En este trabajo nos adentramos en el efecto de los nuevos medios digitales del Diario del Pueblo, uno de los diez periódicos más conocidos del mundo, ante la COVID-19. Los nuevos medios, gracias a ...las ventajas distintivas, desempeñan un papel insustituible en la cobertura informativa de la emergencia sanitaria pública. Frente a esta crisis, los tres nuevos medios (Microblog, Wechat, Douyin ) del Diario del Pueblo realizaron las funciones de los medios de comunicación a través de los informes diferenciados según las características de plataformas y las preferencias de audiencias. El artículo busca presentar y analizar cómo integrar orgánicamente los nuevos medios digitales del Diario del Pueblo para el efecto de transmisión óptima en la sociedad china ante la pandemia de la COVID-19 con base en la recopilación de datos y el análisis de estadísticas.
Introduction
Citri Sarcodactylis Fructus has the effects of relieving cough, removing phlegm, and reducing asthma, but little is known about the metabolic and distribution of its chemical ...constituents in vivo. Therefore, it is necessary to study the metabolism of Citri Sarcodactylis Fructus in vivo.
Objective
We aimed to (1) analyze the distribution of prototype compounds and metabolites of the chemical constituents of Citri Sarcodactylis Fructus in rat and (2) infer the metabolites and metabolic pathways of the chemical constituents.
Materials and methods
A C18 column (3 × 100 mm, 2.6 μm) was used. The mobile phase was water containing 0.1% formic acid (eluent A) and acetonitrile containing 0.1% formic acid (eluent B) at a discharge rate of 0.3 mL/min. Mass spectra of biological samples were collected in electrospray ionization (ESI) positive ion mode in the m/z 100–1500 scan range. The obtained biological samples were then subjected to chemical analysis, including plasma, urine, feces, and heart, liver, spleen, lungs, kidneys, stomach, and small intestine tissues. Prototype compounds and metabolites were identified.
Results
In all, 40 prototype compounds and 78 metabolites, including 26 phase I metabolites and 52 phase II metabolites, were identified using UHPLC–Q/Orbitrap HRMS. Eight possible metabolic pathways (reduction, hydrolysis, dehydration, methylation, hydroxylation, sulfation, glucuronidation, and demethylation) were proposed. The prototype compounds were predominantly distributed in lung tissues. The metabolites were mainly distributed in plasma and kidney tissues.
Conclusion
We systematically investigated the metabolites of Citri Sarcodactylis Fructus in vivo. We suggest metabolic pathways that might be relevant for further metabolic studies and screening of active ingredients of Citrus Sarcodactylis Fructus in vivo.
In this study, we employed UHPLC–Q/Orbitrap HRMS to identify a total of 40 prototype compounds of Citri Sarcodactylis Fructus, primarily including coumarin‐type, flavonoid‐type, and limonoid‐type compounds. Additionally, we identified 78 metabolites, comprising 26 phase I metabolites and 52 phase II metabolites. The metabolic processes observed in vivo primarily involved reduction, hydrolysis, dehydration, methylation, hydroxylation, sulfation, glucuronidation, and demethylation. These findings provide valuable information for further exploring the pharmacological mechanism of action of Citri Sarcodactylis Fructus.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
A dual rhodium/isothiourea catalytic system was developed for the enantiodivergent transformation of terminal alkynes. Under synergistic rhodium/isothiourea dual catalysis, terminal alkynes can be ...creatively utilized as precursors for C1-ammonium enolate species, which subsequently participate in 4 + 2 and 2 + 2 annulation reactions with α,β-unsaturated ketimines or ketones, respectively. A wide range of chiral lactams and lactones were obtained in excellent yields and stereoselectivities (up to >20:1 dr, 98% ee).
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IJS, KILJ, NUK, PNG, UL, UM
This article analyses the representation and reception of the advertising of children’s healthcare products in Chinese television. It engages with the concept of risk to analyse the representation of ...a coherent narrative of young children’s health-related risks comprising messages of environment, nature, nutrition and science. Within the narrative, interconnected risks – risks of everyday living, risks of environment pollution, risk of malnutrition – as well as a wider discourse of ‘risk and protection’ are constructed. This article also analyses parents’ reception of the discourse and their responses to perceived and real health risks contextualised in a neoliberal system marked by medicalised children’s healthcare and ‘truncated’ civic rights in China. This article argues that these institutional conditions reinforce the risk-centred narrative which invokes heightened parental uncertainties and anxieties about childrearing as part of the modern cultural experiences in China.
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NUK, OILJ, SAZU, UKNU, UL, UM, UPUK
Spermatozoa released from testes undergo a maturation process and acquire the capacity to fertilize ova through epididymal transit. The epididymis is divided into four regions, each with unique ...morphology, gene profile, luminal microenvironment and distinct function. To study the functions of relevant genes in the epididymal initial segment (IS), a novel IS-specific mouse model, Lcn9-Cre knock-in (KI) mouse line was generated via CRISPR/Cas9 technology. The TAG stop codon was replaced by a 2A-NLS-Cre cassette, resulting in the co-expression of Lcn9 and Cre recombinase. IS-specific Cre expression was first observed from postnatal day 17. Using the Rosa26.sup.tdTomato reporter mice, the Cre-mediated DNA recombination was detected exclusively in principal cells. The epididymal IS-specific Cre activity in vivo was further confirmed using Lcn9-Cre mice crossed with a mouse strain carrying Tsc1 floxed alleles (Tsc1.sup.flox/+). Cre expression did not affect either normal development or male fecundity. Different from any epididymis-specific Cre mice reported previously, the novel Lcn9-Cre mouse line can be used to introduce entire IS-specific conditional gene editing for gene functional study.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
This article analyses the representation of parental practices in Parenting Science, the first and longest running parenting magazine published in China since 1980. Drawing on Foucault’s work on ...governmentality and biopolitics as well as their current development in cultural studies and sociology of health, this article critically investigates the cultural frames that surround parental practices relating to the health and development of young children. It explores how issues of medicalisation, intensive parenting, responsibility and self-management are represented in the magazine, ‘reflecting’ as well as ‘reinforcing’ dominant cultural ideas of parenting and childrearing in China. Based on a qualitative content analysis of 2295 items from 37 issues of the magazine (1980–2016), including editorials, feature stories, standard articles, Q&As, adverts and other short items, this article has identified three major frames of parental practices in monitoring and facilitating children’s health, development and wellbeing: (1) the medicalisation of children’s health problems, (2) the rise of expert authority and (3) the responsibilisation of parents. This article argues that these frames underpin the construction of an intensive and anxious parenting culture in China and serve as powerful tools of biopolitical control.
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NUK, OILJ, SAZU, UKNU, UL, UM, UPUK
This paper brings together scholarship across sociology, media and communication, and human computer interaction to explore the intersection of digital health and the maternity care system. We draw ...on data (including interviews, focus groups, observations, and analyses of digital media content) from 19 studies involving over 400 women to explore women's experiences of using different forms of digital support such as the Internet, mobile technologies (apps and text messaging), social media, and remote monitoring devices in their reproductive journeys. We use a best fit approach to analysis, mapping our findings to the candidacy framework and notions of trajectory work to understand how women engage in digital health practices to negotiate boundaries between physiology and pathology and to enter dialogue with maternity services during conception, pregnancy and the postnatal period. We propose an integrated revised conceptual framework which explicates intersections between digital and care practices, and micro-level negotiations between women and professionals in the maternal health context. Our revised framework retains the dimensions of candidacy, but it introduces a precursor to the identification of candidacy in the form of ‘understanding normality’. It identifies distinct forms of digital work (e.g. information work, navigation work, machine work) which operate across the candidacy dimensions that women (and partners at times) engage in to negotiate legitimacy when entering into encounters with the maternity care system. Operating conditions (norms around expert motherhood; neoliberal discourses around health optimisation, risk and responsibilisation) provide a broader macro-level context, influencing the micro-level dialogic processes between women and healthcare professionals. Our synthesis highlights digital mediation as a useful filter to understand care systems, distribution of lay/professional responsibilities, relational practices and the (dis)enablement of candidacy.
•How do digital resources mediate eligibility distinctions for maternity services?•We synthesised qualitative data from 19 studies (>400 women) using a best fit approach.•Women utilise digital technologies to interact with maternal healthcare.•Learning what constitutes normality is important for negotiating candidacy.•Digital work is a useful filter to understand negotiations of care.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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