Among rape perception studies, common types of male rape remain understudied. Using a randomized vignette design, I sampled 622 college students from a large Southwestern university to examine how ...victim gender and victim resistance influence blame attributions in party rape and date rape. Results revealed important interactions between victim gender, victim resistance, and rape type. Among other effects, resistance only affected victim blame in date rapes involving male victims. Results indicated that how respondents perceive victim and perpetrator responsibility, and which factors influence these perceptions, vary across rape type and victim gender. Implications for the rape perception literature are discussed.
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3.
Soft Tissue and Uterine Leiomyosarcoma George, Suzanne; Serrano, César; Hensley, Martee L ...
Journal of clinical oncology,
01/2018, Volume:
36, Issue:
2
Journal Article
Peer reviewed
Open access
Leiomyosarcoma (LMS) is one of the most common subtypes of soft tissue sarcoma in adults and can occur in almost any part of the body. Uterine leiomyosarcoma is the most common subtype of uterine ...sarcoma. Increased awareness of this unique histology has allowed for the development of drugs that are specific to LMS and has begun to shed light on the similarities and possible unique aspects of soft tissue and uterine LMS. In this review, we summarize the current understanding of the epidemiology, diagnosis, genomics, and treatment options for LMS.
The current study builds on recent research assessing the decision to impose life imprisonment without the possibility of parole (LWOP), focusing on females convicted in US District Courts. Using ...USSC data from 2010 to 2017 and an intersectional approach, we described the characteristics of life-eligible and life-sentenced women and examined the factors that predict life eligibility among females and males . Black women faced higher odds of life eligibility than White or Hispanic women and life experiences and case processing factors affected life eligibility differently for women and men. These results highlight the importance of intersectionality for understanding gendered sentencing pathways.
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The current study examined jurors’ questions to children in criminal trials assessing children’s allegations of sexual abuse, demonstrating a new avenue for studying how jurors think about, respond ...to, and assess evidence. We used qualitative content analysis to examine jurors’ questions to 134, 5- to 17-year-olds alleging sexual abuse in criminal trial testimonies. Five themes emerged: abuse interactions, contextual details of abuse, children’s reactions to abuse, children’s (delayed) disclosure, and case background details. Jurors often ask about abuse dynamics, the context surrounding abuse, and children’s disclosure processes, reflecting common misconceptions about child sexual abuse (CSA), such as whether it is credible to delay disclosure or maintain contact with an alleged perpetrator. This study improves our understanding of how jurors understand and evaluate children’s reports of alleged CSA, suggesting that jurors may struggle to understand children’s reluctance.
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Researchers have established that rape myths shape perceptions of victims and perpetrators in criminal cases. Researchers have devoted less attention to exploring the impact of child sexual abuse ...(CSA) myths in court. While we know that jurors believe myths and misconceptions about the nature of CSA, no work has explored how these myths appear during the prosecution of CSA cases. The purpose of the present investigation was to assess how defense attorneys apply myths more specific to CSA in the questioning of children testifying about alleged CSA. The present study compliments and expands upon a previous study by St. George and colleagues (2021a), where authors examined the use of rape myths in the questioning of children making allegations of CSA. In the current study, we examined testimonies of 122 children testifying in criminal cases of alleged CSA in the United States. We qualitatively coded 6,384 lines of questioning for references to CSA-focused myths related to the disclosure process, witnesses and privacy issues, assumptions of harm, and the child’s positive relationship with the perpetrator. These myths were common, occurring in over 10% of defense attorneys’ lines of questioning. Disclosure issues were the most frequent, followed by witness and privacy issues, assumptions of harm, and the child’s positive relationship with their perpetrator. In many cases, attorneys employed different strategies across child’s age to highlight these myths. These findings compliment those of prior work suggesting that CSA myths, much like rape myths, are appearing with regularity. Defense attorneys are likely capitalizing on jurors’ misconceptions to undermine children’s believability.
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Leiomyosarcoma Serrano, César; George, Suzanne
Hematology/oncology clinics of North America,
10/2013, Volume:
27, Issue:
5
Journal Article
Peer reviewed
This article presents an overview of the current literature about the biology, pathology, and the clinical management of leiomyosarcoma. In addition, the article emphasizes and discusses the current ...systemic treatment options available for patients with leiomyosarcoma, which range from cytotoxic chemotherapy to target therapies. Particular leiomyosarcoma subtypes, such as uterine leiomyosarcoma and inferior vena cava leiomyosarcoma, are discussed separately.
In sexual assault cases, prosecutorial charging decisions may be influenced by legal factors like offense seriousness and convictability and extralegal rape myths. We use data on sexual assaults in ...Los Angeles, to test for the effects of victim behavior, victim credibility, and "real rape" stereotypes on the decision to file charges. We also test the liberation hypothesis, examining whether rape myths influence the charge decision more in less serious nonpenetrative cases then in penetrative cases. Results show that victim credibility and behavior, but not consistency with real rape stereotypes, affect charging decisions, even after controlling for legally relevant factors, and they influence prosecutors' charging decisions equally in penetrative and nonpenetrative cases. Rape myths also influence the charging decision indirectly via victim cooperation. We conclude that rape myths are incorporated into the criminal justice system's definition of and response to sexual violence, so cannot be addressed by changing case screening policies.
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The majority of gastrointestinal stromal tumors (GIST) harbor an activating mutation in either the KIT or PDGFRA receptor tyrosine kinases. Approval of imatinib, a KIT/PDGFRA tyrosine kinase ...inhibitor (TKI), meaningfully improved the treatment of advanced GIST. Other TKIs subsequently gained approval: sunitinib as a second-line therapy and regorafenib as a third-line therapy. However, resistance to each agent occurs in almost all patients over time, typically due to secondary kinase mutations. A major limitation of these 3 approved therapies is that they target the inactive conformation of KIT/PDGFRA; thus, their efficacy is blunted against secondary mutations in the kinase activation loop. Neither sunitinib nor regorafenib inhibit the full spectrum of KIT resistance mutations, and resistance is further complicated by extensive clonal heterogeneity, even within single patients. To combat these limitations, next-generation TKIs were developed and clinically tested, leading to 2 new USA FDA drug approvals in 2020. Ripretinib, a broad-spectrum KIT/PDGFRA inhibitor, was recently approved for the treatment of adult patients with advanced GIST who have received prior treatment with 3 or more kinase inhibitors, including imatinib. Avapritinib, a type I kinase inhibitor that targets active conformation, was approved for the treatment of adults with unresectable or metastatic GIST harboring a PDGFRA exon 18 mutation, including PDGFRA D842V mutations. In this review, we will discuss how resistance mutations have driven the need for newer treatment options for GIST and compare the original GIST TKIs with the next-generation KIT/PDGFRA kinase inhibitors, ripretinib and avapritinib, with a focus on their mechanisms of action.
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