We have surveyed the 60.1-10 MeV nucleon super(-1) abundances of heavy ions from super(3)He through Fe in 64 large solar energetic particle (LSEP) events observed on board the Advanced Composition ...Explorer from 1997 November through 2005 January. Our main results are (1) the 0.5-2.0 MeV nucleon super(-1) super(3)He/ super(4)He ratio is enhanced between factors of 62-150 over the solar wind value in 29 (646%) events. (2) The Fe/O ratio in most LSEP events decreases with increasing energy up to 660 MeV nucleon super(-1). (3) The Fe/O ratio is independent of CME speed, flare longitude, event size, the super(3)He/ super(4)He ratio, the pre-event Fe/O ratio, and solar activity. (4) The LSEP abundances exhibit unsystematic behavior as a function of M/Q ratio when compared with average solar wind values. (5) The survey-averaged abundances are enhanced with increasing M/Q ratio when compared with quiet coronal values and with average gradual SEP abundances obtained at 5-12 MeV nucleon super(-1). (6) The event-to-event variations in LSEP events are remarkably similar to those seen in CME-driven IP shocks and in super(3)He-rich SEP events. The above results cannot be explained by simply invoking the current paradigm for large gradual SEP events, i.e., that CME-driven shocks accelerate a seed population dominated by ambient coronal or solar wind ions. Instead, we suggest that the systematic M/Q-dependent enhancements in LSEP events are an inherent property of a highly variable suprathermal seed population, most of which is accelerated by mechanisms that produce heavy-ion abundances similar to those observed in impulsive SEP events. This heavy-ion-enriched material is subsequently accelerated at CME-driven shocks near the Sun by processes in which ions with higher M/Q ratios are accelerated less efficiently, thus causing the Fe/O ratios to decrease with increasing energy.
Uptake of NHS Health Checks (NHSHCs) is sub-optimal. This study aimed to increase their uptake using behaviourally informed invitation letters.
Patients registered with 6 general practices in ...Northamptonshire, England who were eligible for an NHSHC between 10 February 2014 and 31 January 2015 were randomized monthly, using a random number generator, to three trial arms: control (standard invitation), sunk costs (resources already allocated) and counterargument (against common barriers to attendance). The outcome measure was uptake of NHSHC by 12 weeks after 31 January.
In total, 6331 patients were randomized. After exclusions, due to ineligibility for the NHSHC, data were analysed for N = 6313 patients: N = 2123 control; N = 2085 counterargument; N = 2105 sunk costs. Overall, 2364 (37.45%) patients attended an NHSHC. Both intervention letters increased uptake compared to control, by 5.46% using counterargument (adjusted odds ratio (AOR) 1.32, CI 1.162-1.51, p < 0.001) and 4.33% using sunk costs (AOR 1.246, CI 1.10-1.42, p < 0.001), with no significant difference between the two.
Behaviourally informed invitation letters, containing sunk costs or counterargument messages, can improve the uptake of NHSHCs. The trial was registered with the International Standard Randomised Controlled Trial Registration Number Scheme (ISRCTN57110614).
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NUK, OILJ, UL, UM, UPUK, VSZLJ
Abstract
STUDY QUESTION
When adjusting for recipient BMI, is donor body mass index (BMI) associated with IVF outcomes in donor oocyte IVF cycles?
SUMMARY ANSWER
Increasing oocyte donor BMI is ...associated with a reduction in clinical pregnancy and live birth rates.
WHAT IS KNOWN ALREADY
Increased BMI has been associated with suboptimal reproductive outcomes, particularly in assisted reproductive technology (ART) cycles. However, it remains unclear if this association implies an effect of BMI on oocyte quality and/or endometrial receptivity.
STUDY DESIGN, SIZE, DURATION
A retrospective cohort study of two hundred and thirty five consecutive fresh donor oocyte IVF cycles from 1 January 2007 through 31 December 2013 at the Massachusetts General Hospital (MGH) Fertility Center.
PARTICIPANTS/MATERIALS, SETTING, METHODS
Analyses included a total of 202 oocyte donors and 235 total cycles. Following adjustments for recipient BMI, the relationship between donor BMI (categorized into quartiles) and IVF outcomes was assessed.
MAIN RESULTS AND THE ROLE OF CHANCE
In the entire (anonymous and known) donor population, a reduced odds of clinical pregnancy (P-trend = 0.046) and live birth (P-trend = 0.06) was observed with increasing BMI quartile. Compared with quartile 1 (BMI 17.8–21.1), odds ratio (OR) (95% CI) of clinical pregnancy was 0.9 (0.4–2.0), 0.5 (0.2–1.1) and 0.5 (0.2–1.1), and OR of live birth was 1.1 (0.5–2.6), 0.6 (0.3–1.2) and 0.6 (0.3–1.2) for quartiles 2 through 4 respectively. In anonymous donors only, the odds of clinical pregnancy (P-trend = 0.02) and live birth (P-trend = 0.03) also declined as BMI quartile increased. Compared with quartile 1 (BMI 17.8–21.1), odds ratio (OR) (95% CI) of clinical pregnancy was 0.7 (0.3–1.7), 0.5 (0.2–1.1) and 0.4 (0.1–0.9), and OR of live birth was 0.9 (0.4–2.2), 0.5 (0.3–1.2) and 0.4 (0.2–1.1) for quartiles 2 through 4 respectively.
LIMITATIONS, REASONS FOR CAUTION
Limitations include the retrospective design, sample size and data from a single institution. Clinical application may not be limited to oocyte donors, though caution should be used prior to applying these principles to the general population. Data should not be interpreted to mean that all oocyte donors should be restricted to a BMI of less than 21.2 kg/m2.
WIDER IMPLICATIONS OF THE FINDINGS
Following adjustments for the respective BMI of the oocyte donor and recipient, this study demonstrates an association of preconception BMI with subsequent IVF outcomes. The observations of this study are consistent with prior animal studies, suggest a possible effect of BMI at the oocyte level prior to fertilization and implantation, and warrant further investigation.
STUDY FUNDING/COMPETING INTERESTS
None.
We have surveyed the energy spectra of approx0.1-100 MeV nucleon super(-1) C, O, and Fe nuclei associated with the passage of 72 interplanetary (IP) shocks observed on board the ACE spacecraft during ...the period 1997 October-2002 October. Our main results are as follows: (1) The spectral fit parameters are independent of the local shock properties. (2) About 7% of the events exhibit increasing Fe/O ratios with energy; the remaining events have Fe/O ratios that either remain constant or decrease with energy. (3) The Fe/O ratio in the shock- associated particles is typically approx30% lower than in the ambient population. (4) The fractionation pattern of the elemental abundances, the O spectra, and the energy-dependence of Fe/O at the IP shocks are remarkably similar to those of the ambient interplanetary suprathermal ion population. We suggest that the IP shocks studied here reaccelerate energetic particle seed spectra composed of ions from impulsive and gradual solar energetic particle events by systematic rigidity-dependent mechanisms in which higher rigidity ions are accelerated less efficiently than lower rigidity ions.
Energetic charged particle detectors characterize a portion of the plasma distribution function that plays critical roles in some physical processes, from carrying the currents in planetary ring ...currents to weathering the surfaces of planetary objects. For several low-resource missions in the past, the need was recognized for a low-resource but highly capable, mass-species-discriminating energetic particle sensor that could also obtain angular distributions without motors or mechanical articulation. This need led to the development of a compact Energetic Particle Detector (EPD), known as the "Puck" EPD (short for hockey puck), that is capable of determining the flux, angular distribution, and composition of incident ions between an energy range of approximately 10 kiloelectronvolts to several megaelectronvolts. This sensor makes simultaneous angular measurements of electron fluxes from the tens of kiloelectronvolts to about 1 megaelectronvolt. The same measurements can be extended down to approximately 1 kiloelectronvolt per nucleon,with some composition ambiguity. These sensors have a proven flight heritage record that includes missions such as MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) and New Horizons, with multiple sensors on each of Juno, Van Allen Probes, and Magnetospheric Multiscale. In this review paper we discuss the Puck EPD design, its heritage, unexpected results from these past missions and future advancements. We also discuss high-voltage anomalies that are thought to be associated with the use of curved foils, which is a new foil manufacturing processes utilized on recent Puck EPD designs. Finally, we discuss the important role Puck EPDs can potentially play in upcoming missions.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Summary Tremendous advances have occurred in our understanding of the pathogenesis of hand osteoarthritis (OA) and these are beginning to be applied to trials targeted at modification of the disease ...course. The purpose of this expert opinion, consensus driven exercise is to provide detail on how one might use and apply hand imaging assessments in disease modifying clinical trials. It includes information on acquisition methods/techniques (including guidance on positioning for radiography, sequence/protocol recommendations/hardware for MRI); commonly encountered problems (including positioning, hardware and coil failures, sequences artifacts); quality assurance/control procedures; measurement methods; measurement performance (reliability, responsiveness, validity); recommendations for trials; and research recommendations.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Angiogenesis is a promising treatment strategy for patients who are not candidates for standard revascularization, because it promotes the growth of new blood vessels in ischemic myocardium.
We ...conducted a randomized, double-blind, placebo-controlled study of basic fibroblast growth factor (bFGF; 10 or 100 microg versus placebo) delivered via sustained-release heparin-alginate microcapsules implanted in ischemic and viable but ungraftable myocardial territories in patients undergoing CABG. Twenty-four patients were randomized to 10 microg of bFGF (n=8), 100 microg of bFGF (n=8), or placebo (n=8), in addition to undergoing CABG. There were 2 operative deaths and 3 Q-wave myocardial infarctions. There were no treatment-related adverse events, and there was no rise in serum bFGF levels. Clinical follow-up was available for all patients (16.0+/-6.8 months). Three control patients had recurrent angina, 2 of whom required repeat revascularization. One patient in the 10-microg bFGF group had angina, whereas all patients in the 100-microg bFGF group remained angina-free. Stress nuclear perfusion imaging at baseline and 3 months after CABG showed a trend toward worsening of the defect size in the placebo group (20.7+/-3.7% to 23.8+/-5.7%, P=0.06), no significant change in the 10-microg bFGF group, and significant improvement in the 100-microg bFGF group (19.2+/-5.0% to 9.1+/-5.9%, P=0.01). Magnetic resonance assessment of the target ischemic zone in a subset of patients showed a trend toward a reduction in the target ischemic area in the 100-microg bFGF group (10.7+/-3.9% to 3. 7+/-6.3%, P=0.06).
This study of bFGF in patients undergoing CABG demonstrates the safety and feasibility of this mode of therapy in patients with viable myocardium that cannot be adequately revascularized.
Red imported fire ants, Solenopsis invicta Buren, are adversely affected by phorid flies in the genus Pseudacteon by instigating defensive behaviors in their hosts, and in turn reducing the ...efficiency of S. invicta foraging. Multiple Pseudacteon species have been released in Texas, and research has been focused on the establishment and spread of these introduced biological control agents. Field experiments were conducted to determine bait particle size selection of S. invicta when exposed to phorid populations. Four different particle sizes of two candidate baits were offered to foragers (one provided by a pesticide manufacturer, and a laboratory-created bait). Foragers selectively were attracted to, and removed more 1–1.4-mm particles than any other bait size. The industry-provided bait is primarily made of particles in the 1.4–2.0 mm size, larger than what was selected by the ants in this study. While there was a preference for foragers to be attracted to and rest on the industry-provided blank bait, S. invicta removed more of the laboratory-created bait from the test vials. There was an abundance of workers with head widths ranging from 0.5–0.75 mm collected from baits. This was dissimilar from a previous study wherein phorid flies were not active and in which large workers were collected in higher abundance at the site. This implies that phorid fly activity caused a shift for red imported fire ant colonies to have fewer large foragers.
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