Chemical modification of phenothiazine‐benzophenone derivatives tunes the emission behavior from triplet states by selecting the geometry of the intramolecular charge transfer (ICT) state. A ...fundamental principle of planar ICT (PICT) and twisted ICT (TICT) is demonstrated to obtain selectively either room temperature phosphorescence (RTP) or thermally activated delayed fluorescence (TADF), respectively. Time‐resolved spectroscopy and time‐dependent density functional theory (TD‐DFT) investigations on polymorphic single crystals demonstrate the roles of PICT and TICT states in the underlying photophysics. This has resulted in a RTP molecule OPM, where the triplet states contribute with 89 % of the luminescence, and an isomeric TADF molecule OMP, where the triplet states contribute with 95 % of the luminescence.
Rapid and efficient utilization of triplet states to generate room temperature phosphorescence (RTP) or highly efficient thermally activated delayed fluorescence (TADF) is achieved by structural modification to give a planar or twisted intramolecular charge transfer (PICT or TICT) geometry, respectively.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Integration of light and phytohormones is essential for plant growth and development. FAR-RED INSENSITIVE 219 (FIN219)/JASMONATE RESISTANT 1 (JAR1) participates in phytochrome A (phyA)-mediated ...far-red (FR) light signaling in Arabidopsis and is a jasmonate (JA)-conjugating enzyme for the generation of an active JA-isoleucine. Accumulating evidence indicates that FR and JA signaling integrate with each other. However, the molecular mechanisms underlying their interaction remain largely unknown. Here, the phyA mutant was hypersensitive to JA. The double mutant fin219-2phyA-211 showed a synergistic effect on seedling development under FR light. Further evidence revealed that FIN219 and phyA antagonized with each other in a mutually functional demand to modulate hypocotyl elongation and expression of light- and JA-responsive genes. Moreover, FIN219 interacted with phyA under prolonged FR light, and MeJA could enhance their interaction with CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) in the dark and FR light. FIN219 and phyA interaction occurred mainly in the cytoplasm, and they regulated their mutual subcellular localization under FR light. Surprisingly, the fin219-2 mutant abolished the formation of phyA nuclear bodies under FR light. Overall, these data identified a vital mechanism of phyA-FIN219-COP1 association in response to FR light, and MeJA may allow the photoactivated phyA to trigger photomorphogenic responses.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
In this study, the measured accelerations of a single smartphone were used to provide an earthquake early warning system. In the presented system, after the smartphone is triggered, the triggering ...event is then classified as an earthquake event or not. Once an earthquake event is detected, the peak ground acceleration is then predicted every second until 10 s after the trigger. These predictions are made by the neural network classifier and predictor embedded in the smartphone, and an alert can be issued if a large peak ground acceleration is predicted. The proposed system is unique among approaches that use crowdsourcing ideas for earthquake early warning because the proposed system provides on-site earthquake early warning. In general, the accuracy rates of the earthquake classifications and peak ground acceleration predictions of the system were quite high according to the results of large amounts of earthquake and non-earthquake data. More specifically, according to said earthquake data, 96.9% of the issued alerts would be correct and 61.9% of the earthquakes that exceeded the threshold would have resulted in an alert being issued before the arrival of the peak ground acceleration. Among the false negative cases, approximate 97.8% would occur because of negative lead time. Using the shake table tests of worldwide and Meinong earthquake datasets, the proposed approach is confirmed to be quite promising.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Computer vision-based approaches are very useful for dynamic displacement measurement, damage detection, and structural health monitoring. However, for the application using a large number of ...existing cameras in buildings, the computational cost of videos from dozens of cameras using a centralized computer becomes a huge burden. Moreover, when a manual process is required for processing the videos, prompt safety assessment of tens of thousands of buildings after a catastrophic earthquake striking a megacity becomes very challenging. Therefore, a decentralized and fully automatic computer vision-based approach for prompt building safety assessment and decision-making is desired for practical applications. In this study, a prototype of a novel stand-alone smart camera system for measuring interstory drifts was developed. The proposed system is composed of a single camera, a single-board computer, and two accelerometers with a microcontroller unit. The system is capable of compensating for rotational effects of the camera during earthquake excitations. Furthermore, by fusing the camera-based interstory drifts with the accelerometer-based ones, the interstory drifts can be measured accurately even when residual interstory drifts exist. Algorithms used to compensate for the camera’s rotational effects, algorithms used to track the movement of three targets within three regions of interest, artificial neural networks used to convert the interstory drifts to engineering units, and some necessary signal processing algorithms, including interpolation, cross-correlation, and filtering algorithms, were embedded in the smart camera system. As a result, online processing of the video data and acceleration data using decentralized computational resources is achieved in each individual smart camera system to obtain interstory drifts. Using the maximum interstory drifts measured during an earthquake, the safety of a building can be assessed right after the earthquake excitation. We validated the feasibility of the prototype of the proposed smart camera system through the use of large-scale shaking table tests of a steel building. The results show that the proposed smart camera system had very promising results in terms of assessing the safety of steel building specimens after earthquake excitations.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Typhoid toxin is an essential virulence factor for
Typhi, the cause of typhoid fever in humans. This toxin has an unusual biology in that it is produced by
Typhi only when located within host cells. ...Once synthesized, the toxin is secreted to the lumen of the
-containing vacuole from where it is transported to the extracellular space by vesicle carrier intermediates. Here, we report the identification of the typhoid toxin sorting receptor and components of the cellular machinery that packages the toxin into vesicle carriers, and exports it to the extracellular space. We found that the cation-independent mannose-6-phosphate receptor serves as typhoid toxin sorting receptor and that the coat protein COPII and the GTPase Sar1 mediate its packaging into vesicle carriers. Formation of the typhoid toxin carriers requires the specific environment of the
Typhi-containing vacuole, which is determined by the activities of specific effectors of its type III protein secretion systems. We also found that Rab11B and its interacting protein Rip11 control the intracellular transport of the typhoid toxin carriers, and the SNARE proteins VAMP7, SNAP23, and Syntaxin 4 their fusion to the plasma membrane. Typhoid toxin's cooption of specific cellular machinery for its transport to the extracellular space illustrates the remarkable adaptation of an exotoxin to exert its function in the context of an intracellular pathogen.
The earthquake early warning (EEW)-research group at National Taiwan University has been developing a microelectromechanical system-based accelerometer called "P-Alert", designed for issuing EEWs. ...The main advantage of P-Alert is that it is a relatively economical seismometer. However, because of the expensive nature of commercial hardware for structural health monitoring (SHM) systems, the application of SHM to buildings remains limited. To determine the performance of P-Alert for evaluating post-earthquake building safety, we conducted a series of steel-frame shaking table tests with incremental damage. We used the fragility curves of different damage levels and the interstory drift ratios (calculated by the measured acceleration of each story using double integration and a filter) to gauge the potential damage levels. We concluded that the acceptable detection of damage for an entire building is possible. With improvements to the synchronization of the P-Alert sensors, we also anticipate a damage localization feature for the stories of a building.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
This study estimates the association between sarcopenia and blood biochemical parameters, nutritional intake, anthropometric measurements, physical performance, and physical activity in patients with ...type 2 diabetes mellitus (T2DM). Participants were recruited from a primary care clinic in Kaohsiung City. According to the diagnosis criteria of the Asian Working Group for Sarcopenia (AWGS) in 2019, 110 patients with T2DM (aged 50–80 years) were divided into three groups: non-sarcopenia (n = 38), possible sarcopenia (n = 31), and sarcopenia (n = 41). Blood samples were collected, and nutritional intake was evaluated by a registered dietitian. A food frequency questionnaire and a Godin leisure-time exercise questionnaire were used to assess their daily vitamin D intake and physical activity. There were significant differences in age, serum vitamin D levels, nutritional intake, anthropometric measurements, and physical performance between the three groups. In elderly patients with T2DM, reduced serum 25-hydroxyvitamin D 25(OH)D levels and daily energy intake were significantly associated with possible sarcopenia. Age, lower BMI, reduced serum 25(OH)D, and reduced dietary protein and vitamin D intake were significantly associated with sarcopenia. These findings may serve as the basis for intervention trials to reduce the prevalence of sarcopenia.
A simple and versatile route for modifying picolinate ligands coordinated to iridium is described. Reacting a μ-chloro iridium(C∧N) dimer (where C∧N is a phenylpyridine-based ligand) with ...bromopicolinic acid (HpicBr) yields the corresponding iridium(C∧N)2(picBr) complexes (1–4 and 11), which were readily modified by a Sonogashira reaction to give eight alkyne-substituted picolinate complexes (5–10, 12, and 13). The luminescent behavior of these complexes shows that the position of substitution about the picolinate ring has an effect on both photophysical behavior as well as the reactivity.
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IJS, KILJ, NUK, PNG, UL, UM
The potential of intramolecular π-π interactions to influence the photophysical properties of diiridium complexes is an unexplored topic, and provides the motivation for the present study. A series ...of diarylhydrazide-bridged diiridium complexes functionalised with phenylpyridine (ppy)-based cyclometalating ligands is reported. It is shown by NMR studies in solution and single crystal X-ray analysis that intramolecular π-π interactions between the bridging and cyclometalating ligands rigidify the complexes leading to high luminescence quantum efficiencies in solution and in doped films. Fluorine substituents on the phenyl rings of the bridge promote the intramolecular π-π interactions. Notably, these non-covalent interactions are harnessed in the rational design and synthesis of the first examples of highly emissive sky-blue diiridium complexes featuring conjugated bridging ligands, for which they play a vital role in the structural and photophysical properties. Experimental results are supported by computational studies.
The structural health monitoring of power transmission towers (PTTs) has drawn increasing attention from researchers in recent years; however, no long-term monitoring of the dynamic parameters of ...PTTs has previously been reported in the literature. This study performed the long-term monitoring of an instrumented PTT. An automated subspace identification technique was used to extract the dynamic parameters of the PTT from ambient vibration measurements taken over approximately ten months in 2017. Ten target modal frequencies were selected to explore the effects of environmental factors, such as temperature and wind speed, as well as the root-mean-square (RMS) acceleration response of the PTT. Variations in the modal frequencies of approximately 2% to 8% were observed during the study period. In general, among the environmental factors, the temperature was found to be the primary cause of decreases in the modal frequencies, except in the case of some of the higher modes. Typhoon Nesat, which affected the PTT on July 29th, 2017, seems to have decreased the modal frequencies of the PTT, especially for the higher modes. This reduction in the modal frequencies seems to have lasted for approximately two and a half months, after which they recovered to their normal state, probably due to a seasonal cool down in temperature. The reduction percentages in the modal frequencies due to Typhoon Nesat were quantified as approximately −0.89% to −1.34% for the higher modes, but only −0.07% to −0.46% for the remaining lower modes. Although the unusual reductions in the modal frequencies are reported in this study, the reason for this phenomenon is not clear yet. Further studies would be required in the future in order to find the cause.
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