Low-carbon micro-alloyed steel containing coarse MnS inclusions was subjected to different thermo-mechanical processing routes to evaluate the effect of microstructure on its Charpy impact properties ...over a range of temperatures. MnS inclusions were found to deteriorate the upper shelf energy (USE) of the steel but its effect on the impact transition temperature was not as detrimental as that due to the presence of TiN particles. MnS inclusions were responsible for the initiation of micro-voids; however, the propagation of the cracks from these depends on the effective grain size and the strength of the matrix. An increase in the density of dislocations and low-angle boundaries enhances the strength and the strain-hardening ability of the ferrite matrix. This helps in retarding the growth of micro-voids, thereby reducing USE and promoting cleavage crack propagation resulting in an increase in its impact transition temperature. Refinement of effective grain size, on the other hand, increases the crack propagation resistance and therefore, improves the low-temperature toughness of the steel. Finish rolling of the steel just above the Ar3 temperature (austenite to ferrite transformation start temperature) or a simple normalizing treatment of the as-rolled plates at a low austenitization temperature is recommended from the point of view of higher impact toughness and lower impact transition temperature.
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IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The MPI‐ESM1.2 is the latest version of the Max Planck Institute Earth System Model and is the baseline for the Coupled Model Intercomparison Project Phase 6 and current seasonal and decadal climate ...predictions. This paper evaluates a coupled higher‐resolution version (MPI‐ESM1.2‐HR) in comparison with its lower‐resolved version (MPI‐ESM1.2‐LR). We focus on basic oceanic and atmospheric mean states and selected modes of variability, the El Niño/Southern Oscillation and the North Atlantic Oscillation. The increase in atmospheric resolution in MPI‐ESM1.2‐HR reduces the biases of upper‐level zonal wind and atmospheric jet stream position in the northern extratropics. This results in a decrease of the storm track bias over the northern North Atlantic, for both winter and summer season. The blocking frequency over the European region is improved in summer, and North Atlantic Oscillation and related storm track variations improve in winter. Stable Atlantic meridional overturning circulations are found with magnitudes of ~16 Sv for MPI‐ESM1.2‐HR and ~20 Sv for MPI‐ESM1.2‐LR at 26°N. A strong sea surface temperature bias of ~5°C along with a too zonal North Atlantic current is present in both versions. The sea surface temperature bias in the eastern tropical Atlantic is reduced by ~1°C due to higher‐resolved orography in MPI‐ESM‐HR, and the region of the cold‐tongue bias is reduced in the tropical Pacific. MPI‐ESM1.2‐HR has a well‐balanced radiation budget and its climate sensitivity is explicitly tuned to 3 K. Although the obtained reductions in long‐standing biases are modest, the improvements in atmospheric dynamics make this model well suited for prediction and impact studies.
Key Points
A higher‐resolution version of MPI‐ESM1.2 is presented, which has a well‐balanced radiation budget and stable ocean circulation
The higher atmospheric resolution improves North Atlantic storm tracks, blocking frequency, and NAO representation
The higher computational costs remain manageable and enable studies of seasonal to decadal predictions and climate impacts
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DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, SIK, UILJ, UKNU, UL, UM, UPUK
We describe a nuclear spin gyroscope based on an alkali-metal-noble-gas comagnetometer. Optically pumped alkali-metal vapor is used to polarize the noble-gas atoms and detect their gyroscopic ...precession. Spin precession due to magnetic fields as well as their gradients and transients can be cancelled in this arrangement. The sensitivity is enhanced by using a high-density alkali-metal vapor in a spin-exchange relaxation free regime. With a K-3He comagnetometer we demonstrate rotation sensitivity of 5 x 10(-7) rad s(-1) Hz(-1/2), equivalent to a magnetic field sensitivity of 2.5 fT/Hz(1/2). The rotation signal can be increased by a factor of 10 using 21Ne with a smaller magnetic moment. The comagnetometer is also a promising tool in searches for anomalous spin couplings beyond the standard model.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
Classically, as a transcription factor family, the E2Fs are known to regulate the expression of various genes whose products are involved in a multitude of biological functions, many of which are ...deregulated in diseases including cancers. E2F is deregulated and hyperactive in most human cancers with context dependent, dichotomous and contradictory roles in almost all cancers. Cancer cells have an insatiable demand for transcription to ensure that gene products are available to sustain various biological processes that support their rapid growth and survival. In this context, cutting-off hyperactivity of transcription factors that support transcription dependence could be a valuable therapeutic strategy. However, one of the greatest challenges of targeting a transcription factor is the global effects on non-cancerous cells given that they control cellular functions in general. Recently, there is growing realization regarding the possibility to target the oncogenic activation of transcription factors to modulate transcription addiction without affecting the normal activity required for cell functions. In this review, we used E2F1 as a prototype transcription factor to address transcription factor activity in cancer cell functions. We focused on melanoma considering that E2F1 executes critical functions in response to UV, an etiological factor of cutaneous melanoma and lies immediately downstream of the CDKN2A/pRb axis, which is frequently deregulated in melanoma. Further, activation of E2F1 in melanomas can also occur independent of loss of CDKN2A. Given its activated status and the ability to transcriptionally control a plethora of genes involved in regulating melanoma development and progression, we review the current literature on its differential role in controlling signaling pathways involved in melanoma as well as therapeutic resistance, and discuss the practical value of weaning melanoma cells from E2F1-mediated transcription dependence for melanoma management.
Broadening the concept of smart grid to include bi-directional interactions between grid and asset electrical components as regards their health conditions would help optimizing maintenance and ...operation actions from asset/grid management side. However, as long as data processing from diagnostic tools requires long and costly expert time, there is no real chance that the knowledge and technology developed in the field of condition monitoring can become broadly available for grid smart management. This article presents algorithms able to automate the acquisition of health information from electrical asset components. Referring to partial discharges, which are associated with the most harmful insulation aging factor, an innovative technique able to reject noise and thus make automatic partial discharge recognition possible, is proposed and its validity assessed. The information from partial discharge measurement, and other diagnostic quantity monitored is translated into a simple and straightforward indication of component health. This assessment can be automatic, dynamic and continuously updating during operation, thus making feasible an effective time-based condition maintenance approach. The outcome of the proposed approach is to contribute keeping asset reliability at a specified level, minimizing disastrous outages and increasing the return of investment. This benefits also optimal electrical component operation and power flow.
Individuals with rheumatoid arthritis (RA) are at risk of developing cardiovascular disease (CVD), but patient perceptions of CVD are not routinely assessed. We performed a systematic literature ...review to evaluate awareness of the association between RA and CVD, and perceived risk of CVD among individuals with RA.
Three electronic databases (MEDLINE, EMBASE, and PubMed) were searched for English language articles between the years of 1990-2018. Search terms pertained to RA, CVD, knowledge, awareness, or perceptions of CVD risk. Abstracts were screened for inclusion/exclusion by two independent reviewers.
A total of 33 abstracts were screened and 6 underwent full review. The overall sample size was 478 subjects and included patients with established RA who were predominantly female with a mean age range of 53 to 64 years. RA disease characteristics relevant to CVD were not uniformly reported, including the use of DMARDs, corticosteroids, or NSAIDs. A high proportion of subjects (range 73 to 97%) were unaware of an increased risk of developing CVD in relation to their RA, and this frequently occurred in those with a greater number of traditional CVD risk factors. Misperceptions about CVD were common, and the majority of subjects misestimated their actual CVD risk.
Individuals with RA at highest risk for CVD report low awareness and perceived risk of this comorbidity. This represents a knowledge gap in need of intervention but must be tailored to patients' needs. An understanding of the system- and individual-level barriers preventing CVD awareness is needed. Only then will approaches to improve CVD screening and management in RA be successful.
We examine whether macroprudential policies and capital controls can enhance financial stability in the face of the risks typically associated with large capital inflows. We construct new indices of ...foreign currency (FX)-related prudential measures, domestic prudential measures, and financial-sector specific capital controls for 51 emerging market economies over the period 1995–2008. Our results indicate that both capital controls and FX-related prudential measures are associated with a lower proportion of FX lending in total domestic bank credit, and with a lower proportion of portfolio debt in total external liabilities. Other prudential policies appear to help restrain the intensity of aggregate credit booms. Experience from the global financial crisis suggests that prudential and capital control policies in place during the boom enhanced economic resilience during the bust.
► We create new indices of financial sector prudential measures and capital controls. ► Capital controls and FX-related measures reduce FX lending by domestic banks. ► They also reduce the share of portfolio debt in total external liabilities. ► Other prudential measures help restrain aggregate credit booms. ► Overall, these various measures enhance the economy's resilience to financial crisis.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
This paper examines the case for using two instruments—the policy interest rate and sterilized foreign exchange market intervention—in emerging market countries seeking to stabilize inflation and ...output while attenuating disequilibrium currency movements. We estimate policy reaction functions for central banks, documenting that indeed both instruments tend to be deployed. We show that whether discretionary monetary policy or inflation targeting is preferable depends on the volatility of shocks relative to the central bank's time inconsistency problem. The use of FX intervention as a second instrument improves welfare under both regimes, but more so under inflation targeting. Overall, a regime of (two-way) sterilized intervention-cum-inflation targeting can result in better outcomes in the presence of imperfect capital mobility/asset substitutability—yielding similar gains to a discretionary policy while still delivering the inflation target.
•FX Intervention can help smooth shocks to the exchange rate.•We examine the case for using FX Intervention as a second monetary policy instrument.•EM central banks, including inflation targeting ones, do tend to use both instruments.•FX intervention raises welfare under both discretion and inflation targeting regimes.•Welfare gains of FX intervention are higher under inflation targeting.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
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