The proposed new Electron–Ion Collider poses a technical and intellectual challenge for the detector design to accommodate the long-term diverse physics goals envisaged by the program. This requires ...a 4π detector system capable of reconstructing the energy and momentum of final state particles with high precision. The Electron-Ion Collider also requires identification of particles of different masses over a wide momentum range.
A diverse spectrum of Particle IDentification detectors has been proposed. Of the four types of detectors for hadron identification, three are based on Ring Imaging Cherenkov Counter technologies, and one is realized by the Time of Flight method. The quest for a novel photocathode, sensitive in the far vacuum ultraviolet wavelength range and more robust than cesium iodide, motivated an R&D programme to explore nano-diamond (ND) based photocathodes, started by a collaboration between INFN and CNR Bari and INFN Trieste. Systematic measurements of the photoemission in different Ar:CH4 and Ar:CO2 gas mixtures with various types of ND powders and Hydrogenated ND (H-ND) powders are reported. A first study of the response of THGEMs coated with different photocathode materials is presented.
The progress of this R&D programme and the results obtained so far by these exploratory studies are described.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The severely atrophic maxilla can present with some challenges during treatment planning with communication between those performing the surgical and prosthetic aspects of the treatment as well as ...communication with the patient as to what is being suggested for treatment. This article will review the decision making process to simplify the communication and understanding of treating the severely atrophic maxilla and based on the Bedrossian classification gives a guideline for the surgical approach to be adapted based on the patient residual anatomy.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The aim of this study was to compare a second-generation bioactive glass putty biomaterial against platelet rich fibrin in treating grade II furcation defects. Subjects were 15 systemically healthy ...patients (10 males and 5 females, ages 20-50 with a mean age of 38.33) with 20 mandibular molar class II furcation defects according to Glickman's classification. The 20 mandibular molar furcation defects were randomly allocated as follows: Group I, 10 furcation defects were treated using bioactive glass (NovaBone) bone graft putty material; Group II, 10 furcation defects were treated using platelet rich fibrin (PRF). Customized acrylic stents were fabricated on study casts and trimmed to the height contour of the teeth to serve as a fixed reference point for measurements. The following measurements were collected: gingival index, plaque index, vertical probing depth (from gingival margin to base of the pocket), clinical attachment level (CEJ to the base of the pocket), and horizontal probing depth of furcation involvement (using stent). Results showed that both groups had improvement in gingival index (GI) and plaque index (PI) at the recall intervals. There was an overall reduction in both vertical and horizontal probing depth in both groups; however, the Putty group (Group I) showed consistently more vertical probing depth reduction than the PRF group (Group II) at the end of third month (P-value = 0.0004), sixth month (P-value = 0.00001), and ninth month (P-value = 0.0004). Our conclusion was that use of bioactive glass osteostimulative biomaterial yields superior clinical results, including increased pocket depth reduction of class II furcation defects as compared to an autologous platelet concentrate. The clinical significance of our findings include the ease of use and superior biologic performance of second-generation putty bioglass biomaterials in furcation defects.
We are developing gaseous photon detectors for Cherenkov imaging applications in the experiments at the future Electron Ion Collider. CsI, converting photons in the far ultraviolet range, is, so far, ...the only photoconverter compatible with the operation of gaseous detectors. It is very delicate to handle due to its hygroscopic nature: the absorbed water vapour decomposes the CsI molecule. In addition, its quantum efficiency degrades under ion bombardment. These are the key reasons to quest for novel, less delicate materials for photocathodes adequate for gaseous photon detectors. Layers of hydrogenated nanodiamond particles have recently been proposed as an alternative material and have shown promising characteristics. The performance of nanodiamond photocathodes coupled to thick GEM-based detectors is the objects of our ongoing R&D. The first phase of these studies includes the characterization of thick GEM coated with nanodiamond layers and the robustness of its photoconverting properties with respect to the bombardment by ions from the multiplication process in the gaseous detector. The approach is described in detail as well as all the results obtained so far within these exploratory studies.
Summary
Chronic postoperative pain is common and can have a negative impact on quality of life. Recent studies show that genetic risk factors are likely to play a role, although only gene‐targeted ...analysis has been used to date. This is the first genome‐wide association study to identify single‐nucleotide polymorphisms associated with the development of chronic postoperative pain based on two independent cohorts. In a discovery cohort, 330 women scheduled for hysterectomy were genotyped. A case–control association analysis compared patients without chronic postoperative pain and the 34 who had severe chronic postoperative pain 3 months after surgery. No single‐nucleotide polymorphisms reached genome‐wide significance, but several showed suggestive associations with chronic postoperative pain (p < 1 × 10−5). Single‐nucleotide polymorphisms with significance p < 1 × 10−5 were followed up in a replication cohort consisting of 203 men and women scheduled for orthopaedic or abdominal surgery. Ten of these patients developed severe chronic postoperative pain. A single‐nucleotide polymorphism in NAV3 was significantly replicated with chronic postoperative pain in the replication cohort (p = 0.009). Meta‐analysis revealed that two loci (IQGAP1 and CRTC3) were significantly associated with chronic postoperative pain at 3 months (IQGAP1 p = 3.93 × 10−6 β = 2.3863, CRTC3 p = 2.26 × 10−6, β = 2.4209). The present genome‐wide association study provides initial evidence for genetic risk factors of chronic postoperative pain and supports follow‐up studies.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Low maxillary bone density associated with physiological bone remodeling and resorption accelerated by the presence or history of periodontal disease can prevent implant placement without either ...ridge and/or sinus augmentation in atrophic maxillary edentulous cases. As an alternative to avoid bone grafting and provide immediacy in restorative treatment care for the patient, remote anchorages to the basal bones of the maxilla of the patient are being used with zygomatic or pterygoid implants. The trans-sinus implant, when indicated can offer a reliable alternative to the zygomatic dental implant in that treatment of the severely edentulous maxilla. This approach is suggested in Bedrossian zones I and II atrophy and when an 'L' (or concave) anterior sinus wall anatomy is present. This approach will be discussed utilizing two case examples on how trans-sinus implants may be considered in treating the maxillary arch.
Abstract Background Bacterial meningitis is a life threatening disease that can be triggered by a CSF leak through an inner ear malformation. Early identification of the specific type of ...cochleovestibular dysplasia and the associated risk of meningitis is of vital importance. Objectives The objective of this review is to collect and discuss available data on the association between inner ear malformations and meningitis in children. Methods Electronic databases were crosschecked for obtaining relevant papers published in the last 20 years, and further cases were identified by hand searching through the references. Demographic data were extracted from full texts, together with information on the severity of hearing impairment, the type of inner ear anomaly, the site of cerebrospinal fluid leak, the number of recurrent meningitis episodes. Results Sixty-seven cases of meningitis related to inner ear malformation have been identified among 45 papers. Mean age at presentation is 3.60 ± 3.00 (range 0.1–14) years. Average diagnostic delay from the first episode of meningitis is 3.44 ± 3.41 (range 0.00–10.00) years. The number of meningitis episodes that occurred before the correct diagnosis and definitive surgical treatment is 3.27 ± 1.81 (range 1.00–10.00). Unilateral hearing impairment affects 70% of patients. Six patients had normal hearing at presentation. Two children are dead from inner-ear-malformation-related meningitis among reviewed reports. Conclusion A high number of paediatric patients carrying inner ear malformations, especially when associated with unilateral hearing impairment, could be at risk to develop recurrent bacterial meningitis. Universal newborn hearing screening programs should prompt a diagnostic work-up even in the case of unilateral hearing impairment, in order to prevent inner ear malformation-related meningitis.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Using array comparative genome hybridisation (CGH) 41 de novo reciprocal translocations and 18 de novo complex chromosome rearrangements (CCRs) were screened. All cases had been interpreted as ...“balanced” by conventional cytogenetics. In all, 27 cases of reciprocal translocations were detected in patients with an abnormal phenotype, and after array CGH analysis, 11 were found to be unbalanced. Thus 40% (11 of 27) of patients with a “chromosomal phenotype” and an apparently balanced translocation were in fact unbalanced, and 18% (5 of 27) of the reciprocal translocations were instead complex rearrangements with >3 breakpoints. Fourteen fetuses with de novo, apparently balanced translocations, all but two with normal ultrasound findings, were also analysed and all were found to be normal using array CGH. Thirteen CCRs were detected in patients with abnormal phenotypes, two in women who had experienced repeated spontaneous abortions and three in fetuses. Sixteen patients were found to have unbalanced mutations, with up to 4 deletions. These results suggest that genome-wide array CGH may be advisable in all carriers of “balanced” CCRs. The parental origin of the deletions was investigated in 5 reciprocal translocations and 11 CCRs; all were found to be paternal. Using customised platforms in seven cases of CCRs, the deletion breakpoints were narrowed down to regions of a few hundred base pairs in length. No susceptibility motifs were associated with the imbalances. These results show that the phenotypic abnormalities of apparently balanced de novo CCRs are mainly due to cryptic deletions and that spermatogenesis is more prone to generate multiple chaotic chromosome imbalances and reciprocal translocations than oogenesis.
The novel MPGD-based photon detectors of COMPASS RICH-1 consist of large-size hybrid MPGDs with multi-layer architecture including two layers of Thick-GEMs and a bulk resistive MicroMegas. The top ...surface of the first THGEM is coated with a CsI film which also acts as photo-cathode. These detectors have been successfully in operation at COMPASS since 2016. Concerning bias-voltage supply, the Thick-GEMs are segmented in order to reduce the energy released in case of occasional discharges, while the MicroMegas anode is segmented into pads individually biased with positive voltage while the micromesh is grounded. In total, there are about ten different electrode types and more than 20000 electrodes supplied by more than 100 HV channels, where appropriate correlations among the applied voltages are required for the correct operation of the detectors. Therefore, a robust control system is mandatory, implemented by a custom designed software package, while commercial power supply units are used. This sophisticated control system allows to protect the detectors against errors by the operator, to monitor and log voltages and currents at 1 Hz rate, and automatically react to detector misbehavior. In addition, a voltage compensation system has been developed to automatically adjust the biasing voltage according to environmental pressure and temperature variations, to achieve constant gain over time. This development answers to a more general need. In fact, voltage compensation is always a requirement for the stability of gaseous detectors and its need is enhanced in multi-layer ones.
In this paper, the HV system and its performance are described in details, as well as the stability of the novel MPGD-based photon detectors during the physics data taking at COMPASS.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
In 2016 we have upgraded the COMPASS RICH by novel gaseous photon detectors based on MPGD technology. Four new photon detectors, covering a total active area of 1.5
m
2
, have been installed in order ...to cope with the challenging efficiency and stability requirements of the COMPASS physics programme. The new detector architecture consists in a hybrid MPGD combination: two layers of THGEMs, the first of which also acts as a reflective photocathode thanks to CsI coating, are coupled to a bulk Micromegas on a pad-segmented anode. These detectors are the first application in an experiment of MPGD-based single photon detectors. Presently, we are further developing the MPGD-based PDs to make them adequate for a setup at the future EIC collider. All aspects of the COMPASS RICH-1 Photon Detectors upgrade are presented: R&D, engineering, mass production, QA and performance; the on-going development for collider application is also presented.
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