DL-Homocysteic acid (DLH, (NH3 )-CH(COOH)-(CH2 )2-SO3-) is extensively in existence as free amino-acid in the central nervous system of mammal. The infrared (IR) and Raman spectra of DL-Homocysteic ...acid (DLH) and its La complex La (DLH)2Cl3 . H2O = LaL2 were measured at high external pressure. The DLH has two pressure-induced phase transitions (near 17 kbar and 37 kbar) and three pressure-phase areas below 50 kbar for there are ten intermolecular hydrogen bonds between the DLH molecules. But there is only one pressure-induced phase transition (near 27 kbar) to be observed in the complex LaL2. These show that the ten intermolecular hydrogen bonds of the DLH molecules changed due to the formation of complex LaL2. In infrared spectra, the changing trend of the pressure sensitivities (dv/dp) of symmetry stretching of SO3- in DLH and asymmetry stretching of SO3- in LaL2 are very different from the other vibrational modes when both compounds undergo high external pressure. In infrared spectra, the average pressur
The bone is a common site for metastasis in hepatocellular carcinoma (HCC). However, bone marrow metastasis from HCC is rarely reported, and its frequency is unclear. Here we report a rare case of ...bone marrow metastasis that presented as bicytopenia originating from HCC without bone metastasis. A 58-year-old man was admitted for investigation of a liver mass with extensive lymph node enlargement that was detected when examining his general weakness and weight loss. Laboratory findings revealed anemia, thrombocytopenia, mild elevated liver enzymes, normal prothrombin time percentage and high levels of tumor markers (α-fetoprotein and des-γ-carboxyprothrombin). Abdominal computed tomography showed multiple enhanced masses in the liver and multiple enlarged lymph nodes in the abdomen. A bone marrow biopsy revealed only a few normal hematopoietic cells and abundant tumor cells. Despite its rarity, bone marrow metastasis should always be suspected in HCC patients even if accompanied by cirrhosis.
Although three-dimensional (3D) bioprinting technology has gained much attention in the field of tissue engineering, there are still several significant engineering challenges to overcome, including ...lack of bioink with biocompatibility and printability. Here, we show a bioink created from silk fibroin (SF) for digital light processing (DLP) 3D bioprinting in tissue engineering applications. The SF-based bioink (Sil-MA) was produced by a methacrylation process using glycidyl methacrylate (GMA) during the fabrication of SF solution. The mechanical and rheological properties of Sil-MA hydrogel proved to be outstanding in experimental testing and can be modulated by varying the Sil-MA contents. This Sil-MA bioink allowed us to build highly complex organ structures, including the heart, vessel, brain, trachea and ear with excellent structural stability and reliable biocompatibility. Sil-MA bioink is well-suited for use in DLP printing process and could be applied to tissue and organ engineering depending on the specific biological requirements.
BACKGROUND AND PURPOSEThe safety and efficacy of tirofiban during endovascular therapy in patients undergoing intravenous thrombolysis with recombinant IV tPA remain unclear. This study aimed to ...investigate the safety and efficacy of intra-arterial tirofiban use during endovascular therapy in patients treated with IV tPA. MATERIALS AND METHODSUsing a multicenter registry, we enrolled patients with acute ischemic stroke who underwent endovascular therapy. Safety outcomes included postprocedural parenchymal hematoma type 2 and/or thick subarachnoid hemorrhage, intraventricular hemorrhage, and 3-month mortality. Efficacy outcomes included the successful reperfusion rate, postprocedural reocclusion, and good outcomes at 3 months (mRS scores of 0-2). The tirofiban effect on the outcomes was evaluated using a multivariable analysis while adjusting for potential confounders. RESULTSAmong enrolled patients, we identified 314 patients with stroke (279 and 35 patients in the no tirofiban and tirofiban groups, respectively) due to an intracranial artery occlusion who underwent endovascular therapy with intravenous thrombolysis. A multivariable analysis revealed no association of intra-arterial tirofiban with postprocedural parenchymal hematoma type and/or thick subarachnoid hemorrhage (adjusted OR, 1.07; 95% CI, 0.20-4.10; P = .918), intraventricular hemorrhage (adjusted OR, 0.43; 95% CI, 0.02-2.85; P = .467), and 3-month mortality (adjusted OR, 0.38; 95% CI, 0.04-1.87; P = .299). Intra-arterial tirofiban was not associated with good outcome (adjusted OR, 2.22; 95% CI, 0.89 -6.12; P = .099). CONCLUSIONSUsing intra-arterial tirofiban during endovascular therapy after IV tPA could be safe.
Composite films with silver nanoparticles (AgNPs), obtained by reduction of AgNO3 using an environmentally friendly method (combined reduction of AgNO3 by trisodium citrate solution and heating), and ...agar as a polymer matrix and a capping agent were prepared by solvent casting method. The surface color of the resulting agar/AgNPs films exhibited the characteristic plasmonic effect of the silver nanoparticles, and the characteristic properties of the composite films were greatly influenced by changing the concentration of AgNPs added. Significant increase in water vapor barrier properties and surface hydrophobicity were observed with increase in the concentration of AgNPs without reduction in the mechanical strength. In addition, the agar/AgNPs films loaded with more than 1 wt% of silver nanoparticles exhibited strong antimicrobial activity against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli O157:H7) bacterial pathogens.
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•Agar/silver nanoparticle composite films were prepared by reduction of AgNO3.•Film properties were dependent on the concentration of silver nanoparticles.•The composite film exhibited improved water vapor, gas barrier and mechanical properties.•The composite film with 1 and 2% of AgNPs showed strong antimicrobial activity.•The film can be potentially used as active packaging systems for preserving food quality and extending the shelf life.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Pristine and Ce doped TiO2 nanoparticles were fabricated for toxic pollutants removal from wastewater. Pristine, 2% Ce and 4% Ce doped TiO2 photocatalysts were produced via hydrothermal route. 4% Ce ...doped TiO2 exhibited 2.41 eV bandgap which is smaller than pure TiO2. The morphology was also investigated and it was established that doping of Ce ions enhanced the surface roughness and reduced the particle size. The surface area was characterized through BET analysis and 4% Ce–TiO2 possess higher surface with large pore diameter which helped the photocatalytic activity. The prepared photocatalysts were investigated on reduction of pollutants from wastewater under visible light. Higher efficiency was obtained for 4% Ce–TiO2 photocatalyst for both model pollutants. The “k” value possessed was also higher for the doped TiO2 catalyst. These analysis reports the optimum level of ceria doping to enhance morphology, surface area and it increased activity than bare TiO2. 4% Ce–TiO2 will be the potential candidate for efficient wastewater management. The 4% Ce doped TiO2 photocatalyst provided 77% and 88% on reducing MB and RhB dyes. The dopant has developed higher surface area, morphology and good recombination rate which reduced the toxic pollutants and changed the wastewater to reuse.
•4% Ce–TiO2 possess higher surface with large pore diameter.•4% Ce–TiO2 explored higher efficiency for both model pollutants.•The “k” value possessed was also higher for the doped TiO2 catalyst.•4% Ce–TiO2 will be the potential candidate for efficient wastewater management.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
A supercapacitor is an efficient energy storage system that acts as an excellent booster to deliver high power density required for batteries and fuel cells. Recently, composite material–based ...supercapacitors have attracted much more interest as promising greener and more capable candidates in energy-saving use. In this work, samarium cobalt oxide–decorated reduced graphene oxide (SmCoO3/rGO) was prepared employing solvothermal route and used as reliable electrode material. The maximum specific capacity achieved was 30.80 mAh/g for 1 A/g of SmCoO3/rGO nanocomposite with capacity retention of 86.95%@5A/g over 5000 charge discharge cycles. Better electrochemical performance of samarium and reduced graphene oxide nanostructures prevent the transfer of electrons through electrochemical active sites, creating electronic and structural diversity of electro active material. In addition, SmCoO3/rGO/AC hybrid supercapacitor device that delivered good energy and power density of 52 W h/kg and 752 W/kg at 1 A/g was designed. 74.28% capacitive retention and 98.26% coulombic efficiency was maintained over 15,000 cycles.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Carbon‐nanotube‐reinforced Cu matrix nanocomposites have been fabricated by molecular‐level mixing of functionalized carbon nanotubes (CNTs) with Cu ions, followed by spark plasma sintering. The ...compressive strengths and Young's moduli of CNT‐reinforced nanocomposites are considerably higher than those of the Cu matrix due to the homogeneously dispersed CNTs embedded in the Cu matrix (see Figure).
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Abstract
The growth in energy devices and the role of supercapacitors are increasingly important in today’s world. Designing an electrode material for supercapacitors using metals that have high ...performance, superior structure, are eco-friendly, inexpensive and highly abundant is essentially required for commercialization. In this point of view, quaternary chalcogenide Cu
2
NiSnS
4
with fascinating marigold flower like microstructured electrodes are synthesized using different concentrations of citric acid (0, 0.05 M, 0.1 M and 0.2 M) by employing solvothermal method. The electrode materials physicochemical characteristics are deliberated in detail using the basic characterization techniques. The electrochemical studies revealed better electrochemical performances, in particular, Cu
2
NiSnS
4
@0.1 M-CA electrode revealed high 1029 F/g specific capacitance at 0.5 A/g current density. Further, it retained 78.65% capacity over 5000 cycles. To prove the practical applicability, a full-cell asymmetric solid-state device is fabricated, and it delivered 41.25 Wh/Kg and 750 Wh/Kg energy and power density at 0.5 A/g. The optimum citric acid added Cu
2
NiSnS
4
electrode is shown to be a promising candidate for supercapacitor applications.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
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