Abstract
Death from acute hemorrhage is a major problem in military conflicts, traffic accidents, and surgical procedures, et al. Achieving rapid effective hemostasis for pre-hospital care is ...essential to save lives in massive bleeding. An ideal hemostasis material should have those features such as safe, efficient, convenient, economical, which remains challenging and most of them cannot be achieved at the same time. In this work, we report a rapid effective nanoclay-based hemostatic membranes with nanoclay particles incorporate into polyvinylpyrrolidone (PVP) electrospun fibers. The nanoclay electrospun membrane (NEM) with 60 wt% kaolinite (KEM1.5) shows better and faster hemostatic performance in vitro and in vivo with good biocompatibility compared with most other NEMs and clay-based hemostats, benefiting from its enriched hemostatic functional sites, robust fluffy framework, and hydrophilic surface. The robust hemostatic bandages based on nanoclay electrospun membrane is an effective candidate hemostat in practical application.
Aluminosilicates, such as montmorillonite, kaolinite, halloysite, and diatomite, have a uniform bidimensional structure, a high surface-to-volume ratio, inherent stiffness, a dual charge ...distribution, chemical inertness, biocompatibility, abundant active groups on the surface, such as silanol (Si-OH) and/or aluminol (Al-OH) groups. These compounds are on the list of U.S. Food and Drug Administration-approved active compounds and excipients and are used for various medicinal products, such as wound healing agents, antidiarrheals, and cosmetics. This review summarizes the wound healing mechanisms related to the material characteristics and the chemical components. Numerous wound dressings with different active components and multiple forms have been studied. Then, medicinal mineral resources for use in hemostatic materials can be developed.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Long-term air contamination and pollution challenges in particulate matter (PM) have raised fervent concerns for public health, e.g., the PM physical damage or the bacteria and virus carried by the ...PM. The desired air filter, seeking both high filtration efficiency and low pressure drop remains challenging. Here, we report a bio-inspired spindle-knot halloysite nanotube microsphere-incorporated nanofiber (HNM-NF) filter with the assembly and shape structures of the spider silk. The resulting HNM-NFs exhibit integrated properties of high surface energy, hydrophilicity and strong PM capture. The spindle-knot structures could shrink the outer pore size on two-dimensional (2D) surface and construct the fluffy 3D reticular architecture, facilitating high-efficiency air pollutant capture (>85.0%) while maintaining low resistance to airflow (~39 Pa). The spindle-knot construction method was applicable to various materials (i.e., Al
2
O
3
, ZnO and TiO
2
) and volume production of the microsphere-incorporated NF cartridge. The diversified spindleknot construction will be valuable for adapting to meet different filtration requirements.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The potential safety hazards and limited lithium resources of lithium‐ion batteries (LIBs) have restricted their practical application. Potassium‐ion batteries (KIBs) are a novel energy storage ...technology with great cost advantages and are a promising alternative to LIBs. However, because of the large ionic radius of K+, the common anode materials used in LIBs exhibit a large volumetric expansion and structural collapse in the process of charging and discharging in a KIB. In this work, the prepared nitrogen‐doped porous carbon fibers (P‐CFs) from bombyx mori silk cocoons via a simple KCl activation and high‐temperature carbonization method. The P‐CFs possess a large specific surface area and one‐dimensional porous structure, offering facile storage and fast transport channels for K+ ions. When used as an anode for KIBs, the P‐CFs exhibit a high reversible specific capacity of 275 mAh·g−1 at a current density of 0.1 A·g−1 after 500 cycles and even retain a capacity of 100 mAh·g−1 after 5000 cycles at 2 A·g−1. This study demonstrates a simple strategy for the low‐cost synthesis of nitrogen‐doped porous carbon fibers from an environmental friendly biomaterial, with excellent electrochemical performance as an anode for KIBs.
Nitrogen‐doped carbon anode has one‐dimensional porous structure and a large specific surface area, which is prepared from bombyx mori silk cocoons via a simple KCl activation and high‐temperature carbonization method. The prepared nitrogen‐doped porous carbon have excellent long‐cycle performance when used as an anode for KIBs, showing a discharge capacity of 100 mAh·g−1 after 5000 cycles at 2 A·g−1.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Use of breath protective equipment (e.g., air-filtering masks) is essential to protect personal health from the serious threat of air contamination and bacterial infection. As core filter layer ...materials of face masks, the nanofiber can be imparted with multifunctionality by nanoparticles modification, such as particulate matter (PM) filtration, bacterial inhibition and so on. Herein, the electrospun filter membranes were developed through incorporating the halloysite nanotubes (HNTs) and zinc oxide nanoparticles with the polycaprolactone (PCL) nanofibers. The composite HNTs-ZnO/PCL nanofibers exhibit high antibacterial efficiency of Staphylococcus aureus (S. aureus, 97.9%) and Escherichia coli (E. coli, 95.9%) bacterial strains. The PM particles filtration performance of HNTs-ZnO/PCL membrane can be obviously improved with an enhanced mechanical strength. Thus, the HNTs-ZnO/PCL nanofiber membranes might be a competitive filtering material for antibacterial protective mask filter layer, and the successful fabrication of the HNTs-ZnO/PCL face masks furtherly indicates the great potential in practical application.
•The nanofiber membarne with the fluffy network structures, was generated incorporation of HNTs and ZnO nanoparticles.•The nanofiber membrane exhibited efficient PM2.5 filtration as well as low airflow resistance.•The nanofiber membrane showed excellent antibacterial effect (E. coli and S. aureus) benefit from HNTs and ZnO.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Segmental bone defects caused by trauma, tumor resection or congenital malformations are often reconstructed with autologous, allogeneic bone grafts or artificial bone materials, of which, about 5% ~ ...10% will have delayed healing or even nonunion of fractures. The loss of periosteum and excessive accumulation of ROS in fracture site leads to the aging of osteoblasts and the decline of their proliferation and differentiation, thus affecting the fracture healing process. In this study, we prepared a functional modified artificial periosteum β-TCP/MnO
/PCL(β-TMP) by electrospinning with a function of catalyzing decomposition of H
O
. We examined the surface morphology of β-TMP, the concentration of Ca, P and Mn of β-TMP, as well as the diameter distribution range of nanofibers on β-TMP. Through X-ray diffraction patterns and Fourier transform infrared spectra, β-TMP was characterized and its hydrophilicity was tested. The release of Mn
and Ca
of 0.1 and 0.05% β-TMP in different pH values (7.4 and 5.5) determined by ICP. We also identified that β-TMP could reduce the level of ROS in cells by lowering the level of H
O
. 0%, 0.05% and 0.1% β-TMP displayed good cell compatibility, cell adhesion and cellular morphology in the condition with or without H
O
. 0.5% β-TMP showed compromised cell compatibility in normal condition, however, the compromised phenotypes could be partially rescued in the present of H
O
. Compared with 0%, 0.05% and 0.1% β-TMP displayed higher osteoblastic differentiation with or without H
O
in BMSCs as well as in MG-63. In sum, β-TMP helped osteogenesis and promoted repair of bone defects.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Segmental bone defects caused by trauma, tumor resection or congenital malformations are often reconstructed with autologous, allogeneic bone grafts or artificial bone materials, of which, about 5% ~ ...10% will have delayed healing or even nonunion of fractures. The loss of periosteum and excessive accumulation of ROS in fracture site leads to the aging of osteoblasts and the decline of their proliferation and differentiation, thus affecting the fracture healing process. In this study, we prepared a functional modified artificial periosteum β‐TCP/MnO2/PCL(β‐TMP) by electrospinning with a function of catalyzing decomposition of H2O2. We examined the surface morphology of β‐TMP, the concentration of Ca, P and Mn of β‐TMP, as well as the diameter distribution range of nanofibers on β‐TMP. Through X‐ray diffraction patterns and Fourier transform infrared spectra, β‐TMP was characterized and its hydrophilicity was tested. The release of Mn2+ and Ca2+ of 0.1 and 0.05% β‐TMP in different pH values (7.4 and 5.5) determined by ICP. We also identified that β‐TMP could reduce the level of ROS in cells by lowering the level of H2O2. 0%, 0.05% and 0.1% β‐TMP displayed good cell compatibility, cell adhesion and cellular morphology in the condition with or without H2O2. 0.5% β‐TMP showed compromised cell compatibility in normal condition, however, the compromised phenotypes could be partially rescued in the present of H2O2. Compared with 0%, 0.05% and 0.1% β‐TMP displayed higher osteoblastic differentiation with or without H2O2 in BMSCs as well as in MG‐63. In sum, β‐TMP helped osteogenesis and promoted repair of bone defects.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Effective and risk-free hemostasis procedures are desirable but remain challenging. Halloysite nanotubes are FDA-approved aluminosilicate mineral materials that have coagulation properties. Herein, ...the poly (lactic acid) electrospun nanofibers with high biocompatibility were connected to halloysite nanotube microspheres to prevent potential distal thrombosis risks arising from detached individual halloysite nanotubes. Compared to halloysite nanotubes, halloysite nanotube microspheres with a diameter of approximately 3.0 μm exhibited tightened incorporation of nanofibers and semi-exposed interaction area on surface. With the addition of 7 wt% halloysite nanotube microspheres, the optimum blood coagulation time in vitro was 171 s. The main functional components of blood adhered to the halloysite nanotube microsphere-incorporated nanofiber membrane, and further, the free platelets were activated, and then a blood clot formed. Thus, the aforementioned halloysite nanotube microsphere-incorporated nanofiber membrane with acceptable air breathability and mechanical properties is a viable candidate as a hemostatic material for compressible hemorrhage control, like bandage.
•Halloysite nanotube microspheres were connected by poly (lactic acid) electrospun nanofibers.•The hemostatic nanofiber membrane exhibited semi-exposed halloysite nanotube microspheres.•Halloysite nanotube microsphere inherited hemostatic properties from halloysite nanotube.•The optimum blood coagulation time in vitro was 171 s.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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•PCL-nHA-nZnO film with good nanoparticles dispersion and 3D nanofiber framework.•PCL-nHA-nZnO film showed excellent antibacterial function.•PCL-nHA-nZnO film has putative application ...in the field of BTI repair.
The bone-tendon interface (BTI) is a graded structure consisting of bone, mineralized and nonmineralized fibrocartilage, and tendons. Due to the complexity of the BTI structure, BTI healing is particularly challenging. To achieve a better material for BTI healing, polycaprolactone (PCL)/hydroxyapatite (HA)/ZnO films were constructed by the electrospinning method; in addition, the relevant material characteristics were tested. After culturing MC3T-E1 cells, ATDC5 cells, mouse primary fibrochondrocytes, and mouse primary tenocytes on films, PCL-5%HA-1%ZnO films (HA and ZnO weight ratios of 5% and 1%, respectively) displayed superior cell compatibility and cell adhesion. PCL-5%HA-1%ZnO films also promoted osteogenesis, chondrogenesis, fibrocartilage formation, and tendon healing. The antibacterial characteristics of PCL-5%HA-1%ZnO films were also identified in this study. The PCL-5%HA-1%ZnO films have great application potential in the field of BTI repair.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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