The detector description is an essential component that is used to analyze data resulting from particle collisions in high energy physics experiments. We will present a generic detector description ...toolkit and describe the guiding requirements and the architectural design for such a toolkit, as well as the main implementation choices. The design is strongly driven by easy of use; developers of detector descriptions and applications using them should provide minimal information and minimal specific code to achieve the desired result. The toolkit will be built reusing already existing components from the ROOT geometry package and provides missing functional elements and interfaces to offer a complete and coherent detector description solution. A natural integration to Geant4, the detector simulation program used in high energy physics, is provided.
ILCDIRAC is a complete distributed computing solution for the Linear Collider community. It's an extension of the DIRAC system and now used by all detector concepts of the LC community. ILCDIRAC ...provides a unified interface to the distributed resources for the ILC Virtual Organization and provides common interfaces to all ILC applications via a simplified API. It supports the overlay of beam-induced backgrounds with minimal impact on the Storage Elements by properly scheduling the jobs attempting to access the files. ILCDIRAC has been successfully used for the CLIC Conceptual Design Report and the ILC SiD Detailed Baseline Design, and is now adopted by the LC community as the official Grid production tool. Members of the CALICE collaboration also use ILCDIRAC within their own Virtual Organization.
A
bstract
The Compact Linear Collider (CLIC) is a proposed future high-luminosity linear electron-positron collider operating at three energy stages, with nominal centre-of-mass energies
s
= 380 GeV, ...1
.
5 TeV, and 3 TeV. Its aim is to explore the energy frontier, providing sensitivity to physics beyond the Standard Model (BSM) and precision measurements of Standard Model processes with an emphasis on Higgs boson and top-quark physics. The opportunities for top-quark physics at CLIC are discussed in this paper. The initial stage of operation focuses on top-quark pair production measurements, as well as the search for rare flavour-changing neutral current (FCNC) top-quark decays. It also includes a top-quark pair production threshold scan around 350 GeV which provides a precise measurement of the top-quark mass in a well-defined theoretical framework. At the higher-energy stages, studies are made of top-quark pairs produced in association with other particles. A study of t
̄
tH production including the extraction of the top Yukawa coupling is presented as well as a study of vector boson fusion (VBF) production, which gives direct access to high-energy electroweak interactions. Operation above 1 TeV leads to more highly collimated jet environments where dedicated methods are used to analyse the jet constituents. These techniques enable studies of the top-quark pair production, and hence the sensitivity to BSM physics, to be extended to higher energies. This paper also includes phenomenological interpretations that may be performed using the results from the extensive top-quark physics programme at CLIC.
We present a study of the response of the highly granular Digital Hadronic Calorimeter with steel absorbers, the Fe-DHCAL, to positrons, muons, and pions with momenta ranging from 2 to 60GeV/c. ...Developed in the context of the CALICE collaboration, this hadron calorimeter utilises Resistive Plate Chambers as active media, interspersed with steel absorber plates. With a transverse granularity of 1×1cm2 and a longitudinal segmentation of 38 layers, the calorimeter counted 350,208 readout channels, each read out with single-bit resolution (digital readout). The data were recorded in the Fermilab test beam in 2010–11. The analysis includes measurements of the calorimeter response and the energy resolution to positrons and muons, as well as detailed studies of various shower shape quantities. The results are compared to simulations based on Geant4, which utilise different electromagnetic and hadronic physics lists.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The future compact linear collider (CLIC) offers a possibility for a rich precision physics programme, in particular in the Higgs sector through the energy staging. This is the first paper addressing ...the measurement of the standard model Higgs boson decay into two muons at 1.4 TeV CLIC. With respect to similar studies at future linear colliders, this paper includes several novel contributions to the statistical uncertainty of the measurement. The latter includes the equivalent photon approximation employed to describe
e
+
e
-
and
e
γ
interactions whenever the virtuality of the mediated photon is smaller than 4 GeV and realistic forward electron tagging based on energy deposition maps in the forward calorimeters, as well as several processes with the Beamstrahlung photons that results in irreducible contribution to the signal. In addition, coincidence of the Bhabha scattering with the signal and background processes is considered, altering the signal selection efficiency. The study is performed using a fully simulated CLIC_ILD detector model. It is shown that the branching ratio for the Higgs decay into a pair of muons BR(
H
→
μ
+
μ
-
) times the Higgs production cross-section in
WW
-fusion
σ
(
H
ν
ν
¯
)
can be measured with 38 % statistical accuracy at
s
=
1.4 TeV
, assuming an integrated luminosity of 1.5 ab
-
1
with unpolarised beams. If 80 % electron beam polarisation is considered, the statistical uncertainty of the measurement is reduced to 25 %. Systematic uncertainties are negligible in comparison to the statistical uncertainty.
Full text
Available for:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The future compact linear collider (CLIC) offers a possibility for a rich precision physics programme, in particular in the Higgs sector through the energy staging. This is the first paper addressing ...the measurement of the standard model Higgs boson decay into two muons at 1.4 TeV CLIC. With respect to similar studies at future linear colliders, this paper includes several novel contributions to the statistical uncertainty of the measurement. The latter includes the equivalent photon approximation employed to describe and interactions whenever the virtuality of the mediated photon is smaller than 4 GeV and realistic forward electron tagging based on energy deposition maps in the forward calorimeters, as well as several processes with the Beamstrahlung photons that results in irreducible contribution to the signal. In addition, coincidence of the Bhabha scattering with the signal and background processes is considered, altering the signal selection efficiency. The study is performed using a fully simulated CLIC_ILD detector model. It is shown that the branching ratio for the Higgs decay into a pair of muons BR( ) times the Higgs production cross-section in WW-fusion can be measured with 38 % statistical accuracy at , assuming an integrated luminosity of 1.5 ab Formula omitted with unpolarised beams. If 80 % electron beam polarisation is considered, the statistical uncertainty of the measurement is reduced to 25 %. Systematic uncertainties are negligible in comparison to the statistical uncertainty.
Full text
Available for:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Purpose: We investigated the molecular effect of the epidermal growth factor receptor (EGFR) inhibitors erlotinib and gefitinib in vivo on all available tumors from patients treated on North American ...Brain Tumor Consortium trials 01-03 and 00-01 for recurrent
or progressive malignant glioma.
Experimental Design: EGFR expression and signaling during treatment with erlotinib or gefitinib were analyzed by Western blot and compared with
pre–erlotinib/gefitinib–exposed tissue or unexposed controls. Tumors were also analyzed for EGFR mutations and for other genomic abnormalities by array-based comparative genomic hybridization. Clinical data were used to
associate molecular features with tumor sensitivity to erlotinib or gefitinib.
Results: Erlotinib and gefitinib did not markedly affect EGFR activity in vivo . No lung signature mutations of EGFR exons 18 to 21 were observed. There was no clear association between erlotinib/gefitinib
sensitivity and deletion or amplification events on array-based comparative genomic hybridization analysis, although novel
genomic changes were identified.
Conclusions: As erlotinib and gefitinib were generally ineffective at markedly inhibiting EGFR phosphorylation in these tumors, other
assays may be needed to detect molecular effects. Additionally, the mechanism of erlotinib/gefitinib sensitivity likely differs
between brain and lung tumors. Finally, novel genomic changes, including deletions of chromosomes 6, 21, and 22, represent
new targets for further research.
The potential for the measurement of the branching ratio of the Standard Model-like Higgs boson decay into a mu+mu- pair at 1.4 TeV CLIC is analysed. The study is performed using the fully simulated ...CLIC_ILD detector concept, taking into consideration all the relevant physics and the beam-induced backgrounds. Despite the very low branching ratio of the H->mu+mu- decay, we show that the product of the branching ratio times the Higgs production cross section can be measured with a statistical uncertainty of 38 percent, assuming an integrated luminosity of 1.5 ab^-1 collected in five years of the detector operation at the 1.4 TeV CLIC with unpolarised beams. With polarised beams (-80%, +30%), the statistical uncertainty is better than 25%.
The future Compact Linear Collider (CLIC) offers a possibility for a rich precision physics programme, in particular in the Higgs sector through the energy staging. This is the first paper addressing ...the measurement of the Standard Model Higgs boson decay into two muons at 1.4 TeV CLIC. With respect to similar studies at future linear colliders, this paper includes several novel contributions to the statistical uncertainty of the measurement. The later includes the Equivalent Photon Approximation and realistic forward electron tagging based on energy deposition maps in the forward calorimeters, as well as several processes with the Beamstrahlung photons that results in irreducible contribution to the signal. In addition, coincidence of the Bhabha scattering with the signal and background processes is considered, altering the signal selection efficiency. The study is performed using a fully simulated CLIC_ILD detector model. It is shown that the branching ratio for the Higgs decay into a pair of muons BR(\({H\rightarrow\mu^+\mu^-}\)) times the Higgs production cross-section in \(WW\)-fusion \(\sigma(H\nu\bar{\nu})\) can be measured with 38% statistical accuracy at \({\sqrt{s} =\text{1.4 TeV}}\), assuming an integrated luminosity of 1.5 ab\(^{-1}\) with unpolarised beams. If 80% electron beam polarisation is considered, the statistical uncertainty of the measurement is reduced to 25%. Systematic uncertainties are negligible in comparison to the statistical uncertainty.
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