This article explores the experience of the Afro-Colombian movement over the course of two peace processes, investigating the relationship between opportunities for participation and effective ...inclusion. The 1991 Constituent Assembly that emerged from the peace processes of the late 1980s presented a particularly open opportunity for civil society participation, and yet the Afro-Colombian movement was unable to gain representation in negotiations for a new constitution. In the 2016 peace process with the Fuerzas Armadas Revolucionarias de Colombia, or FARC, despite insistence from the government that its negotiations with FARC were exclusively bilateral, the Afro movement was able to gain a seat at the table along with its Indigenous counterparts and generate a commitment from both parties to protect ethnic rights, known as the Capitulo Etnico (Ethnic Chapter). In contrast to existing literature that focuses on international actors as drivers of inclusion, we argue that effective inclusion reflects in large part the internal capacity, coherence, and unity of the movements themselves.
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CEKLJ, DOBA, IZUM, KILJ, NUK, ODKLJ, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Familial recurrent hydatidiform mole (RHM) is a maternal-effect autosomal recessive disorder usually associated with mutations of the NLRP7 gene. It is characterized by HM with excessive ...trophoblastic proliferation, which mimics the appearance of androgenetic molar conceptuses despite their diploid biparental constitution. It has been proposed that the phenotypes of both types of mole are associated with aberrant genomic imprinting. However no systematic analyses for imprinting defects have been reported. Here, we present the genome-wide methylation profiles of both spontaneous androgenetic and biparental NLRP7 defective molar tissues. We observe total paternalization of all ubiquitous and placenta-specific differentially methylated regions (DMRs) in four androgenetic moles; namely gain of methylation at paternally methylated loci and absence of methylation at maternally methylated regions. The methylation defects observed in five RHM biopsies from NLRP7 defective patients are restricted to lack-of-methylation at maternal DMRs. Surprisingly RHMs from two sisters with the same missense mutations, as well as consecutive RHMs from one affected female show subtle allelic methylation differences, suggesting inter-RHM variation. These epigenotypes are consistent with NLRP7 being a maternal-effect gene and involved in imprint acquisition in the oocyte. In addition, bioinformatic screening of the resulting methylation datasets identified over sixty loci with methylation profiles consistent with imprinting in the placenta, of which we confirm 22 as novel maternally methylated loci. These observations strongly suggest that the molar phenotypes are due to defective placenta-specific imprinting and over-expression of paternally expressed transcripts, highlighting that maternal-effect mutations of NLRP7 are associated with the most severe form of multi-locus imprinting defects in humans.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The Well-Being of the Elderly: Memory and Aging Maldonado Briegas, Juan José; Sánchez Iglesias, Ana Isabel; Ballester, Sergio González ...
Frontiers in psychology,
05/2020, Volume:
11
Journal Article
Peer reviewed
Open access
The world population increases every day as a consequence of the increase in life expectancy and longevity of humans. There are several factors analyzed in the different studies that have been ...developed on this topic. The research carried out in this field distinguishes biological, cultural, and cognitive factors; some of them describing similar results, while many others showed antagonistic results. Our study was oriented to the accomplishment of a bibliographical revision with the objective to verify the scientific production on "memory, cognitive development, and aging linked with longevity"-international/ national studies were analyzed and identified. The method carried out was through a research in the databases: SciELO, UAM, PePSIC, LILACS, PubMed, PsycINFO, Dialnet, and Teseo; in a period of 10 years, considering the studies published between January 2008 and December 2017. From the results found at first, 16 articles were analyzed after the application of the exclusion criteria. Likewise, we analyzed the relationship of longevity with the level of studies in Spain from a group of people over 60 years of age counted in January 2017. The literature review determined that there are psycho-cultural aspects that have a decisive influence on the increase in longevity, such as the performance of activities with positive mental states, positive emotions and experiences, and the level of studies.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
5.
A Bayesian Model to Predict COVID-19 Severity in Children Domínguez-Rodríguez, Sara; Villaverde, Serena; Sanz-Santaeufemia, Francisco J. ...
The Pediatric infectious disease journal,
08/2021, Volume:
40, Issue:
8
Journal Article
Peer reviewed
Background:
We aimed to identify risk factors causing critical disease in hospitalized children with COVID-19 and to build a predictive model to anticipate the probability of need for critical care.
...Methods:
We conducted a multicenter, prospective study of children with SARS-CoV-2 infection in 52 Spanish hospitals. The primary outcome was the need for critical care. We used a multivariable Bayesian model to estimate the probability of needing critical care.
Results:
The study enrolled 350 children from March 12, 2020, to July 1, 2020: 292 (83.4%) and 214 (73.7%) were considered to have relevant COVID-19, of whom 24.2% required critical care. Four major clinical syndromes of decreasing severity were identified: multi-inflammatory syndrome (MIS-C) (17.3%), bronchopulmonary (51.4%), gastrointestinal (11.6%), and mild syndrome (19.6%). Main risk factors were high C-reactive protein and creatinine concentration, lymphopenia, low platelets, anemia, tachycardia, age, neutrophilia, leukocytosis, and low oxygen saturation. These risk factors increased the risk of critical disease depending on the syndrome: the more severe the syndrome, the more risk the factors conferred. Based on our findings, we developed an online risk prediction tool (https://rserver.h12o.es/pediatria/EPICOAPP/, username: user, password: 0000).
Conclusions:
Risk factors for severe COVID-19 include inflammation, cytopenia, age, comorbidities, and organ dysfunction. The more severe the syndrome, the more the risk factor increases the risk of critical illness. Risk of severe disease can be predicted with a Bayesian model.
Numerous offshore wave energy converter (WEC) designs have been invented; however, none has achieved full commercialization so far. The primary obstacle impeding WEC commercialization is the elevated ...levelized cost of energy (LCOE). Consequently, there exists a pressing need to innovate and swiftly diminish the LCOE. A critical challenge faced by WECs is their susceptibility to extreme wave loads during storms. Promising concepts must demonstrate robust design features to ensure resilience in adverse conditions, while maintaining efficiency in harnessing power under normal sea states. It is anticipated that the initial commercial endeavors will concentrate on near-shore WEC technologies due to the cost advantages associated with proximity to the coastline, facilitating more affordable power transmission and maintenance. In response, this manuscript proposes a pioneering near-shore WEC concept designed with a survivability mode that is engineered to mitigate wave loads during severe sea conditions. Moreover, prior investigations have highlighted favorable resonance properties of this novel concept, enhancing wave power extraction during recurrent energetic sea states. This study employs numerical and physical modelling techniques to evaluate wave loads on the proposed WEC. The results indicate a remarkable 65% reduction in wave loads on the moving floater of the WEC during a range of sea states under the implemented survivability mode.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The question of whether the entrepreneur is born or made, forces us to respond that the entrepreneurial culture clearly breaks with the myth that entrepreneurs are born. Currently, it is considered ...that entrepreneurial skills can be acquired like any other discipline and that is why it should be taught (Timmons, 2003). Their teaching and learning are key to the well-being of the teacher and to the positive achievement of the students. The entrepreneurial culture is an educational objective of developed societies and has its origin in the business culture (Peña Calvo et al., 2015). There are two current models, American and European (Erkkilä, 2000). The one that develops in the Extremadura region (Spain), based on the European model, tries to create a vital state in the participating students that enhances competences such as creativity, personal initiative or self-confidence, elements that try to generate a true motivation to undertake. The motivated, accomplished and positive teacher contributes to that achievement and achieving it favors the well-being of teachers. It's a round trip. It is a "do ut des." In our research, we evaluated four entrepreneurial culture programs in the classroom: "Junioremprende," "Teenemprende," "Experemprende," and "Youthemprende." The teachers involved in the programs are 356, and the valid questionnaires are 154. The students enrolled in the programs are 4800, and the questionnaires valid 1198. In the questionnaire, one of the key questions is "general teacher satisfaction," with 17 common questions for all the programs. An essential question posed is: "I am satisfied with the achievements obtained by my students to participate in the program" The results of our research, according to a seven-point Likert scale, gives a very high degree of teachers' satisfaction. Their satisfaction was centered on the perception of their teachings are conducive to the achievement of his students. The degree of teacher satisfaction for each of the programs and significantly means differences were found with Junior program resulted the more satisfied for teachers. For students, participation in the programs resulted in high development of entrepreneurial competencies. Similarly to teachers results, Junior program was found more significant in developing students' entrepreneurial competencies indicating that entrepreneurial education is very appropriate for children. Findings of this study suggest that entrepreneurial education should be encouraged for students at every stage of education.
Numerical models are key tools to characterize hydrodynamical patterns of coastal environments and anticipate the potential effects of hazardous and extreme events, anthropogenic intervention or ...climate change. In this work, the openTELEMAC-MASCARET modelling system was selected to represent the dynamics of the Minho estuary, a very shallow estuary located at the Northwestern Iberian Peninsula coast. Calibration and validation results confirm the accuracy of the numerical tool, with small root mean square errors, close to null bias and the close to unit correlation and skill coefficients obtained for water level and currents velocity at several estuarine locations. The obtained results depict a tide dominated estuary with a delay in the tide phase and a marked asymmetry in the tide curve that increases upriver. Additionally, an upstream diminution of M2 and an upstream augmentation of M4 was observed, classifying this estuary as flood-dominated. The represented current patterns show that variations in the intensities of the main driving forces alter the behaviour of the hydrodynamical patterns within the estuary, with a clear dependence on bathymetric and topographic characteristics. During flood events, larger estuarine regions become submerged due to the low margins and the wetland characteristics, highlighting the need for accurate numerical models that can be used as a decision-making support tool for effective and integrated estuarine management.
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