TAM and other myeloid‐derived tumor infiltrating cells are reviewed as pivotal players in the tumor microenvironment; implications to anti‐cancer therapy are described.
The microenvironment of solid ...tumors is characterized by a reactive stroma with an abundance of inflammatory mediators and leukocytes, dysregulated vessels and proteolytic enzymes. TAM, major players in the connection between inflammation and cancer, summarize a number of functions (e.g., promotion of tumor cell proliferation and angiogenesis, incessant matrix turnover, repression of adaptive immunity), which ultimately have an important impact on disease progression. Thus, together with other myeloid‐related cells present at the tumor site (Tie2 macrophages and MDSCs), TAM represent an attractive target of novel biological therapies of tumors.
Full text
Available for:
FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
In Northeast Brazil (NEB), severe droughts have high socioeconomic impacts. In this study, the spatial–temporal characteristics of drought were evaluated based on a new drought index at 4‐km spatial ...resolution, derived from regional empirical relationships between a remote sensing‐based index and rain‐gauge‐based standardized precipitation index (SPI), a well‐known drought meteorological index. This index was used to compare the spatial pattern of severe drought events (1982–1983, 1992–1993, 1997–1998, and 2012–2013) of the last 30 years. Strong El Niño related droughts were found to be generally spatially limited, affecting around 30% of NEB and concentrated in the northern part of the region, while 2012 drought, which was not El Niño related, was widespread, reaching 46% of NEB. These results stressed the importance of analyzing droughts at the subregion scale using data with higher spatial resolution. Statistically significant trends (p < 0.05) toward drier conditions detected in the SPI time‐series were linked to the tropical Atlantic Ocean warming trend, which result in an increased drought risk and social vulnerability in the region.
The spatial–temporal characteristics of drought were evaluated based on a new drought index derived from regional empirical relationships between a remote sensing‐based index and a standardized precipitation index.
Spatial and temporal trends of drought index are assessed over Brazilian Northeast.
Significant signal toward drier conditions was identified in most of the study region.
Full text
Available for:
BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Although pre-revascularization ischaemia testing is recommended, the interaction between the extent of ischaemia and myocardial scar with performance of revascularization on patient survival is ...unclear.
We identified 13 969 patients who underwent adenosine or exercise stress SPECT myocardial perfusion scintigraphy (MPS). The percent myocardium ischaemic (%I) and fixed (%F) were calculated using 5 point/20-segment MPS scoring. Patients lost to follow-up (2.8%) were excluded leaving 13 555 patients 35% with history (Hx) of known coronary artery disease (CAD), 65% exercise stress, 61% male, age 66 ± 12. Follow-up was performed at 12-18 months for early revascularization and at >7 years for all-cause death (ACD) (mean follow-up 8.7 ± 3.3 years). All-cause death was modelled using Cox proportional hazards modelling adjusting for logistic-based propensity scores, MPS, revascularization, and baseline characteristics. During FU, 3893 ACD (29%, 3.3%/year) and 1226 early revascularizations (9.0%) occurred. After risk-adjustment, a three-way interaction was present between %I, early revascularization, and HxCAD, such that %I identified a survival benefit with early revascularization in patients without prior myocardial infarction (MI), whereas no such benefit was present in patients with prior MI (overall model χ(2)= 3932, P < 0.001; interaction P < 0.021). Further modelling revealed that after excluding patients with scar >10% total myocardium, %I identified a survival benefit in all patients.
In this large observational series with long-term follow-up, patients with significant ischaemia and without extensive scar were likely to realize a survival benefit from early revascularization. In contrast, the survival of patients with minimal ischaemia was superior with medical therapy without early revascularization.
ABSTRACT
The past two decades have seen dramatic progress in our knowledge of the population of young stars of age $\lt \!200\,$ Myr that lie within $150\,$ pc of the Sun. These nearby, young stars, ...most of which are found in loose, comoving groups, provide the opportunity to explore (among many other things) the dissolution of stellar clusters and their diffusion into the field star population. Here, we exploit the combination of astrometric and photometric data from Gaia and photometric data from GALEX (UV) and 2MASS (near-IR) in an attempt to identify additional nearby, young, late-type stars. Specifically, we present a sample of 146 GALEX UV-selected late-type (predominantly K-type) field stars with Gaia-based distances $\lt \!125\,$ pc (based on Gaia Data Release 1) that have isochronal ages $\lt \!80\,$ Myr even if equal-components binaries. We investigate the spectroscopic and kinematic properties of this sample. Despite their young isochronal ages, only ∼10 per cent of stars among this sample can be confidently associated with established nearby, young moving groups (MGs). These candidate MG members include five stars newly identified in this study. The vast majority of our sample of 146 nearby young star candidates have anomalous kinematics relative to the known MGs. These stars may hence represent a previously unrecognized population of young stars that has recently mixed into the older field star population. We discuss the implications and caveats of such a hypothesis – including the intriguing fact that, in addition to their non-young-star-like kinematics, the majority of the UV-selected, isochronally young field stars within $50\,$ pc appear surprisingly X-ray faint.
Human actions induce and modify droughts. However, scientific gaps remain with respect to how hydrological processes, anthropogenic dynamics, and individuals' perceptions of impacts are intrinsically ...entangled in drought occurrence and evolution. This adds complexity to drought assessment studies that cannot be addressed by the natural and environmental sciences alone. Furthermore, it poses a challenge with respect to developing ways to evaluate human behaviour and its pattern of co-evolution with the hydrological cycle – mainly related to water use and landscape modifications. During fieldwork in Brazil, we observed how drought impacts were experienced by people who were exposed to a multi-year drought. Evaluating our data, it appeared that prospect theory, a behavioural economic theory that is usually applied to explain decision-making processes under uncertainty, has explanatory power regarding what we observed in the field. Therefore, we propose an interdisciplinary approach to improve the understanding of drought impact emergence using this theory. When employing prospect theory in this context, drought impacts are considered failed welfare expectations (“prospects”) due to water shortage. A shifting baseline after prolonged exposure to drought can therefore mitigate experienced drought impacts. We demonstrate that this theory can also contribute to explaining socio-hydrological phenomena, such as reservoir effects. This new approach can help bridge natural science and social science perspectives, resulting in integrated drought management that considers the local context.
Abstract
We study the multiplicity distribution measured in pp collisions at the LHC using a distribution which is derived from the Giovannini equations under the assumption that the evolution ...parameter is energy dependent. We obtain a negative binomial distribution with explicit energy dependence and fit it to three data sets, corresponding to different pseudorapidity and transverse momentum cuts, and also verify the applicability of the model for a fourth data set, corresponding to jets. We find a reasonable agreement with data for all sets.
Historically, during periods of extreme drought, food security in the drylands of the semiarid region of Northeast Brazil (NEB) is under severe risk due to agricultural collapse. The drought that ...started in 2012 continues to highlight the vulnerability of this region, and arid conditions have been detected during the last years mainly in the central semiarid region, covering almost 2% of the NEB. Climate projections show an increase in the area under water stress condition, covering 49% and 54% of the NEB region by 2700 and 2100, respectively, with a higher likelihood with warming above 4 °C. The projections of vegetative stress conditions derived from the empirical model for Vegetation Health Index (VHI) are consistent with projections from vegetation models, where semi-desert types typical of arid conditions would replace the current semiarid bushland vegetation (“caatinga”) by 2100. Due to the impacts of the 2012–2017 drought, public policies have been implemented to reduce social and economic vulnerability for small farmers but are not enough as poor population continues to be affected. In the long term, to make the semiarid less vulnerable to drought, strengthened integrated water resources management and a proactive drought policy are needed to restructure the economy. Integrating drought monitoring and seasonal climate forecasting provides means of assessing impacts of climate variability and change, leading to disaster risk reduction through early warning. Lastly, there is an urgent need for integrated assessments because the possibility that under permanent drought conditions with warming above 4 °C, arid conditions would prevail in NEB since 2060.
Full text
Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Building reservoirs is a response to cope with drought in drylands. However, this human modification to the landscape may trigger both positive and negative effects. Here, we investigate how a ...network of reservoirs influences the propagation of meteorological drought (MD) into hydrological drought (HD) in a large semi-arid catchment in Brazil. We applied 12-month standardized indices to classify droughts. Then, the drought series were compared to each other. The downstreamness concept was used to describe the spatial water distribution. The onset of reservoir drought (RD) was much later than MD, but the delay between MD and RD peaks was even longer. Streamflow drought started with a small delay after MD, but it transformed into a similar RD. RD was initially more severe downstream. When the drought severity was at its highest, upstream and downstream RD equalized. The perceptual model of drought propagation may help in developing reservoir management systems in drylands.
Full text
Available for:
BFBNIB, GIS, IJS, IZUM, KILJ, KISLJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
In regions characterized by a high concentration of small reservoirs, there is often public debate about the effectiveness of these structures in locally adapting to and mitigating drought impacts, ...bearing in mind their potential to modify or induce drought events in downstream areas. In this study, we investigated the influence of a Dense Network of Small Reservoirs (DNR) on the emergence and intensification of drought impacts at catchment scale, as well as their local social benefits. This analysis was based on the Socio‐Hydrological‐Agricultural‐Reservoir (SHARE) model, specially developed for this purpose, with a medium‐sized catchment in the semi‐arid region of Brazil as a case study. We identified that, while a DNR can prolong the effects of a hydrological drought on storage in a large strategic reservoir at the catchment outlet by obstructing surface‐runoff connectivity, it plays a crucial role in mitigating drought impacts at a local level. Specifically, the presence of small reservoirs has the potential to boost local agricultural production by up to 5 times compared to scenarios without these structures. In addition, our simulation results suggest there is a notable reduction in the need for emergency water distribution by water trucks in the presence of a DNR. This study highlights the need for a balanced approach to implementing public policies, weighing the local benefits of small reservoirs against the possible downstream impacts on large reservoirs.
Plain Language Summary
This study analyzed the impact of a dense network of small reservoirs in a semi‐arid region of Brazil on drought effects. Although there is criticism about the use of these structures because they can influence drought events in neighboring areas, our results showed that, locally, these reservoirs are essential for mitigating the impacts of drought. They may prolong the drought in large reservoirs, but they play a crucial role in reducing local impacts, increasing agricultural production by up to five times. In addition, the presence of these reservoirs considerably reduces the need for emergency water distribution by water trucks. The study highlights the importance of a balanced approach when implementing public policies, considering the local benefits of small reservoirs in relation to the possible impacts on more distant areas.
Key Points
We explore the pro's and con's of small reservoirs as drought coping strategy
Evaporation puts more pressure on surface water storage in semi‐arid regions than the demands of small farmers
Small reservoirs boost the local agricultural production up to five times while reducing the need for emergency water supply
Full text
Available for:
FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
PDF
