Indazolium (OC‐6‐11)‐tetrachlorobis(indazole) ruthenate(III), HInd (OC‐6‐11)‐RuCl4ind2, exhibits excellent results in different tumor models in vitro and in vivo. Substitution reactions of this ...ruthenium(III) complex are of special interest for a deeper understanding of its interactions with biologically occurring targets and its mode of action. The indazolium complex salt can be transformed to the neutral, meridionally configurated trisindazole complex (OC‐6‐21)‐RuCl3ind3 in solvents like tetrahydrofuran. The X‐ray crystal structure of this complex could be solved (monoclinic space group P2(1)/n, a = 12.441(3), b = 10.415(3), c = 21.635(4) Å, β = 105.02(1)°). In spite of the paramagnetic RuIII atom most of the coordinated indazole protons could be assigned with the help of two‐dimensional NMR experiments. Additionally, a reduced reaction product of HInd (OC‐6‐11)‐RuCl4ind2 in the physiological solubilizer 2‐pyrrolidone could be isolated and the X‐ray crystal structure of this RuII complex, (OC‐6‐12)‐RuCl2ind4, crystallized with two 2‐pyrrolidones, could be solved (monoclinic space group P2(1)/n, a = 12.139(2), b = 10.426(2), c = 14.426(3) Å, β = 100.06(3)°).
RuCl3ind3 und RuCl2ind4: Zwei neue aus der tumorhemmenden RuIII‐Verbindung HInd (OC‐6‐11)‐RuCl4ind2 erhaltene Rutheniumkomplexe (ind = Indazol)
Indazolium (OC‐6‐11)‐Tetrachlorobis(indazol)ruthenat(III), HInd (OC‐6‐11)‐RuCl4ind2, zeigt ausgezeichnete Ergebnisse in unterschiedlichen Tumormodellen in vitro und in vivo. Substitutionsreaktionen dieses Ruthenium(III)‐Komplexes sind zum besseren Verständnis seines Wirkmechanismus, insbesondere der Wechselwirkung mit biologisch relevanten Molekülen, von großem Interesse. Das Indazolium Komplexsalz kann in Lösungsmitteln wie Tetrahydrofuran in den meridional konfigurierten Trisindazolkomplex (OC‐6‐21)‐RuCl3ind3 überführt werden. Die Kristallstruktur dieses RuIII‐Komplexes konnte gelöst werden (monokline Raumgruppe, P2(1)/n, a = 12.441(3), b = 10.415(3), c = 21.635(4) Å, β = 105.02(1)°). Trotz des paramagnetischen RuIII‐Atoms konnten die Protonen des koordinierten Indazols mit Hilfe zweidimensionaler NMR‐Experimente größtenteils zugeordnet werden. Darüber hinaus konnte ein reduziertes Reaktionsprodukt von HInd (OC‐6‐11)‐RuCl4ind2 im physiologischen Lösevermittler 2‐Pyrrolidon isoliert und die Kristallstruktur dieses RuII‐Komplexes, (OC‐6‐12)‐RuCl2ind4, kristallisiert mit zwei Molekülen 2‐Pyrrolidon, gelöst werden (monokline Raumgruppe, P2(1)/n, a = 12.139(2), b = 10.426(2), c = 14.426(3) Å, β = 100.06(3)°).
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In the crystal structure of the title complex, Co(C6H8N3S)3, the CoIII atom is octahedrally coordinated by three monodeprotonated bidentate 3,5‐dimethyl‐1H‐pyrazole‐1‐thiocarboxamide ligands with ...two thiocarboxamide N atoms in axial positions. The asymmetric unit contains two molecules (A and B) and these molecules are arranged in chains in an alternating fashion connected by N—H⋯S interactions.
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In the title compound, C13H13N5O4·H2O (4,5′‐cyclowyosine·H2O), the cyclization forces a syn arrangement of the aglycon with respect to the sugar moiety. The ribofuranose part of the molecule ...displays a β‐d configuration with an envelope C1′‐endo pucker. The molecules are arranged in columns along the short a axis and are linked to water molecules through O—H⋯O and O—H⋯N hydrogen bonds.
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Hoffmann et al reinvestigated the crystal structure of bechererite from the Tonopah-Belmount mine in Arizona. Bechererite is composed of (001) brucite-like sheets formed by edge-sharing (Zn,Cu)O6 ...octahedra and 1/7 ordered octahedral vacancies.
![[RuCl3ind3] and [RuCl2ind4]...](http://api.summon.serialssolutions.com/2.0.0/image/issn/XR4PS5YY4K/0044-2313/small "[RuCl3ind3] and [RuCl2ind4]: Two New Ruthenium Complexes derived from the Tumor-inhibiting RuIII Compound HInd (OC-6-11)-[RuCl4ind2] (ind = indazole)")
