Background Community-based intervention is an important part of palliative care for advanced cancer patients. However, its role in the health management of advanced cancer patients remains to be ...supported by medical evidence. Objective To evaluate the efficacy of community-involved hospice care for patients with advanced cancer. Methods Wanfang Data Knowledge Service Platform, CNKI, VIP were searched by using Chinese keywords such as "community" "medical model" and "advanced cancer", Cochrane Library, PubMed and Web of Science were searched by using English keywords such as "Community-based" "Model of Palliative Care" "Advanced Cancer" "Quality of Life", to obtain randomized controlled trials (RCTs) related to the efficacy of community-involved hospice care from 2007-01-01 to 2022-05-10 by using Cochrane system evaluation method on 2022-05-22. The quality of RCTs meeting the inclusion criteria was evaluated, and the valid information was extracted for meta-analysis. Results A total of 11 RCTs in English and 9
Pristine and polyethylene glycol assisted antimony tungstate (Sb2WO6) was developed via hydrothermal route. The pristine and surfactant assisted Sb2WO6 were further exemplified to reveal the ...properties of the samples. The bandgap calculated for Sb2WO6, 5 ml PEG- Sb2WO6, 10 ml PEG- Sb2WO6 was 2.78 eV, 2.66 eV and 2.21 eV. The 10 ml PEG assisted sample exhibited narrow bandgap. The Fourier transform infrared spectroscopy (FTIR) spectra of the samples showed metal vibrations and stretching of the water molecules adsorbed. The Raman spectra showed the vibrational modes present in Sb2WO6. The morphology was analyzed employing transmission electron microscope (TEM) for all samples. Pristine Sb2WO6 showed growth of nanorods with higher dimensions with high agglomeration. 5 ml PEG- Sb2WO6 showed the growth of nanorods with lesser agglomeration. 10 ml PEG assisted Sb2WO6 exhibited distinct growth of nanorods with no agglomeration on the surface. The elemental composition was examined employing X-ray Photoelectron Spectroscopy. Prepared product photocatalytic behaviour was tested employing Rhodamine B dye degrading. Different catalyst loading were investigated for degrading the toxic pollutants. 0.2 g 10 ml PEG-Sb2WO6 showed 81% efficiency on degrading the toxic pollutant from wastewater. The OH radicals are accountable for photocatalytic behaviour of prepared photocatalyst. The 10 ml PEG-Sb2WO6 has the good reusability behavior and stable properties after three cycles. The prepared 10 ml PEG- Sb2WO6 photocatalyst will be the potential candidate for the remediation of the water treatment.
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•Pristine and ethylene glycol mediated Sb2WO6 was synthesized by hydrothermal.•Sb2WO6, 5 ml PEG-Sb2WO6, 10 ml PEG-Sb2WO6 bandgap was 2.78, 2.66, 2.21 eV.•Nanorods narrow bandgap helped photocatalyst to be more active under irradiation.•10 ml PEG-Sb2WO6 exhibited 81% efficiency on degrading Rhodamine B pollutant.•10 ml PEG-Sb2WO6 sample be futuristic applicant for dye wastes remediation.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Microstructure and texture development of an AZ61 Mg alloy during equal channel angular pressing (ECAP) was investigated and correlated with the mechanical properties. The microstructure was ...effectively refined by ECAP, and the original fiber texture of the extruded AZ61 alloy was disintegrated and a new texture was gradually developed by repetitive ECAP pressing. After 8 ECAP passes following route B
c, the yield stress is lower than for the as-extruded AZ61 alloy, indicating that the texture softening is dominant over the strengthening due to grain refinement. When route A was used, on the other hand, the yield stress slightly increased after 8 passes. This result is primarily due to a difference in texture. The dominant textures after 8 passes were
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when processed by route B
c and route A, respectively. Tensile ductility increased after ECAP and the effect of ECAP on ductility is more remarkable when the initial grain size is large.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The effects of subinhibitory concentrations (sub-MICs) of antibacterial agents on the biofilm-forming ability of Staphylococcus aureus require further study.
To investigate the effects of sub-MICs of ...chlorhexidine and mupirocin on biofilm formation in clinical meticillin-resistant Staphylococcus aureus (MRSA) isolates.
MRSA isolates were collected from patients with bloodstream infections at a tertiary care hospital. The basal level of biofilm formation and biofilm induction by sub-MICs of chlorhexidine and mupirocin were evaluated by measuring biofilm mass stained with Crystal Violet.
Of the 112 MRSA isolates tested, 63 (56.3%) and 44 (39.3%) belonged to sequence type (ST)5 and ST72 lineages, respectively, which are the predominant healthcare- and community-associated clones in South Korea. ST5 isolates were more likely to have chlorhexidine MIC ≥4 (73.0% vs 29.5%), resistance to mupirocin (23.8% vs 0%), agr dysfunction (73.0% vs 9.1%), and qacA/B gene (58.7% vs 2.3%) compared to ST72 isolates. The basal level of biofilm formation ability was frequently stronger in ST72 isolates compared to ST5 isolates (77.3% vs 12.7%). Sub-MICs of chlorhexidine and mupirocin promoted biofilm formation in 56.3% and 53.6%, respectively, of all isolates. Biofilm induction was more prevalent in ST5 isolates (85.7% for chlorhexidine, 69.8% for mupirocin) than in ST72 isolates (15.9% for chlorhexidine, 27.3% for mupirocin).
Sub-MICs of chlorhexidine and mupirocin promoted biofilm formation in half of the clinical MRSA isolates. Our results suggest that ST5 MRSA biofilm can be induced together with some other bacterial virulent factors following exposure to chlorhexidine, which might confer a survival advantage to this clone in the healthcare environment.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The mammalian target of rapamycin (mTOR) is a highly conserved serine-threonine kinase activated in response to growth factors and nutrients. Because of frequent dysregulation of the mTOR signaling ...pathway in diverse human cancers, this kinase is a key therapeutic target. Redd1 is a negative regulator of mTOR, mediating dissociation of 14-3-3 from tuberous sclerosis complex (TSC)2, which allows formation of a TSC-TSC2 complex. In the present study, we identify TXNIP that inhibits mTOR activity by binding to and stabilizing Redd1 protein. Redd1 and TXNIP expression was induced by a synthetic glucose analog, 2-deoxyglucose (2-DG). Moreover, Redd1 expression in response to 2-DG was regulated by activating transcription factor 4 (ATF4). Overexpression of TXNIP was associated with reduced mTOR activity mediated by an increase in Redd1 level, whereas knockdown of TXNIP using small interfering RNA resulted in recovery of mTOR activity via downregulation of Redd1 during treatment with 2-DG. Interestingly, Redd1 was additionally stabilized via interactions with N-terminal-truncated TXNIP, leading to suppression of mTOR activity. Our results collectively demonstrate that TXNIP stabilizes Redd1 protein induced by ATF4 in response to 2-DG, resulting in potentiation of mTOR suppression. To the best of our knowledge, this is the first study to identify TXNIP as a novel member of the mTOR upstream that acts as a negative regulator in response to stress signals.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Co-precipitation assisted hydrothermal synthesis was employed to prepare Mn3O4 electrocatalysts for efficient electrochemical water oxidation. Tetragonal structure of high crystalline and pure phase ...Mn3O4 nanostructures was confirmed by X-ray diffraction (XRD) spectra. Physical characteristics such as vibration, optical and morphology of the electro catalysts were examined and confirmed by Raman spectra, Fourier Transform Infrared Spectra (FTIR), photoluminescence spectra (PL) and ultra-violet diffuse reflection spectra (UV-DRS) respectively. Mn3O4 electro catalysts were deposited on GCE electrode for investigating the electrochemical behavior. The electrochemical water splitting application was demonstrated by the prepared Mn3O4 electro catalysts in conventional three electrode cell with Hg/HgO as a reference electrode and Pt mesh as a counter electrode. Higher current density of 1.31 mA/g with lowest Tafel slope value of 63 mV/dec was achieved for the prepared electro catalyst synthesized in base pH condition. Good stability of 55% over 12 h long time was achieved for the electro catalysts in alkaline medium under continuous electrochemical reaction with good retention in performance. Hence, the controlled alkaline environmentally synthesized Mn3O4 electro catalysts prepared in this work achieved the good standard of highly efficient electrode material for electrochemical water splitting applications.
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•Controlled alkaline environment favours Mn3O4 electrocatalysts preparation.•Higher current density of 1.31 mA/g with lowest Tafel slope value of 63 mV/dec was achieved.•Good stability of 55% over 12 h long time was achieved.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
A facile synthesis of pristine and g-C3N4 loaded CdWO4 (Cadmium Tungstate) were reported and analyzed the effect of pollutants removal in wastewater. The samples were characterized and the morphology ...of the pristine sample showed the nanostructures with high cluster of layer formed. While adding PEG (Polyethylene glycol), the surface has exhibited less agglomeration and in g-C3N4 added sample the agglomeration was intensely reduced and nanostructures have been clearly found. Photocatalytic performance on cationic dye was investigated under visible light. The efficiency calculated for g–C3N4– CdWO4 sample was 85% for MB. The C/C0 plot gives better degradation. The kinetic study revealed pseudo first order reaction. The g–C3N4–CdWO4 sample exhibited higher “k” value which proved best efficiency on removing the pollutant. g–C3N4–CdWO4 sample will make better reduction on toxic pollutants and be a good candidate in futuristic applications. By carbon based derivates inclusion with photo active materials, the morphology and surface area was greatly improved and it enhances activity of host material and it will be the promising material for industrial applications.
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•Pristine and g-C3N4 loaded CdWO4 were synthesized.•PEG and g-C3N4 explored more less agglomeration.•Calculated efficiency for g–C3N4–CdWO4 was 85% for MB.•g–C3N4–CdWO4 exhibited higher “k” value and proved best pollutant removing efficiency.•g–C3N4–CdWO4 revealed better reduction on toxic pollutants.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Sugar is an indispensable source of energy for plant growth and development, and it requires the participation of sugar transporter proteins (STPs) for crossing the hydrophobic barrier in plants. ...Here, we systematically identified the genes encoding sugar transporters in the genome of maize (Zea mays L.), analyzed their expression patterns under different conditions, and determined their functions in disease resistance. The results showed that the mazie sugar transporter family contained 24 members, all of which were predicted to be distributed on the cell membrane and had a highly conserved transmembrane transport domain. The tissue-specific expression of the maize sugar transporter genes was analyzed, and the expression level of these genes was found to be significantly different in different tissues. The analysis of biotic and abiotic stress data showed that the expression levels of the sugar transporter genes changed significantly under different stress factors. The expression levels of ZmSTP2 and ZmSTP20 continued to increase following Fusarium graminearum infection. By performing disease resistance analysis of zmstp2 and zmstp20 mutants, we found that after inoculation with Cochliobolus carbonum, Setosphaeria turcica, Cochliobolus heterostrophus, and F. graminearum, the lesion area of the mutants was significantly higher than that of the wild-type B73 plant. In this study, the genes encoding sugar transporters in maize were systematically identified and analyzed at the whole genome level. The expression patterns of the sugar transporter-encoding genes in different tissues of maize and under biotic and abiotic stresses were revealed, which laid an important theoretical foundation for further elucidation of their functions.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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