Purpose To assess the health‐related quality of life (HRQoL) of Jordanian children with thalassaemia, identify differences in HRQoL according to socio‐demographic and clinical characteristics of ...participants, and identify factors influencing HRQoL of thalassaemic children in Jordan.
Methods The Pediatric Quality of Life Inventory and socio‐demographic and clinical data forms were used to collect data from a convenience sample of 128 thalassaemic children and 83 healthy children between the ages of 8 to 18 years. Thalassaemic children were recruited from two thalassaemia units during their blood transfusion and treatment visits. Healthy children were recruited from four public schools.
Results Thalassaemic children had significantly lower HRQoL mean scores in all dimensions compared with their healthy counterparts. The lowest mean scores for thalassaemic children were reported for the school functioning and the physical functioning domains (46.71 ± 21.14 and 54.19 ± 15.10), respectively. Regression analysis showed that disease complications and family history of thalassaemia explained 8.5% of the variance in the total HRQoL.
Conclusion This study highlights the negative impact of thalassaemia on the quality of life of children, especially in terms of physical well‐being and school achievement. Healthcare providers, counsellors and school teachers have very important roles in helping these children to overcome these problems and enhance their quality of life.
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BFBNIB, DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, SIK, UILJ, UKNU, UL, UM, UPUK, VSZLJ
Gharaibeh MK, Alsharm S, Al Maaitah R, Heilat HB, Marayan L. Patient Prefer Adherence. 2022;16:403-412 The authors have advised there is an error in the author list and affiliations on page 403. The ...author name "Lina Marayan" should read "Lina Mrayan", the 1st affiliation should read "Faculty of Nursing, Jordan University of Science and Technology, Irbid, Jordan", the 2nd affilation should read "Faculty of Nursing, Al Ahliyya Amman University, Amman, Jordan", and the 5th affiliation should read "Department of Maternal, Child and Family Health, Faculty of Nursing, The Hashemite University, Zarqa, Jordan". Read the original article
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An increased sense of job performance and better job satisfaction can be achieved by receiving social support. In order to fulfil this purpose, this study aimed to determine the relationship between ...social support on the one hand and job performance and job satisfaction on the other hand for the Jordanian insurance industry employees. Survey data were gathered from 269 employees from the Jordanian insurance industry. The PLS 3.0 software was used to process data using the structural equation modelling method. The study’s findings revealed that all social support factors were positively and significantly related to job performance and job satisfaction, including manager support, peer support, friends support, and others’ support. Hence, job performance and job satisfaction in the Jordanian insurance industry can be predicted by studying the existence of social support. The study’s findings concluded that the higher the social support, the higher the job performance and job satisfaction.
The study aimed at investigating the differences in health status of women users and non-users of contraceptive methods and assess differences in contraception quality of life (CQoL) according to ...method used.
Across sectional study with 372 women between the ages of 18 and 49 years old were recruited. Participants completed the health status and the CQoL questionnaire, which was validated using factor analysis combining three factor loading measures with a good Cronbach's alpha reliability coefficient.
Results showed that there were no significant differences in health status between users and non-users. There was a significant difference in QoL according to the method used at the p <0.05 level for the three conditions F (2193) = 6.0 and p = 0.003. Post hoc analysis indicated that the total CQoL was significantly higher in IUD users (M = 55.7, SD = 9.6) than users of natural methods (M = 50, SD = 9.0, p < 0.01). In addition, the total CQoL was significantly higher among women from the southern region (M = 56.7, SD = 9.0) than from the northern and mid-regions (M = 49.5, SD = 0.07 and M = 52, SD = 10, respectively, p < 0.01).
The physiological changes of women's QoL was affected by the use of the IUD method with significantly lower QoL scores than those who used oral contraceptives and non-hormonal methods. In addition, there was no significant difference in health status between users and non-users of contraceptive methods.
The study has implications for contraceptive counselling on quality of life of women users of IUD and women from the south region and provides opportunities for the advancement of the reproductive health services in Jordan.
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A behavioral modeling technique suited to capturing the response of wide-band multifunctional and multichannel amplifiers is introduced. The technique is based on the three-box approximation of the ...Volterra model and takes into account the dependence of the amplifier characteristics on frequency. The model is coupled with a new nonlinear statistical analysis, which enables accurate estimation of intermodulation and cross-modulation distortions of multiple digitally modulated signals. The model parameters can be obtained using simple measurements.
The effective signal-to-noise and distortion ratio (SNDR) at the output of a nonlinear amplifier is defined through the decomposition of the nonlinear output into the correlated output and ...uncorrelated distortion. The analysis is based on the orthogonalisation of the nonlinear behavioual model that allows the accurate estimation of the effective in-band (or co-channel) distortion and, hence, determination of SNDR. The fundamental issues regarding the evaluation of the effective in-band distortion and its effect on digitally modulated signals are discussed. The simulations of in-band distortion and SNDR of WCDMA signals are verified experimentally using feed-forward cancelation.
Irinotecan treats a range of solid tumors, but its effectiveness is severely limited by gastrointestinal (GI) tract toxicity caused by gut bacterial β-glucuronidase (GUS) enzymes. Targeted bacterial ...GUS inhibitors have been shown to partially alleviate irinotecan-induced GI tract damage and resultant diarrhea in mice. Here, we unravel the mechanistic basis for GI protection by gut microbial GUS inhibitors using in vivo models.We use in vitro, in fimo, and in vivo models to determine whether GUS inhibition alters the anticancer efficacy of irinotecan. We demonstrate that a single dose of irinotecan increases GI bacterial GUS activity in 1 d and reduces intestinal epithelial cell proliferation in 5 d, both blocked by a single dose of a GUS inhibitor. In a tumor xenograft model, GUS inhibition prevents intestinal toxicity and maintains the antitumor efficacy of irinotecan. Remarkably, GUS inhibitor also effectively blocks the striking irinotecan-induced bloom of Enterobacteriaceae in immunedeficient mice. In a genetically engineered mouse model of cancer, GUS inhibition alleviates gut damage, improves survival, and does not alter gut microbial composition; however, by allowing dose intensification, it dramatically improves irinotecan’s effectiveness, reducing tumors to a fraction of that achieved by irinotecan alone, while simultaneously promoting epithelial regeneration. These results indicate that targeted gut microbial enzyme inhibitors can improve cancer chemotherapeutic outcomes by protecting the gut epithelium from microbial dysbiosis and proliferative crypt damage.
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In-band distortion of multisines Gharaibeh, K.M.; Gard, K.G.; Steer, M.B.
IEEE transactions on microwave theory and techniques,
08/2006, Volume:
54, Issue:
8
Journal Article
Peer reviewed
Multisine signals are shown to be useful for estimating distortion of communication signals. In particular, a generalized approach for the evaluation of effective in-band distortion in a nonlinear ...amplifier using multisine excitation is presented. The output of the nonlinearity is represented as the sum of uncorrelated components by the transformation of a behavioral model. Simulated and measured results are presented for code-division multiple-access signals
A statistically based modeling technique is developed for characterizing in-band and out-of-band intermodulation and cross-modulation distortions in multichannel amplifier environments. The model is ...based on a new multiple envelope memoryless behavioral model that captures the black-box characteristics of multichannel amplifiers. A power amplifier with a two code-division multiple-access channel signal is characterized experimentally and verifies the approach.
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