This paper outlines the life and work of Paul Otlet (1868–1944). Otlet was a founder of the scholarly disciplines of bibliography, documentation, and information science. As a result of the work he ...undertook with Henri La Fontaine (1854–1943)—specifically, the establishment in 1895 in Brussels of the International Institute of Bibliography, which aimed to construct a Universal Bibliographic Repertory—Otlet has become known as the father of the Internet. Otlet’s grand project, as stated in his Traité de documentation (1934), was never fully realized. Even before his death, the collections he assembled had been dismembered. After his death, the problematic conditions in which Otlet’s personal papers and the collections he had created were preserved meant that his thought and work remained largely unacknowledged. It fell to W. Boyd Rayward, who began to work on Otlet in the late 1960s, to rescue him from obscurity, publishing in 1975 a major biography of the pioneer knowledge entrepreneur and internationalist progenitor of the World Wide Web.
We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study ...were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers.
IRS1 rs1801123, rs1330645, and rs1801278 were genotyped in samples from 36 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Data were analyzed by a retrospective cohort approach modeling the associations with breast and ovarian cancer risks simultaneously. Analyses were stratified by BRCA1 and BRCA2 status and mutation class in BRCA1 carriers.
Rs1801278 (Gly972Arg) was associated with ovarian cancer risk for both BRCA1 (HR, 1.43; 95% confidence interval (CI), 1.06-1.92; P = 0.019) and BRCA2 mutation carriers (HR, 2.21; 95% CI, 1.39-3.52, P = 0.0008). For BRCA1 mutation carriers, the breast cancer risk was higher in carriers with class II mutations than class I mutations (class II HR, 1.86; 95% CI, 1.28-2.70; class I HR, 0.86; 95%CI, 0.69-1.09; P(difference), 0.0006). Rs13306465 was associated with ovarian cancer risk in BRCA1 class II mutation carriers (HR, 2.42; P = 0.03).
The IRS1 Gly972Arg single-nucleotide polymorphism, which affects insulin-like growth factor and insulin signaling, modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers and breast cancer risk in BRCA1 class II mutation carriers.
These findings may prove useful for risk prediction for breast and ovarian cancers in BRCA1 and BRCA2 mutation carriers.
This study examines the cost effectiveness of group follow-up after participation in the Dose Adjustment for Normal Eating (DAFNE) structured education programme for type 1 diabetes.
Economic ...evaluation conducted alongside a cluster randomised controlled trial involving 437 adults with type 1 diabetes in Ireland. Group follow-up involved two group education 'booster' sessions post-DAFNE. Individual follow-up involved two standard one-to-one hospital clinic visits. Incremental costs, quality-adjusted life years (QALYs) gained and cost effectiveness were estimated at 18 months. Uncertainty was explored using sensitivity analysis and by estimating cost effectiveness acceptability curves.
Group follow-up was associated with a mean reduction in QALYs gained of 0.04 per patient (P value, 0.052; 95% CI, -0.08 to 0.01, intra-class correlation (ICC), 0.033) and a mean reduction in total healthcare costs of €772 (P value, 0.020; 95% CI, -1,415 to -128: ICC, 0.016) per patient. At alternative threshold values of €5,000, €15,000, €25,000, €35,000, and €45,000, the probability of group follow-up being cost effective was estimated to be 1.000, 0.762, 0.204, 0.078, and 0.033 respectively.
The results do not support implementation of group follow-up as the sole means of follow-up post-DAFNE. Given the reported cost savings, future studies should explore the cost effectiveness of alternative models of group care for diabetes.
Current Controlled Trials ISRCTN79759174 (assigned: 9 February 2007).
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Smart Nursing June Fabre, MBA, RNC
2008, 2008-12-15
eBook
CE credit available through the North Dakota Nurses Association "Smoothly written and effectively blending hard facts and personal observations, the book is peppered with inspiring success stories ...about "what works" in terms of improving morale and the quality of nursing practice." Sean Clarke, RN, PhD, CRNP University of Pennsylvania School of Nursing "Fabre's not afraid to tackle the tough issuesÖ.Implementing Smart Nursing concepts will result in energy enhancing experiences for your nurses and better care for your patients." \-- Susan Keane Baker, MHA Author, Managing Patient Expectations Too many health care organizations are using short-term fixes to patient health care delivery problems. Patients, however, require long-term solutions that treat the whole person, not just their particular ailment. What the profession needs is Smart Nursing. Smart Nursing provides practical guidance on patient care that every nurse, manager, and health care facility can use to restore patient safety, generate revenue, reduce nurse turnover, and stimulate realistic health care solutions. In this new edition, Fabre presents the recently updated Smart Nursing model. This practical model uses seven basic elements to deliver improved results, improved patient care, and increased employee job satisfaction. These simple yet critical building blocks- caring, respect, simplicity, flexibility, integrity, communication, and professional culture-allow nurses to create a positive work environment, and provide holistic care to patients. Special Features: * Provides practical, cost-effective solutions to business and management problems, such as strategies for improved staffing and retention * Includes guidance on leadership and mentoring, building high-performance teams, and accelerating professional development * Presents strategies and recommendations for developing strong relationships with staff for increased communication and efficiency
Tells a story of children with learning problems responding to scientific inquiry while practicing their literacy learning in ways their teachers never anticipated. Notes the students exhibited ...greater focus, more positive interactions, and a sustained interest. Suggests that the children not only learned scientific concepts, but also had many ways to practice the language arts for literacy development. (SG)
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The impact of the children's order over the last 10 years Duffy, Joe; Taylor, Brian; Mc Call, Susannah ...
Child care in practice : Northern Ireland journal of multi-disciplinary child care practice,
04/2006, Volume:
12, Issue:
2
Journal Article
Peer reviewed
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