Abstract
The large‐scale applicability of Zn‐metal anodes is severely impeded by the issues such as the dendrite growth, complicated hydrogen evolution, and uncontrollable passivation reaction. ...Herein, a negatively charged carboxylated double‐network hydrogel electrolyte (Gelatin/Sodium alginate‐acetate, denoted as Gel/SA‐acetate) has been developed to stabilize the interfacial electrochemistry, which restructures a type of Zn
2+
ion solvent sheath optimized via a chain‐liquid synergistic effect. New hydrogen bonds are reconstructed with water molecules by the zincophilic functional groups, and directional migration of hydrated Zn
2+
ions is therefore induced. Concomitantly, the robust chemical bonding of such hydrogel layers to the Zn slab exhibits a desirable anti‐catalytic effect, thereby greatly diminishing the water activity and eliminating side reactions. Subsequently, a symmetric cell using the Gel/SA‐acetate electrolyte demonstrates a reversible plating/stripping performance for 1580 h, and an asymmetric cell reaches a state‐of‐the‐art runtime of 5600 h with a high average Coulombic efficiency of 99.9 %. The resultant zinc ion hybrid capacitors deliver exceptional properties including the capacity retention of 98.5 % over 15000 cycles, energy density of 236.8 Wh kg
−1
, and high mechanical adaptability. This work is expected to pave a new avenue for the development of novel hydrogel electrolytes towards safe and stable Zn anodes.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Natural killer/T cell lymphoma (NKTCL) is an aggressive and heterogeneous entity of non-Hodgkin lymphoma, strongly associated with Epstein-Barr virus (EBV) infection. To identify molecular subtypes ...of NKTCL based on genomic structural alterations and EBV sequences, we performed multi-omics study on 128 biopsy samples of newly diagnosed NKTCL and defined three prominent subtypes, which differ significantly in cell of origin, EBV gene expression, transcriptional signatures, and responses to asparaginase-based regimens and targeted therapy. Our findings thus identify molecular networks of EBV-associated pathogenesis and suggest potential clinical strategies on NKTCL.
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•Integrated analysis provides insight into the molecular classification in NKTCL•EBV lytic genes play an important role on NKTCL pathogenesis•Genomic alteration-based molecular subtypes associate with clinical outcomes•MYC, histone acetylation, and PD-L1/2 are potential therapeutic targets of NKTCL
Xiong et al. propose an updated molecular subtyping scheme based on integrated analysis of the genomic and transcriptomic features of natural killer/T cell lymphoma from patient biopsies, and provide insights into pathogenesis and therapeutic targeting of the disease.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
This article proposes an equal-distance surrounding control method for second-order nonlinear multiagent systems (MASs) to encircle multiple moving targets with guaranteed collision avoidance. First, ...a distributed estimator is developed to approximate the center of moving targets. Then, an adaptive distributed control law is designed for the MASs to accomplish equal-distance surrounding collaboratively. In particular, conditions for assuring asymptotical stability for the closed-loop MAS are derived. Finally, experimental results with unmanned surface vessels are reported to substantiate the effectiveness of the proposed coordinated surrounding control method.
This article proposes a distributed bearing-only controller for multiple unmanned surface vessels (USVs) to encircle and rotate evenly around a motional target with inter-USV topologies. The ...distributed control law consists of three terms, i.e., a bearing-only estimation term to approximate the target state, an upper-level surrounding term to fulfill the target-surrounding mission, and a single-vessel regulation term to track the upper-level signal. Significantly, technical conditions are derived to guarantee the asymptotical stability of the closed-loop system. Finally, experimental results on a real platform composed of three HUSTER-0.3 USVs and a target vessel are conducted to substantiate the effectiveness of the proposed controller.
Highly reversible plating/stripping in aqueous electrolytes is one of the critical processes determining the performance of Zn‐ion batteries, but it is severely impeded by the parasitic side reaction ...and dendrite growth. Herein, a novel electrolyte engineering strategy is first proposed based on the usage of 100 mM xylitol additive, which inhibits hydrogen evolution reaction and accelerates cations migration by expelling active H2O molecules and weakening electrostatic interaction through oriented reconstruction of hydrogen bonds. Concomitantly, xylitol molecules are preferentially adsorbed by Zn surface, which provides a shielding buffer layer to retard the sedimentation and suppress the planar diffusion of Zn2+ ions. Zn2+ transference number and cycling lifespan of Zn∥Zn cells have been significantly elevated, overwhelmingly larger than bare ZnSO4. The cell coupled with a NaV3O8 cathode still behaves much better than the additive‐free device in terms of capacity retention.
A novel electrolyte engineering strategy based on the usage of a small amount of xylitol additive is first proposed, which inhibits the competitive hydrogen evolution reaction and accelerates cations migration by expelling active H2O molecules and weakening the electrostatic interaction between Zn2+ and SO42− ions in the primary solvation shell through oriented reconstruction of hydrogen bonds.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
In this brief, a distributed surrounding control problem is investigated for multiple unmanned surface vessels (USVs) with varying interconnection topologies. A distributed estimation-and-control ...hierarchical framework is developed, where an individual estimator is designed for a USV to predict the state of the target in an interconnection network with jointly dwellingly connected topologies. Thereby, the vessels could be governed to encircle the target in a convex hull, which evenly rotate around the target at the center. Moreover, asymptotical stability conditions are derived to guarantee the feasibility of the proposed surrounding controller. Finally, experiments are conducted for a real multi-USV system consisting of three 1.6 meters-long vessels and a differential GPS station, to verify the effectiveness of the proposed controller.
This article proposes a distributed guiding-vector-field (DGVF) controller for cross-domain unmanned systems (CDUSs) consisting of heterogeneous unmanned aerial vehicles (UAVs) and unmanned surface ...vehicles (USVs), to achieve coordinated navigation whereas maneuvering along their prescribed paths. In particular, the DGVF controller provides a hierarchical architecture of an upper level heterogeneous guidance velocity controller and a lower level signal tracking regulator. Therein, the upper level controller is to govern multiple heterogeneous USVs and UAVs to approach and maneuver along the prescribed paths and coordinate the formation simultaneously, whereas the low-level regulator is to track the corresponding desired guidance signals provided by the upper level module. Significantly, the heterogeneous coordination among neighboring UAVs and USVs is achieved merely by the lightweight communication of a scalar (i.e., the additional virtual coordinate), which substantially decreases the communication and computational costs. Sufficient conditions assuring asymptotical convergence of the closed-loop system are derived in the presence of the exponentially vanishing tracking errors. Finally, real-lake experiments are conducted on a self-established cross-domain heterogeneous platform consisting of three M-100 UAVs, two HUSTER-16 USVs, a HUSTER-12C USV, and a WiFi 5G wireless communication station to verify the effectiveness of the present DGVF controller.
Treatment-resistant schizophrenia (TRS) is common and debilitating. A subgroup of patients even has clozapine-resistant schizophrenia (CRS). We aimed to evaluate the efficacy and safety of ...electroconvulsive therapy (ECT) augmentation of clozapine for CRS. Systematic literature search of randomized controlled trials (RCTs) reporting on ECT augmentation of clozapine in CRS. Co-primary outcomes included symptomatic improvement at post-ECT assessment and study endpoint. Eighteen RCTs (n = 1769) with 20 active treatment arms were identified and meta-analyzed. Adjunctive ECT was superior to clozapine regarding symptomatic improvement at post-ECT assessment (Standardized Mean Difference (SMD) = -0.88, 95% Confidence Interval (CI): −1.33 to −0.44; I2 = 86%, P = 0.0001) and endpoint assessment (SMD: −1.44, 95%CI: −2.05 to −0.84; I2 = 95%, P < 0.00001), separating as early as week 1–2 (SMD = −0.54, 95%CI: −0.88 to −0.20; I2 = 77%, P = 0.002). Adjunctive ECT was also superior regarding study-defined response at post-ECT assessment (53.6% vs. 25.4%, Risk Ratio (RR) = 1.94, 95%CI: 1.59–2.36; I2 = 0%, P < 0.00001, number-needed-to-treat (NNT) = 3, 95%CI: 3–5) and endpoint assessment (67.7% vs. 41.4%, RR = 1.66, 95%CI: 1.38–1.99; I2 = 47%, P < 0.00001, NNT = 4, 95%CI: 3–8), and remission at post-ECT assessment (13.3% vs. 3.7%, RR = 3.28, 95%CI: 1.80–5.99; I2 = 0%, P = 0.0001, NNT = 13, 95%CI: 6–100) and endpoint assessment (23.6% vs. 13.3%, RR = 1.80, 95%CI: 1.39 to 2.35; I2 = 5%, P < 0.0001, NNT = 14, 95%CI: 6–50). Patient-reported memory impairment (24.2% vs. 0%; RR = 16.10 (95%CI: 4.53–57.26); I2 = 0%, P < 0.0001, number-needed-to-harm (NNH) = 4, 95%CI: 2–14) and headache (14.5% vs 1.6%; RR = 4.03 (95%CI: 1.54–10.56); I2 = 0%, P = 0.005, NNH = 8, 95%CI: 4–50) occurred more frequently with adjunctive ECT. No significant group differences were found regarding discontinuation and other adverse effects. Despite increased frequency of self-reported memory impairment and headache, ECT augmentation of clozapine is a highly effective and relatively safe treatment for CRS.
CRD42018089959
•Treatment-resistant schizophrenia is common and debilitating, and clozapine-resistant schizophrenia (CRS) poses a particluar clinical dilemma.•ECT augmentation of clozapine is a highly effective and safe treatment for CRS.•ECT Augmentation of clozapine increased frequency of self-reported memory impairment and headache.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Adolescents' family obligation is a cultural strength that shows enduring prevalence in China. Given that the meaning of family obligation has undergone rapid changes in recent decades, it is crucial ...to examine the role of family obligation in adolescent adjustment in contemporary China. More importantly, although past research has investigated the consequences of family obligation on adolescents' adjustment, little is known about the antecedents of Chinese adolescents' family obligation. Using a two‐wave longitudinal sample of 450 Chinese adolescents (mean age = 13.78 years, SD = .71 years; 49% female) and their parents, the current research explored two questions. First, this study examined the role of family obligation in adolescents' academic achievement, externalizing problems, and internalizing problems over early adolescence. Second, this study explored the role of parents in predicting Chinese adolescents' family obligation, specifically whether parental expectations or parental acceptance was predictive of adolescents' family obligation over time. Third, this study investigated whether family obligation is an underlying mechanism between parenting and Chinese adolescents' adjustment. Results showed that Chinese adolescents' family obligation was longitudinally associated with increased academic achievement and reduced externalizing problems. Moreover, perceived parental acceptance, but not parental expectations, was longitudinally associated with Chinese adolescents' greater family obligation. Notably, family obligation mediated the longitudinal effect of parental acceptance on Chinese adolescents' externalizing problems. By studying both the consequences and antecedents of Chinese adolescents' family obligation, this study helps provide a comprehensive understanding of this cultural strength.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Tailor-made carbonaceous-based cathodes with zincophilicity and hydrophilicity are highly desirable for Zn-ion storage applications, but it remains a great challenge to achieve both advantages in the ...synthesis. In this work, a template electrospinning strategy is developed to synthesize nitrogen and phosphorous co-doped hollow porous carbon nanofibers (N, P-HPCNFs), which deliver a high capacity of 230.7 mAh g
at 0.2 A g
, superior rate capability of 131.0 mAh g
at 20 A g
, and a maximum energy density of 196.10 Wh kg
at the power density of 155.53 W kg
. Density functional theory calculations (DFT) reveal that the introduced P dopants regulate the distribution of local charge density of carbon materials and therefore facilitate the adsorption of Zn ions due to the increased electronegativity of pyridinic-N. Ab initio molecular dynamics (AIMD) simulations indicate that the doped P species induce a series of polar sites and create a hydrophilic microenvironment, which decreases the impedance between the electrode and the electrolyte and therefore accelerates the reaction kinetics. The marriage of ex situ/in situ experimental analyses and theoretical simulations uncovers the origin of the enhanced zincophilicity and hydrophilicity of N, P-HPCNFs for energy storage, which accounts for the faster ion migration and electrochemical processes.
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