A 850kW wind turbine gearbox, widely used in wind farms, was used to perform efficiency tests of different wind turbine gear oil formulations.
One mineral and three polyalpholephin commercially ...available lubricants were chosen, all them are ISO VG 320 wind turbine gear oils.
Study the influence of different gear oil technologies in the overall gearbox transmission efficiency is the main objective of this work.
The results show that different energetic efficiency and different oil particle counting were obtained even when the same base oil is used.
•One mineral and three polyalpholephin ISO VG 320 wind turbine gear oils were chosen.•A 850kW wind turbine gearbox was considered to perform efficiency tests.•Different oil formulations, even with the same base oil, promote different energetic efficiency.•Different oil formulations promote lower particle counting through oil analysis.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The treatment of children with attention deficit hyperactivity disorder (ADHD) and Tourette syndrome (TS) has been problematic because methylphenidate (MPH)--the most commonly used drug to treat ...ADHD--has been reported to worsen tics and because clonidine (CLON)--the most commonly prescribed alternative--has unproven efficacy.
The authors conducted a multicenter, randomized, double-blind clinical trial in which 136 children with ADHD and a chronic tic disorder were randomly administered CLON alone, MPH alone, combined CLON + MPH, or placebo (2 x 2 factorial design). Each subject participated for 16 weeks (weeks 1-4 CLON/placebo dose titration, weeks 5-8 added MPH/placebo dose titration, weeks 9-16 maintenance therapy).
Thirty-seven children were administered MPH alone, 34 were administered CLON alone, 33 were administered CLON + MPH, and 32 were administered placebo. For our primary outcome measure of ADHD (Conners Abbreviated Symptom Questionnaire--Teacher), significant improvement occurred for subjects assigned to CLON (p < 0.002) and those assigned to MPH (p < 0.003). Compared with placebo, the greatest benefit occurred with combined CLON + MPH (p < 0.0001). CLON appeared to be most helpful for impulsivity and hyperactivity; MPH appeared to be most helpful for inattention. The proportion of individual subjects reporting a worsening of tics as an adverse effect was no higher in those treated with MPH (20%) than those being administered CLON alone (26%) or placebo (22%). Compared with placebo, measured tic severity lessened in all active treatment groups in the following order: CLON + MPH, CLON alone, MPH alone. Sedation was common with CLON treatment (28% reported moderate or severe sedation), but otherwise the drugs were tolerated well, including absence of any evident cardiac toxicity.
Methylphenidate and clonidine (particularly in combination) are effective for ADHD in children with comorbid tics. Prior recommendations to avoid methylphenidate in these children because of concerns of worsening tics are unsupported by this trial.
Five fully formulated wind turbine gear oils were characterised. The gear oils have 320 ISO VG grade and different formulations: ester, mineral, PAO, PAG and mineral+PAMA.
A back-to-back FZG test ...machine, with re-circulating power, was used and a torque-cell was included on the test rig in order to measure the torque loss. Eight thermocouples were included to monitor the temperatures in different locations of the test rig.
Tests at 1.13, 2.26 and 6.79m/s were performed for different FZG load stages: K1, K5, K7 and K9. Both gearboxes were jet-lubricated with an oil flow of 3l/min. The input flow temperature was kept almost constant (80 ±1°C).
Friction generated between the meshing teeth, shaft seals and rolling bearing losses was predicted.
•Five wind turbine gear oils were selected. Density and viscosities were measured.•A back-to-back FZG machine was used and a torque cell included to measure the torque loss.•Torque loss was measured for a type C40 FZG gears.•Tests at 1.13, 2.26 and 6.79 m/s were performed at K1, K5, K7 and K9 load stages.•A torque loss model was developed and validated.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The immune privilege of the eye has been thought to be dependent on physical barriers and absence of lymphatic vessels. However, the immune privilege may also involve active immunologic processes, as ...recent studies have indicated. The purpose of the present study was to investigate whether human retinal pigment epithelial (RPE) cells can induce apoptosis in activated T cells.
Fas ligand (FasL) expression was detected by flow cytometry and immunohistochemistry. Cultured RPE cells were cocultured with T-cell lines and peripheral blood lymphocytes for 6 hours to 2 days. Induction of apoptosis was detected by 7-amino-actinomycin D and annexin V staining.
Retinal pigment epithelial cells expressed FasL and induced apoptosis in activated Fas+ T cells. Blocking of Fas-FasL interaction with antibody strongly inhibited RPE-mediated T-cell apoptosis. Retinal pigment epithelial cells induced apoptosis in several activated T-cell populations and T-cell lines, including T-cell antigen receptor (TCR)-CD3-negative T-cell lines. In contrast, RPE cells induced little or no apoptosis in resting peripheral T cells. Major histocompatibility complex (MHC) class II monoclonal antibodies, which block alloactivation, had no inhibitory effect on RPE-mediated T-cell apoptotic responses in MHC class II-specific CD4+ T-cell lines.
Retinal pigment epithelial cells express FasL and induce TCR-independent apoptosis in activated human T cells through Fas-FasL interaction. Retinal pigment epithelial cells may constitute an immunologic functional barrier against potentially harmful T cells.
We report on Bayesian parameter estimation of the mass and equatorial radius of the millisecond pulsar PSRJ0030+0451, conditional on pulse-profile modeling of Neutron Star Interior Composition ...Explorer X-ray spectral timing event data. We perform relativistic ray-tracing of thermal emission from hot regions of the pulsar’s surface. We assume two distinct hot regions based on two clear pulsed components in the phase-folded pulse-profile data; we explore a number of forms (morphologies and topologies) for each hot region, inferring their parameters in
addition to the stellar mass and radius. For the family of models considered, the evidence (prior predictive probability of the data) strongly favors a model that permits both hot regions to be located in the same rotational hemisphere. Models wherein both hot regions are assumed to be simply connected circular single-temperature spots, in particular those where the spots are assumed to be reflection-symmetric with respect to the stellar origin, are strongly disfavored. For the inferred configuration, one hot region subtends an angular extent of only a few degrees (in spherical coordinates with origin at the stellar center) and we are insensitive to other structural details; the second hot region is far more azimuthally extended in the form of a narrow arc, thus requiring a larger number of parameters to describe. The inferred mass M and equatorial radius Req are, respectively, -1.34+ M 0.16 0.15 and-12.71+ km 1.19 1.14 , while the compactness = -GM R c 0.156+ eq 2 0.010 0.008 is more tightly constrained; the credible interval bounds reported here are approximately the 16% and 84% quantiles in marginal posterior mass.
Planetary gearboxes used in wind turbines very often have premature bearing and gear failures, some of them related to the lubricants used. Five fully formulated wind turbine gear oils with the same ...viscosity grade and different formulations were selected and their physical characterization was performed. The lubricant tribological behaviour in a thrust ball bearing was analyzed. A modified Four-Ball Machine was used to assemble the bearings. They were submitted to an axial load and the tests were performed at velocities ranging between 150 and 1500rpm. Experimental results for the operating temperatures and for the internal friction torque are presented.
► Five wind turbine gear oils were selected. Density and viscosities were measured. ► Frictional behaviour of a thrust ball bearing (51107). ► A modified Four-Ball Machine was used and tests were performed between 150 and 1500rpm. ► Operating temperatures and internal friction torque, power loss and heat evacuated are presented. ► Rolling and sliding friction torques were determined.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
For pt.III see ibid., vol.470, no.1, p.349-63 (1996). Combines data from the three preceding papers in order to analyze the multi wave-band variability and spectral energy distribution of the Seyfert ...1 galaxy NGC 4151 during the 1993 December monitoring campaign. The source, which was near its peak historical brightness, showed strong, correlated variability at X-ray, ultraviolet, and optical wavelengths. The strongest variations were seen in medium-energy (~1.5 keV) X-rays, with a normalized variability amplitude (NVA) of 24%. Weaker (NVA=6%) variations (uncorrelated with those at lower energies) were seen at soft gamma-ray energies of ~100 keV. No significant variability was seen in softer (0.1-1 keV) X-ray bands. In the ultraviolet/optical regime, the NVA decreased from 9% to 1% as the wavelength increased from 1275 to 6900 Aring. These data do not probe extreme ultraviolet (1200 Aring to 0.1 keV) or hard X-ray (250 keV) variability. The phase differences between variations in different bands were consistent with zero lag, with upper limits of lsim0.15 day between 1275 Aring and the other ultraviolet bands, lsim0.3 day between 1275 Aring and 1.5 keV, and lsim1 day between 1275 and 5125 Aring. These tight limits represent more than an order of magnitude improvement over those determined in previous multi-wave-band AGN monitoring campaigns. The ultraviolet fluctuation power spectra showed no evidence for periodicity, but were instead well fitted with a very steep, red power law (ales-2.5)
We evaluated the clinical results of subfascial endoscopic perforating vein surgery (SEPS) in patients with severe chronic venous insufficiency (CVI) (clinical class 4-6) and assessed the hemodynamic ...changes associated with SEPS using air plethysmography (APG).
Forty-five patients with severe CVI who had undergone SEPS were evaluated. Clinical score and venous hemodynamics, as measured by APG before operation and at 1 month and 1 year after operation, were compared using the Wilcoxon signed rank test. Patient satisfaction (on a visual analogue scale of 0 to 100%) was also assessed.
There were 29 men and 16 women; their mean age was 60 years (range, 37-83). Thirty-five patients (78%) had active venous ulcers; the ulcers' mean size was 7.8 +/- 11.9 cm2 and the mean duration of ulceration was 9 +/- 10 months. There were no hospital deaths. Postoperative complications were uncommon (one groin wound infection and one case of thrombophlebitis). At a mean follow-up of 15 +/- 9 months, 34 ulcers (97%) had healed. The cumulative ulcer healing was 82% at 3 months. There were five recurrent ulcers (15%). Significant improvement was seen in the clinical scores (10 +/- 3 before operation, 6 +/- 4 at 1 month, and 4 +/- 3 at 1 year after operation). The venous filling index was also significantly improved after operation; this improvement was maintained at 1-year follow-up (7.36 +/- 6.23 ml/sec before operation, 3.63 +/- 3.90 ml/sec at 1 month, and 3.14 +/- 2.06 ml/sec at 1 year). The degree of patient satisfaction was also remarkable, with 74 +/- 17% and 90 +/- 12% satisfaction at 1-month and 1-year follow-up, respectively.
SEPS is a safe and effective treatment for patients with severe CVI. It leads to hemodynamic improvement, with rapid ulcer healing, and it is associated with a high degree of patient satisfaction.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
We hypothesized that technetium-99m-ethylene dicysteine-metronidazole (99mTc-EC-MN) localizes to brain tissue that is hypoxic but viable. This study prospectively evaluated the relationship between ...neurological outcome and uptake of 99mTc-EC-MN in peri-infarcted regions of the brain.
Eight patients with acute ischemic stroke in the territory of the left middle cerebral artery underwent 99mTc-EC-MN and 99mTc-ethyl cysteinate dimer (ECD) brain SPECTs on the same day during the subacute stage (10.3+/-2.5 days). The infarct volumes from 99mTc-ECD images (IV(ECD)), infarct volumes from diffusion-weighted MRI images (IV(DW)), and hypoxic volume (HV) from 99mTc-EC-MN images were calculated. The net infarct volume (NIV(ECD)) was defined as IV(ECD) minus HV. The National Institutes of Health Stroke Scale scores were measured on admission and days 1, 3, 7, and 30.
IV(ECD) was greater than IV(DW). The lesion-to-normal count-density ratios of 99mTc-EC-MN ranged from 1.80 to 5.96. HV was 60.2+/-65.2 cm3, and the mean percent HV was 24.5+/-28.1% of IV(ECD). NIV(ECD) was 162.6+/-133.4 cm3 and was significantly smaller than IV(ECD). NIV(ECD) was significantly correlated with National Institutes of Health Stroke Scale score at 1 month and was a significant predictor of neurological deficit at 1 month.
99mTc-EC-MN brain SPECT can detect hypoxic tissue after acute ischemic stroke and, in combination with 99mTc-ECD brain SPECT, is useful in predicting neurological outcome in ischemic stroke patients.
The origin of a compact millimeter (mm, 100-250 GHz) emission in radio-quiet active galactic nuclei (RQ AGN) remains debated. Recent studies propose a connection with self-absorbed synchrotron ...emission from the accretion disk X-ray corona. We present the first joint ALMA (\(\sim\)100 GHz) and X-ray (NICER/XMM-Newton/Swift; 2-10 keV) observations of the unobscured RQ AGN, IC 4329A (\(z = 0.016\)). The time-averaged mm-to-X-ray flux ratio aligns with recently established trends for larger samples (Kawamuro et al. 2022, Ricci et al. 2023), but with a tighter scatter (\(\sim\)0.1 dex) compared to previous studies. However, there is no significant correlation on timescales of less than 20 days. The compact mm emission exhibits a spectral index of \(-0.23 \pm 0.18\), remains unresolved with a 13 pc upper limit, and shows no jet signatures. Notably, the mm flux density varies significantly (factor of 3) within 4 days, exceeding the contemporaneous X-ray variability (37% vs. 18%) and showing the largest mm variations ever detected in RQ AGN over daily timescales. The high amplitude variability rules out scenarios of heated dust and thermal free-free emission, pointing toward a synchrotron origin for the mm radiation in a source of \(\sim\)1 light day size. While the exact source is not yet certain, an X-ray corona scenario emerges as the most plausible compared to a scaled-down jet or outflow-driven shocks.}
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