The study of the
I=1,
J
PC
=0
++ states with the OBELIX detector in the channel
p
̄
p→K
±K
0
Sπ
∓
at three different target densities is reported. The data show the evidence for an extra scalar state ...with mass 1.29±0.01 GeV/
c
2 and width 0.080±0.005 GeV/
c
2.
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IJS, IMTLJ, KILJ, KISLJ, NUK, SBCE, SBJE, UL, UM, UPCLJ, UPUK
This paper presents a 4-Mb phase-change memory experimental chip using an MOS transistor as a cell selector. A cascode bit-line biasing scheme allows read and write voltages to be fed to the storage ...element with adequate accuracy. The chip was integrated with 3-V 0.18-/spl mu/m CMOS technology and experimentally evaluated. A read access time of 45 ns was measured together with a write throughput of 5 MB/s, which represents an improved performance as compared to present NOR Flash memories. Cell current distributions on the 4-Mb array proved chip functionality and a good working window, thus demonstrating the feasibility of a stand-alone phase-change memory with standard CMOS fabrication process.
The OBELIX spectrometer, studying at the Low Energy Antiproton Ring (LEAR) of CERN the
N̄N annihilation, has collected annihilation data with very low momentum
p̄(≈ 50
MeV/c). The results of the ...spin-parity analysis on the
p̄p annihilation into four and five pions are briefly described.
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IJS, IMTLJ, KILJ, KISLJ, NUK, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The results of the spin-parity analysis of
pp → 2π
+2π
−
annihilations at very low momentum
p
(≈ 50 MeV/
c) are reported. To describe the data the production of the
ϱ,
f
2,
a
2 and
a
1 mesons and the ...presence of the ππ interaction in
S-wave (the σ term) in the final state are necessary. The best fit solution requires also the presence of a ϱ′ state of mass and width
M = 1.282 ± 0.037,
Γ = 0.236 ± 0.036 GeV/
c
2 and of a heavy pion π(1300) of mass and width
M = 1.275 ± 0.015,
Γ = 0.218 ± 0.100 GeV/
c
2. The measured fraction of the annihilation cross section into 2
π
+2
π
− is (7.61 ± 0.35) · 10
−2.
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IJS, IMTLJ, KILJ, KISLJ, NUK, SBCE, SBJE, UL, UM, UPCLJ, UPUK
We describe a case of ALL with the t(4;11) (q21;q23) translocation in which both surface markers and molecular analyses suggest an unusual early T cell involvement. While the morphologic and ...cytochemical studies showed an undifferentiated pattern, immunophenotypic data were suggestive of a very immature cell population which stained only for TdT and CD7. Moreover, in contrast to previous reports but in agreement with the immunologic findings, the IgH gene region retained a germline configuration. T cell receptor beta and gamma chain gene loci also showed a germline pattern, in accordance with the expansion of immature CD7+, TdT+ T cells.
We measured the in flight annihilation frequencies and cross sections of reactions
np → π
+π
0,π
+η
and
K
+
K
S
in the antineutron momentum range between 50 and 400 MeV/c. The annihilation ...frequencies of these channels from the different allowed initial states were calculated and some information about the
np
annihilation dynamics were obtained. The first determination of the D-wave contribution in this momentum range was also obtained.
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IJS, IMTLJ, KILJ, KISLJ, NUK, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The partial wave analysis of the reaction
pp → π
+π
−π
0
at rest has been performed for the first time by using high-statistics data sets collected in hydrogen targets at three different densities. ...The different mixtures of partial waves corresponding to our samples allow a reliable determination of each contribution. This technique is crucial in the identification of the exotic candidate
f
2(1565) which can be produced by
1
S
0,
3
P
1 and
3
P
2 initial states. The amplitude analysis was performed in the frame of the
K-Matrix and
P-Vector approach. It requires presence of the exotic candidates
f
0(1500) and
f
2(1565) with the following masses and total widths: (1449 ± 20)MeV, (114 ± 30)MeV and (1507 ± 15)MeV, (130 ± 20)MeV respectively. In addition to
f
0(980),
f
0(1300)
f
2(1270) and ϱ(770), a clear evidence of
I = 1,
J
P
= 1
− signal, which we identify with ϱ(1450), is obtained.
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IJS, IMTLJ, KILJ, KISLJ, NUK, SBCE, SBJE, UL, UM, UPCLJ, UPUK
This paper shows some results obtained by assaying the genotoxic activity on procaryotic and eucaryotic cells of some water-soluble psoralen derivatives. In particular, six newly synthesized ...derivatives of 5-methoxypsoralen (5-MOP) and of 8-methoxypsoralen (8-MOP) were tested; in previous studies they showed a strong anti-proliferative activity and a slight phototoxic effect; moreover, in view of a clinical use in the therapy of hyperproliferative skin diseases, these drugs should be less toxic than their parent compounds because of their good water solubility which could lead to a more efficient absorption and excretion. All the compounds tested here have shown genotoxic activity on both procaryotic and eucaryotic systems: however, on the procaryotic cells the water-soluble derivatives were less genotoxic than their respective parent compounds 5-MOP and 8-MOP. Quite different results were obtained on V79 Chinese hamster cells, showing that, in general, the 8-methoxy-derivatives are more mutagenic than the methoxy-ones, although the 5-MOP itself was shown to be highly genotoxic in this system. This fact confirms that a conclusive estimate of the genotoxic risk related to the use of new drugs cannot be drawn from the results obtained on a single biological system.
A patient with Philadelphia positive (Ph'+) acute lymphoblastic leukemia (ALL), in remission for over 4 years, developed an acute myeloblastic leukemia (AML), M2-type. During the second disease, the ...blast cells displayed a typical t(8;21)(q22;q22) translocation, in the absence of the Ph' chromosome. This is the first observation in the same patient of two leukemias displaying different cell phenotypes and each associated to one of the most characteristic chromosome changes. Cytogenetic characteristics and clinical aspects of the diseases are suggestive for the occurrence of two independent leukemic processes.
Several lines of evidence underscore a possible role of voltage-gated Na+ channels (NaCH) in epilepsy. We compared the regional distribution of mRNAs coding for Na+ channel alpha subunit I, II and ...III in brains from control and kainate-treated rats using non-radioactive in situ hybridization with subtype-specific digoxigenin-labelled cRNA probes. Labelling intensity was evaluated by a densitometric analysis of digitized images. Heterogeneous distribution of the three Na+ channel mRNAs was demonstrated in brain from adult control rats, which confirmed previous studies. Subtype II mRNAs were shown to be abundant in cerebellum and hippocampus. Subtype I mRNAs were also detected in these areas. Subtype III mRNAs were absent in cerebellar cortex, but significantly expressed in neurons of the medulla oblongata and hippocampus. The three subtypes were differentially distributed in neocortical layers. Subtype II mRNAs were present in all of the layers, but mRNAs for subtypes I and III were concentrated in pyramidal cells of neocortex layers IV-V. During kainate-induced seizures, we observed an increase in Na+ channel II and III mRNA levels in hippocampus. In dentate gyrus, subtype III mRNAs increased 3 h after KA administration to a maximum at 6 h. At this latter time, a lower increase in NaCh III mRNAs was also recorded in areas CA1 and CA3. NaCh III overexpression in dentate gyrus persisted for at least 24 h. In the same area, NaCh II mRNAs were also increased with a peak 3 h after KA injection and a return to control levels by 24 h. No changes in NaCh I mRNAs were seen. The KA-induced up-regulation in NaCh mRNAs probably resulted in an increase in hippocampal neuronal excitability.
