Dimers of vancomycin (Van), linked by a rigid metal complex, Pt(en)(H2O)22+, exhibit potent activities (MIC ∼0.8 μg/mL, ∼720 times more potent than that of Van itself) against vancomycin-resistant ...enterococci (VRE). The result suggests that combining metal complexation and receptor/ligand interaction offers a useful method to construct multivalent inhibitors.
Is the Rate-of-Change Oscillator Profitable? Chong, Terence Tai-Leung; Leung, Ka Wai; Yuen, Ho Yin
Journal of Investing,
08/2011, Volume:
20, Issue:
3
Journal Article, Trade Publication Article
Peer reviewed
The authors evaluate the profitability of trading rules associated with the rate of change (ROC) oscillator. The ROC is an oscillator indicating the trend of the price of a security. Using the data ...of 13 major stock market indices, they find that the rule generated by the crossing of ROC and its exponential moving average performs extremely well in the stock markets of greater China. PUBLICATION ABSTRACT
Objective:
To examine the extent of neonatal morbidity and its relation with infant size in newborns diagnosed with clavicular fracture after vaginal birth.
Methods:
A retrospective case-control ...study was performed on all the infants diagnosed with clavicular fractures and born vaginally between July 1997 and June 2000. For each index case, a control matched for gestational age (within l week), birth weight (within 100 g), and delivered within the same 24-hour period (8
am to 8
am), was selected at random from the delivery suite registry. If a control could not be identified within the period, the search was extended to the previous or the following 24-hour period, and the birth weight criterion relaxed to within 250 g. The overall neonatal outcome was compared between the two groups and the morbidity was further analyzed according to whether the infants were large for gestational age (LGA) or not.
Results:
Clavicular fracture, found in 1.6% (151 of 9540) of vaginal births, was associated with increased incidence of instrumental delivery (
P = .001) and shoulder dystocia (
P = .013). The associated morbidity were Erb palsy (
P = .007), which was more often found in the LGA infants (
P = .055), and cephalhematoma (
P = .031), which was only found in the non-LGA infants (odds ratio 4.48, 95% confidence interval 1.23, 16.30). On multivariable analysis, clavicular fracture was excluded as a significant factor in these outcomes after adjusting for the effect of instrumental delivery and shoulder dystocia.
Conclusion:
Neonatal clavicular fracture is of little clinical significance, and it does not reflect quality of care.
Although many attempts have been made to identify tumour-specific alpha-fetoprotein (AFP) glycoforms or other serological markers for the diagnosis of hepatocellular carcinoma (HCC), none of the ...available markers has, so far, shown satisfactory sensitivity and specificity. Here we aimed to apply classification tree and neural network algorithms to interpret the levels of multiple serological liver markers to improve overall specificity and sensitivity, particularly with a view to discriminating between liver cirrhosis with and without HCC.
We developed classification trees and neural networks that identified serological liver marker profiles comprising AFP, alpha1-antitrypsin (A1AT), alpha2-macroglobulin (A2MG), thyroxine-binding globulin (TBG), transferrin and albumin as well as sex and age, which might permit the diagnosis of HCC. Data were collected from 65 HCC patients, 51 patients with liver cirrhosis alone (LC) and 51 normal healthy subjects.
The generated classification trees and neural networks showed similar diagnostic values in differentiating HCC from LC. The classification trees identified AFP, A1AT and albumin as the most important classification parameters, whereas the neural networks identified A2MG, AFP, A1AT and albumin as the predominant factors. The classification logic of the classification trees indicated that more HCC cases could be identified among cases with slightly elevated AFP levels by using the serum levels of A1AT and albumin. The neural networks were also useful for the identification of the HCC cases when the AFP levels were below 500 ng/ml (p < 0.005). The neural networks could identify HCC cases with AFP levels within the normal range, but the classification trees could not. By combining the conventional AFP test and the neural networks, the overall diagnostic sensitivity for HCC was significantly increased from 60.0 to 73.8% (p < 0.05) while maintaining a high specificity (88.2%). The sensitivities for tumors of different sizes were similar.
The neural network algorithm appeared to be more powerful than the classification tree algorithm in the identification of the distinctive serological liver marker profiles for the diagnosis of the HCC subgroup without significant elevation in serum AFP levels. By incorporating serological levels of other liver markers and including data from a large number of patients and control subjects, it should prove possible to develop a versatile neural network for early diagnosis of HCC.
To assess the cardiometabolic risk & arterial stiffness in Chinese women who had a previous history of pre-eclampsia (PE).
We performed a case–control study to assess 50 women with history of severe ...PE and 643 normal controls from participants in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study. All subjects underwent physical examination, 75 gram OGTT, and fasting lipid profile and assessment of Augmentation index (AI) and pulse wave velocity (PWV) of the carotid artery at 7–11years after the index pregnancy.
Women with PE have significantly higher AI (26.5±8.5 vs 17.5±8.4; p<0.001) and PWV (7.9±1.2 vs 6.4±0.7ms; p<0.001). After adjustment for confounding variables, women with PE had significant higher rates of hypertension 56.0 vs 1.4%; aOR (95% CI): 58(21–160), diabetes mellitusa 12.0 vs 0.5%; aOR (95% CI): 13(1.9–81) and metabolic syndrome 26.0 vs 4.4%; 3.5(1.4–8.8).
Women with history of PE have exceedingly high cardiometabolic risk in future and warrant a comprehensive long term evaluation and primary prevention program.
W. Tam: None. R. Ma: None. R. Ozaki: None. T. Lao: None. E. Liu: None. S. Singh: None. M. Chan: None. J. Chan: None.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
480.
189-POS Tam, Wing Hung; Ma, Ronald Ching-wan; Ozaki, Risa ...
Pregnancy hypertension,
01/2015, Volume:
5, Issue:
1
Journal Article
Objectives To assess the cardiometabolic risk & arterial stiffness in Chinese women who had a previous history of pre-eclampsia (PE). Methods We performed a case–control study to assess 50 women with ...history of severe PE and 643 normal controls from participants in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study. All subjects underwent physical examination, 75 gram OGTT, and fasting lipid profile and assessment of Augmentation index (AI) and pulse wave velocity (PWV) of the carotid artery at 7–11 years after the index pregnancy. Results Women with PE have significantly higher AI (26.5 ± 8.5 vs 17.5 ± 8.4; p < 0.001) and PWV (7.9 ± 1.2 vs 6.4 ± 0.7ms; p < 0.001). After adjustment for confounding variables, women with PE had significant higher rates of hypertension 56.0 vs 1.4%; aOR (95% CI): 58(21–160), diabetes mellitusa 12.0 vs 0.5%; aOR (95% CI): 13(1.9–81) and metabolic syndrome 26.0 vs 4.4%; 3.5(1.4–8.8). Conclusions Women with history of PE have exceedingly high cardiometabolic risk in future and warrant a comprehensive long term evaluation and primary prevention program. Disclosures W. Tam: None. R. Ma: None. R. Ozaki: None. T. Lao: None. E. Liu: None. S. Singh: None. M. Chan: None. J. Chan: None.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
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