The activity of Au nanoparticle-loaded P25 TiO2 (Au/P25) plasmonic photocatalysts, evaluated by the oxidative decomposition of formic acid in water under visible light irradiation, was enhanced up to ...3 times by simply mixing Au/P25 with photocatalytically inactive h-BN nanosheets as a result of electron transfer from photoexcited Au/TiO2 to the h-BN nanosheets and retardation of the charge recombination.
Antibody-drug conjugates (ADCs) are potent cytotoxic drugs linked to antibodies through chemical linkers, and allow specific targeting of drugs to neoplastic cells. The expression of CD22 is limited ...to B-cells, and we show that CD22 is expressed on the vast majority of non-Hodgkin's lymphomas (NHLs). An ideal target for an ADC for the treatment of NHL would have limited expression outside the B-cell compartment and be highly effective against NHL. We generated an ADC consisting of a humanized anti-CD22 antibody conjugated to the anti-mitotic agent maytansine with a stable linker (anti-CD22-MCC-DM1). Anti-CD22-MCC-DM1 was broadly effective in in vitro killing assays on NHL B-cell lines. We did not find a strong correlation between in vitro potency and CD22 surface expression, internalization of ADC or sensitivity to free drug. We show that anti-CD22-MCC-DM1 was capable of inducing complete tumor regression in NHL xenograft mouse models. Further, anti-CD22-MCC-DM1 was well tolerated in cynomolgus monkeys and substantially decreased circulating B-cells as well as follicle size and germinal center formation in lymphoid organs. These results suggest that anti-CD22-MCC-DM1 has an efficacy, safety and pharmacodynamic profile that support its use as a treatment for NHL.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Histone macroH2A is an unusual core histone that contains a large non-histone region, and a region that resembles a full length H2A. We examined the conservation of this novel structural arrangement ...by cloning chicken macroH2A cDNAs and comparing them to their rat counterparts. The amino acid sequences of the two known macroH2A subtypes are >95% identical between these species despite evolutionary separation of ~300 million years. The H2A region of macroH2A is completely conserved, and thus is even more conserved than conventional H2A in these species. The origin of the non-histone domain was examined by comparing its sequence to proteins found in bacteria and RNA viruses. These comparisons indicate that this domain is derived from a gene that originated prior to the appearance of eukaryotes, and suggest that the non-histone region has retained the basic function of its ancestral gene.
Frequency hopping spread spectrum and direct sequence spread spectrum are two main spread coding technologies in communication systems. Frequency hopping sequences are needed in frequency hopping ...code-division multiple-access (FH-CDMA) systems. In this paper, four algebraic and a combinatorial constructions of optimal sets of frequency hopping sequences with new parameters are presented, and a number of bounds on sets of frequency hopping sequences are described.
A (v, k, /spl lambda//sub a/, /spl lambda//sub c/) optical orthogonal code (OOC) C is a family of (0, 1)-sequences of length v and weight k satisfying the following two correlation properties: (1) .../spl Sigma//sub 0/spl les/t/spl les/v-1/x/sub t/x/sub t+i//spl les//spl lambda//sub a/ for any x=(x/sub 0/,x/sub 1/,/spl middot//spl middot//spl middot/,x/sub v-1/)/spl isin/C and any integer i not equivalent 0 mod v; and (2) /spl Sigma//sub 0/spl les/t/spl les/v-1/x/sub t/y/sub t+i//spl les//spl lambda//sub b/ for any x=(x/sub 0/,x/sub 1/,/spl middot//spl middot//spl middot/, x/sub v-1/) /spl isin/ C, y=(y/sub 0/,y/sub 1/,/spl middot//spl middot//spl middot/,y/sub v-1/) /spl isin/C with x/spl ne/y, and any integer i, where the subscripts are taken modulo v. The study of optical orthogonal codes is motivated by an application in optical code-division multiple-access communication systems. In this paper, upper bounds on the size of an optical orthogonal code are discussed. Several new constructions for optimal optical orthogonal codes with weight k/spl ges/4 and correlation constraints /spl lambda//sub a/=/spl lambda//sub c/=1 are described by means of optimal cyclic packings. Many new infinite series of such optimal optical orthogonal codes are thus produced.
Bispecific antibodies using the transferrin receptor (TfR) have shown promise for boosting antibody uptake in brain. Nevertheless, there are limited data on the therapeutic properties including ...safety liabilities that will enable successful development of TfR-based therapeutics. We evaluate TfR/BACE1 bispecific antibody variants in mouse and show that reducing TfR binding affinity improves not only brain uptake but also peripheral exposure and the safety profile of these antibodies. We identify and seek to address liabilities of targeting TfR with antibodies, namely, acute clinical signs and decreased circulating reticulocytes observed after dosing. By eliminating Fc effector function, we ameliorated the acute clinical signs and partially rescued a reduction in reticulocytes. Furthermore, we show that complement mediates a residual decrease in reticulocytes observed after Fc effector function is eliminated. These data raise important safety concerns and potential mitigation strategies for the development of TfR-based therapies that are designed to cross the blood-brain barrier.
Frequency hopping multiple access (FHMA) spread-spectrum communication systems employing multiple frequency-shift keying (MFSK) as data modulation technique are investigated from a combinatorial ...approach. A correspondence between optimal frequency hopping (FH) sequences and partition-type difference packings is first established. By virtue of this correspondence, FHMA systems with a single optimal FH sequence each are constructed from various combinatorial structures such as affine geometries, cyclic designs, and difference families. Combinatorial recursive constructions are also presented. Many new infinite series of optimal FH sequences are thus obtained. These new FH sequences are also useful in ultra wideband (UWB) communication systems.
A rare, multisystemic intravascular proliferative disorder was identified postmortem in eight cats. The majority of these cats died or were euthanized following episodes of dyspnea, lethargy, and ...anorexia. Microscopic examination revealed occlusive, intraluminal proliferations of spindle cells within small vessels. The heart was consistently involved, and myocardial dysfunction was the probable cause of illness in all cats. Immunohistochemically, the majority of intravascular cells expressed von Willebrand factor, and a smaller number expressed smooth muscle actin, compatible with a dual population of endothelial cells and pericytes, suggesting a reactive rather than a neoplastic process. Four cases of a similar feline vascular disorder from the veterinary literature are reviewed. The histopathology resembles reactive angioendotheliomatosis in humans, a benign cutaneous intravascular endothelial and pericytic proliferative condition. However, in contrast, this feline disease is multisystemic and fatal. We propose the name "feline systemic reactive angioendotheliomatosis" for this unique, idiopathic disorder of domestic cats.
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NUK, OILJ, SAZU, UKNU, UL, UM, UPUK
A (v,k,/spl lambda/) optical orthogonal code C is a family of (0,1) sequences of length v and weight k satisfying the following correlation properties: 1) /spl Sigma//sub 0/spl les/t/spl ...les/v-1/x/sub t/x/sub t+i//spl les//spl lambda/ for any x=(x/sub 0/, x/sub 1/, ..., x/sub v-1/)/spl isin/C and any integer i/spl ne/0(mod v); 2) /spl Sigma//sub 0/spl les/t/spl les/v-1/x/sub t/y/sub t+i//spl les//spl lambda/ for any x=(x/sub 0/, x/sub 1/, ..., x/sub v-1/)/spl isin/C, y=(y/sub 0/, y/sub 1/, ..., y/sub v-1/)/spl isin/C with x/spl ne/y, and any integer i, where the subscripts are taken modulo v. A (v,k,/spl lambda/) optical orthogonal code (OOC) with /spl lfloor/(1/k)/spl lfloor/(v-1/k-2)/spl lfloor/(v-2/k-2)/spl lfloor//spl middot//spl middot//spl middot//spl lfloor/(v-/spl lambda//k-/spl lambda/)/spl rfloor/: M/spl rfloor//spl rfloor//spl rfloor/ codewords is said to be optimal. OOCs are essential for success of fiber-optic code-division multiple-access (CDMA) communication systems. The use of an optimal OOC enables the largest possible number of asynchronous users to transmit information efficiently and reliably. In this paper, various combinatorial constructions for optimal (v,4,1) OOCs, such as those via skew starters and Weil's theorem on character sums, are given for v/spl equiv/0 (mod 12). These improve the known existence results on optimal OOCs. In particular, it is shown that an optimal (v,4,1) OOC exists for any positive integer v/spl equiv/0 (mod 24).
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