We present the goals, strategy and first results of the OmegaWhite survey: a wide-field high-cadence g-band synoptic survey which aims to unveil the Galactic population of short-period variable stars ...(with periods <80 min), including ultracompact binary star systems and stellar pulsators. The ultimate goal of OmegaWhite is to cover 400 deg2 along the Galactic plane reaching a depth of g = 21.5 mag (10σ), using OmegaCam on the VLT Survey Telescope (VST). The fields are selected to overlap with surveys such as the Galactic Bulge Survey and the VST Photometric Hα Survey of the Southern Galactic Plane for multiband colour information. Each field is observed using 38 exposures of 39 s each, with a median cadence of ∼2.7 min for a total duration of two hours. Within an initial 26 deg2, we have extracted the light curves of 1.6 million stars, and have identified 613 variable candidates which satisfy our selection criteria. Furthermore, we present the light curves and statistical properties of 20 sources which have the highest likelihood of being variable stars. One of these candidates exhibits the colours and light-curve properties typically associated with ultracompact AM CVn binaries, although its spectrum exhibits weak Balmer absorption lines and is thus not likely to be such a binary system. We also present follow-up spectroscopy of five other variable candidates, which identifies them as likely low-amplitude δ Sct pulsating stars.
Unleashing the immune system by PD-1 and/or CTLA-4 blockade can cause severe immune-related toxicity necessitating immunosuppressive treatment. Whether immunosuppression for toxicity impacts survival ...is largely unknown.
Using data from the prospective nationwide Dutch Melanoma Treatment Registry (DMTR), we analyzed the association between severe toxicity and overall survival (OS) in 1,250 patients with advanced melanoma who were treated with immune checkpoint inhibitors (ICI) in first line between 2012 and 2017. Furthermore, we analyzed whether toxicity management affected survival in these patients.
A total of 1,250 patients were included, of whom 589 received anti-PD1 monotherapy, 576 ipilimumab, and 85 combination therapy. A total of 312 patients (25%) developed severe (grade ≥3) toxicity. Patients experiencing severe ICI toxicity had a significantly prolonged survival with a median OS of 23 months compared with 15 months for patients without severe toxicity hazard ratio (HR
) = 0.77; 95% confidence interval (CI), 0.63-0.93. Among patients experiencing severe toxicity, survival was significantly decreased in patients who received anti-TNF ± steroids for steroid-refractory toxicity compared with patients who were managed with steroids only (HR
= 1.61; 95% CI, 1.03-2.51), with a median OS of 17 and 27 months, respectively.
Patients experiencing severe ICI toxicity have a prolonged OS. However, this survival advantage is abrogated when anti-TNF is administered for steroid-refractory toxicity. Further prospective studies are needed to assess the effect of different immunosuppressive regimens on checkpoint inhibitor efficacy.
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In quantum mechanics, the process of measurement is a subtle interplay between extraction of information and disturbance of the state of the quantum system. A quantum non-demolition (QND) measurement ...minimizes this disturbance by using a particular system--detector interaction that preserves the eigenstates of a suitable operator of the quantum system. This leads to an ideal projective measurement. We present experiments in which we carry out two consecutive measurements on a quantum two-level system, a superconducting flux qubit, by probing the hysteretic behaviour of a coupled nonlinear resonator. The large correlation between the results of the two measurements demonstrates the QND nature of the readout method. The fact that a QND measurement is possible for superconducting qubits strengthens the notion that these fabricated mesoscopic systems are to be regarded as fundamental quantum objects. Our results are also relevant for quantum-information processing for protocols such as state preparation and error correction. PUBLICATION ABSTRACT
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From multi-epoch adaptive optics imaging and integral field unit spectroscopy, we report the discovery of an expanding and narrowly confined bipolar shell surrounding the helium nova V445 Puppis ...(Nova Puppis 2000). An equatorial dust disc obscures the nova remnant, and the outflow is characterized by a large polar outflow velocity of 6720 +/- 650 km s-1 and knots moving at even larger velocities of 8450 +/- 570 km s-1. We derive an expansion parallax distance of 8.2 +/- 0.5 kpc and deduce a pre-outburst luminosity of the underlying binary of log L/L = 4.34 +/- 0.36. The derived luminosity suggests that V445 Puppis probably contains a massive white dwarf accreting at high rate from a helium star companion making it part of a population of binary stars that potentially lead to supernova Ia explosions due to accumulation of helium-rich material on the surface of a massive white dwarf.
Dune development along highly dynamic land–sea boundaries is the result of interaction between vegetation and dune size with sedimentation and erosion processes. Disentangling the contribution of ...vegetation characteristics from that of dune size would improve predictions of nebkha dune development under a changing climate, but has proven difficult due to the scarcity of spatially continuous monitoring data. This study explored the contributions of vegetation and dune size to dune development for locations differing in shelter from the sea. We monitored a natural nebkha dune field of 8 ha, along the coast of the island Texel, the Netherlands, for 1 year using an unmanned aerial vehicle (UAV) with camera. After constructing a digital surface model and orthomosaic we derived for each dune (1) vegetation characteristics (species composition, vegetation density, and maximum vegetation height), (2) dune size (dune volume, area, and maximum height), (3) degree of shelter (proximity to other nebkha dunes and the sheltering by the foredune). Changes in dune volume over summer and winter were related to vegetation, dune size and degree of shelter. We found that a positive change in dune volume (dune growth) was linearly related to initial dune volume over summer but not over winter. Big dunes accumulated more sand than small dunes due to their larger surface area. Exposed dunes increased more in volume (0.81 % per dune per week) than sheltered dunes (0.2 % per dune per week) over summer, while the opposite occurred over winter. Vegetation characteristics did not significantly affect dune growth in summer, but did significantly affect dune growth in winter. Over winter, dunes dominated by Ammophila arenaria, a grass species with high vegetation density throughout the year, increased more in volume than dunes dominated by Elytrigia juncea, a grass species with lower vegetation density (0.43 vs. 0.42 (m3 m−3) week−1). The effect of species was irrespective of dune size or distance to the sea. Our results show that dune growth in summer is mainly determined by dune size, whereas in winter dune growth was determined by vegetation type. In our study area the growth of exposed dunes was likely restricted by storm erosion, whereas growth of sheltered dunes was restricted by sand supply. Our results can be used to improve models predicting coastal dune development.
Summary
Background
The double‐blind, placebo‐controlled food challenge test (DBPCFC) is the gold standard in cashew nut allergy. This test is costly, time consuming and not without side effects. ...Analysis of IgE reactivity to cashew nut components may reduce the need for food challenge tests.
Methods
In a prospective and multicentre study, children with suspected cashew nut allergy underwent a DBPCFC with cashew nut. Specific IgE to cashew nut and to the components Ana o 1, 2 and 3 were determined. A skin prick test (SPT) with cashew nut extract was performed.
The association between the outcome of the food challenge test and specific IgE to Ana o 1, 2 and 3 was assessed with logistic regression analyses, unadjusted and adjusted for other diagnostic variables. Discriminative ability was quantified with a concordance index (c).
Results
A total of 173 children (103 boys, 60%) with a median age of 9 years were included. About 79% had a positive challenge test outcome. A steep rise in the risk of a positive challenge was observed for specific IgE to each individual component Ana o 1, 2 and 3 with estimated risks up to approximately 100%. Median values of Ana o 1, 2, 3 were 1.29 kU/l (range 0–100 kU/l), 4.77 kU/l (range 0–100 kU/l) and 8.33 kU/l (range 0–100 kU/l) respectively and varied significantly (p < 0.001). Specific IgE to Ana o 1, 2 and 3 was better distinguished between cashew‐allergic and tolerant children (c = 0.87, 0.85 and 0.89, respectively) than specific IgE to cashew nut or SPT (c = 0.76 and 0.83, respectively).
Conclusion
The major cashew nut allergens Ana o 1, 2 and 3 are each individually predictive for the outcome of food challenge tests in cashew‐allergic children.
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BFBNIB, DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, SIK, UILJ, UKNU, UL, UM, UPUK
X-shooter is the first 2nd generation instrument of the ESO Very Large Telescope (VLT). It is a very efficient, single-target, intermediate-resolution spectrograph that was installed at the ...Cassegrain focus of UT2 in 2009. The instrument covers, in a single exposure, the spectral range from 300 to 2500 nm. It is designed to maximize the sensitivity in this spectral range through dichroic splitting in three arms with optimized optics, coatings, dispersive elements and detectors. It operates at intermediate spectral resolution (R ~ 4000−17 000, depending on wavelength and slit width) with fixed échelle spectral format (prism cross-dispersers) in the three arms. It includes a 1.8″ × 4″ integral field unit as an alternative to the 11′′ long slits. A dedicated data reduction package delivers fully calibrated two-dimensional and extracted spectra over the full wavelength range. We describe the main characteristics of the instrument and present its performance as measured during commissioning, science verification and the first months of science operations.
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Historic Mortars Válek, Jan; Groot, Caspar J. W. P; Hughes, John J
2012, 20120519, 2015-03-18, Volume:
7
eBook
This volume focuses on research and practical issues connected with mortars on historic structures. The book is divided into four sections: Characterisation of Historic Mortars, Repair Mortars and ...Design Issues, Experimental Research into Properties of Repair Mortars, and Assessment and Testing. The papers present the latest work of researchers in their field. The individual contributions were selected from the contributions to the 2nd Historic Mortars Conference, which took place in Prague, September, 22-24, 2010. All papers were reviewed and improved as necessary before publication. This peer review process by the editors resulted in the 34 individual contributions included in here. One extra paper reviewing and summarising State-of-the-Art knowledge covered by this publication was added as a starting and navigational point for the reader. The editors believe that having these papers in print is important and they hope that it will stimulate further research into historic mortars and related subjects.
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FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
ABSTRACT
A key tool astronomers have to investigate the nature of extragalactic transients is their position on their host galaxies. Galactocentric offsets, enclosed fluxes, and the fraction of light ...statistic are widely used at different wavelengths to help infer the nature of transient progenitors. Motivated by the proposed link between magnetars and fast radio bursts (FRBs), we create a face-on image of the Milky Way using best estimates of its size, structure, and colour. We place Galactic magnetars, pulsars, low-mass, and high-mass X-ray binaries on this image, using the available distance information. Galactocentric offsets, enclosed fluxes, and fraction of light distributions for these systems are compared to extragalactic transient samples. We find that FRBs follow the distributions for Galactic neutron stars closest, with 24 (75 per cent) of the Anderson–Darling tests we perform having a p-value greater than 0.05. This suggests that FRBs are located on their hosts in a manner consistent with Galactic neutron stars on the Milky Way’s light, although we cannot determine which specific neutron star population is the best match. The Galactic distributions are consistent with other extragalactic transients much less often across the range of comparisons made, with type Ia SNe in second place, at only 33 per cent of tests exceeding 0.05. Overall, our results provide further support for FRB models invoking isolated young neutron stars, or binaries containing a neutron star.
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