Baicalein is a medicinally important flavonoid present in
, which has numerous biological benefits like anti-oxidant, anti-inflammatory, antihepatotoxicity, anticancer properties, etc. Recent studies ...have revealed that baicalein is an efficient antihepatoma agent and has the strongest antiproliferative effect toward cancerous bladder cell lines, and suppression of cell cycle progression in prostate cancer cells. This natural substance has a high commercial value because it strengthens the heart and cerebral vessels and protects the nervous system and also reduces diabetes and diabetic complications. In addition, baicalein is known to decrease inflammatory markers such as IL-1β, IL-6 and TNF-α. In this review, we have attempted to compile the list of recent therapeutic patents of baicalein used for treating different disorders.
Background: India is 5th worst hit nation by COVID-19 with 5.2 lacs deaths attributable to the disease. To counteract this global tragedy, many research articles have highlighted the role of various ...haematological and inflammatory biomarkers in assessing the severity of the disease. Materials and Methods: A retrospective analysis of 100 RT-PCR confirmed COVID-19 patients was undertaken. The patients were initially categorised into mild, moderate, and severe categories based on SpO2 levels & clinical symptoms at the time of admission. The blood sample was analysed for haematological and inflammatory biomarkers including NLR, IL-6, CRP, ESR and Serum ferritin. The data obtained was compared between severe and non-severe (mild+moderate) categories. Results: On correlating NLR with disease severity, patients with non-severe disease had a mean of 3.7 whereas it was 6.7 in the severe group, signaling that patient with severe disease had significantly high NLR compared to non-severe patients. The inflammatory markers studied, ESR, CRP & Serum ferritin- all three of them showed markedly increased mean values in severe patients. However, in our study, IL-6 levels were not found to correlate with severity of COVID-19. On performing ANOVA t test, NLR, ESR and serum ferritin were found to be significantly correlated with disease severity (p-value<0.05) but no significant correlation was found with IL-6. Conclusions: Our study highlights the importance of taking into consideration the values of NLR, ESR, CRP and serum ferritin as a screening tool at the time of initial presentation of COVID-19 patients to triage those requiring intensive care for optimum utilisation of limited resources.
Necrotizing Fascitis- A Tale of Two Cases Puri, Sarandeep Singh; Dubey, Suparna; Trisal, Monal ...
JK science : journal of medical education and research,
10/2022, Volume:
24, Issue:
4
Journal Article
Peer reviewed
Blood vessels Discussion Necrotizing fasciitis (NF) is a rare dangerous lifethreatening disorder which is caused by a bacterial infection. According to study done by O'Loughlin et al7 the most common ...organisms isolated included Streptococcus 65.1 %, and Staphylococcus 34.2%. ...clinicians and pathologists have to collaborate while rendering the diagnosis of Necrotising Fascitis. Clinicians must practice increased vigilance when treating patients with erythema, pain, and fever in order not to miss this rare but life-threatening condition Department of Pathology, School of Medical Sciences and Research , Sharda University, Plot No. 32-34, Knowledge Park III, Greater Noida, Uttar Pradesh 201306.
Full text
Available for:
IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Offshore meteoric groundwater (OMG) has long been hypothesized to be a driver of seafloor geomorphic processes in continental margins worldwide. Testing this hypothesis has been challenging because ...of our limited understanding of the distribution and rate of OMG flow and seepage, and their efficacy as erosive/destabilizing agents. Here we carry out numerical simulations of groundwater flow and slope stability using conceptual models and evolving stratigraphy—for passive siliciclastic and carbonate margin cases—to assess whether OMG and its evolution during a late Quaternary glacial cycle can generate the pore pressures required to trigger mechanical instabilities on the seafloor. Conceptual model results show that mechanical instabilities using OMG flow are most likely to occur in the outer shelf to upper slope, at or shortly before the Last Glacial Maximum sea‐level lowstand. Models with evolving stratigraphy show that OMG flow is a key driver of pore pressure development and instability in the carbonate margin case. In the siliciclastic margin case, OMG flow plays a secondary role in preconditioning the slope to failure. The higher degree of spatial/stratigraphic heterogeneity of carbonate margins, lower shear strengths of their sediments, and limited generation of overpressures by sediment loading may explain the higher susceptibility of carbonate margins, in comparison to siliciclastic margins, to mechanical instability by OMG flow. OMG likely played a more significant role in carbonate margin geomorphology (e.g., Bahamas, Maldives) than currently thought.
Plain Language Summary
The flow of fresh to brackish groundwater has been proposed as an important process shaping the seafloor. However, we still have a poor understanding of how groundwater behaves in the sub‐seafloor and whether it can erode seafloor sediments. In this study, we test this hypothesis by using conceptual and realistic numerical models of two common types of seafloor margins—siliciclastic and carbonate—to assess the role of groundwater in making the seafloor susceptible to erosion. We show that the flow of groundwater offshore could have driven seafloor erosion close to the shelf break during the Last Ice Age, when sea level was lower than at present. Carbonate margins are more susceptible to this type of failure than siliciclastic margins. This may be explained by the higher variability in sediment properties across carbonate margins as well as the lower strength of their sediments. Groundwater has likely played an important role in shaping the seafloor in carbonate margins, and it may be responsible for landforms such as canyons, scars, and depressions in the Bahamas and the Maldives.
Key Points
Offshore meteoric groundwater (OMG) flow can drive mechanical instabilities in the outer shelf to upper slope
Such instabilities occur at, or shortly after, the Last Glacial Maximum sea‐level lowstand
Carbonate margins are more susceptible to mechanical instability by OMG than siliciclastic margins
Full text
Available for:
BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Methane gas hydrates have increasingly become a topic of interest because of their potential as a future energy resource. There are significant economical and environmental risks associated with ...extraction from hydrate reservoirs, so a variety of multiphysics models have been developed to analyze prospective risks and benefits. These models generally have a large number of empirical parameters which are not known a priori. Traditional optimization-based parameter estimation frameworks may be ill-posed or computationally prohibitive. Bayesian inference methods have increasingly been found effective for estimating parameters in complex geophysical systems. These methods often are not viable in cases of computationally expensive models and high-dimensional parameter spaces. Recently, methods have been developed to effectively reduce the dimension of Bayesian inverse problems by identifying low-dimensional structures that are most informed by data. Active subspaces is one of the most generally applicable methods of performing this dimension reduction. In this paper, Bayesian inference of the parameters of a state-of-the-art mathematical model for methane hydrates based on experimental data from a triaxial compression test with gas hydrate-bearing sand is performed in an efficient way by utilizing active subspaces. Active subspaces are used to identify low-dimensional structure in the parameter space which is exploited by generating a cheap regression-based surrogate model and implementing a modified Markov chain Monte Carlo algorithm. Posterior densities having means that match the experimental data are approximated in a computationally efficient way.
Full text
Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The major aim of the present study was to assess “Personality, Coping Strategies and Youth Problems in Engineering Students.” A sample of 80 engineering hostellers from Manipal University Jaipur, ...aged between 18-21 years were selected using the purposive technique of sampling. Big Five Inventory BFI 9 , Coping Strategies Inventory CSI 28, and Youth Problem Inventory YPI 17 were used to assess the variables in the study. The obtained data were analyzed using the statistical technique of Pearson Correlation. The findings revealed that a significant relationship exists between personality and coping strategies. But each personality dimension does not have a significant relationship with each of the youth problems (family, personal, educational, and socio-emotional). Also, no significant relationship has been found between coping strategies and youth problems. However, a significantly negative relationship has been found between problem-focused engagement and personal problems.
Keywords: personality, coping strategies, youth problems, engineering students
Background: Chronic otitis media (COM) is a recurrent infection of the middle ear and/or mastoid air cells affecting 2-3% of global population. Mastoidectomy is the mainstay of the treatment of COM. ...Bone drilling during mastoidectomy procedure exposes both the ears to acoustic trauma leading to sensorineural hearing loss. The present study was conducted to assess the possible deleterious effect of drilling on hearing of contralateral normal ear by monitoring pre-operative and post-operative pure tone audibility (PTA) and otoacoustic emissions (OAE). Aims and objectives were to evaluate the effect of drill- generated noise on hearing in non-operated ear during mastoidectomy in terms of hearing loss, its nature and duration and recovery of hearing loss.Methods: An observational study was carried out in ENT department at SMS medical college and hospital, Jaipur. Total 40 patients were studied. Pre-operative and post-operative PTA and OAE were studied and compared. Mean drilling time during mastoid surgery was also studied.Results: Out of 40 subjects, maximum patients were 11-20 years of age group (37.5%) with female preponderance (57.5%). All had undergone mastiodectomy. Only 6 (15%) subjects had transient sensorineural hearing loss of contralateral normal ear as determined by comparing pre-operative and post-operative PTA and OAE. The mean recovery time was 2-3 days. The study had shown significant effect of drill generated noise on hearing of contralateral healthy ear following mastoidectomy.Conclusions: Drill-generated noise can’t be lowered to a great extent therefore drilling time should be minimized during mastoid surgeries.
Background: COVID-19 is an infectious disease caused by a newly discovered coronavirus, and has spread around the world in a deadly pandemic. The first case of COVID-19 was reported from Wuhan, China ...in December 2019. This is also called as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because of its homology with SARS virus. The most common hematological manifestation of coronavirus is lymphopenia which is due to depletion of lymphocytes by coronavirus infection. Other manifestations are neutrophilia and mild thrombocytopenia. Literature is full of quantitative hematological parameters but the researches on morphology of white blood cells is still ongoing. We at our institute done study on 60 confirmed positive cases of COVID-19, and analyzed those peripheral smears in terms of morphology of white blood cells.Methods: The study was done using peripheral smear staining with methylene blue stain and was screened for various changes in white blood cells in peripheral smear.Results: Changes in the white blood cells were examined in the peripheral smear and findings were made in the tabular form.Conclusions: To conclude that all these changes are due to the virus infecting them or are secondary to pathogenesis of COVID disease, needs to be evaluated by larger studies.
The abstract nature of quantum mechanics makes it difficult to visualize. This is one of the reasons it is taught in the language of mathematics. Without an opportunity to directly observe or ...interact with quantum phenomena, students struggle to develop conceptual understandings of its theories and formulas. In this paper we present the process of designing a digital game that supplements introductory quantum mechanics curricula. We present our design process anchored on three key challenges: 1) drawing upon students' past experiences and knowledge of classical mechanics while at the same time helping them break free of it to understand the unique qualities and characteristics of quantum mechanics; 2) creating an environment that is accurate in its depiction of the mathematical formulations of quantum mechanics while also playful and engaging for students; and 3) developing characters that are relatable to players but also do not reinforce gender stereotypes. Our design process can serve as a useful resource for educational game designers by providing a model for addressing these challenges.
PDF
