Objective:
To evaluate short-term (2003–2014) cancer incidence and mortality trends in Italy.
Methods:
Italian Cancer Registries data, available in the AIRTUM database, from 17 out of 20 regions were ...used. The number of incident cases and deaths were estimated for those registries and those years with incomplete information. Age-standardized rates, overall and stratified by geographic area, region, sex, cancer site, and major age group, were computed. Time trends were expressed as annual percent change of rates.
Results:
In Italy, among males, incidence rates for all cancers showed during 2003–2014, a significant decrease (−0.9%/year), with stronger reductions in the northwest (−1.3%/year) and northeast (−2.0%/year since 2006) than in central (−0.7%/year) and southern (−0.4%/year) areas. Among females, a weak but significant overall reduction was detected (−0.1%/year), with a stronger decrease in the northwest (−0.5%/year). Incidence increased among women in the south (0.3%/year) of Italy. Mortality decreased in both sexes (−1.0%/year among males and −0.5%/year among females), but not in the south, where rates had a stable tendency.
Conclusions:
Incidence among males decreased, supported by trends for prostate, lung, colorectal, and urinary bladder cancers; among females the. The overall cancer incidence trend was stable, or even decreasing, in the northern and central areas and increasing in the southern areas, due to lung, thyroid, and melanoma rising trends. Study results provided information on the outcomes, in terms of cancer incidence and mortality, of primary and secondary prevention measures employed by regional health systems.
Full text
Available for:
NUK, OILJ, SAZU, UKNU, UL, UM, UPUK
Abstract
Background
Diabetes is a health emergency: in Italy over 3 million people are diabetics. In Lazio region a high percentage of population is affected by diabetes. Data are collected from two ...Italian population surveillance systems, Passi during 2015-18 and Passi d'Argento (PdA) during 2016-2018; this trasversal study was conducted to investigate diabetes awareness and clinical management in Lazio.
Methods
Passi and PdA collect representative data providing a telephone interview with a standardized questionnaire to a representing sample (18-69 and over 65 aged respectively), randomly selected and sex-and-age stratified. In both questionnaires a diabetes section assesses diagnosis, knowledge of HbA1c, health setting and number of annual checks. Data refer to whom affirm to be diagnosed with diabetes. Results are shown by prevalence and 95% CI.
Results
Diabetes prevalence grows with age, it does not reach 1% in people under 50 years, it is 9% for the age group 50-69 years and 20% in over 75. Serious economic difficulties and low education level are related to higher prevalence. Among diabetics, 18.7% (15.42-22.46) from Passi and 24.2% (20.29- 28.61) from PdA ignore HbA1c. About clinical management, 1.5% (0.73-2.90) in Passi do not receive any care from doctor; the whole sample of PdA receives medical care. Most of the respondents in both surveillance are managed by diabetes care team (43.76% in Passi - 39.87% in PdA), reporting to receive care about three times a year on average. No significant differences are observed between economic and education levels.
Conclusions
High percentage of diabetics, not knowing HbA1c, are not aware about disease. Patient empowerment is necessary to gain control over disease and increases capacity to act on it. Health education should be improved and diagnostic and therapeutic pathways, recently introduced in Lazio Region, should be better structured. Population surveillances allow to plan and evaluate programs and interventions.
Key messages
Fight the lack of awareness with patient empowerment to gain control over diabetes. Population surveillances are valuable tools to plan and evaluate programs and interventions in Public Health.
Full text
Available for:
NUK, OILJ, UL, UM, UPUK, VSZLJ
The molecular features of hepatitis C virus (HCV) replication in human fetal hepatocytes (HFHs) were addressed in this study. Using a competitive reverse-transcription polymerase chain reaction ...(RT-PCR) assay for the quantitation of HCV-RNA molecules, the highest level of viral replication was detected 30 days' postinfection. At this time point, viral particles of 41 to 45 nm in diameter accumulated in the cell cytoplasm. Their density in cell extracts and culture medium was distributed between heavy (1.180-1.360 g/cm3) and light fractions (1.105-1.050 g/cm3) of a sucrose gradient, while, in the serum inoculum, they had a positive fraction at 1.180 g/cm3. In infected HFHs, minus-strand HCV RNA was observed in fractions displaying a sedimentation coefficient of 28 S to 18 S, while plus-strand HCV RNA showed a peak restricted to the 21 S fraction; the HCV RNA of serum inoculum had a sedimentation coefficient of 38 to 40 S, which revealed the presence of HCV RNA of unique positive polarity. The 21 S RNA fraction of cell extracts was resistant to 20 minutes of RNase I digestion, while the same incubation time totally inactivated a comparable amount of HCV RNA purified from the serum inoculum, revealing the presence of completely and/or partially double-stranded HCV-RNA molecules in the infected cells. Detection in HFHs of replicative forms and replicative intermediates suggests that the dynamic profile of HCV replication in these cells is similar to that described in other flaviviruses. (Hepatology 1997 Nov;26(5):1328-37)
Full text
Available for:
BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
: In this study we examined two unrelated patients affected with the lethal variant of junctional epidermolysis bullosa with pyloric atresia (PA‐JEB) who were found to carry mutations in the ...integrin β4 subunit gene (ITGB4). Although in both patients Northern blot analysis showed only a 50% reduction in the level of ITGB4 transcript, a complete lack (patient 1) or a strong reduction (patient 2) of β4 immunoreactivity was observed in the skin. Using immunoprecipitation analysis, integrin β4 could not be visualized in patient 1 cells while a markedly reduced amount (∼20%) of normal sized β4 chains was detected in patient 2. These data suggested the presence of ITGB4 mutations that interfere with both mRNA and protein stability. Using molecular analysis, patient 1 was shown to be a compound heterozygous for a single amino acid deletion (ΔN318) and a not yet identified mutation that induces a very rapid decay of the encoded mRNA transcript. Patient 2 was, instead, a compound heterozygous for a novel 4‐bp tandem duplication (4298–4299ins4) and a previously described missense mutation (R252C). Our data support the notion that PA‐JEB lethal phenotypes associated with a markedly decreased/absent α6β4 expression can be due not only to the presence of null alleles, but also to specific mutations leading to protein instability and/or altered function.
Full text
Available for:
BFBNIB, DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
The impact of a screening programme on colorectal cancer (CRC) incidence in its target population depends on several variables, including coverage with invitations, participation rate, positivity ...rate of the screening test, compliance with an invitation to second-level assessment and endoscopists' sensitivity. We propose a synthetic indicator that may account for all the variables influencing the potential impact of a screening programme on CRC incidence.
We defined the 'rate of advanced adenoma on the target population' (AA-TAP) as the rate of patients who received a diagnosis of advanced adenoma within a screening programme, divided by the programme target population. We computed the AA-TAP for the CRC Italian screening programmes (biennial faecal immunochemical test, target population 50-69 year olds) using the data of the Italian National Survey from 2003 to 2016, overall and by region, and assessed the association between AA-TAP and CRC incidence fitting a linear regression between the trend of regional CRC incidence rates in 50-74 year old subjects and the cumulative AA-TAP.
In 2016, the AA-TAP at a national level was 105×100 000, whereas significant differences were observed between the northern and central regions (respectively 126 and 149×100 000) and the South and Islands (36×100 000). The cumulative AA-TAP from 2004 to 2012 was significantly correlated with the difference between CRC incidence rates in 2013-2014 and those in 2003-2004 (p=0.009).
The AA-TAP summarises into a single indicator the potential impact of a screening programme in reducing CRC incidence rates.
Objective:
To evaluate the trends of colorectal cancer (CRC) incidence and mortality rates from 2003 to 2014 in Italy by age groups and regions.
Methods:
We used the data of 48 cancer registries from ...17 Italian regions to estimate standardized incidence and mortality rates overall and by sex, age groups (<50, 50–69, 70+ years), and geographic area (northwest, northeast, center, south, and islands). Time trends were expressed as annual percent change in rates (APC) with 95% confidence intervals (95% CI).
Results:
Incidence rates decreased from 104.3 (2003) to 89.9 × 100,000 (2014) in men and from 64.3 to 58.4 × 100,000 in women. Among men, incidence decreased during 2007–2010 (APC −4.0, 95% CI −6.0 to −1.9) and 2010–2014 (APC −0.7, 95% CI −1.4 to 0.0), while in women it linearly decreased during the whole period (APC −1.1, 95% CI −1.4 to −0.8). Mortality rates showed a linear reduction both in men (APC −0.7, 95% CI −1.0 to −0.3) and women (APC −0.9, 95% CI −1.2 to −0.6) and decreased respectively from 41.1 to 39.2 × 100,000 and from 24.6 to 23.1 × 100,000.
In the 50- to 69-year-old range (screening target age), incidence showed a prescreening increase, followed by a peak after screening started, and a decline thereafter. Incidence and mortality rates significantly decreased in all areas but in the south and islands, where incidence increased and mortality remained stable.
Conclusions:
A renewed commitment by all regional health systems to invest in primary (i.e., lifestyle) and secondary (i.e., screening programs) prevention is of utmost importance.
Full text
Available for:
NUK, OILJ, SAZU, UKNU, UL, UM, UPUK
PDF
