Driven by the recent improvement in additive manufacturing technologies, we designed a detector that can be fully printed with a standard and commercial 3D printer. The main goals of this research ...concern the marginal design and construction costs, the reproducibility/modularity of the products, and the reduced assembly time. During the first phase of this research, after determining the most suitable material, we produced 10 examples of detectors.
Recent genome-wide (GW) scans have identified several independent loci affecting human stature, but their contribution through the different skeletal components of height is still poorly understood. ...We carried out a genome-wide scan in 12,611 participants, followed by replication in an additional 7,187 individuals, and identified 17 genomic regions with GW-significant association with height. Of these, two are entirely novel (rs11809207 in CATSPER4, combined P-value = 6.1×10-8 and rs910316 in TMED10, P-value = 1.4×10-7) and two had previously been described with weak statistical support (rs10472828 in NPR3, P-value = 3×10-7 and rs849141 in JAZF1, P-value = 3.2×10-11). One locus (rs1182188 at GNA12) identifies the first height eQTL. We also assessed the contribution of height loci to the upper- (trunk) and lower-body (hip axis and femur) skeletal components of height. We find evidence for several loci associated with trunk length (including rs6570507 in GPR126, P-value = 4×10-5 and rs6817306 in LCORL, P-value = 4×10-4), hip axis length (including rs6830062 at LCORL, P-value = 4.8×10-4 and rs4911494 at UQCC, P-value = 1.9×10-4), and femur length (including rs710841 at PRKG2, P-value = 2.4×10-5 and rs10946808 at HIST1H1D, P-value = 6.4×10-6). Finally, we used conditional analyses to explore a possible differential contribution of the height loci to these different skeletal size measurements. In addition to validating four novel loci controlling adult stature, our study represents the first effort to assess the contribution of genetic loci to three skeletal components of height. Further statistical tests in larger numbers of individuals will be required to verify if the height loci affect height preferentially through these subcomponents of height.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Piezoelectric micromachined ultrasonic transducers (PMUTs) have the potential for broad bandwidth, thus enabling high resolution imaging. However, previous PMUTs had fractional bandwidths of only ...~50% or smaller because of the thick multilayer PMUT structure. Here, we demonstrate broadband PZT PMUTs that achieve a 97% fractional bandwidth by utilizing a thinner structure excited at two adjacent mechanical vibration modes. PMUTs were fabricated and characterized in the mechanical, electrical and acoustic domains, and a 30 μm × 200 μm ribbon PMUT demonstrates a large displacement sensitivity of 500 nm/V in air and pressure response of 0.3 kPa/V in fluid, equivalent to 13.6 kPa/V average pressure on the PMUT surface, measured 1.4 mm away from the PMUT.
Theoretical predictions of the proton--neutron mass difference and measurements of the proton's charge radius require inputs from the Compton amplitude subtraction function. Model-dependent and ...non-relativistic calculations of this subtraction function vary significantly, and hence it contributes sizeable uncertainties to the aforementioned physical quantities. We report on the use of Feynman-Hellmann methods in lattice QCD to calculate the subtraction function from first principles. In particular, our initial results show anomalous high-energy behaviour that is at odds with the prediction from the operator product expansion (OPE). Therefore, we investigate the possibility that this unexpected behaviour is due to lattice artifacts, by varying the lattice spacing and volume, and comparing different discretisations of the vector current. Finally, we explore a Feynman-Hellmann implementation that is less sensitive to short-distance contributions and show that the subtraction function's anomalous behaviour can be attributed to these short-distance contributions. As such, this work represents the first steps in achieving a complete understanding of the Compton amplitude subtraction function.
Lattice determination of Sigma-Lambda mixing Horsley, R.; Najjar, J.; Nakamura, Y. ...
Physical review. D, Particles, fields, gravitation, and cosmology,
04/2015, Volume:
91, Issue:
7
Journal Article
Open access
Isospin breaking effects in baryon octet (and decuplet) masses are due to a combination of up and down quark mass differences and electromagnetic effects and lead to small mass splittings. Between ...the Sigma and Lambda this mass splitting is much larger, this being mostly due to their different wave functions. However when isospin is broken, there is a mixing between these states. We describe the formalism necessary to determine the QCD mixing matrix and hence find the mixing angle and mass splitting between the Sigma and Lambda particles due to QCD effects.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
This paper presents recent lattice QCD calculations of transverse spin densities of quarks in hadrons.
2
2
This contribution is based on Refs. M. Göckeler, et al., Phys. Rev. Lett. 98 (2007) 222001; ...D. Brömmel, et al., QCDSF Collaboration.
arXiv:hep-lat/0708.2249.
Based on our simulation results for the tensor generalized form factors, we find substantial correlations between spin and coordinate degrees of freedom in the nucleon and the pion. They lead to strongly distorted transverse spin densities of quarks in the nucleon and a surprisingly non-trivial transverse spin structure of the pion. Following recent arguments by Burkardt M. Burkardt, Phys. Rev. D 72 (2005) 094020, our results imply that the Boer–Mulders function
h
1
⊥
, describing correlations of the transverse spin and intrinsic transverse momentum of quarks, is large and negative for up-quarks in the proton and the
π
+
. This supports the recent hypothesis that all Boer–Mulders functions are alike
arXiv:0705.1573, and also provides additional motivation for future studies of azimuthal asymmetries in
π
p
Drell-Yan production at, e.g., COMPASS.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Fifty consecutive patients who underwent 52 formal hepatic resections (excluding isolated wedge resections) for metastatic colorectal cancer were analyzed to determine whether DNA content was of ...prognostic significance. The Dukes' stages of the colorectal primaries were: A (10%), B (20%), C (40%), D (28%), and unknown in 2%. Four patients whose liver metastases were discovered at the time of resection of the primary bowel cancer underwent concomitant liver resection, and the remaining patients underwent delayed resections. The hepatic resections performed were right lobectomy (50%), extended right lobectomy (19%), left lobectomy (13%), left lateral segmentectomy (6%), left lobectomy and right wedge (6%), extended left lobectomy (4%), and right lobectomy and left wedge (2%). The overall morbidity rate was 29%. The in-hospital mortality rate was 9%. As of November 1991, 36 patients have recurred. The 5-year actuarial survival was 28%. Flow cytometry could be performed on 37 archival specimens, 15 of which were found to be diploid whereas 22 were aneuploid. All metastases from Dukes A colorectal primaries demonstrated a diploid DNA content. In addition, there was no difference in actuarial survival between diploid and aneuploid tumors. These data suggest that in selected patients, formal hepatic resection of colorectal liver metastases can be performed with an acceptable morbidity rate, mortality rate, and survival, but ploidy of the resected tumor is not of prognostic significance.
We report a deletion of 1p36.3 in a child with microcephaly, mental retardation, broad forehead, deep set eyes, depressed nasal bridge, flat midface, relative prognathism, and abnormal ears. The ...phenotype is consistent with that described for partial monosomy for 1p36.3. Reverse chromosome painting and microsatellite and Southern blot analyses were used to map the extent of the deletion. Fluorescence in situ hybridisation (FISH) analysis using probes from every telomere indicates that the rearrangement is likely to be a chromosomal truncation or rearrangement involving subtelomeric repetitive DNA. The deletion was identified by screening a sample of children and adults with idiopathic mental retardation. In conjunction with previous work on this sample, we estimate that 7.4% of the group have subtelomeric rearrangements.
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