Jenner, Gjessing, Cox, Davies-Jones, Hullin, and Hanna (1967) have presented some biochemical and clinical studies of a patient who showed a remarkably precisely timed manic-depressive psychosis. For ...the last eleven years the patient has been alternately depressed and lethargic for 24 hours, then elated for 24 hours, and so on almost without fail. Harding, Jeavons, Jenner, Drummond, Sheridan and Howells (1966) published electroencephalographic studies showing the 48-hour rhythm in the patient's electroencephalogram. The harmonic mean, the mean abundance and variability of the alpha rhythm all showed a striking 48-hour cycle. A number of similar patients have been described and are conveniently listed by Menninger-Lerchenthal (1960), Richter (1960), and Bunney and Hartmann (1965). Jenner (1965) made some suggestions about possibly heuristically helpful electronic analogues which might appropriately represent some of the underlying mechanisms of the 48-hour syndromes.
1. Thirteen children who had ingested iron salts were treated with a combination of enteral and parenteral Desferrioxamine. Although all recovered, a review of the literature indicates that criteria ...are not available to determine whether the treatment was responsible for their survival.
2. Three of 9 dogs recovered when treated with enteral and intravenous See Table XII. in Source Pdf. Desferrioxamine, which was started 1 hour after the administration of a L D.100 dose of ferrous sulfate.
3. Desferrioxamine does not prevent the absorption of the quantities of iron involved in acute iron poisoning.
4. Further studies are essential to: (a) establish criteria for determining the quantity of Desferrioxamine to use in individual cases so that maximum effectiveness will be achieved without producing serious toxicity, and (b) to determine whether toxicity from the iron-desferrioxamine complex can be prevented.
OBJECTIVE Previous studies have suggested that burn blister fluid (BBF) may be detrimental to the healing of the underlying wound bed. In this study, the effects of burn blister fluid on cultured ...keratinocyte proliferation and differentiation were examined and quantitated using various techniques.
METHODS At three different concentrations (2%, 10%, 20% in 20% fetal bovine serum/complete culture medium), 19 BBFs were tested in triplicate using 12 populations of cultured keratinocytes. All BBFs were collected from partial thickness burns within 72 hours of injury. BBF was added on day 4 of the keratinocyte culture. The effect on proliferation and viability was assessed using trypan blue dye exclusion. Multiparameter flow cytometric analysis was used to quantitate population kinetics and cell size distribution. Keratinocyte differentiation was determined using immunohistochemical staining of differentiation markers and quantitation of cornified envelope formation.
RESULTS Relative to control fluid, the BBF caused a variable effect on proliferation, ranging from 67% inhibition to 103% stimulation, with an overall 4% inhibition. The range of keratinocyte viability was narrower, with a similar overall 4% reduction. Using flow cytometry to analyze RNA/DNA content and cell size, The BBF caused a subtle shift in keratinocyte population kinetics and cell size distribution toward larger, less rapidly dividing cells. The BBF had no significant effect on expression of the differentiation markers, filaggrin and involucrin. Finally, the BBF did not alter terminal differentiation as it did not influence formation of cornified envelopes (BBF = 9.1 +/- 4.8%, control = 9.9 +/- 6.6%).
CONCLUSION Previous biochemical analysis has shown that BBF consists primarily of human serum filtrate with locally produced acute reactants. Our study suggests that BBF is biologically similar to serum and does not significantly alter keratinocyte proliferation or differentiation in vitro.
CEO to CEO Riemersma, Mary J; Shively, Robert A; Goodwin, Robert K ...
Association Management,
09/2003, Volume:
55, Issue:
9
Trade Publication Article
Association executives discuss two questions about association leadership: 1. In a challenging economic environment, what should an association never cut from its budget and why? 2. What's your ...organization's spam policy, and how do you ensure that you're not over-communicating with your members via e-mail? Mary J Riemersma of the California Association of Marriage and Family Therapists says that key projects or activities that the members most value should not be cut from an association's budget. The association's leadership must have a clear understanding of what is most valued. Robert K Goodwin of the Points of Light Foundation, though, says there should be no sacred cows, as every area of administrative and program focus may experience some cuts. Marian L Heard of the United Way of Massachusetts says her organization's goal is to ensure that its communication is tuned to the preferences and interests of its donors.
The authors give a step-by-step description of their effort to develop patient-outcome criteria to be used in measuring the effectiveness of nursing care. Their measurement instrument has not yet ...been completed, and they will appreciate input from readers on such issues as population selection and refinement of measurement techniques. This research is supported by grant number NU 016 49-01 from the Bureau of Health Services Research, U.S. Public Health Service, Department of Health, Education, and Welfare.
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Ebstein's anomaly represents an anatomic, pathologic, and physiologic spectrum. There have been few hemodynamic correlates for the observed auscultatory events. Multiple components of the first sound ...and "ejection" sounds are frequently described. Cardiac catheterization, intracardiac sound-pressure studies (Telco), and cineangiograms were performed in three patients with Ebstein's anomaly who had a prominent early systolic sound. The right ventricular pressure pulse was abnormal in all; an initial delta-wave configuration, followed by a more rapid pressure rise, produced a prolonged rise to peak pressure. The right ventricular pressure pulse is not that of a conduction defect alone; rather it suggests that the altered pattern of ventricular contraction and abnormal leaflet placement are contributing factors. The early systolic sound was recorded in the atrialized right ventricle or right ventricle in all. It occurred just after the peak of the c wave in the atrialized right ventricle. In the right ventricle the sound occurred at the point where initial slow delta portion of right ventricular pressure pulse gave rise to rapid upstroke. The early systolic sound most likely occurs when the large, sail-like tricuspid valve reaches the limit of systolic excursion. The sound has been designated as the "sail sound," and may be the most specific auscultatory event in Ebstein's anomaly.
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