ABSTRACT
Rapid bursts at optical wavelengths have been reported for several accreting white dwarfs. In these bursts, the optical luminosity can increase by up to a factor of 30 in less than an hour, ...before fading on time-scales of several hours, and the energy release can reach ~1039 erg (‘micronovae’). Several systems have also shown these bursts to be semirecurrent on time-scales of days to months, and the temporal profiles of these bursts strongly resemble those observed in Type-I X-ray bursts in accreting neutron stars. It has been suggested that the observed micronovae may be the result of localized thermonuclear runaways in the surface layers of accreting white dwarfs. Here we propose a model in which the magnetic confinement of accretion streams on to the accreting magnetic white dwarf may trigger localized thermonuclear runaways. The model proposed to trigger micronovae appears to favour magnetic systems with both a high white dwarf mass and a high mass-transfer rate.
We realize indirect partial measurement of a transmon qubit in circuit quantum electrodynamics by interaction with an ancilla qubit and projective ancilla measurement with a dedicated readout ...resonator. Accurate control of the interaction and ancilla measurement basis allows tailoring the measurement strength and operator. The tradeoff between measurement strength and qubit backaction is characterized through the distortion of a qubit Rabi oscillation imposed by ancilla measurement in different bases. Combining partial and projective qubit measurements, we provide the solid-state demonstration of the correspondence between a nonclassical weak value and the violation of a Leggett-Garg inequality.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
Despite the improved survival rates of patients with advanced stage melanoma since the introduction of ICIs, many patients do not have (long‐term) benefit from these treatments. There is evidence ...that the exposome, an accumulation of host‐extrinsic factors including environmental influences, could impact ICI response. Recently, a survival benefit was observed in patients with BRAF wild‐type melanoma living in Denmark who initiated immunotherapy in summer as compared to winter. As the Netherlands lies in close geographical proximity to Denmark and has comparable seasonal differences, a Dutch validation cohort was established using data from our nationwide melanoma registry. In this study, we did not observe a similar seasonal difference in overall survival and are therefore unable to confirm the Danish findings. Validation of either the Dutch or Danish findings in (combined) patient cohorts from other countries would be necessary to determine whether this host‐extrinsic factor influences the response to ICI‐treatment.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
The objective of this study was to derive and validate a prognostic nomogram to predict disease-specific survival (DSS) after a curative intent resection of perihilar cholangiocarcinoma (PHC).
A ...nomogram was developed from 173 patients treated at Memorial Sloan Kettering Cancer Center (MSKCC), New York, USA. The nomogram was externally validated in 133 patients treated at the Academic Medical Center (AMC), Amsterdam, The Netherlands. Prognostic accuracy was assessed with concordance estimates and calibration, and compared with the American Joint Committee on Cancer (AJCC) staging system. The nomogram will be available as web-based calculator at mskcc.org/nomograms.
For all 306 patients, the median overall survival (OS) was 40 months and the median DSS 41 months. Median follow-up for patients alive at last follow-up was 48 months. Lymph node involvement, resection margin status, and tumor differentiation were independent prognostic factors in the derivation cohort (MSKCC). A nomogram with these prognostic factors had a concordance index of 0.73 compared with 0.66 for the AJCC staging system. In the validation cohort (AMC), the concordance index was 0.72, compared with 0.60 for the AJCC staging system. Calibration was good in the derivation cohort; in the validation cohort patients had a better median DSS than predicted by the model.
The proposed nomogram to predict DSS after curative intent resection of PHC had a better prognostic accuracy than the AJCC staging system. Calibration was suboptimal because DSS differed between the two institutions. The nomogram can inform patients and physicians, guide shared decision making for adjuvant therapy, and stratify patients in future randomized, controlled trials.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The EAT-Lancet commission recently suggested that transformation to healthy diets by 2050 will require a reduction of at least 50% in consumption of foods such as red meat and sugar, and a doubling ...in the global consumption of fruits, vegetables, nuts, and legumes. A diet rich in plant-based foods and with fewer animal source foods confers both improved health and environmental benefits. Notably, the risk of vitamin B12 deficiency increases when consuming a diet low in animal products. Humans are dependent on animal foods such as dairy products, meat, fish and eggs. Vitamin B12 deficiency is common worldwide, especially in populations with low consumption of animal foods because of low socioeconomic status, ethical reasons, or because of their lifestyle (i.e., vegans). According to the European Food Safety Authoroty, the recommended adequate intake of vitamin B12 is 4.0 μg/d for adults, and vitamin B12 requirements are higher during pregnancy and lactation. Infants and children from deficient mothers and elderly people are at risk for vitamin B12 deficiency. Diagnosis of vitamin B12 deficiency is hampered by low specificity of available biomarkers, and there is no consensus yet regarding the optimal definition of low vitamin B12 status. In general, a combination of at least two biomarkers is recommended. Therefore, this review presents an overview of vitamin B12 biochemistry and its biomarkers. We further summarize current recommendations of vitamin B12 intake, and evidence on the associations of vitamin B12 intake from different nutrient-dense animal foods with vitamin B12 status markers. Finally, potential consequences of low vitamin B12 status on different health outcomes for pregnant women, infants and elderly are presented.
In this paper, we present the results of the first systematic search for counterparts to nearby ultraluminous X-ray sources (ULXs) in the near-infrared (NIR). We observed 62 ULXs in 37 galaxies ...within 10 Mpc and discovered 17 candidate NIR counterparts. The detection of 17 out of 62 ULX candidates points to intrinsic differences between systems that show and those that do not show infrared emission. For six counterparts, we conclude from the absolute magnitudes and – in some cases – additional information such as morphology and previously reported photometric or spectroscopic observations, that they are likely background active galactic nuclei or ULXs residing in star clusters. 11 counterparts have absolute magnitudes consistent with them being single red supergiant stars. Alternatively, these systems may have larger accretion discs that emit more NIR light than the systems that we do not detect. Other scenarios such as emission from a surrounding nebula or from a compact radio jet are also possible, although for Holmberg II X-1 the NIR luminosity far exceeds the expected jet contribution. The 11 possible red supergiant counterparts are excellent candidates for spectroscopic follow-up observations. This may enable us to measure the mass function in these systems if they are indeed red supergiant donor stars where we can observe absorption lines.
We present the latest results from a spectroscopic survey designed to uncover the hidden population of AM Canum Venaticorum (AM CVn) binaries in the photometric data base of the Sloan Digital Sky ...Survey (SDSS). We selected ∼2000 candidates based on their photometric colours, a relatively small sample which is expected to contain the majority of all AM CVn binaries in the SDSS (expected to be ∼50).
We present two new candidate AM CVn binaries discovered using this strategy: SDSS J104325.08+563258.1 and SDSS J173047.59+554518.5. We also present spectra of 29 new cataclysmic variables, 23 DQ white dwarfs and 21 DZ white dwarfs discovered in this survey.
The survey is now approximately 70 per cent complete, and the discovery of seven new AM CVn binaries indicates a lower space density than previously predicted. From the essentially complete g ≤ 19 sample, we derive an observed space density of (5 ± 3) × 10−7 pc−3; this is lower than previous estimates by a factor of 3.
The sample has been cross-matched with the GALEX All-Sky Imaging Survey data base, and with Data Release 9 of the United Kingdom Infrared Telescope (UKIRT) Infrared Deep Sky Survey (UKIDSS). The addition of UV photometry allows new colour cuts to be applied, reducing the size of our sample to ∼1100 objects. Optimizing our follow-up should allow us to uncover the remaining AM CVn binaries present in the SDSS, providing the larger homogeneous sample required to more reliably estimate their space density.
Early evaluation of writing readiness is essential to predict and prevent handwriting difficulties and its negative influences on school occupations. An occupation-based measurement for kindergarten ...children has been previously developed: Writing Readiness Inventory Tool In Context (WRITIC). In addition, to assess fine motor coordination two tests are frequently used in children with handwriting difficulties: the modified Timed Test of In-Hand Manipulation (Timed TIHM) and the Nine-Hole Peg Test (9-HPT). However, no Dutch reference data are available.
To provide reference data for (1) WRITIC, (2) Timed-TIHM and (3) 9-HPT for handwriting readiness assessment in kindergarten children.
Three hundred and seventy-four children from Dutch kindergartens in the age of 5 to 6.5 years (5.6±0.4 years, 190 boys/184 girls) participated in the study. Children were recruited at Dutch kindergartens. Full classes of the last year were tested, children were excluded if there was a medical diagnosis such as a visual, auditory, motor or intellectual impairment that hinder handwriting performance. Descriptive statistics and percentiles scores were calculated. The score of the WRITIC (possible score 0-48 points) and the performance time on the Timed-TIHM and 9-HPT are classified as percentile scores lower than the 15th percentile to distinguish low performance from adequate performance. The percentile scores can be used to identify children that are possibly at risk developing handwriting difficulties in first grade.
WRITIC scores ranged from 23 to 48 (41±4.4), Timed-TIHM ranged from 17.9 to 64.5 seconds (31.4± 7.4 seconds) and 9-HPT ranged from 18.2 to 48.3 seconds (28.4± 5.4). A WRITIC score between 0-36, a performance time of more than 39.6 seconds on the Timed-TIHM and more than 33.8 seconds on the 9-HPT were classified as low performance.
The reference data of the WRITIC allow to assess which children are possibly at risk developing handwriting difficulties.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
We report the discovery of a linear relationship between the root mean square (rms) variability amplitude and the mean flux in the accreting white dwarf binary system MV Lyrae. Our light curve, ...obtained with the Kepler satellite, spans 633 d with quasi-continuous 58.8-s cadence resolution. We show, for the first time, that how this cataclysmic variable displays linear rms-flux relations similar to those observed in many other black hole binaries, neutron star binaries and active galactic nuclei. The phenomenological similarity between the rms-flux relation observed here and in other X-ray binaries suggests a common physical origin for the broad-band variability, independent of source type, mass or size of the compact accretor. Furthermore, we infer the viscosity parameter, α, and disc scale height, H/R, using two independent methods. In both cases, both values are found to be uncomfortably high to be accommodated by the disc instability model.
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BFBNIB, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK
Patients with long duration of atrial fibrillation (AF), enlarged atria, or failed catheter ablation have advanced AF and may require more extensive treatment than pulmonary vein isolation.
The aim ...of this study was to investigate the efficacy and safety of additional ganglion plexus (GP) ablation in patients undergoing thoracoscopic AF surgery.
Patients with paroxysmal AF underwent pulmonary vein isolation. Patients with persistent AF also received additional lines (Dallas lesion set). Patients were randomized 1:1 to additional epicardial ablation of the 4 major GPs and Marshall's ligament (GP group) or no extra ablation (control) and followed every 3 months for 1 year. After a 3-month blanking period, all antiarrhythmic drugs were discontinued.
Two hundred forty patients with a mean AF duration of 5.7 ± 5.1 years (59% persistent) were included. Mean procedure times were 185 ± 54 min and 168 ± 54 min (p = 0.015) in the GP (n = 117) and control groups (n = 123), respectively. GP ablation abated 100% of evoked vagal responses; these responses remained in 87% of control subjects. Major bleeding occurred in 9 patients (all in the GP group; p < 0.001); 8 patients were managed thoracoscopically, and 1 underwent sternotomy. Sinus node dysfunction occurred in 12 patients in the GP group and 4 control subjects (p = 0.038), and 6 pacemakers were implanted (all in the GP group; p = 0.013). After 1 year, 4 patients had died (all in the GP group, not procedure related; p = 0.055), and 9 were lost to follow-up. Freedom from AF recurrence in the GP and control groups was not statistically different whether patients had paroxysmal or persistent AF. At 1 year, 82% of patients were not taking antiarrhythmic drugs.
GP ablation during thoracoscopic surgery for advanced AF has no detectable effect on AF recurrence but causes more major adverse events, major bleeding, sinus node dysfunction, and pacemaker implantation. (Atrial Fibrillation Ablation and Autonomic Modulation via Thoracoscopic Surgery AFACT; NCT01091389).
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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