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hits: 129
11.
  • Correcting mitochondrial fu... Correcting mitochondrial fusion by manipulating mitofusin conformations
    Franco, Antonietta; Kitsis, Richard N; Fleischer, Julie A ... Nature, 12/2016, Volume: 540, Issue: 7631
    Journal Article
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    Open access

    Mitochondria are dynamic organelles that exchange contents and undergo remodelling during cyclic fusion and fission. Genetic mutations in MFN2 (the gene encoding mitofusin 2) interrupt mitochondrial ...
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12.
  • BH3-Triggered Structural Re... BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX
    Gavathiotis, Evripidis; Reyna, Denis E.; Davis, Marguerite L. ... Molecular cell, 11/2010, Volume: 40, Issue: 3
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    Open access

    BAX is a proapoptotic BCL-2 family member that lies dormant in the cytosol until converted into a killer protein in response to cellular stress. Having recently identified the elusive trigger site ...
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13.
  • An interconnected hierarchi... An interconnected hierarchical model of cell death regulation by the BCL-2 family
    Chen, Hui-Chen; Kanai, Masayuki; Inoue-Yamauchi, Akane ... Nature cell biology, 10/2015, Volume: 17, Issue: 10
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    Open access

    Multidomain pro-apoptotic BAX and BAK, once activated, permeabilize mitochondria to trigger apoptosis, whereas anti-apoptotic BCL-2 members preserve mitochondrial integrity. The BH3-only molecules ...
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14.
  • An Integrated Model of RAF ... An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling
    Karoulia, Zoi; Wu, Yang; Ahmed, Tamer A. ... Cancer cell, 09/2016, Volume: 30, Issue: 3
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    Open access

    The complex biochemical effects of RAF inhibitors account for both the effectiveness and mechanisms of resistance to these drugs, but a unified mechanistic model has been lacking. Here we show that ...
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15.
  • Chemical modulation of cyto... Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis
    Gitego, Nadege; Agianian, Bogos; Mak, Oi Wei ... Nature communications, 12/2023, Volume: 14, Issue: 1
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    The BCL-2 family protein BAX is a major regulator of physiological and pathological cell death. BAX predominantly resides in the cytosol in a quiescent state and upon stress, it undergoes ...
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16.
  • Direct and selective small-... Direct and selective small-molecule activation of proapoptotic BAX
    Gavathiotis, Evripidis; Reyna, Denis E; Bellairs, Joseph A ... Nature chemical biology, 07/2012, Volume: 8, Issue: 7
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    BCL-2 family proteins are key regulators of the apoptotic pathway. Antiapoptotic members sequester the BCL-2 homology 3 (BH3) death domains of proapoptotic members such as BAX to maintain cell ...
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17.
  • Bax regulates primary necro... Bax regulates primary necrosis through mitochondrial dynamics
    Whelan, Russell S; Konstantinidis, Klitos; Wei, An-Chi ... Proceedings of the National Academy of Sciences - PNAS, 04/2012, Volume: 109, Issue: 17
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    The defining event in apoptosis is mitochondrial outer membrane permeabilization (MOMP), allowing apoptogen release. In contrast, the triggering event in primary necrosis is early opening of the ...
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18.
  • ASXL1 mutations are associa... ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine
    Rahmani, Nora E; Ramachandra, Nandini; Sahu, Srabani ... Blood cancer journal, 09/2021, Volume: 11, Issue: 9
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    The BCL2-inhibitor, Venetoclax (VEN), has shown significant anti-leukemic efficacy in combination with the DNMT-inhibitor, Azacytidine (AZA). To explore the mechanisms underlying the selective ...
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19.
  • Modulating mitofusins to co... Modulating mitofusins to control mitochondrial function and signaling
    Zacharioudakis, Emmanouil; Agianian, Bogos; Kumar Mv, Vasantha ... Nature communications, 07/2022, Volume: 13, Issue: 1
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    Mitofusins reside on the outer mitochondrial membrane and regulate mitochondrial fusion, a physiological process that impacts diverse cellular processes. Mitofusins are activated by conformational ...
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20.
  • Hydrocarbon double-stapling... Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic
    Bird, Gregory H.; Madani, Navid; Perry, Alisa F. ... Proceedings of the National Academy of Sciences - PNAS, 08/2010, Volume: 107, Issue: 32
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    The pharmacologic utility of lengthy peptides can be hindered by loss of bioactive structure and rapid proteolysis, which limits bioavailability. For example, enfuvirtide (Fuzeon, T20, DP178), a ...
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