Hypofractionated radiotherapy(27-32 Gy/3-4 fractions)was performed in the 3 dogs diagnosed as plasma cell tumors, since complete resection by surgical operation was impossible. In all cases, their ...tumors were disappeared within 1 to 4 months after radiotherapy. In case1, recurrence has not been noted during a follow-up period of 19 months. Cases 2 and 3 have not showed recurrence for 13 and 6 months, respectively. These results indicated that hypofractionated radiotherapy is effective for canine plasma cell tumors, since reduction of the local mass was seen within a few months.