Ontology for management of food safety Chaplinskyy, Y.
Scientific Works of National University of Food Technologies,
8/2023, Volume:
29, Issue:
4
Journal Article
Resistive Plate Chambers (RPCs) cover a surface of about 4000 m 2 , equivalent to 16 m 3 of gas volume both in ATLAS and CMS experiments at the Large Hadron Collider (LHC). The use of a relatively ...expensive Freon (R134a) - based gas mixture makes unavoidable their operation in closed-loop gas systems. It has been observed that the return gas of RPCs operated in background conditions similar to those foreseen at LHC contains a large amount of impurities, which are potentially dangerous for the long-term operation of these systems. During the past few years several RPCs have been operated in the intense radiation field of the CERN Gamma Irradiation Facility (GIF) in order to study the production of typical impurities, mainly fluoride ions, molecules of the Freon group and hydrocarbons. A systematic characterization of cleaning agents has also been performed. Moreover, the tests suggest an optimized configuration of filters, currently under long-term validation at the GIF set-up. The new filter configuration optimizes the filtering capacity for H 2 O, O 2 and RPC typical impurities. An important feature of the new configuration is the increase of the cycle duration for each purifier, that results in better system stability, reduced system downtime and, if needed, it permits to increase comfortably the gas flow in the detectors during the high luminosity running periods at LHC. The filtering optimization studies are complemented with a finite element simulation of the gas flow distribution in the RPCs, aiming at its eventual optimization. A preliminary study on the standard configuration for the RPC gas distribution shows regions in which the gas velocity is 10-100 times lower than in others. With a gas flow of 1 volume exchange every 4 hours (considered the lower limit for a safe operation without radiation) these regions represent about one third of the whole detector surface. The extension of these areas increases dramatically when decreasing the gas flow. A new RPC prototype with a flexible distribution of gas inlets and outlets has been built in order to experimentally quantify the impact of those critical regions on the detector performance and also to verify if a new, more effective solution can be found. The basic idea is that the regions with very low gas velocity define the overall gas flow needed for the detector operation. An efficient removal of the "used" gas mixture inside the RPC volume would permit the reduction of the overall gas flow rate and thus would cut down the operation cost of the large gas systems, without affecting the RPC detector's performance.
Two structurally distinct series of SCD (Δ9 desaturase) inhibitors (1 and 2) have been previously reported by our group. In the present work, we merged the structural features of the two series. This ...led to the discovery of compound 5b (CVT-12,012) which is highly potent in a human cell-based (HEPG2) SCD assay (IC50=6nM). This compound has 78% oral bioavailability in rats and is preferentially distributed into liver (76 times vs plasma) with relatively low brain penetration. In a five-day study (sucrose fed rats) compound 5b significantly reduced SCD activity in a dose-dependent manner as determined by GC analysis of fatty acid composition in plasma and liver, and significantly reduced liver triglycerides versus the control group (∼50%).
We combined the features of two structurally distinct series of SCD inhibitors that were previously reported by our group. This led to the discovery of compound CVT-12,012 which has single-digit nanomolar potency in a human HEPG2 SCD assay, 78% oral bioavailability in rats, and is preferentially distributed into liver. In a 5-day study (high sucrose diet, rat) CVT-12,012 significantly reduced liver triglycerides versus the control group (∼50%).
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
We discovered a structurally novel SCD inhibitor CVT-11,563 (IC50 119nM, HEPG2 assay), selective against Δ5 and Δ6 desaturases, with excellent PK parameters (F=90% and dAUC 935ngh/mL). This compound ...was found to have moderately selective liver distribution and low brain penetration. In a 5-day study CVT-11,563 significantly reduced SCD activity in plasma and liver.
We discovered a structurally novel SCD (Δ9 desaturase) inhibitor 4a (CVT-11,563) that has 119nM potency in a human cell-based (HEPG2) SCD assay and selectivity against Δ5 and Δ6 desaturases. This compound has 90% oral bioavailability (rat) and excellent plasma exposure (dAUC 935ngh/mL). Additionally, 4a shows moderately selective liver distribution (three times vs plasma and adipose tissue) and relatively low brain penetration. In a five-day study (high sucrose diet, rat) compound 4a significantly reduced SCD activity as determined by GC analysis of fatty acid composition in plasma and liver. We describe the discovery of 4a from HTS hit 1 followed by scaffold replacement and SAR studies focused on DMPK properties.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The actuality of the usage of decision-making approach based on the ontologies and context is shown. The actuality of the implementation of the aspects system for decision-making is considered. The ...known approaches to the use of aspects of decision-making are analyzed. A ontologies which describe the context and its implementation for specific decision-making tasks is considered. The aspects ontology and its components for decision-making are presented. The main characteristics of the aspects system and dimensions of consideration are presented.
Carbon stocks and accumulation rates in humus and peat horizons of the contiguous soil series of forest and bog ecosystems have been studied in the Central Forest State Biosphere Reserve, Tver ...Region. Upland soil types (soddy podzolic, brown, and white podzolic) have been compared to paludified (peat-enriched gley podzolic and peaty gley) and bog soils differing in trophic status, including those of upland, transitional, and lowland bogs. The results show that carbon stocks in mineral soils are many times smaller than in waterlogged soils and an order of magnitude smaller than in bog soils. Mineral and bog soils are characterized by similar rates of carbon accumulation averaged over the entire period of their existence. The highest rate of carbon accumulation has been noted for the soils of waterlogged habitats, although this process may be periodically disturbed by fires and other stress influences.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
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