Microbial communities associated with animals exert powerful influences on host physiology, regulating metabolism and immune function, as well as complex host behaviors. The importance of ...host-microbiome interactions for maintaining homeostasis and promoting health raises evolutionarily complicated questions about how animals and their microbiomes have coevolved, and how these relationships affect the ways that animals interact with their environment. Here, we review the literature on the contributions of host factors to microbial community structure and corresponding influences of microbiomes on emergent host phenotypes. We focus in particular on animal behaviors as a basis for understanding potential roles for the microbiome in shaping host neurobiology.
The gut microbiome is increasingly implicated in modifying susceptibility to and progression of neurodegenerative diseases (NDs). In this review, we discuss roles for the microbiome in aging and in ...NDs. In particular, we summarize findings from human studies on microbiome alterations in Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, and Huntington's disease. We assess animal studies of genetic and environmental models for NDs that investigate how manipulations of the microbiome causally impact the development of behavioral and neuropathological endophenotypes of disease. We additionally evaluate the likely immunological, neuronal, and metabolic mechanisms for how the gut microbiota may modulate risk for NDs. Finally, we speculate on cross-cutting features for microbial influences across multiple NDs and consider the potential for microbiome-targeted interventions for NDs.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Abstract
The Type Ia supernova (SN Ia) LSQ14fmg exhibits exaggerated properties that may help to reveal the origin of the “super-Chandrasekhar” (or 03fg-like) group. The optical spectrum is typical ...of a 03fg-like SN Ia, but the light curves are unlike those of any SNe Ia observed. The light curves of LSQ14fmg rise extremely slowly. At −23 rest-frame days relative to
B
-band maximum, LSQ14fmg is already brighter than
mag before host extinction correction. The observed color curves show a flat evolution from the earliest observation to approximately 1 week after maximum. The near-infrared light curves peak brighter than −20.5 mag in the
J
and
H
bands, far more luminous than any 03fg-like SNe Ia with near-infrared observations. At 1 month past maximum, the optical light curves decline rapidly. The early, slow rise and flat color evolution are interpreted to result from an additional excess flux from a power source other than the radioactive decay of the synthesized
56
Ni. The excess flux matches the interaction with a typical superwind of an asymptotic giant branch (AGB) star in density structure, mass-loss rate, and duration. The rapid decline starting at around 1 month past
B
-band maximum may be an indication of rapid cooling by active carbon monoxide (CO) formation, which requires a low-temperature and high-density environment. These peculiarities point to an AGB progenitor near the end of its evolution and the core degenerate scenario as the likely explosion mechanism for LSQ14fmg.
Host-associated microbiomes are emerging as important modifiers of brain activity and behavior. Metabolic, immune, and neuronal pathways are proposed to mediate communication across the so-called ...microbiota-gut-brain axis. However, strong mechanistic evidence, especially for direct signaling between microbes and sensory neurons, is lacking. Here, we discuss microbial regulation of short-chain fatty acids, neurotransmitters, as-yet-uncharacterized biochemicals, and derivatives of neuromodulatory drugs as important areas for assessing microbial interactions with the nervous system.
While microbiomes are emerging as important modifiers of neurophysiology and behavior, pathways for microbial modulation of neuronal activity are poorly understood. Jameson et al. discuss microbial interactions with dietary molecules, neurotransmitters, uncharacterized biochemicals, and neuromodulatory drugs as important areas for continued research toward uncovering mechanisms for microbial signaling to neurons.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
SN 2014J in M82 is the closest detected Type Ia supernova (SN Ia) in at least 28 yr and perhaps in 410 yr. Despite its small distance of 3.3 Mpc, SN 2014J is surprisingly faint, peaking at ...V = 10.6 mag, and assuming a typical SN Ia luminosity, we infer an observed visual extinction of A
V
= 2.0 ± 0.1 mag. But this picture, with R
V
= 1.6 ± 0.2, is too simple to account for all observations. We combine 10 epochs (spanning a month) of HST/Space Telescope Imaging Spectrograph (STIS) ultraviolet through near-infrared spectroscopy with HST/Wide Field Camera 3 (WFC3), Katzman Automatic Imaging Telescope, and FanCam photometry from the optical to the infrared and nine epochs of high-resolution TRES (Tillinghast Reflection Echelle Spectrograph) spectroscopy to investigate the sources of extinction and reddening for SN 2014J. We argue that the wide range of observed properties for SN 2014J is caused by a combination of dust reddening, likely originating in the interstellar medium of M82, and scattering off circumstellar material. For this model, roughly half of the extinction is caused by reddening from typical dust (E(B − V) = 0.45 mag and R
V
= 2.6) and roughly half by scattering off Large Magellanic Cloud-like dust in the circumstellar environment of SN 2014J.
We study the optical light curve (LC) relations of Type Ia supernovae (SNe Ia) for their use in cosmology using high-quality photometry published by the Carnegie Supernova Project (CSP-I). We revisit ...the classical luminosity decline rate (Δm15) relation and the Lira relation, as well as investigate the time evolution of the (B − V) color and B(B − V), which serves as the basis of the color-stretch relation and Color-MAgnitude Intercept Calibrations (CMAGIC). Our analysis is based on explosion and radiation transport simulations for spherically symmetric delayed-detonation models (DDT) producing normal-bright and subluminous SNe Ia. Empirical LC relations can be understood as having the same physical underpinnings, i.e., opacities, ionization balances in the photosphere, and radioactive energy deposition changing with time from below to above the photosphere. Some three to four weeks past maximum, the photosphere recedes to 56Ni-rich layers of similar density structure, leading to a similar color evolution. An important secondary parameter is the central density c of the WD because at higher densities, more electron-capture elements are produced at the expense of 56Ni production. This results in a Δm15 spread of 0.1 mag in normal-bright and 0.7 mag in subluminous SNe Ia and 0.2 mag in the Lira relation. We show why color-magnitude diagrams emphasize the transition between physical regimes and enable the construction of templates that depend mostly on Δm15 with little dispersion in both the CSP-I sample and our DDT models. This allows intrinsic SN Ia variations to be separated from the interstellar reddening characterized by E(B − V) and RB. Invoking different scenarios causes a wide spread in empirical relations, which may suggest one dominant scenario.
We present ultraviolet (UV) observations of six nearby Type Ia supernovae (SNe Ia) obtained with the Hubble Space Telescope, three of which were also observed in the near-IR (NIR) with Wide-Field ...Camera 3. UV observations with the Swift satellite, as well as ground-based optical and NIR data provide complementary information. The combined data set covers the wavelength range 0.2–2 μm. By also including archival data of SN 2014J, we analyse a sample spanning observed colour excesses up to E(B − V) = 1.4 mag. We study the wavelength-dependent extinction of each individual SN and find a diversity of reddening laws when characterized by the total-to-selective extinction R
V
. In particular, we note that for the two SNe with E(B − V) ≳ 1 mag, for which the colour excess is dominated by dust extinction, we find R
V
= 1.4 ± 0.1 and R
V
= 2.8 ± 0.1. Adding UV photometry reduces the uncertainty of fitted R
V
by ∼50 per cent allowing us to also measure R
V
of individual low-extinction objects which point to a similar diversity, currently not accounted for in the analyses when SNe Ia are used for studying the expansion history of the Universe.
We present a comprehensive set of optical and near-infrared (NIR) photometric and spectroscopic observations for SN 2014ck, extending from pre-maximum to six months later. These data indicate that SN ...2014ck is photometrically nearly identical to SN 2002cx, which is the prototype of the class of peculiar transients named SNe Iax. Similar to SN 2002cx, SN 2014ck reached a peak brightness M
B = −17.37 ± 0.15 mag, with a post-maximum decline rate Δm
15(B) = 1.76 ± 0.15 mag. However, the spectroscopic sequence shows similarities with SN 2008ha, which was three magnitudes fainter and faster declining. In particular, SN 2014ck exhibits extremely low ejecta velocities, ∼3000 km s−1 at maximum, which are close to the value measured for SN 2008ha and half the value inferred for SN 2002cx. The bolometric light curve of SN 2014ck is consistent with the production of
$0.10^{+0.04}_{-0.03} \,\mathrm{M}_{{\odot }}$
of 56Ni. The spectral identification of several iron-peak features, in particular Co ii lines in the NIR, provides a clear link to SNe Ia. Also, the detection of narrow Si, S and C features in the pre-maximum spectra suggests a thermonuclear explosion mechanism. The late-phase spectra show a complex overlap of both permitted and forbidden Fe, Ca and Co lines. The appearance of strong Ca ii λλ7292, 7324 again mirrors the late-time spectra of SN 2008ha and SN 2002cx. The photometric resemblance to SN 2002cx and the spectral similarities to SN 2008ha highlight the peculiarity of SN 2014ck, and the complexity and heterogeneity of the SNe Iax class.
Abstract
We present and analyze a near-infrared (NIR) spectrum of the underluminous Type Ia supernova SN 2020qxp/ASASSN-20jq obtained with NIRES at the Keck Observatory, 191 days after
B
-band ...maximum. The spectrum is dominated by a number of broad emission features, including the Fe
ii
at 1.644
μ
m, which is highly asymmetric with a tilted top and a peak redshifted by ≈2000 km s
−1
. In comparison with 2D non-LTE synthetic spectra computed from 3D simulations of off-center delayed-detonation Chandrasekhar-mass (
M
ch
) white dwarf (WD) models, we find good agreement between the observed lines and the synthetic profiles, and are able to unravel the structure of the progenitor’s envelope. We find that the size and tilt of the Fe
ii
1.644
μ
m profile (in velocity space) is an effective way to determine the location of an off-center delayed-detonation transition (DDT) and the viewing angle, and it requires a WD with a high central density of ∼4 × 10
9
g cm
−3
. We also tentatively identify a stable Ni feature around 1.9
μ
m characterized by a “pot-belly” profile that is slightly offset with respect to the kinematic center. In the case of SN 2020qxp/ASASSN-20jq, we estimate that the location of the DDT is ∼0.3
M
WD
off center, which gives rise to an asymmetric distribution of the underlying ejecta. We also demonstrate that low-luminosity and high-density WD SN Ia progenitors exhibit a very strong overlap of Ca and
56
Ni in physical space. This results in the formation of a prevalent Ca
ii
0.73
μ
m emission feature that is sensitive to asymmetry effects. Our findings are discussed within the context of alternative scenarios, including off-center C/O detonations in He-triggered sub-
M
Ch
WDs and the direct collision of two WDs. Snapshot programs with Gemini/Keck/Very Large Telescope (VLT)/ELT-class instruments and our spectropolarimetry program are complementary to mid-IR spectra by the James Webb Space Telescope (JWST).
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