effective screening and early detection are critical to improve the prognosis of gastric cancer (GC). Our study aims to explore noninvasive multianalytical biomarkers and construct integrative models ...for preliminary risk assessment and GC detection. Whole genomewide methylation marker discovery was conducted with CpG tandems target amplification (CTTA) in cfDNA from large asymptomatic screening participants in a high‐risk area of GC. The methylation and mutation candidates were validated simultaneously using one plasma from patients at various gastric lesion stages by multiplex profiling with Mutation Capsule Plus (MCP). Helicobacter pylori specific antibodies were detected with a recomLine assay. Integrated models were constructed and validated by the combination of multianalytical biomarkers. A total of 146 and 120 novel methylation markers were found in CpG islands and promoter regions across the genome with CTTA. The methylation markers together with the candidate mutations were validated with MCP and used to establish a 133‐methylation‐marker panel for risk assessment of suspicious precancerous lesions and GC cases and a 49‐methylation‐marker panel as well as a 144‐amplicon‐mutation panel for GC detection. An integrated model comprising both methylation and specific antibody panels performed better for risk assessment than a traditional model (AUC, 0.83 and 0.63, P < .001). A second model for GC detection integrating methylation and mutation panels also outperformed the traditional model (AUC, 0.82 and 0.68, P = .005). Our study established methylation, mutation and H. pylori‐specific antibody panels and constructed two integrated models for risk assessment and GC screening. Our findings provide new insights for a more precise GC screening strategy in the future.
What's new?
Genetic and epigenetic markers and environmental factors including Helicobacter pylori promote gastric cancer. Here, the authors established methylation, mutation and H. pylori‐specific antibody biomarker panels based on the analysis of precancerous lesions and gastric cancer cases to construct and validate two integrative models. The risk assessment model aimed to identify suspicious precancerous lesions and gastric cancer cases among asymptomatic screening participants and the detection model to further distinguish gastric cancer from suspected cases. The models showed better performance than a traditional model and high feasibility, paving the way for a noninvasive multianalytical approach for risk assessment and gastric cancer detection.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
AbstractThe deep surrounding rock under true triaxial stress is easy to break at the new excavation face, which will induce engineering disasters to threaten personnel and equipment. Many studies ...have shown that the intermediate principal stress (IPS) has a great influence on rock failure. To accurately understand the influence of IPS on the gradual failure mechanism of the new excavation face under true triaxial stress and extract the key precursor information of rock failure, this study is based on true triaxial tests of acoustic emission (AE) monitoring, which provides a creative explanation to the phenomenon that sometimes the sudden increase of the AE counts rate (ACR) and the energy release rate (ERR) changes asynchronously. This paper analyzes the influence of IPS on the crack type in the failure process, studies the transitional behavior and gradual evolution of AE dominant frequency, and presents the precursor information index for rock failure. The results show that the sudden increase times of ACR and ERR under different IPS values are different. The rock under lower IPS is prone to produce intergranular fracture with low energy consumption, while the rock under higher IPS is prone to produce transgranular fracture with high energy consumption. Near the peak stress, the dominant frequency at lower IPS shows obvious downward transitional behavior, and the dominant frequency under higher IPS presents downward and upward transitional behavior. This study verified that tIII−max can be used as the key precursor information for predicting rock failure.
Tibetan Plateau is known as the roof of the world. Due to the continuous uplift of the Tibetan Plateau, many active fault zones are present. These active fault zones such as the Anninghe fault zone ...have a significant influence on the formation of special geomorphology and the distribution of geological hazards at the eastern edge of the Tibetan Plateau. The Anninghe fault zone is a key part of the Y-shaped fault pattern in the Sichuan-Yunnan block of China. In this paper, high-resolution topographic data, multitemporal remote sensing images, numerical calculations, seismic records, and comprehensive field investigations were employed to study the landslide distribution along the active part of the Anninghe. The influence of active faults on the lithology, rock mass structures and slope stress fields were also studied. The results show that the faults within the Anninghe fault zone have damaged the structure and integrity of the slope rock mass, reduced the mechanical strength of the rock mass and controlled the slope failure modes. The faults have also controlled the stress field, the distribution of the plastic strain zone and the maximum shear strain zone of the slope, thus have promoted the formation and evolution of landslides. We find that the studied landslides are linearly distributed along the Anninghe fault zone, and more than 80% of these landslides are within 2–3 km of the fault rupture zone. Moreover, the Anninghe fault zone provides abundant substance for landslides or debris flows. This paper presents four types of sliding mode control of the Anninghe fault zone, e.g., constituting the whole landslide body, controlling the lateral boundary of the landslide, controlling the crown of the landslide, and constituting the toe of the landslide. The results presented merit close attention as a valuable reference source for local infrastructure planning and engineering projects.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Soil salinity affects the expression of serine/arginine-rich (SR) genes and isoforms by alternative splicing, which in turn regulates the adaptation of plants to stress. We previously identified the ...cassava spliceosomal component 35 like (SCL) and SR subfamilies, belonging to the SR protein family, which are extensively involved in responses to abiotic stresses. However, the post-transcriptional regulatory mechanism of cassava arginine/serine-rich (RS) subfamily in response to salt stress remains to be explored. In the current study, we identified 37 genes of the RS subfamily from 11 plant species and systematically investigated the transcript levels of the RS40 and RS31 genes under diverse abiotic stress conditions. Subsequently, an analysis of the conserved protein domains revealed that plant RS subfamily genes were likely to preserve their conserved molecular functions and played critical functional roles in responses to abiotic stresses. Importantly, we found that overexpression of MeRS40 in Arabidopsis enhanced salt tolerance by maintaining reactive oxygen species homeostasis and up-regulating the salt-responsive genes. However, overexpression of MeRS40 gene in cassava reduced salt tolerance due to the depression of its endogenous gene expression by negative autoregulation of its own pre-mRNA. Moreover, the MeRS40 protein interacted with MeU1-70Ks (MeU1-70Ka and MeU1-70Kb) in vivo and in vitro, respectively. Therefore, our ?ndings highlight the critical role of cassava SR proteins in responses to salt stress in plants.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The anionic redox reaction (ARR) has become a hot topic in battery research due to its ability to provide high energy density. Nevertheless, there are still many issues in Na-based layered oxides ...with the ARR, such as large voltage hysteresis, lattice oxygen loss, irreversible structural changes, and cation migration in the TM layer, resulting in structural collapse and poor electrochemical performance. Herein, a series of Na2/3Fe1/3MgxMn2/3−xO2 cathodes are synthesized using a traditional solid-state reaction method. The effectiveness of Mg substitution amounts and site occupancy in regulating the reversibility of the ARR has been explored using various experimental techniques. Surprisingly, the well-designed Na/TM-site Mg substituted P2-Na2/3Fe1/3Mg1/12Mn7/12O2 exhibits an extremely high initial reversible capacity of ∼253.21 mA h g−1, equivalent to ∼0.94 e− transfer, which is contributed by both cationic and anionic redox reactions as confirmed by hard X-ray absorption spectroscopy (hXAS) and soft X-ray absorption spectroscopy (sXAS) analyses. In addition, the improved cycling and high-rate performance of the P2-Na2/3Fe1/3Mg1/12Mn7/12O2 are achieved by a well-maintained crystal structure and the highly reversible anionic redox reaction of O2−/On−. These in-depth studies provide crucial knowledge for the development and understanding of cathode materials with a highly reversible ARR for low-cost and high-energy sodium-ion batteries.
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