Almost without exception, everything human beings undertake involves a choice. In recent years there has been a growing interest in the development and application of quantitative statistical methods ...to study choices made by individuals with the purpose of gaining a better understanding both of how choices are made and of forecasting future choice responses. In this primer the authors provide an unintimidating introduction to the main techniques of choice analysis and include detail on themes such as data collection and preparation, model estimation and interpretation and the design of choice experiments. A companion website to the book provides practice data sets and software to estimate the main discrete choice models such as multinomial logit, nested logit and mixed logit. This primer will be an invaluable resource to students as well as of immense value to consultants and professionals, researchers and anyone else interested in choice analysis and modelling.
The nature of the first genetic polymer is the subject of major debate
. Although the 'RNA world' theory suggests that RNA was the first replicable information carrier of the prebiotic era-that is, ...prior to the dawn of life
-other evidence implies that life may have started with a heterogeneous nucleic acid genetic system that included both RNA and DNA
. Such a theory streamlines the eventual 'genetic takeover' of homogeneous DNA from RNA as the principal information-storage molecule, but requires a selective abiotic synthesis of both RNA and DNA building blocks in the same local primordial geochemical scenario. Here we demonstrate a high-yielding, completely stereo-, regio- and furanosyl-selective prebiotic synthesis of the purine deoxyribonucleosides: deoxyadenosine and deoxyinosine. Our synthesis uses key intermediates in the prebiotic synthesis of the canonical pyrimidine ribonucleosides (cytidine and uridine), and we show that, once generated, the pyrimidines persist throughout the synthesis of the purine deoxyribonucleosides, leading to a mixture of deoxyadenosine, deoxyinosine, cytidine and uridine. These results support the notion that purine deoxyribonucleosides and pyrimidine ribonucleosides may have coexisted before the emergence of life
.
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FZAB, GEOZS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Abstract
We report here radio follow-up observations of the optical tidal disruption event (TDE) AT 2019azh. Previously reported X-ray observations of this TDE showed variability at early times and a ...dramatic increase in luminosity, by a factor of ∼10, about 8 months after optical discovery. The X-ray emission is mainly dominated by intermediate hard-soft X-rays and is exceptionally soft around the X-ray peak, which is
L
X
∼ 10
43
erg s
−1
. The high cadence 15.5 GHz observations reported here show an early rise in radio emission followed by an approximately constant light curve, and a late-time flare. This flare starts roughly at the time of the observed X-ray peak luminosity and reaches its peak about 110 days after the peak in the X-ray, and a year after optical discovery. The radio flare peaks at
ν
L
ν
∼ 10
38
erg s
−1
, a factor of two higher than the emission preceding the flare. In light of the late-time radio and X-ray flares, and the X-ray spectral evolution, we speculate a possible transition in the accretion state of this TDE, similar to the observed behavior in black hole X-ray binaries. We compare the radio properties of AT 2019azh to other known TDEs, and focus on the similarities to the late-time radio flare of the TDE ASASSN-15oi.
This paper argues that several of the poor labor market outcomes observed in the Great Recession can be traced back to a change in the demand pattern for skilled workers that started with the tech ...bust of 2000. In particular, we show that around the year 2000, the demand for cognitive tasks underwent a reversal. In response, highskilled workers moved down the occupational ladder and increasingly displaced lower-educated workers in less skill-intensive jobs. While these effects were present before the financial crisis of 2008, they became more obvious after jobs associated with the housing bubble disappeared.
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BFBNIB, CEKLJ, INZLJ, IZUM, KILJ, NMLJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK, ZRSKP
Cross education is the strength gain or skill improvement transferred to the contralateral limb following unilateral training or practice. The present study examined the transfer of both strength and ...skill following a strength training program. Forty participants (20M, 20F) completed a 6-wk unilateral training program of dominant wrist flexion or dorsiflexion. Strength, force variability, and muscle activity were assessed pretraining, posttraining, and following 6 wk of detraining (retention). Analyses of covariance compared the experimental limb (trained or untrained) to the control (dominant or nondominant). There were no sex differences in the training response. Cross education of strength at posttraining was 6% ( P < 0.01) in the untrained arm and 13% ( P < 0.01) in the untrained leg. Contralateral strength continued to increase following detraining to 15% in the arm ( P < 0.01) and 14% in the leg ( P < 0.01). There was no difference in strength gains between upper and lower limbs ( P > 0.05). Cross education of skill (force variability) demonstrated greater improvements in the untrained limbs compared with the control limbs during contractions performed without concurrent feedback. Significant increases in V-wave amplitude ( P = 0.02) and central activation ( P < 0.01) were highly correlated with contralateral strength gains. There was no change in agonist amplitude or motor unit firing rates in the untrained limbs ( P > 0.05). The neuromuscular mechanisms mirrored the force increases at posttraining and retention supporting central drive adaptations of cross education. The continued strength increases at retention identified the presence of motor learning in cross education, as confirmed by force variability.
We examined cross education of strength and skill following 6 wk of unilateral training and 6 wk of detraining. A novel finding was the continued increase in contralateral strength following both training and detraining. Neuromuscular adaptations were highly correlated with strength gains in the trained and contralateral limbs. Motor learning was evident in the trained and contralateral limbs during contractions performed without concurrent feedback.
Liquid/gas diffusion layers (LGDLs), which are located between the catalyst layer (CL) and bipolar plate (BP), play an important role in enhancing the performance of water splitting in proton ...exchange membrane electrolyzer cells (PEMECs). They are expected to transport electrons, heat, and reactants/products simultaneously with minimum voltage, current, thermal, interfacial, and fluidic losses. In this study, the thin titanium-based LGDLs with straight-through pores and well-defined pore morphologies are comprehensively investigated for the first time. The novel LGDL with a 400 μm pore size and 0.7 porosity achieved a best-ever performance of 1.66 V at 2 A cm −2 and 80 °C, as compared to the published literature. The thin/well-tunable titanium based LGDLs remarkably reduce ohmic and activation losses, and it was found that porosity has a more significant impact on performance than pore size. In addition, an appropriate equivalent electrical circuit model has been established to quantify the effects of pore morphologies. The rapid electrochemical reaction phenomena at the center of the PEMEC are observed by coupling with high-speed and micro-scale visualization systems. The observed reactions contribute reasonable and pioneering data that elucidate the effects of porosity and pore size on the PEMEC performance. This study can be a new guide for future research and development towards high-efficiency and low-cost hydrogen energy.
This phase 3 multicenter, randomized, double-blind, placebo-controlled 2-year trial compared the efficacy and safety of intravenous belimumab with those of placebo, plus standard therapy, in patients ...with active lupus nephritis. More patients who received belimumab had a primary efficacy renal response than those who received placebo.
Abstract
Recently, the accretion geometry of the black hole X-ray binary Cyg X-1 was probed with the X-ray polarization. The position angle of the X-ray-emitting flow was found to be aligned with the ...position angle of the radio jet in the plane of the sky. At the same time, the observed high polarization degree could be obtained only for a high inclination of the X-ray-emitting flow, indicating a misalignment between the binary axis and the black hole spin. The jet, in turn, is believed to be directed by the spin axis; hence, a similar misalignment is expected between the jet and binary axes. We test this hypothesis using very long (up to about 26 yr) multiband radio observations. We find a misalignment of 20°–30°. However, contrary to the earlier expectations, the jet and binary viewing angles are found to be similar, while the misalignment is seen between the position angles of the jet and the binary axis on the plane of the sky. Furthermore, the presence of the misalignment calls into question our understanding of the evolution of this binary system.
Abstract
The optical-ultraviolet transient AT 2021loi is located at the center of its host galaxy. Its spectral features identify it as a member of the Bowen fluorescence flare (BFF) class. The first ...member of this class was considered to be related to a tidal disruption event, but enhanced accretion onto an already active supermassive black hole was suggested as an alternative explanation. Having occurred in a previously known unobscured active galactic nucleus, AT 2021loi strengthens the latter interpretation. Its light curve is similar to those of previous BFFs, showing a rebrightening approximately 1 yr after the main peak (which was not explicitly identified but might be the case in all previous BFFs). An emission feature around 4680 Å, seen in the preflare spectrum, strengthens by a factor of ∼2 around the optical peak of the flare and is clearly seen as a double-peaked feature then, suggesting a blend of N
iii
λ
4640 with He
ii
λ
4686 as its origin. The appearance of O
iii
λ
3133 and possible N
iii
λλ
4097, 4103 (blended with H
δ
) during the flare further support a Bowen fluorescence classification. Here we present ZTF, ATLAS, Keck, Las Cumbres Observatory, NEOWISE-R, Swift AMI, and Very Large Array observations of AT 2021loi, making it one of the best-observed BFFs to date. It thus provides some clarity on the nature of BFFs but also further demonstrates the diversity of nuclear transients.
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