Here we report a high precision measurement of electron beam polarization using Compton polarimetry. The measurement was made in experimental Hall A at Jefferson Lab during the CREX experiment in ...2020. A precision of dP/P = 0.36% was achieved detecting the back-scattered photons from the Compton scattering process. This is the highest precision in a measurement of electron beam polarization using Compton scattering ever reported, surpassing the ground-breaking measurement from the SLD Compton polarimeter. Such precision reaches the level required for the future flagship measurements to be made by the MOLLER and SoLID Experiments.
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SR 49059, a new potent and selective orally active, nonpeptide vasopressin (AVP) antagonist has been characterized in several in vitro and in vivo models. SR 49059 showed high affinity for V1a ...receptors from rat liver (Ki = 1.6 +/- 0.2) and human platelets, adrenals, and myometrium (Ki ranging from 1.1 to 6.3 nM). The previously described nonpeptide V1 antagonist, OPC-21268, was almost inactive in human tissues at concentrations up to 100 microM. SR 49059 exhibited much lower affinity (two orders of magnitude or more) for AVP V2 (bovine and human), V1b (human), and oxytocin (rat and human) receptors and had no measurable affinity for a great number of other receptors. In vitro, AVP-induced contraction of rat caudal artery was competitively antagonized by SR 49059 (pA2 = 9.42). Furthermore, SR 49059 inhibited AVP-induced human platelet aggregation with an IC50 value of 3.7 +/- 0.4 nM, while OPC-21268 was inactive up to 20 microM. In vivo, SR 49059 inhibited the pressor response to exogenous AVP in pithed rats (intravenous) and in conscious normotensive rats (intravenous and per os) with a long duration of action (> 8 h at 10 mg/kg p.o). In all the biological assays used, SR 49059 was devoid of any intrinsic agonistic activity. Thus, SR 49059 is the most potent and selective nonpeptide AVP V1a antagonist described so far, with marked affinity, selectivity, and efficacy toward both animal and human receptors. With this original profile, SR 49059 constitutes a powerful tool for exploring the therapeutical usefulness of a selective V1a antagonist.
Precision Møller polarimetry for PREX-2 and CREX King, D. E.; Jones, D. C.; Gal, C. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
09/2022, Volume:
1045
Journal Article
Peer reviewed
Open access
The PREX-2 and CREX experiments in Hall A at Jefferson Lab are precision measurements of parity violating elastic electron scattering from complex nuclei. One requirement was that the incident ...electron beam polarization, typically ≈ 90%, be known with 1% precision. Here, we commissioned and operated a Møller polarimeter on the beam line that exceeds this requirement, achieving a precision of 0.89% for PREX-2, and 0.85% for CREX. The uncertainty is purely systematic, accumulated from several different sources, but dominated by our knowledge of the target polarization. Our analysis also demonstrates the need for accurate atomic wave functions in order to correct for the Levchuk Effect. We describe the details of the polarimeter operation and analysis, as well as (for CREX) a comparison to results from a different polarimeter based on Compton scattering.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Charged particle multiplicity distributions in positron-proton deep inelastic scattering at a centre-of-mass energy
s
=
319
GeV are measured. The data are collected with the H1 detector at HERA ...corresponding to an integrated luminosity of 136 pb
-
1
. Charged particle multiplicities are measured as a function of photon virtuality
Q
2
, inelasticity
y
and pseudorapidity
η
in the laboratory and the hadronic centre-of-mass frames. Predictions from different Monte Carlo models are compared to the data. The first and second moments of the multiplicity distributions are determined and the KNO scaling behaviour is investigated. The multiplicity distributions as a function of
Q
2
and the Bjorken variable
x
bj
are converted to the hadron entropy
S
hadron
, and predictions from a quantum entanglement model are tested.
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Precision Møller polarimetry for PREX-2 and CREX King, D.E.; Jones, D.C.; Gal, C. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
01/2023, Volume:
1045
Journal Article
Peer reviewed
Open access
The PREX-2 and CREX experiments in Hall A at Jefferson Lab are precision measurements of parity violating elastic electron scattering from complex nuclei. One requirement was that the incident ...electron beam polarization, typically ≈90%, be known with 1% precision. We commissioned and operated a Møller polarimeter on the beam line that exceeds this requirement, achieving a precision of 0.89% for PREX-2, and 0.85% for CREX. The uncertainty is purely systematic, accumulated from several different sources, but dominated by our knowledge of the target polarization. Our analysis also demonstrates the need for accurate atomic wave functions in order to correct for the Levchuk Effect. We describe the details of the polarimeter operation and analysis, as well as (for CREX) a comparison to results from a different polarimeter based on Compton scattering.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The impact of adjuvant chemotherapy (CT) in the management of radically resected stage IB non-small cell lung cancer (NSCLC) is highly debated. The aim of this study was to evaluate the outcome of ...this category of patients treated at our institution.
We retrospectively analysed the survival data of patients with pathologic stage IB NSCLC, who received at least 1 cycle of adjuvant CT. CT was planned to be platinum based and to be delivered for 6 cycles.
One hundred and twelve consecutively treated patients were evaluated.
median age 60 years, median tumor diameter 4 cm, 87% underwent lobectomy and 13% pneumonectomy, 58% had visceral pleural involvement (VPI). After a median follow up of 46 months, the estimated 5-year disease-free (DFS) and overall survival (OS) rates were 68% and 77%, respectively. The mean number of CT cycles was 5.2 (range 3-6), with 82% of patients receiving ≥ 5 cycles. The median cisplatin dose intensity (DI) was 22 mg/m(2)/week, and the relative DI was 85%. Median total cisplatin (CDDP) dose/patient was 416 mg/m(2). A total of 31 (27.6%) relapses were recorded, of which 81% were distant. Multivariate analysis showed no significant interaction between overall survival and the following variables: gender, type of surgery, histology, tumor volume, VPI.
Our results compare favorably with the historical data evaluating the outcome of stage IB patients treated by surgery alone in a customary medical setting. Overall, our data support the use of adjuvant CT in stage IB NSCLC patients.
In-orbit performance of Herschel-HIFI Roelfsema, P. R.; Helmich, F. P.; Teyssier, D. ...
Astronomy and astrophysics (Berlin),
01/2012, Volume:
537
Journal Article
Peer reviewed
Open access
Aims. In this paper the calibration and in-orbit performance of the Heterodyne Instrument for the Far-Infrared (HIFI) is described. Methods. The calibration of HIFI is based on a combination of ...ground and in-flight tests. Dedicated ground tests to determine those instrument parameters that can only be measured accurately using controlled laboratory stimuli were carried out in the instrument level test (ILT) campaign. Special in-flight tests during the commissioning phase (CoP) and performance verification (PV) allowed the determination of the remaining instrument parameters. The various instrument observing modes, as specified in astronomical observation templates (AOTs), were validated in parallel during PV by observing selected celestial sources. Results. The initial calibration and in-orbit performance of HIFI has been established. A first estimate of the calibration budget is given. The overall in-flight instrument performance agrees with the original specification. Issues remain at only a few frequencies.
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