In high momenta range, the construction of a Ring Imaging CHerenkov (RICH) detector for the particle identification at the future Electron Ion Collider (EIC) is a complicated task. A compact collider ...setup imposes to construct a RICH with a short radiator length, hence limiting the number of photons. The number of photons can be increase by choosing to work in far UV region. However, as standard fused-silica windows are opaque below 165 nm, therefore, a windowless RICH approach could be a possible choice. In the far UV range, CsI is a widely used photo-cathode (PC) to detect photons, but because of its hygroscopic nature, it is very delicate to handle. Its Quantum Efficiency (QE) degrades in high intensity ion fluxes. These are the key reasons to search a novel, less delicate PC with sensitivity in the far UV region. Hydrogenated nanodiamond films are proposed as an alternative PC material and shown to have promising characteristics. The performance of nanodiamond PC coupled to THGEM-based detectors is the objects of our ongoing R & D.
The first phase of these studies includes the characterization of THGEMs coated with nanodiamont PC, the comparison of the effective QE in vacuum and in gaseous atmospheres, the hardness respect to the PC bombardment by ions from the multiplication process. The approach is described in detail as well as all the results obtained so far with these exploratory studies.
Abstract
The COMPASS RICH-1 detector underwent major upgrade in 2016 with the installation of four
novel MPGD-based photon detectors. They consist of large-size hybrid MPGDs with multi-layer
...architecture composed of two layers of Thick-GEMs and bulk resistive Micromegas. A dedicated high
voltage power supply system, realized with commercial devices, has been put in operation to
protect the detectors against errors by the operator, monitor and log voltages and currents at a 1 Hz rate, and automatically react to detector misbehavior; it includes also the HV compensation for
the detector gas pressure and temperature variations.
The needs posed to the high voltage
power supply systems by the operation of Micro Pattern Gaseous Detectors pushed the development of
a novel single channel HV system able to overcome the performance of the commercial devices in
terms of high-resolution diagnostic features and intelligent dynamic voltage control. In this talk
the COMPASS HV system and its performance are illustrated, as well as the stability of the novel
MPGD-based photon detectors during the physics data taking at COMPASS. The performance of the
novel single channel power supply system when connected to a single photon Micro Pattern Gaseous
Detector is presented in realistic working condition during a test beam with the preliminary
results of multiple channels operation.
Hepatic veno-occlusive disease (VOD) is a frequent and severe complication of hematopoietic stem cell transplantation (HSCT) affecting 9.6–17.3 % of cases. 200 HSCT, performed between January 1995 ...and March 2013 in our Paediatric HSCT Centre in Trieste, were retrospectively analysed to evaluate the frequency of VOD and to identify the associated risk factors. The frequency of VOD according to the Seattle criteria was 17 %, within the range reported in literature. The mortality rate was 37.5 % (75 out of 200 transplantations) in the general population and 73.5 % (25 out of 34) in VOD patients (
p
< 0.05). Veno-occlusive disease significantly decreased from 38 % (1995–2000) to 8 % (2007–2013)
p
< 0.05. Univariate and multivariate analyses identified sepsis and pre-transplant ferritin levels above 1000 ng/ml as two significant risk factors for VOD, while the use of tacrolimus appeared to be associated with a lower VOD risk. Veno-occlusive disease still remains an important cause of transplant-related mortality even if it appears to have decreased over the last few years.
Full text
Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Experiments at the future Electron Ion Collider require excellent hadron identification in a broad momentum range, in harsh conditions. A RICH capable to fulfill the PID requirements of the EIC could ...use MPGD-based photon detectors with solid photocathodes for covering large surfaces at affordable cost, providing good effciency, high resolution and compatibility with magnetic field. Photon detectors realized by coupling THGEMs and Micromegas have been successfully operated at the RICH-1 detector of the COMPASS Experiment at CERN since 2016. A similar technology could be envisaged for an EIC RICH, provided a large improvement in the photon position resolution is achieved. An R&D effort in this direction is ongoing at INFN Trieste. Few prototypes with smaller pixel size (down to 3 mm x 3 mm) have been built and tested in the laboratory with X-Ray and UV LED light sources. A modular mini-pad detector prototype has also been tested at the CERN SPS H4 beamline. New data acquisition and analysis software called Raven DAQ and Raven Decoder have been developed and used with the APV-25 based Scalable Readout System (SRS), for the modular mini-pad prototype tests. The main characteristics of the new mini-pad hybrid MPGD-based detector of single photons are described and preliminary results of laboratory and beam tests are presented.
In the mesozooplanktonic community of the coastal upwelling system of the Ría de Vigo (NW Spain), the euphausiid Nyctiphanes couchii has been identified for the first time in temperate waters of the ...NE Atlantic as the intermediate host for cystacanths of Rhadinorhynchus sp. Parasites were identified using morphological characters described in 20 cystacanths. The hooks of the proboscis were arranged in 14 rows of 26 hooks each, while the hooks of the basal circle were only slightly erected and were longer than remaining spines. A maximum-likelihood estimation (ML) tree inferred from the 18S rRNA data set of Palaeacantocephala revealed that our specimens belong to a highly supported clade with Rhadinorhynchus sp., Pararhadinorhynchus sp. and Transvena annulospinosa. Nonetheless, our morphological and phylogenetic analyses suggested that the status of Rhadinorhynchus pristis should be re-examined. The prevalences of parasites were 0.0019% and 0.0001% for frontal and coastal summer communities, and 0.0068% and 0.0008% for coastal and oceanic autumn communities, respectively. The presence of these cystacanths in different mesozooplankton communities throughout the study suggests that the recruitment of parasites may be affected by the oceanography.
Breast cancer is the most common type of cancer among women worldwide. Short-term postsurgical recovery is complicated by many factors, including imbalanced inflammatory and immune response, acute ...pain associated with functional impairment, and chronic postmastectomy pain (CPMP), developed by about 25-60% of patients. Opioids, most common drugs used for treatment of cancer pain, are immunosuppressive, and therefore, they might directly and/or indirectly influence long-term cancer recurrence. Moreover, they also produce endocrinopathy, which consists primarily of hypothalamic-pituitary-gonadal axis or hypothalamic-pituitary-adrenal axis dysfunction. The interindividual variability in both CPMP and opioid response is believed to be largely underlined by genetic variability in the gene locus for μ-opioid receptor (OPRM1) that modulates opioid pharmacodynamics. For this reason, OPRM1 genotype may play a key role both in short-term postmastectomy outcome and in long-term follow-up, becoming a new biomarker for breast cancer recurrence in patients suffering from chronic postmastectomy pain managed by opioid therapy. Hence OPRM1 might be used in near future to customize the opioid therapy, avoiding not only opioid side effects but also the disease progression. In this review we evaluate the literature state of the art on this topic and possible steps towards obtaining the safest individualized postmastectomy analgesic therapy. Therefore, a personalized pain treatment strategy might be useful to both manage pain and control cancer disease progression.
Surgical treatment of odontogenic cysts of the jaws accounts for a significant percentage of dental surgery procedures. Additionally, a wide range of procedures and augmentation materials are used in ...the reconstruction of these osseous defects. The authors present a study including histology of surgical treatment of odontogenic cysts using a Biphasic Calcium Sulfate composite bone graft cement (Bond Apatite®).
Full text
Available for:
CMK, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The design of a Ring Imaging CHerenkov (RICH) detector for the identification of high momentum particles at the future Electron Ion Collider (EIC) is extremely challenging by using current ...technology. Compact collider setups impose to construct RICH with short radiator length, hence limiting the number of generated photons. The number of detected photons can be increased by selecting the far UV region. As standard fused-silica windows is opaque below 165 nm, a windowless RICH can be a possible approach. CsI is widely used photocathode (PC) for photon detection in the far UV range. Due to its hygroscopic nature it is very delicate to handle. In addition, its Quantum Effciency (QE) degrades in high intensity ion fluxes. These are the key reasons to quest for novel PC with sensitivity in the far UV region. Recent development of layers of hydrogenated nanodiamond powders as an alternative PC material and their performance, when coupled to the THick Gaseous Electron Multipliers (THGEM)-based detectors, are the objects of an ongoing R&D. We report here some preliminary results on the initial phase of these studies.
Dental implants have become an option for replacement of lost canine teeth in cats. Although cats appear to manage well after a canine extraction, complications such as lip entrapment can occur after ...maxillary canine tooth extraction. Even cats with a complicated crown fracture of the maxillary canine tooth that have had root canal therapy can develop lip entrapment. This can lead to painful lip ulcers and potential need for further dental treatment. Canine tooth replacement with a dental implant and prosthodontic crown is, in the authors’ experience, a predictable option that can be offered to clients who would like to replace a lost canine tooth. This report will discuss 2 long-term cases of maxillary canines replaced by dental implants/crowns.
Full text
Available for:
CMK, NUK, OILJ, SAZU, UKNU, UL, UM, UPUK
40.
Allergies aux fruits Lefevre, S.; Gregori, M.; Astier, C. ...
Revue française d'allergologie (2009),
December 2020, Volume:
60, Issue:
8
Journal Article
Peer reviewed
Open access
Les allergies aux fruits sont fréquentes, représentant pour les fruits de Rosacées 14 % des allergies rapportées et 5 % pour les fruits croisant avec le latex. Elles peuvent être liées à une ...sensibilisation primaire aux pollens ou isolées. Le concept d’allergie aux fruits est complexe pour le praticien en raison des difficultés de définition du fruit variable selon les classifications, l’évaluation du risque d’allergie croisée et les particularités des expressions cliniques de l’allergie alimentaire en fonction des allergènes impliqués. Cette mise au point précise les définitions botanique, culinaire et allergologique du fruit, les principales familles d’allergènes responsables d’allergies alimentaires, les particularités cliniques, diagnostiques et thérapeutiques de l’allergie aux fruits. La sensibilisation peut survenir par sensibilisation respiratoire (réactivité croisée pollens-fruits) ou par sensibilisation primaire aux fruits par voie digestive ou par contact. Les épitopes végétaux peuvent être continus ou discontinus. Le comportement thermique des allergènes, leur résistance à la digestion, leur stabilité en milieu acide permettent de caractériser leur risque. L’allergénicité varie souvent avec le cultivar, le mode de conservation, les technologies agro-alimentaires utilisées (cuisson, appertisation, fermentation, texturisation, hydrolyse, filtration…). Le diagnostic s’établit sur la base d’un algorithme basé sur l’anamnèse, les prick tests aux aliments natifs, la recherche d’IgE spécifiques, le test de réintroduction. Il convient de souligner l’importance d’utiliser les aliments natifs pour la réalisation des tests cutanés en raison de la sensibilité particulière des allergènes végétaux à la dénaturation. Le traitement se base sur l’éviction des fruits incriminés. Des essais d’immunothérapie aux allergènes de fruits sont à l’étude. Les protocoles de tolérance utilisant des fruits à différents temps de cuisson sont prometteurs pour les allergènes thermolabiles.
Fruit allergies are frequent, representing for Rosaceae fruits 14 % of reported allergies and 5 % for fruits crossing with latex. They can be linked to a primary sensitization to pollens or isolated. The concept of fruit allergy is complex for the practitioner because of the difficulties in defining the fruit, variable according to classifications, the evaluation of the risk of cross-allergy and the particularities of the clinical expressions of a food allergy according to the allergens involved. This review specifies the botanical, culinary and allergological definitions of fruit, the main families of allergens responsible for food allergies, and the clinical, diagnostic and therapeutic particularities of fruit allergy. Sensitization can occur by respiratory sensitization (pollen-fruit cross-reactivity) or by primary sensitization to fruit by the digestive tract or by contact. Plant epitopes may be continuous or discontinuous. The thermal behaviour of allergens, their resistance to digestion and their stability in an acidic environment makes it possible to characterise their risk. Allergenicity often varies with the cultivar, the method of preservation, the food processing technologies used (cooking, canning, fermentation, texturisation, hydrolysis, filtration, etc.). The diagnosis is established on the basis of an algorithm based on anamnesis, prick-tests with native foods, the search for the specific IgE, the reintroduction test. The importance of using native foods for skin testing should be stressed because of the particular sensitivity of plant allergens to denaturation. The treatment is based on the removal of the offending fruit. Immunotherapy trials with fruit allergens are under study. Tolerance protocols using fruits at different cooking times are promising for thermolabile allergens.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
PDF
