Soils are subject to varying degrees of direct or indirect human disturbance, constituting a major global change driver. Factoring out natural from direct and indirect human influence is not always ...straightforward, but some human activities have clear impacts. These include land‐use change, land management and land degradation (erosion, compaction, sealing and salinization). The intensity of land use also exerts a great impact on soils, and soils are also subject to indirect impacts arising from human activity, such as acid deposition (sulphur and nitrogen) and heavy metal pollution. In this critical review, we report the state‐of‐the‐art understanding of these global change pressures on soils, identify knowledge gaps and research challenges and highlight actions and policies to minimize adverse environmental impacts arising from these global change drivers. Soils are central to considerations of what constitutes sustainable intensification. Therefore, ensuring that vulnerable and high environmental value soils are considered when protecting important habitats and ecosystems, will help to reduce the pressure on land from global change drivers. To ensure that soils are protected as part of wider environmental efforts, a global soil resilience programme should be considered, to monitor, recover or sustain soil fertility and function, and to enhance the ecosystem services provided by soils. Soils cannot, and should not, be considered in isolation of the ecosystems that they underpin and vice versa. The role of soils in supporting ecosystems and natural capital needs greater recognition. The lasting legacy of the International Year of Soils in 2015 should be to put soils at the centre of policy supporting environmental protection and sustainable development.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
The 6-GHz multibeam maser survey – I. Techniques Green, J. A.; Caswell, J. L.; Fuller, G. A. ...
Monthly notices of the Royal Astronomical Society,
January 2009, Volume:
392, Issue:
2
Journal Article
Peer reviewed
Open access
A new seven-beam 6–7 GHz receiver has been built to survey the Galaxy and the Magellanic Clouds for newly forming high-mass stars that are pinpointed by strong methanol maser emission at 6668 MHz. ...The receiver was jointly constructed by Jodrell Bank Observatory (JBO) and the Australia Telescope National Facility (ATNF) and allows simultaneous coverage at 6668 and 6035 MHz. It was successfully commissioned at Parkes in 2006 January and is now being used to conduct the Parkes–Jodrell multibeam maser survey of the Milky Way. This will be the first systematic survey of the entire Galactic plane for masers of not only 6668-MHz methanol, but also 6035-MHz excited-state hydroxyl. The survey is two orders of magnitude faster than most previous systematic surveys and has an rms noise level of ∼0.17 Jy. This paper describes the observational strategy, techniques and reduction procedures of the Galactic and Magellanic Cloud surveys, together with deeper, pointed, follow-up observations and complementary observations with other instruments. It also includes an estimate of the survey detection efficiency. The 111 d of observations with the Parkes telescope have so far yielded >800 methanol sources, of which ∼350 are new discoveries. The whole project will provide the first comprehensive Galaxy-wide catalogue of 6668-MHz and 6035-MHz masers.
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BFBNIB, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK
We have conducted a Galactic plane survey of methanol masers at 6668 MHz using a seven-beam receiver on the Parkes telescope. Here we present results from the first part, which provides sensitive ...unbiased coverage of a large region around the Galactic Centre. Details are given for 183 methanol maser sites in the longitude range 345° through the Galactic Centre to 6°. Within 6° of the Galactic Centre, we found 88 maser sites, of which more than half (48) are new discoveries. The masers are confined to a narrow Galactic latitude range, indicative of many sources at the Galactic Centre distance and beyond, and confined to a thin disc population; there is no high-latitude population that might be ascribed to the Galactic bulge. Within 2° of the Galactic Centre the maser velocities all lie between −60 and +77 km s−1, a range much smaller than the 540 km s−1 range observed in CO. Elsewhere, the maser with highest positive velocity (+107 km s−1) occurs, surprisingly, near longitude 355° and is probably attributable to the Galactic bar. The maser with the most negative velocity (−127 km s−1) is near longitude 346°, within the longitude–velocity locus of the near side of the ‘3-kpc arm’. It has the most extreme velocity of a clear population of masers associated with the near and far sides of the 3-kpc arm. Closer to the Galactic Centre the maser space density is generally low, except within 0.25 kpc of the Galactic Centre itself, the ‘Galactic Centre zone’, where it is 50 times higher, which is hinted at by the longitude distribution, and confirmed by the unusual velocities.
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The accuracy of state‐of‐the‐art global barotropic tide models is assessed using bottom pressure data, coastal tide gauges, satellite altimetry, various geodetic data on Antarctic ice shelves, and ...independent tracked satellite orbit perturbations. Tide models under review include empirical, purely hydrodynamic (“forward”), and assimilative dynamical, i.e., constrained by observations. Ten dominant tidal constituents in the diurnal, semidiurnal, and quarter‐diurnal bands are considered. Since the last major model comparison project in 1997, models have improved markedly, especially in shallow‐water regions and also in the deep ocean. The root‐sum‐square differences between tide observations and the best models for eight major constituents are approximately 0.9, 5.0, and 6.5 cm for pelagic, shelf, and coastal conditions, respectively. Large intermodel discrepancies occur in high latitudes, but testing in those regions is impeded by the paucity of high‐quality in situ tide records. Long‐wavelength components of models tested by analyzing satellite laser ranging measurements suggest that several models are comparably accurate for use in precise orbit determination, but analyses of GRACE intersatellite ranging data show that all models are still imperfect on basin and subbasin scales, especially near Antarctica. For the M2 constituent, errors in purely hydrodynamic models are now almost comparable to the 1980‐era Schwiderski empirical solution, indicating marked advancement in dynamical modeling. Assessing model accuracy using tidal currents remains problematic owing to uncertainties in in situ current meter estimates and the inability to isolate the barotropic mode. Velocity tests against both acoustic tomography and current meters do confirm that assimilative models perform better than purely hydrodynamic models.
Key Points
Tide model accuracy assessmentImproved accuraciesTidal current estimates
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Bacteriophages have been envisioned as tools to control a variety of foodborne pathogenic bacteria. Salmonella is a foodborne pathogen that is a threat to public health around the world. Contaminated ...tomatoes have been associated with several Salmonella outbreaks. Hence, the objective of this work was to identify and characterize different lytic bacteriophages against Salmonella Newport, as one of top ten Salmonella serovars associated with human salmonellosis in North America, and then apply these phages to enhance the safety of cherry tomatoes. Four lytic phages against Salmonella Newport were selected based on their ability to lyse a majority of the 26 screened Salmonella serovars. The selected phages belong to Myoviridae (vB_SnwM_CGG4-1, vB_SnwM_CGG4-2) and Siphoviridae (vB_SnwM_CGG3-1, vB_SnwM_CGG3-2) families. They were found to be stable at different temperatures and pH, have latent periods ranging from 53 to 65 min and burst sizes from 92 to 177. In addition, the two Myoviridae phages have a lower frequency of developing bacteriophage insensitive mutants when compared with the Siphoviridae phages. No significant change in virulence gene expression was observed in the developed bacteriophage insensitive mutants when compared to the parental phage sensitive strain. Furthermore, the vB_SnwM_CGG4-1 genome revealed no homology to virulence or lysogenic genes. A phage cocktail was used to control the growth of S. Newport in broth medium and on contaminated cherry tomato. Complete inhibition of bacterial growth in broth medium was observed at 25 °C for 24 h. In addition, a 4.5 log10 unit reduction in the bacterial count was observed when applying the phage cocktail onto contaminated tomatoes stored at 22 °C for 3 days. These findings suggest that the isolated phages can be used for biocontrol of S. Newport to improve the safety of ready-to-eat (RTE) produce.
•Four lytic and broad host range Salmonella phages were isolated and characterized.•No homology to virulence or lysogenic genes was observed in the sequenced phage.•Phage cocktail completely inhibited S. Newport growth in broth medium.•Phage cocktail caused 4.5 log10 unit reduction in S. Newport count onto tomatoes.•The isolated phages can be used to improve the safety of ready-to-eat produce.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Summary
Background
Data on the use of biologic therapy and malignancy risk are inconsistent due to limited long‐term robust studies.
Objectives
To assess the malignancy risk in patients with ...secukinumab‐treated psoriasis, psoriatic arthritis (PsA) and ankylosing spondylitis (AS).
Methods
This integrated safety analysis from both the secukinumab clinical trial programme and postmarketing safety surveillance data included any patient receiving at least one approved dose of secukinumab with a maximum of 5 years of follow‐up. Safety analyses evaluated the rate of malignancy using exposure‐adjusted incidence rates EAIR; incidence rates per 100 patient treatment‐years (PTY). Standardized incidence ratios (SIRs) were reported using the Surveillance, Epidemiology, and End Results Program (SEER) database as a reference population. Crude incidence of malignancy was also reported using postmarketing surveillance data.
Results
Safety data from 49 clinical trials with secukinumab‐treated patients were included: 10 685 patients with psoriasis, 2523 with PsA and 1311 with AS. Across indications over a 5‐year period, the EAIR of malignancy was 0·85 per 100 PTY 95% confidence interval (CI) 0·74–0·98 in secukinumab‐treated patients, corresponding to 204 patients per 23 908 PTY. Overall, the observed vs. expected number of malignancies from secukinumab clinical trial data were comparable, as indicated by an SIR of 0·99 (95% CI 0·82–1·19) across indications. The estimated crude cumulative incidence reporting rate per 100 PTY for malignancy was 0·27 in the postmarketing surveillance data across indications with a cumulative exposure of 285 811 PTY.
Conclusions
In this large safety analysis, the risk of malignancy was low for up to 5 years of secukinumab treatment. These data support the long‐term use of secukinumab in these indications.
What is already known about this topic?
Secukinumab is approved for the treatment of moderate‐to‐severe psoriasis, psoriatic arthritis, ankylosing spondylitis and nonradiographic axial spondyloarthritis.
Clinical studies in these indications have reported low exposure‐adjusted incidence rates (EAIR) of malignancies at one year, but there is currently a lack of longer‐term data on the incidence of malignancy in secukinumab‐treated patients.
What does this study add?
The cumulative EAIR of malignancy is 0·85 per 100 patient years 95% confidence interval (CI) 0·74–0·98 in secukinumab‐treated patients across indications.
The observed vs. expected number of malignancies were comparable, as indicated by a standardized incidence rate of 0·99 (95% CI 0·82–1·19).
This assessment provides a broader understanding of the safety of secukinumab, and supports its long‐term use in these chronic systemic immune‐mediated conditions.
Linked Comment: P.C.M. van de Kerkhof. Br J Dermatol 2021; 185:879.
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Summary
Background In previous studies, etanercept significantly improved plaque psoriasis and was well tolerated.
Objectives To examine further the efficacy and safety of etanercept and to assess ...maintenance of treatment effect after dose reduction of etanercept.
Methods In this multicentre 24‐week study in the U.S.A., Canada and Western Europe, patients were at least 18 years old; had active, clinically stable plaque psoriasis involving at least 10% of body surface area; had a minimum Psoriasis Area and Severity Index (PASI) of 10 at screening; and had received or were a candidate to receive systemic psoriasis therapy or phototherapy. During the first 12 weeks of the study, patients were randomly assigned to receive by subcutaneous injection etanercept twice weekly (BIW) at a dose of 50 mg or 25 mg, or placebo BIW in a double‐blind fashion. During the second 12 weeks, all patients received etanercept 25 mg BIW. The primary endpoint was a 75% or greater improvement from baseline in PASI (PASI 75) at 12 weeks.
Results Five hundred and eighty‐three subjects were randomized and received at least one dose of study drug. At week 12, a PASI 75 was achieved by 49% of patients in the etanercept 50 mg BIW group, 34% in the 25 mg BIW group, and 3% in the placebo group (P < 0·0001 for each etanercept group compared with placebo). At week 24 (after 12 weeks of open‐label 25 mg etanercept BIW), a PASI 75 was achieved by 54% of patients whose dose was reduced from 50 mg BIW to 25 mg BIW, by 45% of patients in the continuous 25 mg BIW group, and by 28% in the group that received placebo followed by etanercept 25 mg BIW. Etanercept was well tolerated throughout the study.
Conclusions Etanercept provided clinically meaningful benefit to patients with chronic plaque psoriasis, with no apparent decrease in efficacy after dose reduction.
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Observations of interstellar dust are often used as a proxy for total gas column density NH. By comparing Planck thermal dust data (Release 1.2) and new dust reddening maps from Pan-STARRS 1 and ...2MASS, with accurate (opacity-corrected) H i column densities and newly published OH data from the Arecibo Millennium survey and 21-SPONGE, we confirm linear correlations between dust optical depth τ353, reddening E(B − V), and the total proton column density NH in the range (1-30) × 1020 cm−2, along sightlines with no molecular gas detections in emission. We derive an NH/E(B − V) ratio of (9.4 1.6) × 1021 cm−2 mag−1 for purely atomic sightlines at b > 5 ° , which is 60% higher than the canonical value of Bohlin et al. We report a ∼40% increase in opacity 353 = τ353/NH, when moving from the low column density (NH < 5 × 1020 cm−2) to the moderate column density (NH > 5 × 1020 cm−2) regime, and suggest that this rise is due to the evolution of dust grains in the atomic interstellar medium. Failure to account for H i opacity can cause an additional apparent rise in 353 of the order of a further ∼20%. We estimate molecular hydrogen column densities N H 2 from our derived linear relations, and hence derive the OH/H2 abundance ratio of XOH ∼ 1 × 10−7 for all molecular sightlines. Our results show no evidence of systematic trends in OH abundance with N H 2 in the range N H 2 ∼ (0.1−10) × 1021 cm−2. This suggests that OH may be used as a reliable proxy for H2 in this range, which includes sightlines with both CO-dark and CO-bright gas.
Recent studies have suggested that changing direction is associated with significant additional energy expenditure. A failure to account for this additional energy expenditure of turning has ...significant implications in the design and interpretation of health interventions. The purpose of this study was therefore to investigate the influence of walking speed and angle, and their interaction, on energy expenditure in 20 healthy adults (7 female; 28±7 yrs). On two separate days, participants completed a turning protocol at one of 16 speed- (2.5, 3.5, 4.5, 5.5 km∙h-1) and angle (0, 45, 90, 180°) combinations, involving three minute bouts of walking, interspersed by three minutes seated rest. Each condition involved 5 m of straight walking before turning through the pre-determined angle with the speed dictated by a digital, auditory metronome. Tri-axial accelerometry and magnetometry were measured at 60 Hz, in addition to gas exchange on a breath-by-breath basis. Mixed models revealed a significant main effect for speed (F = 121.609, P < 0.001) and angle (F = 19.186, P < 0.001) on oxygen uptake (Formula: see text) and a significant interaction between these parameters (F = 4.433, P < 0.001). Specifically, as speed increased, Formula: see text increased but significant increases in Formula: see text relative to straight line walking were only observed for 90° and 180° turns at the two highest speeds (4.5 and 5.5 km∙hr-1). These findings therefore highlight the importance of accounting for the quantity and magnitude of turns completed when estimating energy expenditure and have significant implications within both sport and health contexts.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Research on depression stigma is needed to gain more insight into the underlying construct and to reduce the level of stigma in the community. However, few validated measurements of depression stigma ...are available in the Netherlands. Therefore, this study first sought to examine the psychometric properties of the Dutch translation of the Depression Stigma Scale (DSS). Second, we examined which demographic (gender, age, education, partner status) and other variables (anxiety and knowledge of depression) are associated with personal and perceived stigma within these samples.
The study population consisted of an adult convenience sample (n = 253) (study 1) and a community adult sample with elevated depressive symptoms (n = 264) (study 2). Factor structure, internal consistency, and validity were assessed. The associations between stigma, demographic variables and anxiety level were examined with regression analyses.
Confirmatory factor analysis supported the validity and internal consistency of the DSS personal stigma scale. Internal consistency was sufficient (Cronbach's alpha = .70 (study 1) and .77 (study 2)). The results regarding the perceived stigma scale revealed no clear factor structure. Regression analyses showed that personal stigma was higher in younger people, those with no experience with depression, and those with lower education.
This study established the validity and internal consistency of the DSS personal scale in the Netherlands, in a community sample and in people with elevated depressive symptoms. However, additional research is needed to examine the factor structure of the DSS perceived scale and its use in other samples.
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