Focused fluid flow through sub-seafloor pipes and chimneys, and their seafloor manifestations as pockmarks, are ubiquitous. However, the dynamics of flow localization and evolution of fluid escape ...structures remain poorly understood. Models based on geomechanical mechanisms like hydro-fracturing and porosity wave propagation offer some useful insights into fluid flow and escape dynamics, but face limitations in capturing features like mobilized granular matter, especially in the upper sediment layers where the link between fracture and pockmark is not always clear. Here, we propose a mathematical model based on the multiphase theory of porous media, where changes in subsurface and seafloor morphology are resolved through seepage-induced erosion, fluidization, transport, and re-deposition of granular material. Through simulation of an idealized scenario of gas escape from overpressured shallow gas reservoir, we demonstrate that our model can capture flow localization and formation of pipes, chimneys, and pockmarks. Our simulations show (1) formation of conical focused-flow conduits with a brecciated core and annular gas channels; (2) pockmarks of W and ring shapes; and (3) pulsed release of gas. Sediment erodibility and flow anisotropy control the morphology of focused fluid flow and escape structures, while permeability shows negligible impact. While the geological setting for this study is theoretical, we show that our results have real-world analogs.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Medical emergency situations in dental clinics have been contemplated to be an issue in most of the countries by reason of dentist's lack of knowledge and preparedness to attend emergency situations ...in dental offices. The aim of this paper is to observe the knowledge, attitude, and perceived confidence of the general dental practitioners regarding emergency medical care and its practical application. Questionnaire on knowledge assessment was circulated among 500 dentists using printed questionnaire formats and various social media platforms. The questionnaire included details on treating hypertensive patients, cardiopulmonary resuscitation training, accessibility of medical emergency equipments in the dental clinics, prevalence of medical emergency cases in the dental office and the self-assessed competence to handle medical emergency situations in the dental clinics. Data was surveyed and scrutinized using the Statistical Package for Social Sciences (SPSS), version 17 (SPSS Inc., Chicago IL). Descriptive statistics was tabulated and Chi square tests was applied. 500 general dental practitioners pan India were involved in the study (294 were females and 207 were males). They were grouped into different age groups (20-30 yrs, 30-40 yrs, 40-50 yrs, 50 and above) and experience (0-5 yrs, 5-10 yrs and more than 10 years). 279 participants did not attend any medical emergency training whereas, 222 participants from all groups attended training program. It was observed that with increased experience in the field, the knowledge, awareness and confidence to treat medical emergency situation in the dental clinics was better. Dentists should update themselves from time-to-time with the latest technologies in the field and need to attend training programs to handle any medical emergency situations in the dental offices. Medical emergencies in a dental clinic can be encountered at any point of time and the clinician should have apt knowledge in handling such situations. Majority of the dentists feel subdued in managing medical situations in dental offices. Training and workshops for handling medical situations in the dental offices should be mandated at the undergraduate and postgraduate levels. This will help the dentist to shape one's confidence in managing such situations without apprehension. Availability of proper infrastructure and equipments is recommended in every dental clinics so as to ease the handling of the situation. This paper enlightens the need of basic life support training on regular basis among the dentists to improve the competence among them and to improve the confidence in handling such situations.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The spread of SARS-CoV-2 virus accompanied by public availability of abundant sequence data provides a window for the determination of viral evolutionary patterns. In this study, SARS-CoV-2 genome ...sequences were collected from seven countries in the period January 2020-December 2022. The sequences were classified into three phases, namely, pre-vaccination, post-vaccination, and recent period. Comparison was performed between these phases based on parameters like mutation rates, selection pressure (d
/d
ratio), and transition to transversion ratios (T
/T
). Similar comparisons were performed among SARS-CoV-2 variants. Statistical significance was tested using Graphpad unpaired
-test. The analysis showed an increase in the percent genomic mutation rates post-vaccination and in recent periods across all countries from the pre-vaccination sequences. Mutation rates were highest in NSP3, S, N, and NSP12b before and increased further after vaccination. NSP4 showed the largest change in mutation rates after vaccination. The d
/d
ratios showed purifying selection that shifted toward neutral selection after vaccination. N, ORF8, ORF3a, and ORF10 were under highest positive selection before vaccination. Shift toward neutral selection was driven by E, NSP3, and ORF7a in the after vaccination set. In recent sequences, the largest d
/d
change was observed in E, NSP1, and NSP13. The T
/T
ratios decreased with time. C→U and G→U were the most frequent transitions and transversions. However, U→G was the most frequent transversion in recent period. The Omicron variant had the highest genomic mutation rates, while Delta showed the highest d
/d
ratio. Protein-wise d
/d
ratio was also seen to vary across the different variants.IMPORTANCETo the best of our knowledge, there exists no other large-scale study of the genomic and protein-wise mutation patterns during the time course of evolution in different countries. Analyzing the SARS-CoV-2 evolutionary patterns in view of the varying spatial, temporal, and biological signals is important for diagnostics, therapeutics, and pharmacovigilance of SARS-CoV-2.
We conducted two‐dimensional numerical simulations to investigate the mechanisms underlying the strong spatiotemporal correlation observed between submarine landslides and gas hydrate dissociation ...due to glacial sea‐level drops. Our results suggest that potential plastic deformation or slip could occur at localized and small scales in the shallow‐water portion of the gas hydrate stability zone (GHSZ). This shallow‐water portion of the GHSZ typically lies within the area enclosed by three points: the BGHSZ–seafloor intersection, the seafloor at ∼600 m below sea level (mbsl), and the base of the GHSZ (BGHSZ) at ∼1,050 mbsl in low‐latitude regions. The deep BGHSZ (>1,050 mbsl) could not slip; therefore, the entire BGHSZ was not a complete slip surface. Glacial hydrate dissociation alone is unlikely to cause large‐scale submarine landslides. Observed deep‐water (much greater than 600 mbsl) turbidites containing geochemical evidence of glacial hydrate dissociation potentially formed from erosion or detachment in the GHSZ pinch‐out zone.
Plain Language Summary
Many submarine landslides spatiotemporally correlate with gas hydrate dissociation. However, direct mechanical evidence supporting whether the overpressure and deformation due to glacial sea‐level drop‐induced hydrate dissociation are adequate for triggering submarine landslides is lacking. Here, we present two‐dimensional thermal‐hydraulic‐chemical and geomechanical models of a gas‐hydrate system in response to glacial sea‐level drops and conduct sensitivity analyses of the model behavior under a wide range of key conditions from a global perspective. Our simulations suggest that glacial hydrate dissociation might induce plastic deformation or slip at localized and small scales only possibly within the shallow‐water portion of the hydrate stability zone. The deep part (>1,050 m below sea level) of the bottom boundary of the hydrate stability zone could not slip; therefore, the entire bottom boundary of the hydrate stability zone was not a complete slip surface. We demonstrate that glacial hydrate dissociation alone is unlikely to trigger large‐scale submarine landslides. Our work highlights the vicinity of the upper limit of the hydrate stability zone (where the base of the hydrate stability zone intersects the seafloor) as an important area for investigating overpressure and focused fluid flow, localized plastic deformation or slip, and downslope sediment transport related to glacial hydrate dissociation.
Key Points
Glacial hydrate dissociation might cause potential plastic deformation or slip at localized and small scales in shallow parts of the GHSZ
The large deformation surface at the BGHSZ boundary of the potential plastic deformation zone was not a complete slip surface
Glacial sea‐level drop‐induced gas hydrate dissociation alone is unlikely to have caused large‐scale submarine landslides
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Extra domain A of cellular fibronectin (FN-EDA) is known to cause insulin resistance, atherosclerosis, tissue fibrosis, ischemic stroke and exaggerated myocardial reperfusion injury through Toll-like ...receptor 4 (TLR4). However, the FN-EDA-TLR4 interacting site is not well established. Therefore, in-silico approaches have been used to study FN-EDA and TLR4 interactions at the interface. In the present study, molecular docking studies of FN-EDA with TLR4-myeloid differentiation factor 2 (MD2) heterodimer have been performed to unravel the FN-EDA-TLR4 interacting sequence. Furthermore, the modulatory role of FN-EDA adjacent domains FNIII(11) and FNIII(12) on its interaction with TLR4-MD2 was investigated. The results show that FN-EDA interacting sequence "SPEDGIRELF" selectively interacts with TLR4 directly near its central and C-terminal domain region. The regulatory domains, FN type III 11 facilitate and 12 impede the FN-EDA-TLR4 interaction. Furthermore, the molecular dynamic simulation studies confirmed that FN-EDA forms a stable complex with TLR4-MD2 heterodimer. In conclusion, FN-EDA interacts and forms a stable complex through its "SPEDGIRELF" sequence at the central and C-terminal domain region of TLR4. The revelation of FN-EDA and TLR4 interacting sites may help design novel therapeutics for drug discovery research.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The migration of methane through the gas hydrate stability zone (GHSZ) in the marine subsurface is characterized by highly dynamic reactive transport processes coupled to thermodynamic phase ...transitions between solid gas hydrates, free methane gas, and dissolved methane in the aqueous phase. The marine subsurface is essentially a water-saturated porous medium where the thermodynamic instability of the hydrate phase can cause free gas pockets to appear and disappear locally, causing the model to degenerate. This poses serious convergence issues for the general-purpose nonlinear solvers (e.g., standard Newton), and often leads to extremely small time-step sizes. The convergence problem is particularly severe when the rate of hydrate phase change is much lower than the rate of gas dissolution. In order to overcome this numerical challenge, we have developed an all-at-once Newton scheme tailored to our gas hydrate model, which can handle rate-based hydrate phase change coupled with equilibrium gas dissolution in a mathematically consistent and robust manner.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Aim: The study aims to identify significant personality predictors of selfie-taking behavior among college and school-going students. Methods: The sample size consists of 50 boys and 50 girls (n = ...100) between the age range of 16-23 years from various schools and colleges of Delhi NCR. The tools used in the study were Cattell's 16 Personality Factors and Selfitis Behavior Scale. Results: The results of the study depicted a positive correlation of selfitis behavior with perfectionism and sensitivity. However, self-reliance, reasoning, and emotional stability showed a negative correlation with selfitis behavior. Furthermore, the results of the study showed that girls have more selfitis behavior as compared to boys and the college group have more selfitis behavior than that of the school group. ANOVA and linear regression were used to analyze data. Conclusion: Social media is the strongest tool of communication nowadays. "Selfies" are a growing social networking technique for self-disclosure. Use of social media is focusing on the physical aspect and allowing posting and amending pictures that are creating concerns about body image, poor self-esteem, loneliness, and depression among students. The overall results suggest that while selfies provide individuals with the potential of enhancing self-disclosure, they also demonstrate some risky and unhealthy behaviors. Therefore, predicting personality traits could be considered an effective variable to sensitize them before the deterioration of their mental health.
Cochlear Implantation in Goldenhar Syndrome Gupta, Shubhangi; Samdani, Sunil; Vaishnav, Jairaj Kumar ...
Indian journal of otolaryngology, and head, and neck surgery,
12/2022, Volume:
74, Issue:
Suppl 3
Journal Article
Peer reviewed
Goldenhar syndrome is a rare genetic condition characterized by hemifacial microsomia, mandibular hypoplasia, auricular malformations, and epibulbar dermoids. The syndrome has both sporadic and ...familial occurrence. Incidence of congenital hearing loss in these patients is 1:1000 in children with a male to female ratio of 3:2. In our case study we report a case of Goldenhar Syndrome who underwent cochlear implantation. The patient had right side microtia, right hemifacial microsomia and right side torticollis, pterygium in her right eye, right hypoplastic thumb and unilateral right side kidney. Radiologically, there was narrow duplicated internal auditory canal on right side with absent right cochlear nerve with normal anatomy on left side and the left side showed malformed facial nerve at tympani segment and second genu. Therefore, the patient was planned for left side cochlear implantation. Intraoperatively, there were malformed ossicles with anomalous facial nerve covering whole of oval window and partially the round window. Thus, a separate cochleostomy was done. Impedance was < 5 Hertz in all electrodes and electrically evoked action potential (ECAP) thresholds were obtained on all electrodes.
Introduction Most centers in low- to mid-income countries (LMICs) lack facilities for a comprehensive instrumented gait analysis (IGA) which is often considered the preferred method for assessment of ...the functional results of surgery in children with spastic diplegia. We aimed to study if there were any changes in the Gross Motor Function Classification System (GMFCS) levels and Functional Mobility Scale (FMS) scores after surgery and whether they can be used as an indirect indicator of change in the functional status of a child. Methods This prospective study was conducted at the Pediatric Orthopedic unit of a teaching hospital on spastic diplegic children requiring surgical intervention. GMFCS levels and FMS scores were recorded before the surgery and at each follow-up visit, with the latest record being two years post-surgery. The change in the scores was indicated as an improvement, deterioration, or no change from the baseline and compared to the score of the preceding visit. In addition, it was examined whether the age at surgery had any effect on the temporal change in the scores. Results A total of 25 children were included for analysis after excluding those who failed to fulfill the predefined inclusion and exclusion criteria. Both the GMFCS levels and FMS scores improved from the third month to one-year post-surgery, after which a few patients had a worsening of their scores at the two years follow-up visit. The age at which surgery was performed had no significant effect on the pattern of change in the scores. Most children sought consultations with the physical therapy department only when they visited the surgical team for follow-up. Conclusion This study shows that surgical interventions do improve the functional outcomes in children with spastic CP when assessed using FMS scores while maintaining an undeteriorated GMFCS level in most children. While a peak improvement can be expected one year after surgery in most patients, possible of worsening from baseline scores do exist, and the parents must be informed of the same. Any decision for surgery must involve the parents, and the usefulness of postoperative physical therapy must be impressed upon them before the surgery and during each follow-up visit too.
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