Abstract
Change management is the embodiment of an enterprise’s core competence. It provides competitive differentiation and effectively adapts to the ever-changing world. This paper explores the ...implications of intelligent finance on change management and provides insights into how organizations can effectively manage change to achieve the desired outcomes. The study examines the case of Ping An (Ping An Insurance (Group) Company of China, Ltd.), a leading insurance company in China that has successfully implemented intelligent finance and change management strategies. The paper begins with a literature review that provides an overview of the concept of intelligent finance, the relevance of change management in the context of intelligent finance, models, and frameworks for intelligent finance, and approaches to change management. The study then presents a case analysis of Ping An, including descriptive statistics, inferential statistics, regression analysis, and qualitative findings. The paper concludes with implications for practice and theory, contributions of the study, and recommendations for future research. Overall, this paper contributes to the growing literature on intelligent finance and change management and provides practical insights for organizations seeking to adopt intelligent finance.
Lipid nanoparticles (LNPs) have been commonly used as a vehicle for nucleic acids, such as small interfering RNA (siRNA); the surface modification of LNPs is one of the determinants of their delivery ...efficiency especially in systemic administration. However, the applications of siRNA‐encapsulated LNPs are limited due to a lack effective systems to deliver to solid tumors. Here, we report a smart surface modification using a charge‐switchable ethylenediamine‐based polycarboxybetaine for enhancing tumor accumulation via interaction with anionic tumorous tissue constituents due to selective switching to cationic charge in response to cancerous acidic pH. Our polycarboxybetaine‐modified LNP could enhance cellular uptake in cancerous pH, resulting in facilitated endosomal escape and gene knockdown efficiency. After systemic administration, the polycarboxybetaine‐modified LNP accomplished high tumor accumulation in SKOV3‐luc and CT 26 subcutaneous tumor models. The siPLK‐1‐encapsulated LNP thereby accomplished significant tumor growth inhibition. This study demonstrates a promising potential of the pH‐responsive polycarboxybetaine as a material for modifying the surface of LNPs for efficient nucleic acid delivery.
Schematic illustration of DSPE‐PGlu(DET‐Car)30 and siRNA‐encapsulated PGlu(DET‐Car)30 LNPs
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
5‐Aminolevulinic acid (5‐ALA) is an amino acid that can be metabolized into a photosensitizer, protoporphyrin IX (PpIX) selectively in a tumor cell, permitting minimally invasive photodynamic ...diagnosis/therapy. However, some malignant tumor cells have excess intracellular labile iron and facilitate the conversion of PpIX into heme, which compromises the therapeutic potency of 5‐ALA. Here, we examined the potential of chelation of such unfavorable intratumoral labile iron in photodynamic therapy (PDT) with 5‐ALA hydrochloride, using polymeric iron chelators that we recently developed. The polymeric iron chelator efficiently inactivated the intracellular labile iron in cultured cancer cells and importantly enhanced the accumulation of PpIX, thereby improving the cytotoxicity upon photoirradiation. Even in in vivo study with subcutaneous tumor models, the polymeric iron chelator augmented the intratumoral accumulation of PpIX and the PDT effect. This study suggests that our polymeric iron chelator could be a tool for boosting the effect of 5‐ALA‐induced PDT by modulating tumor microenvironment.
Polymeric iron chelators efficiently inactivated the intracellular labile iron in cultured cancer cells and importantly enhanced the accumulation of 5‐aminolevulinic acid‐induced protoporphyrin IX, thereby improving the cytotoxicity upon photoirradiation. Even in in vivo study with subcutaneous tumor models, the polymeric iron chelator augmented the intratumoral accumulation of protoporphyrin IX and the effect of photodynamic therapy.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Artificial intelligence poses a particular challenge in its application to finance/treasury management because most treasury functions are no longer physical processes, but rather virtual processes ...that are increasingly highly automated. Most finance/treasury teams are knowledge workers who make decisions and conduct analytics within often dynamic frameworks that must incorporate environmental considerations (foreign exchange rates, GDP forecasts), internal considerations (growth needs, business trends), as well as the impact of any actions on related corporate decisions which are also highly complex (e.g., hedging, investing, capital structure, liquidity levels). Artificial intelligence in finance and treasury is thus most analogous to the complexity of a human nervous system as it encompasses far more than the automation of tasks. Similar to the human nervous system, AI systems in finance/treasury must manage data quickly and accurately, including the capture and classification of data and its integration into larger datasets. At present, the AI network neural system has been gradually improved and is widely used in many fields of treasury management, such as early warning of potential financial crisis, diagnosis of financial risk, control of financial information data quality and mining of hidden financial data, information, etc.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The enhanced permeability and retention (EPR) effect is fundamental to tumor-targeted drug delivery using nanoparticles. However, recent studies reported heterogeneity of the EPR effect, and ...companion diagnostics are considered to be key to predicting and optimizing the benefits of the EPR effect. Here, as a new material to simply endow the function of companion diagnostics to nanoparticles, we designed a poly(ethylene glycol) (PEG) derivative conjugated with low molecular fluorescent dye through synthetic substrate linker that can be cleaved in response to MMP-2, which is overexpressed in tumor extracellular matrix. Upon tumor accumulation, the low molecular fluorescent dye is released from the PEG and quickly excreted to urine, thereby reporting its tumor accumulation level as a fluorescent signal in the urine. In this study, this urinary reporter was conjugated with albumin, and the functionalized albumin exhibited efficient accumulation in various tumors. Importantly, the functionalized albumin exhibited significantly higher excretion of the fluorescent dye in the urine in mice with tumors compared with those without tumors. The PEG derivatives proposed in this study may be a promising tool to predict the EPR effect in individual cancer patients.
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•PEG derivatives permitted potential urinary monitoring of the EPR effect.•Urinary monitoring suggested dynamics of the EPR effect.•Considerable intra-/extravasation could be observed in various tumor models.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Various cancer cells overexpress L-type amino acid transporter 1 (LAT1) to take up a large number of neutral amino acids such as phenylalanine and methionine, and LAT1 transporter should be a ...promising target for cancer diagnosis and therapy. However, only a few studies reported drug delivery systems targeting LAT1 probably due to limited knowledge about the interaction between LAT1 and its substrate. Here, we developed polymers having methionine (Met)- or cysteine (Cys)-like structures on their side chains to examine their affinity with LAT1. While both the Met- and Cys-modified polymers exhibited efficient cellular uptake selectively in cancer cells, the Met-modified polymers exhibited higher cellular uptake efficiency in an LAT1-selective manner than the Cys-modified polymers. In the in vivo study, the intraperitoneally injected Met-modified polymers showed appreciable tumor-selective accumulation in the peritoneal dissemination model, and importantly, Met-modified polymers conjugated with photosensitizers exhibited significant therapeutic effects upon photoirradiation with reduced photochemical damage to normal organs. Our results may provide important knowledge about the polymer-LAT1 interaction, and the Met-modified polymers should offer a new concept for designing LAT1-targeting drug delivery systems.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Intravenously injected high-dose vitamin C (VC) induces extracellular H2O2, which can penetrate into the tumor cells and suppress tumor growth. However, extracellular labile iron ions in the tumor ...decompose H2O2 via the Fenton reaction, limiting the therapeutic effect. In this regard, we recently developed a polymeric iron chelator that can inactivate the intratumoral labile iron ions. Here, we examined the effect of our polymeric iron chelator on the high-dose VC therapy in in vitro and in vivo. In the in vitro study, the polymeric iron chelator could inactivate the extracellular labile iron ions and prevent the unfavorable decomposition of VC-induced H2O2, augmenting pro-oxidative damage to DNA and inducing apoptosis in cultured cancer cells. Even in the in vivo study, the polymeric iron chelator significantly improved the antitumor effect of VC in subcutaneous DLD-1 and CT26 tumors in mice, while conventional iron chelators could not. This work indicates the importance of modulating tumor-associated iron ions in the high-dose VC therapy and should contribute to a better understanding of its mechanism.
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IJS, KILJ, NUK, PNG, UL, UM
Currently, the isolated development of energy in the coal mining areas and the energy supply mode based on coal power generation and grid power supply can no longer satisfy the requirements for ...implementing clean coal-mining and building a new energy development pattern that is green, low-carbon, and recyclable. Therefore, it is necessary to build integrated energy microgrids in the coal mining areas to enhance the comprehensive utilization of energy and control carbon emissions in these areas. This study explores the demand for and natural advantages of integrated energy microgrids application in the coal mining areas, proposes an integrated energy microgrid framework, and analyzes the development elements of the framework: new energy generation, energy storage, associated energy utilization, multi-energy coupling, and optimal scheduling of energy. A material‒energy‒carbon hub model is established in the coal mining areas, realizing low-carbon operation optimization based on carbon ‒ energy synergy of integrated energy microgrids in typical coal mining areas. The results indicate that the application of integrated energy microgrids in coal mining areas can fully exploit and efficiently integrate the advantages of resources such as wind, solar energy, gas, air heat, and gushing water heat, and energy storage devices can further improve the match degree between energy supply and load demand, thereby reducing the amount of power purchased from the power grid and the carbon emissions from electricity consumption in the coal mining areas. The low-carbon operation optimization process takes into account the carbon‒energy coupling of various types of equipment and supports the formulation of low-carbon and economical operation strategies. This study is expected to provide new concepts and technical support for the high-quality economic and social development of coal mining areas.
Recent interest in preventing the development of osteoporosis has focused on the regulation of redox homeostasis. However, the action of lycopene (LYC), a strong natural antioxidant compound, on ...osteoporotic bone loss remains largely unknown. Here, we show that oral administration of LYC to OVX rats for 12 weeks reduced body weight gain, improved lipid metabolism, and preserved bone quality. In addition, LYC treatment inhibited ROS overgeneration in serum and bone marrow in OVX rats, and in BMSCs upon H
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stimulation, leading to inhibiting adipogenesis and promoting osteogenesis during bone remodeling. At the molecular level, LYC improved bone quality via an increase in the expressions of FoxO1 and Runx2 and a decrease in the expressions of PPARγ and C/EBPα in OVX rats and BMSCs. Collectively, these findings suggest that LYC attenuates osteoporotic bone loss through promoting osteogenesis and inhibiting adipogenesis via regulation of the FoxO1/PPARγ pathway driven by oxidative stress, presenting a novel strategy for osteoporosis management.
Antennas with complex radiation characteristics can enhance the adaptability of radiofrequency systems in complex electromagnetic environments. However, The realization of complex targets is ...extremely challenging for conventional antenna design methods. It is difficult to find a suitable initial topology of the antenna with complex radiation characteristics. Therefore, in this paper, topology optimization is used to explore the initial structure with complex radiation properties. A two‐dimensional lossy thin layer model based on the transitional boundary condition is constructed, and target field functions for complex radiation are proposed. To verify the effectiveness of the algorithm, a high gain antenna with 10.2 dBi is realized, which has the highest aperture efficiency compared with the literature in similar directions. Then, for more complex targets, the radiation patterns of arbitrary direction null, arbitrary direction beam, and equal‐amplitude dual beam are realized, respectively. The topology optimization algorithm provides a new approach for the design of complex multitarget antennas.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK